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Category: AAI Rejuvenation Clinic Blog

March 21, 2021 by Joseph Fermin 0 Comments


Taking control of your hormones gives you better control in life; and with a vast knowledge of our hormones, it is possible to control growth and almost every part of our development and body functionality.


Hormones are tiny chemical substances that travel from the endocrine glands to the intended location through the bloodstream. Because there are many different types of hormones and their functions vary from type-to-type, their destinations will differ based on the function it is meant to perform. 

Hormones greatly influence the growth, development, and activity of an organism. It is important to note that hormones are produced in response to various stimuli (internal or external. They circulate through the bloodstream and based on the response they will exert their influence on certain organs called target organs. They can either speed up (excites), slow down (inhibits), or alter the activities of their target organs.

This is why hormones play such an enormous role in aging. Certain hormones will speed up or slow down growth functions and development as mentioned above. This is why kid’s and teenagers’ hormones are always said to be out of whack. They are speeding up and slowing down as kids age quickly in the beginning and then as they get older it tapers off. 

Our target organs have cells with unique receptor molecules on their surfaces. The appropriate hormones then fit into these receptor molecules to engage in their function. These functions are achieved by either affecting the permeability of the cell to certain substances, promoting protein synthesis, or increasing the activity of certain enzymes for that organ.

This is where certain hormones can be affected by things such as human growth hormone treatment and anti-aging techniques. When these processes are disrupted or changed around, we may be able to slow down hormones that cause us to age faster. 

Hormones also assist the nervous system in coordinating the various parts of the body to develop harmoniously. Therefore, many hormones work on maintaining a consistent internal environment. Some hormones directly impact growth and development while others may be focused on agility. Some hormones also may affect several organs at once while others only target specific areas. 

Typically, the body responds to hormones slowly. Examples of slow responses would be growth in general, sexual maturity, and pregnancy. Each of these could take months to years rather than a few hours. The exception is that a few hormones bring about a rapid response, i.e., adrenaline. 

Testosterone levels are a great example of hormones that may come about quickly but then drop off at a gradual rate in men after the age of 30 or 40. Testosterone is a younger boy will have a quick adrenaline response to sexual maturity but as they get older that response will slow and become less prevalent. Of course, unless you engage in testosterone therapy. 

Seeing that hormones have a powerful effect on the body systems, their production must be balanced as an imbalance can produce very severe outcomes. Serious illnesses can arise if an endocrine organ malfunctions and produces too much or too little of its hormones.



Humans have several glands that produce secretions. Some of which deliver their secretion to wherever they are needed through ducts. There are known as exocrine glands, Hormones however are produced and secreted from glands that do not have ducts called endocrine glands or ductless glands. A ductless gland as the name implies does not have a duct or tube through which its secretions are carried away into the body system.

While the exocrine gland pours its secretions out of the body, endocrine glands are glands of internal secretion Hormones produced by these glands pass directly into the bloodstream. The blood plasma then distributes these hormones to the target organ. 

The body requires only a small number of hormones to bring about their effects on an organ or system, these amounts in the blood are usually regulated by some feedback mechanism. If it is overproduced, a signal is sent to the production center to stop production. If it is lacking, a signal is sent to begin production and secretion. Once the effects of the hormones are over, they are destroyed in the liver and excreted from the body through urine, some within minutes and others lasting for days.

How this relates to hormone therapy is that these hormones can be blocked/altered from reaching the cell receptors mentioned before. If the function, is not completed or able to work then this can have anti-aging effects as the process is slowed down some. 


The Endocrine system comprises all the endocrine glands in the human body. The human body consists of different endocrine glands positioned at specific areas of the body. These glands could be discrete like thyroid and adrenals, or a group(s) of cells within an organ such as the cells in the pancreas that produce insulin. 

Before considering the different types of glands, their function, effects of over secretion, and deficiency, it is important to consider a small body at the base of the forebrain. It sits just above the pituitary gland called the hypothalamus and it regulates activities such as temperature control, sleep, and thirst. It also collects information from the brain and sense organs while monitoring the level of hormones in the blood. It acts as a link between the nervous system and the endocrine system.


There are essentially seven endocrine glands in the human body. Each has a list of hormonal secretions. These glands are: 

  1. Pituitary Gland
  2. Thyroid Gland
  3. Adrenal Medulla
  4. Adrenal Cortex
  5. Pancreas
  6. Ovaries
  7. Testes

But the glands we mostly focus on when it comes to hormonal therapy are the pituitary, thyroid, ovaries, adrenal medulla, and testes. This is because the easiest hormones to control with anti-aging are melatonin, DHEA, testosterone, estrogen, endorphins, and so on. 


The pituitary gland is also referred to as the master gland this is because its hormones control the activities of the other glands. It is located at the base of the brain, just below the hypothalamus and it consists of two lobes – the anterior lobe and the posterior lobe. The anterior lobe secretes hormones such as growth hormones, gonadotropins, thyroid-stimulating hormones, adrenocorticotropic hormone, and prolactin. The posterior lobe however releases oxytocin and antidiuretic hormone.

While the pituitary gland controls a lot of different hormones, we can zone in on the growth hormone and the effects it has on aging. 


Growth hormones are produced mainly during childhood or adolescence, it is produced from the pituitary gland and is stimulated by the growth hormone-releasing factor from the hypothalamus. Its release is influenced by the age of an individual, sometimes stress and exercise.

Growth hormones are targeted at most tissues in the body to promote growth, increase cell production and muscle mass. It also helps in the regulation of protein metabolisms, carbohydrates, and fats. This is done by enhancing protein synthesis, breaking down stored fats, and decreasing the uptake of glucose by cells while increasing the level of glucose in the blood.

The growth hormone is one of the main hormones that can be impacted by hormone therapy in an effort to create an absence in the growth hormone itself. By blocking this hormone from its receptors, you can slow down age-development for the physical appearance. 

Because the idea is to mimic the hormone produced by the pituitary gland, the injections are made identical in the labs. They then are set out to be administered by injection therapy from a medical professional. These injections go into the fatty tissues of the body. Likely you will go a series of injections ever so often. 


The essential duty of the thyroid-stimulating hormone as the name implies is to regulate the secretion of thyroid hormones from the thyroid gland and therefore; like the thyroid gland, plays its role in growth and metabolism, and skin function. 

While the specific hormones are the ones that would be altered under the thyroid gland it is still important to address TSH as means to anti-aging because it is the starting point for the thyroid functions. 


Adrenocorticotropic secretion is majorly caused by stress stimuli such as pain, shock, infection, or extreme cold. It stimulates the growth of adrenal glands and the release of hormones such as cortisol from the adrenal cortex.

Stress plays a major factor in our aging as more stress ages our bodies faster. That’s why regulating our cortisol levels can be a major factor in hormone therapy treatment. 

For instance, if you are lacking or have excessive levels of ACTH this may be treated. 

Deficiency: The lack of ACTH would decrease the secretion of hormones from the adrenal glands. In severe cases the person would h the inability of an individual to cope with stress, therefore, leading to the death of such a one.

Excess/Over secretion: On the other hand, leads to the excessive release of hormones from the adrenal glands.


The thyroid gland is a butterfly-shaped gland located at the neck region, just below the larynx. It produces and stores the triiodothyronine (T3) and thyroxine (T4) hormones, these hormones are similar in chemical structures and perform basically the same function in the body.

The thyroid gland in particular has been linked to aging. This is because increased aging has been directly correlated with lower TSH levels as briefly mentioned.   


The release of the T3 and T4 are stimulated by the secretion of the Thyroid-stimulating hormone from the pituitary gland. These hormones accelerate the rate of metabolism by causing the breakdown of glucose and fats to release energy and increasing cellular respiration and production of heat, they also enhance the physical growth and mental development of an individual.

Deficiency: The lack of these hormones is known as hypothyroidism. In infants, it leads to cretinism which results in mental, physical, and sexual retardation. In adults, however, it results in a decrease in the rate of metabolism, goiter, a significant drop in body temperature, and weight gain since less food is respired.

Excess/Over secretion: Known as hyperthyroidism this leads to an increase in metabolic rate which would result in an increase in heart rate, oxygen consumption, and body temperature. It could also lead to over anxiety and weight loss and in some cases the growth of tissues behind the eye known as exophthalmos resulting in the protrusion of the eyeballs from the eye orbits.


The adrenal medulla occupies the center of the adrenal gland and produces the hormone adrenaline (epinephrine), which is secreted in times of fright, anger, stress, and anxiety.


The adrenaline has several functions, including;

1.      The increase of body blood sugar by speeding up the breakdown of glycogen into glucose in the liver and muscles.

2.      It helps to increase the metabolic rate and thereby more energy Is released into the tissues for respiration.

3.      It helps in the increase of muscle strength and acts as fatigue resistance.

4.      It helps in the increase of heart rate and a rise in blood pressure to ensure a faster passage of oxygen and glucose to the muscles.

5.      It aids in the constriction of arteries in the skin causing pallor, thereby channeling more blood to the muscles.

6.      It increases blood coagulation, relaxes the bronchiole, and increases airflow in the lungs.

7.      It causes the dilation of the pupils to enhance vision.

8.      It contracts the hair muscles, causing “goose pimples”.

Deficiency: The lack of adrenaline causes a decrease in blood glucose level and blood pressure.

Excess/Over secretion: causes the elevation of the blood sugar level, heart rate, and blood pressure.

Note: People with stressful lifestyles are constantly secreting adrenaline into the bloodstream. This constantly prepares their body for action, fight, or flight. But since the action is never taken, continued exposure to that lifestyle and an extended secretion of adrenaline may become harmful to the body. This could result in muscle tension and headaches (migraine). Or even high blood pressure which can lead to hypertension. Hypertension can turn into strokes and heart diseases, as well as fatigue, pain in the stomach, and even diarrhea.

All these are serious causes that lead to aging more quickly than someone who has a more relaxed lifestyle. 


While the adrenal cortex plays a huge role in hormones for the body, it doesn’t play a massive role in hormones that affect aging. The adrenal cortex is more known for blood pressure regulation. While the adrenal cortex does play a role in also regulating your metabolism and immune system, they don’t have the main hormones that are worked within hormone therapy. 



The pancreas is another organ that plays a vital role in our lives but not one that has to do with hormones and anti-aging qualities. Its function relies heavily on how we respond to high and low blood sugar and are the production of insulin. 


The Ovaries are located at the pelvis and produce estrogen and progesterone. This is where what is commonly referred to as the youth hormones can be worked with to slow down the process of aging. 


The production of estrogen is stimulated in the pituitary gland and during ovary development. It essentially controls the formation and development of the female sex organs and secondary sex characteristics e.g., breast development and hair growth. It also controls the menstrual cycle, the development of mammary glands, and promotes sexual urge.

Estrogen naturally falls as women get older. 

Deficiency: A lack of the secretion of estrogen would lead to underdevelopment of the reproductive system and secondary sex characteristics.

Excess/Over secretion: This would lead to an abnormal urge for sex.


Also known as the pregnancy hormone, progesterone is produced during ovulation and helps maintain the lining of the uterus after ovulation. It also helps in the implantation of a fertilized egg in the wall of the uterus as well as the development of breasts during the later month of pregnancy.

Deficiency: A lack of progesterone secretion may lead to the abortion of the fertilized egg from the uterus since it is not implanted in the walls of the uterus.

Excess/Over secretion: would lead to an irregular menstrual cycle, underdevelopment of the mammary gland, and abortion of fertilized egg.


The testes are located at the scrotum and produce the hormones Testosterone and androsterone. These hormones are responsible for the development of male physical characteristics.


Testosterone is a tropic hormone and is stimulated from the pituitary gland during the development of the testes. It controls the development of the primary and secondary sex characteristics in adults such as muscular body, deep and loud voice, and hair growth. It also increases sexual urges and promotes blood circulation and cell respiration.

Testosterone naturally decreases as men get older. Different therapies can help combat this. They mostly come in the forms of:

  • Pills,
  • Gels
  • Patches
  • Injections
  • Creams

Deficiency: Lack of testosterone will result in poor development of the reproductive system and underdeveloped secondary sex characteristics.

Excess/Over secretion: would lead to an early onset of secondary sexual characteristics in adolescent males and a high sexual urge.


Having discovered the different types of glands and the hormones they secrete. I am certain you found something common amongst them, and this is that they have an optimal level by which they function. If they fall short or go above this level it can lead to severe consequences that sometimes include death. Besides anti-aging, these reasons are also why hormonal therapy can be relevant.

Hormonal optimization is done after an assessment is carried out to determine the levels of hormones in the body, if it is below its threshold, plans are developed to improve hormonal functions. And if your body is not secreting hormones as it should, HRT could be your option.

Common signs that you may need hormonal therapy are:

  • Mood changes such as irritability. 
  • Physical changes such as unexplained weight loss or weight gain.
  • Low libido
  • Changes in bowel/bladder habits
  • Increased risk of bone loss due to aging, fatigue, and probably failures of alternative treatments. 

Using this therapy could quickly restore quality of life with an increase in energy and less fatigue. Symptoms would also greatly be reduced.


Aging is a natural phenomenon that happens to every individual over an extended period of time. The rate at which an individual ages can be directly traced to the reduction in hormonal secretion. The levels of hormones reduce with age. Although some hormones will remain at the same level from youth while a few others increase. But even when the levels of hormones do not decrease, endocrine functions generally reduce with age because hormone receptors become less sensitive.

But with advanced knowledge and technology, aging can be greatly slowed down by the careful manipulation of the secretion of these hormones. As specific hormones could be optimized or replaced to increase life expectancy and physical changes that may come as a result of aging.

Aging is not only a factor of how old that individual is but also a function of many factors such as lifestyle and stress. An individual consistently under stress for example will age twice the speed as an individual that exercises moderately and eats healthily. All these functions are directly or indirectly under the control of the hormones we’ve listed above. 

Hormone optimization or replacement could also be a great way to combat age-related conditions such as:

  • low testosterone in men, 
  • perimenopause, menopause, or post-menopause syndrome for women
  • Treat deficiencies 

Deficiencies can only be treated after a test is done. The basic three reasons why people do hormone replacement and optimization are for disease prevention, physical appearance, and feeling better.

Predominantly hormone growth therapy and testosterone therapy are the two therapies most commonly used. Having said that there are more options available than just those two. 


Glands produce very important hormones that are related to aging processes, this includes estrogen, melatonin, endorphins, and testosterone. Listed below are some hormonal therapies that would help the fight to reduce aging while maintaining a younger-looking appearance. 


Melatonin plays a large responsibility in sleep cycle control. It also determines the adequate amount of sleep essential for emotional, mental, and physical well-being. Someone who is sleep deprived is generally more apt to illness or develop a decreased ability to fight off common cold and viruses than persons who have an adequate amount of melatonin. Melatonin is widely called the “wonder drug” and is said to extend life expectancy by up to 25%.

It is also known to locate and destroy free radicals that increase the risks of cancer and heart disease. But by the time one clocks the age of 40, there is a lower production of melatonin. However, with melatonin therapy and supplements in minute doses, it tricks the body into believing that we are much younger than we are. Although, it should be taken under caution and a strict recommendation. This is because it should not be taken under certain conditions and age ranges.


Endorphins are hormones the brain releases when we exercise. When we exercise its production and distribution are increased. It enhances the mood of an individual making one feel good and happy. Research proves that a high level of endorphins keeps individuals active while maintaining a positive attitude. This helps reduce stress and the damage stress would often cause our bodies. During HRT, these chemicals can be induced by helping an individual reduce stress and thereby slow aging.


Estrogen is considered one of the strongest hormones in the body. Aside from helping to prevent breast cancer, heart disease, and bone loss, its level also affects various tissues and organ systems. These range from bones to liver as well as the brain and excreta. It also helps women maintain strength and flexibility of the skin, reproductive organs, blood vessels, and tissues during childbearing and beyond.

This is why going for estrogen therapy, supplements and cream would improve wrinkles. The dermatologic literature is full of studies demonstrating the benefits of estrogen on skin thickness, levity, hydration, and hydration. As a woman goes through menopause, she notices changes in her skin that were previously not there. The need for maintaining adequate estrogen levels for maintaining youthful skin is therefore essential.


Testosterone helps promote the ability of the body to use up the protein in the formation of bone, muscles, and skin. Men about the age of 40 to 70 often experience a decrease in the levels of testosterone secreted by the body. But like women, they also have the option to use hormone replacement therapies after appropriate consultations and when determined suitable by physicians.

Through the use of any of the before mentioned medications usually, a client will undergo testosterone therapy for life once started. Some of the most common gels taken are Androgel and Testim.

Androderm is one of the most common patches while some men prefer to use injection which the most common one is Depo-Testosterone. 


DHEA which is also fondly called the “fountain of youth” hormone is produced by the adrenal glands, it is directly connected to our immune capacity, memory, and energy levels as it plays a vital role in our bone strength and density. It also plays a role in the way in which each person could handle stress. DHEA is also available as a supplement, as are estrogen, testosterone, melatonin, and estrogen replacement therapy.


ACTH is also known as the body’s stress hormone. Oftentimes, chronic stress has a negative influence on our aging process. ACTH stimulates the adrenal gland to secrete and disperse cortisol through the body. Although cortisol is necessary for many-body operations, when it is released as a response to stress, it may lead to negative effects such as poor skin condition, weight change, premature aging of immune cells, aches, fatigue, pains, and insomnia.


Progesterone can help in the improvement of skin conditions, help sleep and anxiety, and is equally important to women’s health. It is synergistic with estrogen,


Some other hormones, including melatonin, help with sleep. Vitamin D is also a hormone and can improve immunity and skin enhancement. Pregnenolone helps with cognition. Metformin for weight reduction and so forth.

Consumers however should bear in mind that any hormone supplements should be taken with great caution, as too much may create even greater hormone imbalances within the body. Discussing hormone supplementation with a doctor is essential for those in their mid-40s or older. It is imperative to consult with a proven clinician with a lot of expertise as taking certain hormones without consultation and dosage without prescription could cause more harm than good.

Why Is AAI Clinic Your Best Bet Right Now?

  1. AAI Is Affiliated With FDA And HIPAA Compliant Pharmacies: AAI Clinics places a high value on quality and sets the same standard for the pharmaceutical products their patients use. They purchase and receive supplies only from the best, government-approved pharmaceuticals in the world. In turn, these pharmaceutical Companies deliver their goods quickly. As a patient of AAI, the chances that you are getting the best healthcare around the world are around 80 percent. 
  2. Continuous Support from Wellness Advisors: In most health care services, support and communication cease when your payment is due or when you’ve gotten your share of the treatment. That is not to be said of AAI Clinic. You can always ask questions as it concerns your health and gets the feedback you tightly deserve.

Should an issue arise regarding the product you are using or you have a 

complaint, there is a customer service team readily available to cater to your needs.

As a patient with AAI Clinic treatment no less than family is guaranteed. 

  1. Availability of Individual Protocols: AAI Clinic does not offer its service to their patients in groups or packs under the understanding that each patient’s needs are different. The service is listed for a one-on-one basis, therefore adequate attention is given to patients.  In cases, often than not, this method helps to administer the right treatment to those who need it.
  2.  Effective Follow Up: AAI Clinic experts keep up with your health progress. They give you extra-patient care. Not only will you be able to get feedback from them, but they will also be getting from you on how the therapy is going, the supplements you are using, or possibly the anti-aging serum that may have been prescribed to you.
  3. Powerful Reviews From Around The Nation: AAI Rejuvenation Clinic has gained fame for its amazing result nationwide and is fast rising to become the Number 1 Rejuvenation Clinic around the world. With its amazing quality services and offers, past patients have left positive reviews leaving AAI highly-ranked on Google. 

Start With AAI Rejuvenation 

AAI Rejuvenation is a nationwide HRT clinic that can help you get started with a specific therapy customized for you. We have an in-depth due diligence process that helps us determine what your health looks like. With this, we can determine what therapies may be appropriate options to improve your quality of life. Contact us today!

hormone replacement therapy

December 2, 2020 by Joseph Fermin 0 Comments

Testosterone Therapy For Women, Guide to HRT for Women 5 (1)

The body undergoes a lot of changes as one ages, which includes the decline of hormones that play a huge role in overall health. Some of the body functions naturally reduce the testosterone levels in the body. Especially when a woman is aging and approaching menopause, they are likely to experience a decline in testosterone, which is normal. When the symptoms of menopause start becoming apparent, Hormone replacement therapy (HRT) is used to address them. 

Do Women Need TRT?

Female bodies need testosterone, which they convert into female sex hormones. Women produce enough estrogen and testosterone to last through puberty and young adulthood. While significant amounts of testosterone are produced, it is usually converted into estrogen, the female sex hormone. The primary use of testosterone in women is to maintain good vaginal & menstrual health, enhance sex drive, boost fertility, strengthen bones, and boost breast health. 

The standard testosterone levels for women often lie between 15 to 70 ng/dl of blood. When the testosterone levels go below 15 ng/dl, the results might be low sex drive, vaginal dryness, fertility problems, osteoporosis, changes in breast tissues, and irregular/no menstrual periods.

However, high testosterone levels, ie more than 70 ng/dl translate to a condition known as polycystic ovarian syndrome among other effects. This condition negatively impacts monthly periods affecting your ability to ovulate. It is also abbreviated as PCOS and can cause different symptoms like infertility caused by lack of ovulation which makes it difficult to get pregnant. It also associated with skin-related problems like acne, dandruff, oily skin, and dark-patched skin. PCOS can also cause irregular or non-existent periods, miscarriage, infertility, ovarian cysts, and excess hair growth on the toes, back, face, chest, thumbs, and stomach.

Unbalanced testosterone in females affects the general health, so, women need TRT to treat abnormally low testosterone levels in the body.

How to Know When Its For You

The level of testosterone changes throughout the life of a woman. It’s also common for the level to change at different points of the day and during the menstrual cycle. When there is any form of testosterone imbalance the woman’s health is at risk of deterioration. Here are some of the symptoms that can be easily noticed as a sign of low testosterone and a need for TRT treatment.

Weakened Muscles 

The weakness of muscles comes with a number of different side effects. You will notice sluggishness and high levels of fatigue. Weak muscles often manifest with age decline, and as time elapses, mundane tasks tend to be hard to accomplish timely.

Sleep Disturbances 

Sleep patterns tend to change. That may result in irregular resting periods. It may also bring about unwanted weight gain and if experiencing such, you might want to consider TRT which corrects the situation.

Low Sex Drive

While testosterone is known as the ‘male hormone’, it is also present in females. In fact, low testosterone levels might affect how a woman reacts to sexual advances. It might in turn affect her sexual satisfaction. In addition to that, some other sexually related anomalies might arise such as the dryness of the vagina, irregular menstrual cycle, and fertility problems.

Loss Of Bone Density 

Testosterone is a key player in the maintenance of the bone structure. Decreased levels usually affect the strength of the bones. It might affect the health of your joints which might result in constant aches.

It is paramount to remember that this area is still being researched. These symptoms might also appear in other ailments. A trained doctor needs to check for other complications before diagnosis. They might look for depression, stress, the transition to menopause, or thyroid disease to ascertain that the symptoms are an indication of low testosterone levels.

To understand testosterone deficiency in a woman’s body, you need to understand some of the causes of low testosterone levels. The two main causes are.


Menopause is the most common cause of low testosterone for women who have advanced in age. During menopause, the functions of the ovaries tend to seize. With the seize in the function it’s quite automatic that the levels of testosterone will significantly drop.

Ovarian And Pituitary Trauma

The level of testosterone may drop for young women if there is an underlying issue with the ovaries or the pituitary gland. The issue might arise from a number of reasons for example during delivery or even an accident.

A less common cause of low testosterone level in women is:

Vitamin Deficiency

Younger women are the most susceptible to this type of complication. Vitamin deficiencies are usually caused by a number of genetic errors where the body is unable to absorb vitamin b12, zinc, folate, glutamine, and others. Amino acids and vitamins are responsible for the production of testosterones.

Benefits of TRT in Women

Low-T in women also has its implications. However, testosterone replacement therapy has both immediate and long term benefits to the body. Here are some of the immediate benefits.

Better Skin

As you get older the collagen levels tend to get depleted and that results in wrinkling and aging of the skin. Testosterone replacement therapy plays a key role in fighting this sagging of the skin. The presence of testosterone brings back the production of collagen to its former self. After a few visits to the doctor’s office, you might notice brighter and less wrinkly skin.

Improved Mood and Energy 

As per the symptoms you have noticed that a low testosterone level comes with a feeling of fatigue and sluggishness. Testosterone replacement therapy tends to push that cloud away.  You become more energetic and more zealous than you have been. A balanced level of testosterone in the body tends to bring about a feel-good mood and thwarts the feeling of depression.

Hair Regrowth

As a direct side effect, you can easily notice the thickening of hair follicles so as to stop hair fall out. Do not expect new hair follicles to appear cause that’s impossible. The only thing that happens is that hair growth is stimulated and hair might pop out of follicles that were once unresponsive.

Here are some long term benefits 

Balanced Sugar Levels 

When the body becomes unresponsive to insulin as a result of unhealthy eating, you are usually at a high risk of getting complications. Testosterone replacement therapy in women tends to alter such body malfunctions. The presence of testosterone helps in making the body more responsive to insulin. Over time the therapy fosters the growth of muscle cells that respond timely to insulin while there is the presence of high sugar levels.

Strengthening of Bones

When the body lacks testosterone the bones tend to lack density and are brittle. This puts a woman’s skeletal structure at a high risk of fractures. Testosterone replacement therapy helps in maintaining the health of the bone cells and enhances bone growth. As a woman continues to age the therapy ensures the bones remain healthy and strong.

Prevention of Heart Disease

Heart diseases affect all ages as opposed to previous ideas that they only affect the old. The healthiness of the heart is always important to avoid any complications within your body. With the continued testosterone replacement therapy the body, in general, tends to regain proper functioning as seen from the previous benefits. When the body has a hormonal balance cardiovascular risks are at all times low.

Regained Sex Drive

With a low libido, most women tend to become frustrated and that affects the interaction with the opposite gender that includes the spouse. Testosterone replacement therapy has proven evidence of changing the levels of your sex drive. It has a positive track record for improving the libido for both men and women alike. For women who are post-menopausal that are facing a lowered level of sex drive, testosterone replacement therapy combined with other hormone therapy tends to bring back the flickering sexual flare. Apart from bringing back the sex drive, sensual satisfaction is also achieved. The dryness of the vagina and other complications are fine-tuned.

Other HRT Options for Women

Just like testosterone, estrogen levels drop when women get to menopause. When experiencing menopausal symptoms, HRT is used. It is also referred to as estrogen replacement therapy, hormone therapy, or menopausal hormone therapy, and is compounded differently depending on the patient’s health. There are different ways of taking HRT as explained below;

Estrogen Tablets

The estrogen tablets are common than other methods of HRT and are taken once every day. Some types of estrogen tablets have a somewhat complicated schedule, but most are simple and are taken without food. Two of the unique advantages is that estrogen tablets can be used to reduce the chances of contracting osteoporosis and reduces the likelihood of menopause symptoms.

Vaginal Estrogen

There are also other forms of estrogen applied directly to the vagina. These are effective for issues such as burning or pain during sex, vaginal dryness, and itchiness. They could come in the form of insertable rings, tablets, or creams and for obvious reasons, they all use different dosing schedules. For instance, creams can be applied a few times a week while vaginal tablets can be used every day before changing the dosing to a few times every week. Vaginal rings, on the other hand, are mostly replaced after a period of three months.

Estrogen Patches

The estrogen patches are worn on the waistline and depending on the dosage, sometimes could be for a week or can be changed once or twice within the week. This is a good alternative if you don’t like taking daily tablets. It might also help avoid some of the side effects that come with using other HRT methods like blood clots and indigestion.

Topical Estrogen

You could also use creams, sprays, and gels for your HRT treatment. Either of these options is rubbed into the skin once a day at specific areas depending on the type. For instance, you might be required to rub it into your wrist, arm, legs, and shoulders, etc.


Another alternative for HRT treatment is implants which are small pellets inserted mostly around your tummy. The pellet releases the hormone into the body and is replaced after it gets depleted, usually after a few months.

HRT Treatment Routines

With the different HRT options, there are two distinct treatment routines for you to consider, sequential or cyclical HRT and continuous combined HRT.

Cyclical HRT

If you are already experiencing menopausal symptoms and you are under the combined treatment routine but still get your periods, then you might need to start cyclical HRT. Monthly HRT is one of the two types of cyclical HRT where you are required to take both estrogen and progestogen. This is usually taken during the final two weeks of your menstrual cycle and is mostly recommended for women with regular periods. The second type of cyclical HRT is the 3-monthly HRT which is taken on a daily basis. You will also need to take it with progestogen for two weeks every three months and is mostly recommended for those women with irregular periods.

Continuous Combined HRT

The combined HRT is best for postmenopausal women. If you haven’t had your periods for about a year, then you are considered a postmenopausal woman. With the combined HRT, you are required to take both estrogen and progestogen on a daily basis.

How to Get Treatment

You are experiencing most or some of the symptoms suggestive of the need for TRT treatment, but do you know where to begin? Your safest and most convenient option would be finding an anti-aging clinic that offers HRT treatment. To get the best treatment, you will need to find a clinic that specializes in your needs. 

So, you will be looking for an anti-aging clinic that deals with hormone therapy and other anti-aging treatments. The following are some of the top factors to consider when choosing a clinic for TRT treatment.

Professionalism and Friendly Customer Service

You will be getting your hormone therapy treatment indefinitely, so it is important to find an anti-aging clinic with friendly customer service. After shortlisting the clinics you are interested in, make an inquiry call, or sent an email and pay attention to how they respond to you. Are they kind and willing to answer your questions and take you through the procedure? Bad customer service is a turnoff, so find a place where you will be treated well. In addition to friendly customer service, professionalism is equally important. Is the communication professional, and how presentable is the website? 

Check for Reviews

What other patients say about a certain clinic should tell you a lot. Search online for any reviews you can get, and check what people are complaining about or what they highly commend about the clinic. An anti-aging clinic with good reviews and ratings is always a good option. And while it is good to check the good reviews, the bad reviews will also tell you a lot about where they fall short. Also, you can ask your friends and family to recommend any good clinics they know about. 

Skill and Experience

Experience and skill matter a lot. They make part of the most important factors to look out for before choosing an anti-aging clinic. Hormone therapy is a delicate kind of treatment, so having a skilled professional do it for you is vital. Also, the amount of experience matters since your provider already knows the common mistakes done during the process and how to avoid them. 

Calm and Relaxing Environment

If you are personally visiting the clinic, look for one with a relaxing and calm environment. And even if you are going the online way, then ensure that the process is stress-free. The last thing you would want is to have the treatment abruptly stopped halfway without an explanation or have to deal with very difficult people. This would stress you up, which beats that purpose of the treatment. 

Personalized Experiences

You will also want to look for a clinic that offers personalized experiences for you since TRT treatment does not work the same for everybody. Find a clinic offering a personalized approach for TRT treatment. From a customized treatment plan to the expected recovery times, you want to find a clinic run by experts offering nothing but the best anti-aging practices. What’s more, they should be able to provide a detailed consultation before the treatment. You want a deep insight on what the treatment looks like, vague information and a rushed consultation is not going to provide that for you. 

Once you decide on the best anti-aging clinic, treatment will likely begin immediately. You already know what your symptoms are, the next phase would be an in-depth consultation and bloodwork carried out. This helps to ascertain your needs and tailor a treatment plan just for you.

Take Away

After you begin your HRT treatment, keep your doctor updated about any changes and new symptoms you may begin to experience. In addition to your treatment, ensure to maintain a healthy lifestyle as it also goes a long way. From physical fitness to healthy diets and managing bad habits like drinking and smoking. A good TRT treatment combined with a healthy lifestyle will definitely go a long way. Also, the clinic you choose to work with plays a huge role in the overall results you get for TRT treatment. To that end, you might want to consider working with AAI Rejuvenation Clinic which will create a personalized TRT treatment based on your needs in the most reliable and convenient way possible.

November 2, 2020 by Joseph Fermin 0 Comments

Testosterone Replacement Therapy(TRT) Review 5 (2)

Testosterone, being one of the hormones that are produced in the testicles, plays a big part in the man’s body functioning. It affects a couple of things in the body. These may include muscle mass, production of red blood cells, production of sperm, sex drive, and bone density.

The levels of testosterone are at their highest when one is going through adolescence but they tend to drop as you continue to age. Consequently, this has negative effects on the body. And as the levels dwindle, you might find yourself leaning towards the idea of testosterone therapy because it has been referred to as the fountain of youth. This might be very alluring. While it can be true, you should also remember that there are several misconceptions in regards to how testosterone replacement therapy works and its benefits. 

To that end, here are some of the benefits of having TRT.

Benefits of Testosterone Replacement Therapy 

Most of the testosterone replacement therapy is done by individuals that have been diagnosed with low testosterone levels or other medical conditions. They are the ones who show a significant difference between the before and after the therapy. While the benefits are common, TRT does not work entirely the same for every individual since everyone has their own needs. If one is medically considered to have normal testosterone levels, they will feel little to no difference when there is an increase in testosterone levels in the body.

Here are some of the benefits that you are likely to experience after going through testosterone replacement therapy as a way to counter low testosterone levels.

An Increment in Muscles

As a matter of science, testosterone is the culprit that plays a part in building muscles. When there is an increase in testosterone, the muscle mass within the body can significantly increase and as a result, you will have a lot of energy coursing through you. Muscle mass does not mean that you automatically gain strength that you were previously lacking. The strength will come as a result of you putting in work and doing some strength workouts. So you get the best results when you combine both of them.

Tougher bones

Without a doubt, an older man has more fragile bones when compared to a younger one. As you age, your bone density drops with the drop in testosterone levels and this make them weak and brittle. With high doses of testosterone replacement therapy, the body regains the capability of absorbing and replacing bone tissue hence improving bone density. The denser your spine and hip bone are the greater you are at swift mobility and athletic proficiency. On that same note, testosterone replacement therapy does not prevent you from getting bone fractures.

Improved Heart Condition

Several risks, including those associated with heart problems, come from having low testosterone levels. Testosterone is an important ingredient in the formation of red blood cells as they are produced within the bone marrow. In addition to that, an increase in testosterone helps in strengthening muscles hence improving the state of your day-to-day mundane activities.

Improved Sex Drive

Normally, testosterone plays a key part in responding to sexual stimuli. The higher the levels of testosterone the higher the sexual activity that you will find yourself engaging in. Men who have advanced in age are highly likely to face some challenges that may include erectile dysfunction and low libido. Testosterone replacement therapy can help an individual that has low libido improve in bed if it is a result of the decrease in testosterone. Erectile dysfunction can stem from other conditions within the body which cannot be corrected by testosterone replacement therapy alone.

Better Quality of Life

When the production of testosterone decreases radically it might affect the overall state of mind of an individual. You might start showing signs of fatigue, depression, and ill-temper. This reduces the quality of life and may result in poor decision making, poor interactions, and a decline in mental health, etc. Testosterone replacement therapy is considered to be great in improving moods and generally, the quality of life.

Better Reasoning 

High levels of testosterone have been proven to be responsible for how you relate to your immediate environment. It helps in swiftness in the processing of thought and verbal memory. Older men who have given testosterone replacement therapy a try have shown an improved thinking capability and reduced risks of getting Alzheimer’s.

Face and Body Hair Growth

While some men are effortlessly able to grow beards, some still struggle, which is not their fault. Scientifically it has been proven that high levels of testosterone play a key part in ensuring the growth of facial and body hair. With testosterone replacement therapy one is likely to notice a difference when it comes to beard growth. As much as beard growth can be affected by genetics, the testosterone replacement will help boost the growth of facial hair at a faster rate compared to other men with low testosterone.

Improve Sperm Production 

Testosterone is also a key ingredient in the formation of sperm. When you fall under the normal testosterone levels then you are likely to experience a low sperm count. Testosterone replacement therapy administered properly helps to ensure that your testosterone levels are balanced and at a normal measure in the body. This ensures the never-ending process of sperm production is continued efficiently.

Testosterone Replacement Therapy Reviews 

Below are some of the experiences of different people as well as thoughts on how testosterone replacement therapy is making a change.

A forty-seven-year-old male who has been on the therapy recounts how his first experience of the injection was a little bit painful followed by soreness that would last for a week or so. The good thing is that in the long run, the therapy helped him very much so that he started feeling a change in his mood. He is more positive about how he views himself and has more energy to face life

Another patient says the therapy has worked for him after having used it for five years. The only problem he had is that he had to go for weekly injections through and through. He had to commit to it to start enjoying the results. The main take away from his experience is that the therapy has to be conducted frequently to enjoy the desired changes.

A patient in his late twenties was diagnosed with low testosterone levels. He always had a bad mood and he was overweight. Due to the fact, his testosterone levels were low the body created much higher estrogen levels to fill the void. A few months after the introduction of testosterone replacement therapy a zeal for life has been rekindled

A retired navy vet also tried the testosterone replacement therapy and he was over the moon. Having spent ten years in the navy his body had undergone a lot of stress. His moods were on the low and his energy levels were fluctuating. With an introduction to testosterone replacement therapy within two weeks, he has testified that things are starting to change for the better. He has regained his energy and his sleep pattern is shaping up.

A fifty-year-old law enforcement officer had a lot to say in regards to the testosterone replacement therapy. His line of works requires him to be more active and very alert but his advancement in age was proving to be a thorn. When he started the testosterone replacement therapy at the age of forty he was suffering like many others who had the signs and symptoms of an individual with low testosterone levels. From his recent remarks, he has stated that he feels young again. His energy is high, great sleep, gaining muscle mass, quick recovery from injuries and finally, his mood has had a dramatic improvement.

A review from a medical practitioner who seems to show no bias leaning towards any direction states that the therapy comes with a bit of testosterone pill dependency. He explains that the individual that is suffering from testosterone deficiency will have to consume the testosterone supplements without any foreseeable end. When you are introduced to testosterone replacement therapy your body eventually reacts to it and you start feeling better than before. A big difference can be experienced when one halts taking the supplements before the body fully recovers. Continued use of the supplements might end up slowing or even stopping the natural ability of the body to create its testosterone, which is very alarming.


From the reviews, it is evident that a lot of people are more aware of their health and always looking for ways of getting better.

Testosterone has so much functionality in our body than we might think. Men need a proper amount of testosterone to ensure the body functions to its optimal levels. The proper amount can not be easily stated because different individuals have different body types.

The introduction of testosterone replacement therapy is great when supplemented with other physical activities and dietetics. Taking walks can give you a lot of energy boosts and having a lot of foods that have roughage accompanied by proteins helps in the building of muscle mass.

The benefits that come with the introduction of testosterone replacement therapy are endless. They might include improved libido and other sexual activities, increased bone density, better sleep, improved body composition, and a decreased risk of heart disease.


Testosterone replacement therapy just like any other medication has slight side effects on the body. Continuous testosterone injections might affect the skin and cause skin rashes. Some other patients might experience swelling of breasts and ankles if they don’t manage their protocol correctly.

Seeking a physician diagnosis must be paramount. Because they can guide you in the right direction when it comes to delivering

AAI reviews

As much as different people have interacted with AAI over the years they can attest to having similar experiences that are worth their monetary equivalence. One of the patients that have been having trouble accessing the facility due to the fact he has an involving job and the far distance had a great understanding of how AAI can deliver the services to him in a unique fashion. 

One of the physicians at AAI ensured that all the prescribed medication was mailed to the patient’s home address and clear directions as to administer the dosage were attached to the parcel. Even with the distance being a challenge AAI proved to cater to the patient’s needs wherever he was. The reviews from the patients are very uplifting as the therapy is bringing a great difference when compared to his former self. They include: reduced joint pains, body fat reduction, increased productivity, and better sleep.

As a matter of professionalism, AAI is at the top of the flock. The medical personnel that is present have proven to know their way around customer service and customer satisfaction. One client recounts how his queries were responded to. The physician that he interacted with showed a quick response, offered sound advice, and great product support. Also, the clinic only deals with quality products from trusted pharmacies. Finally, in regards to pricing, the services offered are pocket-friendly.

Bottom Line

Testosterone replacement therapy is among the ways by which you can improve your levels of testosterone. It’s very effective and the results are more noticeable in men that have low testosterone due to a medical condition. Patients under testosterone replacement therapy show a great improvement in their libido levels, energy, and better quality of living. 

The best way to ensure that the therapy remains effective over a long period is by ensuring it is matched with a proper diet, regular exercise, and proper relaxation. The takeaway is that always ensure you have consulted a medical professional that has your best interest at heart. AAI clinic provides a wide range of medical professionals that you can interact with in regards to testosterone replacement therapy. Contact us today and see if therapy is right for you!

August 8, 2020 by Joseph Fermin 0 Comments

Thymosin Alpha 1: Reduces the Mortality COVID-19 by the Restoration T-cells. 5 (8)

Thymosin stimulates the development of T-cells. Throughout your childhood years, growing up, your white blood cells, called lymphocytes, pass through the thymus, where they transformed into T-cells.

Once T-cells have fully matured in the thymus, they migrate to the lymph nodes (groups of immune system t-cells) throughout the body, where they aid the immune system in helping fighting disease. Also, some lymphocytes, regardless if they reside in the lymph nodes or thymus in the body, can develop into cancers, also (known as Hodgkin disease, and non-Hodgkin lymphomas), and can also be harmful to the cell.

Though the thymus gland is only active until puberty as we grow, the endocrine and the lymphatic gland plays a significant role in the body of your long-term body health.

Enhances the function of specific immune cells called T-cells and dendritic cells. Help eradicate unhealthy cells and stop the infection or cancer growth. Exhibits antibacterial, antifungal properties, and Suppresses tumor growth.

The thymus is a tiny gland in the body organ behind the breastbone that plays a vital role in the immune system and the endocrine system. The thymus begins to atrophy (decay) during puberty, its effect in “training” the T lymphocytes to fight infections and even cancer in the body.

The Anatomy of the Body

The thymus gland lies in the chest in the body, directly behind the breastbone (sternum), and in front of the heart in the area between the lungs called the anterior mediastinum. Sometimes, however, the thymus gland is found in another (ectopic) location, such as in the neck, the thyroid gland, or on the lung’s (the pleura) near the area where the blood vessels and bronchi enter the lungs.

It is named the thymus due to its shape being similar to that of a thyme leaf—pyramid-shaped with two lobes. The two portions of the thymus are broken down into lobules. These lobules have an outer cortex occupied by immature T lymphocytes, and an inner medulla occupied by mature T lymphocytes.

It is considered a lymphoid organ (an organ of the immune system) similar to the tonsils, adenoids, and spleen.

Cells of the Thymus

Several different cell types are present within the thymus gland:

  • Epithelial cells: cells that line body surfaces and cavities
  • Kulchitsky cells: cells that are the hormone-producing cells of the thymus or neuroendocrine cells
  • Thymocytes: cells that become mature T lymphocytes

The thymus gland is also home to some macrophages. Macrophages are known as the “garbage trucks” of the immune system because they eat foreign matter. Dendritic cells and a few B lymphocytes (the types of lymphocytes that produce antibodies) also reside in the thymus.

Interestingly, the thymus gland also contains some myoid (muscle-like) cells.

Changes With Age

The thymus gland is large in infants, but after infancy, it grows and reaches its maximum size during puberty. After puberty, the thymus gland shrinks and becomes replaced mainly with fat.

The gland is tiny in older adults, but can sometimes atrophy prematurely in response to severe stress. The term used to describe the atrophy of the thymus gland with age is “thymic involution.”


The thymus gland is very active from before birth until puberty. It functions as both a lymphatic organ and an endocrine organ (an organ of the endocrine system that produces hormones). To understand the role the thymus gland plays in immunity, it’s helpful to first distinguish between T lymphocytes and B lymphocytes.

T-Cells vs. B-Cells

T-cells (also known as T lymphocytes or thymus-derived lymphocytes) mature in the thymus gland and play a central role in cell-mediated immunity, meaning the batteries themselves are active in fighting off foreign invaders such as bacteria, viruses, cancer cells, and more.

In contrast, B lymphocytes are part of the humoral immune system and produce antibodies directed at specific invaders.

T-Cell Training Ground

As part of the adaptive immune system, the thymus can be thought of as the T lymphocytes’ training ground. During childhood, immature T-cells (called progenitor cells) originate in the bone marrow travel via the bloodstream to the thymus gland, where they mature and differentiate into specialized T-cells.

Types of T-Cells

T-cells in the thymus differentiate into three primary types.

  • Cytotoxic T-cells. The word cytotoxic means “to kill.” These cells are responsible for directly killing infected cells.
  • Helper T-cells. These cells are responsible for producing antibodies by B-cells and activating other types of T-cells to address a foreign invader.
  • Regulatory T-cells. These cells function as “police.” They suppress both B-cells and other T-cells.

Positive and Negative Selection

The immature T-cells that leave the bone marrow enter the thymus in the cortex (known as the thymus). During “training,” these cells are taught to recognize antigens associated with foreign cells and matter in a positive selection process. Cells are positively for usefulness.

Once the T-cells have learned to recognize specific pathogens, they travel to the medulla to undergo “negative selection.” In the medulla, the mature T-cells introduced to the body’s antigens. Since T-cells that would react with the body’s antigens could attack a person’s cells, they eliminated. T-cells negatively selected for autoimmunity, and these self-attacking cells either die or turn into regulatory cells.

Not all T-cells make it through this selection process, and only around 2% eventually make it through positive and negative selection.

The survivors exposed to hormones produced by the thymus gland complete their maturation before being released to do their job (circulating in the bloodstream or waiting in the lymph nodes for foreign invaders).

Hormone Production

The thymus gland produces several hormones, including:

  • Thymopoietin and thymulin which are hormones that assist in the process where T-cells differentiate into different types
  • Thymosin, which accentuates the immune response as well as stimulating pituitary hormones such as growth hormone
  • Thymic humoral factor, which acts similarly to thymosin, but increases the immune response to viruses in particular

The thymus gland may produce small amounts of hormones produced in other areas of the body, such as melatonin and insulin. Cells in the thymus gland (such as epithelial cells) also have receptors through which other hormones can regulate its function.


The mature T-cells derived have a few significant roles.


T-cells are part of the adaptive immune system, in which each T-cell has trained to recognize a particular antigen. When exposed to a foreign cell, cytotoxic T-cells lock onto the battery and kill it with assistance from the helper and regulatory T-cells, It will also be referred to as cell-mediated immunity, as it involves the use of immune cells to fight infections.


In general, T-cells barricaded in the cortex of the thymus, so they do not become sensitized to the body’s cells. However, the process of adverse selection in the medulla used to get rid of cells that accidentally have become sensitized to “self.

This function helps prevent the development of autoimmune disorders, which are medical conditions in which the body attacks its tissues rather than foreign invaders. If the thymus gland removed early in life, a person could develop one of these disorders.

Anti Aging

In recent years it’s been determined that aging isn’t merely a process in which the body wears out, but is an active process. In other words, we designed to age. The involution of the thymus gland may be a form of programmed aging, with the complexity (beginning around age 60) being the trigger for the deterioration of the immune system with age.

This decrease is immunity resulting from thymus involution can increase the risk of infections and reduce the response to vaccines.

Several studies have looked at methods to delay the atrophy of the thymus with hopes of slowing the aging process. Early studies suggest that calorie restriction may slow the atrophy, but the research is still in its infancy.

Diseases and Disorders

Some several diseases and disorders can affect the thymus gland, ranging from genetic disorders that are evident at birth to cancers that are most common in older adults. These disorders can lead to problems with immunity and autoimmunity, such as myasthenia gravis4 and hypogammaglobulinemia.

Hypoplasia/Aplasia of the Thymus

The developmental disorder called DiGeorge syndrome is an uncommon condition marked by a significant reduction or absence of thymus function. Caused by a gene mutation, and children with the disease will have severe immunodeficiency, a high risk of infections, and hypoparathyroidism.

Thymic Follicular Hyperplasia

Enlargement (hyperplasia) of lymphoid follicles in the thymus gland often seen in autoimmune diseases such as myasthenia gravis, Graves’ disease, and lupus.

Thymic Cysts

On their own, thymic cysts are often an incidental finding, but they can be important because they sometimes hide cancer (thymoma or lymphoma).

Tumors of the Thymus Gland

Thymomas are tumors that arise in thymic epithelial cells of the thymus gland and may be benign (usually harmless) or malignant (cancerous). They may occur in the usual location of the thymus gland in the mediastinum and in other regions where the thymus gland sometimes located, such as the neck, thyroid gland, or lungs. Other tumors that may occur in the thymus include thymic lymphomas, germ cell tumors, and carcinoids.

The symptoms of thymomas may be related to the tumor’s location in the chest (such as shortness of breath). Still, these tumors may also be discovered due to paraneoplastic syndromes associated with cancer. There are several of these types of conditions.

  • Myasthenia Gravis (MG). The autoimmune condition myasthenia gravis occurs in roughly 25% of people with thymomas, but may also occur with thymic hyperplasia. MG is an autoimmune neuromuscular disease caused by problems in communication between nerves and muscles. It characterized by profound weakness of muscles (both in the extremities and respiratory muscles—this can lead to breathing problems).
  • Pure Red Cell Aplasia. This condition is a rare autoimmune disorder in which T-cells are directed against red blood cells’ precursors, leading to severe anemia. It occurs in roughly 5% of people with thymomas.
  • Hypogammaglobulinemia. Hypogammaglobulinemia (low levels of antibodies) occurs in approximately 10% of people with thymomas.

Thymomas may also cause a condition referred to as thymoma-associated multiorgan autoimmunity. This condition is similar to the rejection seen in some people who have had organ transplants (graft vs. host disease). In this case, the thymic tumor produces T-cells that attack a person’s body.


Surgery to remove the thymus gland may be done for several reasons. One is for congenital heart surgery. A congenital heart condition is a congenital disability of the heart. Due to the location of the thymus gland, surgeons must remove to gain access to the center in infants.

Another common reason for this surgery is for a person with thymic cancer. Also, myasthenia gravis (MG) is another condition treated with thymectomy. When the thymus gland removed, roughly 60% of people with myasthenia gravis achieved remission.

However, it can take months to years for these effects to be apparent with myasthenia gravis. When used for MG, surgery usually done between puberty and middle age to avoid the potential consequences of removing the thymus gland earlier.

Consequences of Thymus Removal

The thymus gland provides a critical role in cell-mediated immunity. Fortunately, a significant part of this benefit occurs before birth (the T-cells formed during development in the uterus are long-lasting).

However, there are potential consequences of removal early in life, like when the thymus is removed during heart surgery in infants. It appears that early dismissal can increase the risk of developing infections. The development of autoimmune diseases (such as autoimmune thyroid disease), the risk of atopic disease (allergies, asthma, and eczema), and possibly the risk of cancer, like T-cells, perform a vital role in preventing cancer.

There is also some evidence that thymus removal may be associated with premature aging of the immune system.

A Word From AAI Rejuvenation Clinic

The thymus gland is a tiny gland that virtually disappears with age but plays a vital role in immunity and autoimmunity for a person’s lifetime. As changes in the thymus gland have linked with the aging of the immune system, and such virus-like COVID-19, researchers study ways to delay the atrophy. Since many autoimmune diseases have increased significantly in recent years, more will likely learn about the proper health of this gland in the future.

May 7, 2019 by admin 0 Comments

Post Cycle Therapy & well-Structured Testosterone Therapy 5 (8)

The Post Cycle Therapy (PCT), and Testosterone Injections Therapy goes hand on hand, Most men embarking on a testosterone injectable therapy replacement protocol are doing so as a result of medical reason or age-related issues that are affecting their life.

Now patients with problems and that face their low testosterone, the related concerns and do not allow fully experience the decline associated with maintaining extended periods of low hormones levels and will usually benefit from comprehensive testosterone therapy.

Note: that the specific drug and dose prescribed will depend on the particular information contained within each patient medical file and medical reason, as well as the individual goals patients.


  • Day 1. (50–250 mg) of testosterone injection.
  • Day 2. Two estrogen blocker or inhibitor.
  • Day 3. One injectable of an amino acid or vitamin B-vitamin.
  • Day 5. One estrogen blocker or inhibitor by mouth.
  • Day 6. One injection of a (250–800 units) of testosterone secretagogue.
  • Day 7. One estrogen blocker or inhibitor (sometimes two estrogen blockers a week is enough, But depending on the patient file).
  • Day 7. One injection of a (250–800 units) of testosterone secretagogue.

Example: This protocol for a man focused on muscle development (reversing lean muscle loss), Muscle development protocols, also work well in patients that may react to therapy with too much aromatization (estrogen accumulation).

Men are experiencing excessive aromatization and lean muscle depletion who are focused on rebuilding muscle, with Peptides.

Note: that the specific drug and dose prescribed will depend on the particular information contained within each patient medical file, as well as the individual patient goals.


  • Day 1. (50–150 mg) of a combination of testosterone esters,
    (15–30 units) Sermorelin Peptides before Bedtime.
  • Day 2. Two estrogen blocker or inhibitor,
    (15–30 units) Sermorelin Peptides before Bedtime.
  • Day 3. One injection of an amino acid or B-vitamin,
    (15–30 units) Sermorelin Peptides before Bedtime.
  • Day 4. Combination of (50–150 mg) testosterone esters,
    (15–30 units) Sermorelin Peptides before Bedtime.
  • Day 5. One estrogen blocker or inhibitor by mouth,
    (15–30 units) Sermorelin Peptides before Bedtime.
  • Day 6. One injection of a (250–800 units) of testosterone secretagogue.
  • Day 7. One estrogen blocker or inhibitor (sometimes two estrogen blockers a week is enough, But depending on the patient file).
  • Day 7. One injection of a (250–800 units) of testosterone secretagogue.

This weekly cycle would typically continue for 6–9 months, before a break period in which the body is allowed to normalize and reactivate your natural production.

What is Sermorelin?

Sermorelin is a peptide comprised of the first 29 amino acids of endogenous GH; the sequence is the same as endogenous GHRH. As we age, our body produces less and less of our vital hormones, including GH. Studies have revealed that sermorelin can restore GH RNA concentrations to youthful levels, which subsequently stimulates the production of insulin-like growth factor-1 (IGF-1).

Remember: When you are artificially manipulating your testosterone levels, some other functions of the body stop operating since endogenous testosterone production is shut down because of the presence of high levels of exogenous hormone. You will need Post Cycle Therapy on your break from testosterone therapy.

Break Period: Generally referred to as the Post Cycle Therapy (PCT), consists of medications that are formulated to reactivate the dormant systems that we have not used while your testosterone Injections therapy.

The essential functions that need to reactivate with your
Post Cycle Therapy:

  • FSH (follicle-stimulating hormone): This will stimulate sperm production in the testes.
  • LH (luteinizing hormone): This will stimulate testosterone production in the testes.

The reason why is because estrogen accumulation after extended periods of high testosterone levels, and water retention can cause, decreased libido, and other side effects associated with high estradiol levels from past testosterone therapy.

Well-structured Testosterone Injection Therapy

Following Results:

  • Week One: If you have never received testosterone injections before and are suffering from hypogonadism (clinically low testosterone), you should begin to experience invaluable changes just 3 or 4 days after your first administration. You should sleep better and have more energy.
  • Week Two: Morning erections make a significant comeback! In men with erectile dysfunction problems, morning erections help to determine if their problems stem from a psychological or a physiological problem.
  • Week Three: You will begin to notice a sense of clarity as your cognitive function improves. Your ability to recall information and your articulation will improve. You will suddenly realize that you feel more mentally sharp and able, which will allow you to better cope with stress and pressure.
  • The End of Month One: Your energy levels should be noticeably increased throughout the day.
  • Month Two: The same health manifestations that you were experiencing throughout your first month should continue to develop and improve. Your energy levels should still be increasing, and you should have a stronger “go-getter” attitude.
  • Month Three: There should now be a significant, noticeable difference in your energy level and output. Your workouts will require less effort and will yield quicker, more visible results. The time you need for muscle healing and recuperation after exercise should be reduced.
  • Month Four: By now, your endurance, stamina, exercise potential, and overall performance ability should supersede all your expectations. If you have never been on testosterone therapy before your first program and you have been eating well and exercising from the beginning, you will be surprised at the level of transformation you have experienced. Furthermore, it will be evident that these results and this amount of energy output would not be possible without restoring your testosterone levels to the numbers had in your youth.
  • Month Five: The changes and improvements in your physical performance, ability, and growth will be fantastic. If you were experiencing mental problems such as sadness, depression, anxiety, or even mental fatigue, by now you should notice substantial progress in your ability to deal with unpleasant or challenging scenarios and circumstances. Remember that all the other positive changes you have experienced will also contribute to a sense of self-improvement. This makes you naturally feel better about your progression and growth. More importantly, the physiological changes in brain chemical secretion add to your sense of fulfillment, happiness, and overall well-being.
  • Month Six: All individuals are receiving testosterone experience different effects by six months of therapy. What you experience will also depend on how many cycles of testosterone therapy you have participated in previously. Sometimes, a user’s sense of improvement begins to dwindle or remain stagnant. The body can become used to the type, or ester, of testosterone that is being used if the same therapy is continued for more than 1 or 2 years. Also, because other processes in the body cease to function when testosterone levels are manipulated using testosterone injections, the benefits of therapy begin to diminish and the “feel good” scenarios that were being experienced stopped.

Well-structured Sermorelin Therapy:

Month one:

  • Increased energy
  • Deeper, more restful sleep
  • Improved stamina
  • A more content state of mind

Month Two:

  • Reduced belly fat
  • Improved metabolism
  • The return of some muscle tone
  • Improved skin tone and fewer wrinkles
  • Stronger hair and nails

Month Three:

  • Increased mental focus
  • Improved flexibility and joint health
  • More feelings of drive and ambition
  • Enhanced sex drive and performance

Month Four:

  • Improved mental acuity
  • Better skin elasticity
  • Further improved appearance of the hair and nails
  • Continued weight loss
  • Increased lean muscle mass

Month Five:

  • Continued loss of belly fat
  • Improved skin tone with the reduced appearance of wrinkles
  • Noticeably fuller, healthier hair

Month Six:

  • A 5–10% reduction in body fat, without diet or exercise
  • A 10% increase in lean muscle mass
  • Significantly improved physique
  • Increased vitality dies to organ regrowth (vital organs, including the brain, shrink with age)

March 5, 2019 by Joseph Fermin 0 Comments

What is Follicle Stimulating Hormone (FSH)? 5 (9)

What is Follicle Stimulating Hormone

What is Follicle Stimulating Hormone (FSH), is one of the gonadotrophic hormones, and the other being a Luteinizing Hormone (LH). The pituitary gland releases both into the bloodstream and body, and Follicle Stimulating Hormone (FSH) is one of the hormones essential for the development function of women’s ovaries and men’s testes. In women, Follicle Stimulating Hormone (FSH) stimulates the growth in the ovary before the release of an egg from one follicle to the ovulation. It also increases estradiol production. In men, Stimulating Follicle Hormone (FSH) acts on the Sertoli cells of the testes to stimulate sperm production (spermatogenesis).

How is Follicle Stimulating Hormone (FSH) control?

The release of Follicle Stimulating Hormone (FSH) is regulated by the levels of some circulating hormones released by the ovaries and testes. This system is called the hypothalamic–pituitary–gonadal axis. The gonadotropin-releasing hormone is published in the hypothalamus and the receptors in the anterior pituitary gland to stimulate both the synthesis release of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The released Follicle Stimulating Hormone (FSH) is carried in the bloodstream, where it binds to receptors in the testes and the ovaries. Using this mechanism Follicle Stimulating Hormone (FSH), along with Luteinizing Hormone (LH), can control the functions of the ovaries and testes.

follicle stimulating hormone

In women, when hormone levels are deficient, and it has complication the menstrual cycle, this is sensed by nerve cells in the hypothalamus. These cells produce the more gonadotrophin-releasing hormone, which in turn stimulates the pituitary gland to produce more Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH), and release these into the bloodstream. The rise in Follicle Stimulating Hormone (FSH) and stimulates the growth of the follicle in the ovary, and the cells of the follicles produce increasing amounts of estradiol. In turn, this production of these hormones is sensed by the hypothalamus, and pituitary gland and less gonadotrophin-releasing hormone and Follicle Stimulating Hormone (FSH) will be released, However, as the follicle grows, and more and more estrogen is produced from the follicles, it simulates a surge in luteinizing hormone (LH) and Follicle Stimulating Hormone (FSH), which stimulates the released egg from a mature follicle – ovary.

During women menstrual cycle, there is a rise the Follicle Stimulating Hormone (FSH) secretion in the first half of the period and stimulates follicular growth in the ovary, after ovulation, each month the ruptured follicle forms and Corpus luteum that produces high levels of progesterone. This inhibits the release of stimulating Follicle Stimulating Hormone (FSH), and towards the end of the cycle the Corpus luteum breaks down, and progesterone production decreases. The next menstrual period begins when Follicle Stimulating Hormone (FSH) starts the production again, and get back to normal…

follicle stimulating hormone

Now In men, the production of Follicle Stimulating Hormone (FSH) is regulated by levels of testosterone and inhibin, both produced by the testes. Follicle Stimulating Hormone (FSH) regulates testosterone levels and when this rise they are sensed by nerve cells in the hypothalamus so that gonadotropin-releasing hormone secretion and consequently Follicle Stimulating Hormone (FSH) is decreased. The opposite occurs when testosterone levels drop. This is known as a ‘Negative Feedback in the body’ control so that the production of testosterone remains steady. But the sensed by cells in the anterior pituitary gland rather than the hypothalamus.

What happens if you have too much Follicle Stimulating Hormone (FSH)?

Most often, and raised levels of Follicle Stimulating Hormone (FSH) are a sign of malfunction in the ovary or testis. If the gonads fail to create enough estrogen, testosterone and inhibit, the right feedback control of Follicle Stimulating Hormone (FSH) production from the pituitary gland is lost, and the levels of both Follicle Stimulating Hormone (FSH) will rise. This condition is called hypogonadotropic-hypogonadism and is associated with primary ovarian failure or testicular failure. This is seen in states such as Klinefelter’s syndrome in men and Turner syndrome in women.

In women, Follicle Stimulating Hormone (FSH) levels also start to rise naturally in women around the menopausal period, reflecting a reduction in the function of the ovaries and decline of estrogen and progesterone production.

There are rare pituitary conditions that can raise the levels of Follicle Stimulating Hormone (FSH) in the bloodstream. This overwhelms the regular negative feedback and can cause ovarian hyperstimulation syndrome in women ovaries.

Symptoms: This includes enlarging of the ovaries and potentially dangerous accumulation of fluid in the abdomen, and triggered the rise in ovarian steroid output. Which leads to pain and other problems in the pelvic area of the body.

What happens if don’t produce enough Follicle Stimulating Hormone (FSH)?

In women, lack of Follicle-Stimulating-Hormone (FSH) leads to incomplete development in puberty o poor ovarian function (ovarian failure), and In this situation ovarian follicles do not grow properly and do not release in the egg, thus leading to infertility. Since levels of Follicle-Stimulating-Hormone (FSH) in the bloodstream are low, this condition is called hypogonadotropic-hypogonadism. This condition is called Kallman’s syndrome, which is associated with a reduced sense of smell.

Sufficient Follicle-Stimulating-Hormone (FSH), this action is also needed for proper sperm production in men, in case of complete absence of Follicle Stimulating in men, and the lack of puberty and infertility due no production of sperm is called (azoospermia). Partial Follicle-Stimulating-Hormone (FSH) deficiency in young men, can also cause delayed puberty and low sperm production, called (oligozoospermia), but fathering a child may still be possible. Follicle-Stimulating-Hormone (FSH) occurs after puberty; there will be a similar loss of fertility…

March 4, 2019 by Joseph Fermin 0 Comments

What is Luteinizing Hormone (LH) and Testosterone 4.5 (12)

What is Luteinizing Hormone &
The Productions of Testosterone

If you google the word Luteinizing Hormone or (LH), most of the articles you will find talks about the role of luteinizing hormone in women. There is very no info about the part of Luteinizing Hormone in men. While it may seem like a female hormone due to its role in ovulation, a surge of Luteinizing Hormone is a trigger that causes the ovary to release the egg, in the body. If you’ve been trying to conceive or have a baby your wife, significant other may be monitoring her Luteinizing Hormone levels. If she has trouble with ovulation, your doctor may prescribe medications that help with ovulation.

Many of this medication help stimulate the body to produce more Luteinizing Hormone (LH) and its cousin hormone, Stimulating Follicle Hormone (FSH). If you are not trying to conceive, or get pregnant, she may be on hormonal birth control pills. These pills prevent ovulation by blocking Stimulating Follicle Hormone and Luteinizing Hormone. It is one of the manliest hormones in your body. You can think of Luteinizing Hormone as a tiny drill sergeant that commands the Leydig Cells in the testicle to produce testosterone. When Luteinizing Hormone is present, the Leydig Cells generate Testosterone, when it is not, they don’t. Luteinizing Hormone is commander and chief of your Testosterone and critically crucial for sperm production count, muscle building, and overall sexual health.

Male hormones have a clinical nature to them. Luteinizing Hormone (LH) signals the testicle to produce Testosterone. Testosterone seeps out of the testis and into the bloodstream, where it circulates the body and put to good use. Manly things like growing chest hair, increase muscle and your voice deep are some of the effects.

Luteinizing Hormone or (LH)

The brain monitors the blood testosterone levels;

  • If they drop too low, it will send a signal to the pituitary gland to send out more Luteinizing Hormone (LH) to kick start testosterone production.
  • If your testosterone is chronically low (as in the case with hypogonadism or Low Testosterone), the brain will respond by increasing the level of Luteinizing Hormone (LH).
  • If testosterone is chronically higher (as in the case with using testosterone therapy, other performance enhancers or steroids), the brain will shut down production of Luteinizing Hormone (LH). When testosterone therapy is stopped, without post-therapy, men can experience a “crash” as Testosterone levels plummet, but with a post-therapy, the brain lags in re-starting the machinery to generate Luteinizing Hormone.

Getting Tested:

To measure Luteinizing Hormone (LH) levels, you will need to get blood work in a hormone clinic done. Because, doctors will order blood to estimate a panel of hormones which usually includes Stimulating Follicle Hormone, Luteinizing Hormone, Testosterone, Estrogen and They may also add Estrodial, Prolactin which will provide additional information into the insight into your hormonal health and a physical to know your body composition.

In a typical day, Luteinizing Hormone (LH) and Testosterone levels cycle from high to low. When getting blood work done to measure hormone levels, it is important to note the time of day that the analysis was performed to understand the values better.

Testosterone naturally will peak first thing in the morning (partially responsible for morning “wood”). For this reason, doctors prefer to regulate hormones between 8-10am to get a snapshot of your hormone panel profile when Testosterone level is likely to be highest.

When preparing for a Luteinizing Hormone test and to sure your doctor is aware of a few things like:

  • Current Prescription Taking: Current or past use of testosterone therapy. (If you are using anything at the gym or in supplements stores and you aren’t quite sure), you should bring it with your doctor about the appointment.
  • The Use Of Marijuana or THC: It may decrease the number of hormones levels, including Luteinizing Hormone.
  • Medical Radioactive Tracer: This can interfere with the test
  • Normal levels Luteinizing Hormone Range For Adult Males: 1–10 mIU/mL.

They are different labs report different reference ranges, and based on the exact way that they perform the blood work test. From a review of various lab reports, Values lower than 1.0 or higher than 10.0 typically indicate some problem.

For average men, Luteinizing Hormone (LH) typically falls somewhere between 4-7mIU/mL with drops and surges (about 6) throughout the day. Values below 4 and above seven may be considered borderline, and are useful to look at when compared to other hormones, particularly Testosterone and Prolactin.

In the studies that we have reviewed and found that these types of conditions have shown, and can significant drops in testosterone levels and minimal effect in Luteinizing Hormone (LH). Occasionally, Luteinizing Hormone may show up a little low, but often it is entirely in the normal range.

Therefore, low testosterone levels accompanied with normal Luteinizing Hormone (LH) levels often indicate the cause of Low Testosterone can tremendously help to diagnose the condition and also help to create a game plan for treating the cause while managing symptoms of low Testosterone.untitled-design-16

Whats the Causes of high Luteinizing Hormone in Men?

If Luteinizing Hormone (LH) is high and testosterone is low. Then some damage is causing the testicle, or the pituitary gland is trying to compensate by going into overdrive and flooding the balls. With extra Luteinizing Hormone in hopes that it will encourage higher Testosterone production. In cases like this, Luteinizing Hormone levels are often off the charts high sometimes double or triple the average values.

Common causes for this include:

  • Chromosome Abnormalities: Such as Klinefelter’s syndrome
  • Childhood Problems: Such as testicle or testicular torsion, The injury that causes significant damage to testicular tissue
  • Viral Infection: (most commonly mumps) that damages the testis.
  • Radiation exposure or chemotherapy
  • Testicular cancer
  • Borderline High Luteinizing Hormone (LH) levels

Medications or untreated autoimmune disorders can cause slightly elevated Luteinizing Hormone (LH) levels (8.0 – 10.0 range). Some studies have linked Celiac’s Disease with elevated somewhat Luteinizing Hormone (LH). Men with the untreated disease can have moderately high Luteinizing Hormone levels, that usually return to normal upon starting a gluten-free diet.

What causes low Luteinizing Hormone in Men?

The most common reason for Luteinizing Hormone deficiency in men is the use of external androgens (testosterone, other performance enhancers or non-medication). External androgens can trick the brain into thinking the body is producing naturally high levels of testosterone which low down production of luteinizing hormone (LH) and consequently natural testosterone production.

The second most common cause of low Luteinizing Hormone (LH) levels is a health issue, and can directly impact the function of the pituitary in the brain, Most common causes of the pituitary malfunction can include genetic conditions, such as Prader-Willi Syndrome or Kallman’s Syndrome and can cause other problems like:

  • Pituitary tumors (cancerous and benign)
  • Hyperprolactinemia
  • Head trauma
  • Various Medications
  • Auto-immune disorders
  • Borderline low Luteinizing Hormone (LH) results

Luteinizing Hormone levels in the 1.0 – some things can cause 3.0 range. Like, reduce temporarily imbalance hormones: such as overtraining, endurance. They are significantly under or overweight Alcohol consumption spikes in insulin medications or other drugs. High-stress Chronic conditions: that can cause hormone imbalance: such as diabetes, insulin resistance, various auto-immune disorders and can create borderline or low levels of Luteinizing Hormone (LH).


January 28, 2019 by Joseph Fermin 0 Comments

The importance of Testosterone Post Cycle Therapy? 5 (5)

Why Is Testosterone
Post Cycle Therapy Is Need It?

Why is Post Cycle Therapy (PCT) is perhaps the most critical aspect of testosterone use? The concept of the post cycle therapy (PCT), did not exist before the late 1980s, and 1990s and the mechanisms by which testosterone affected, the body were not wholly understood during the 1950s, 1960s, and 1970s.

This period were doctors, scientists, and testosterone injections users were only beginning to learn about the dynamics of testosterone and how they affect the endocrine system. We believed and understood since the beginning of testosterone injections use, the administration of testosterone resulted in triggering the body’s negative loop of the (HPTA) Hypothalamic Pituitary Testicular Axis. That endogenous Testosterone production would result become suppressed and shut down. The, unfortunately, is during the early periods of testosterone use between the 1950s and 1990, there was limited access to the compounds or knowledge or effectively.

Today it is a very different story. Now scientific and medical understanding of bio-identical testosterone use has soared exponentially since the old ‘golden era’ days of looking young and testosterone therapy use in athletics. Countless developments of beneficial compounds for hormonal recovery after testosterone therapy use, alongside the increased scientific and medical knowledge, has enabled testosterone use and its associated endocrine disruptions. The proper knowledge on how to recover the body’s from Hypothalamic Pituitary Testicular Axis (HPTA). Through post cycle therapy (PCT), we can not only emerge from their testosterone therapy while holding on to almost all of their benefits, but they can also increase the chances upwards to 90 percent or higher range of emerging with a fully healthy (HPTA).

Following the use of exogenous testosterone injections, the majority of users will experience what has been a hormonal crash or post cycle therapy crash, which is a physical environment in which key hormones essential is has been suppressed or shut down. The critical hormones in question are Luteinizing Hormone (LH), Follicle Stimulating Hormone (FSH), and subsequently (and are most importantly), for our natural testosterone. The Luteinizing Hormone (LH), and the Follicle Stimulating Hormone (FSH), known as phototropism. These hormones increase Testosterone secretion. Also alongside low levels of these hormones, to balance the essential hormones that have been thrown off balance, whereby Testosterone levels will be small, and most of the time, depending on the factors, estrogen levels will be higher than usual, and levels of Cortisol a steroid hormone that destroys muscle tissue. With the testosterone levels low and Cortisol levels in the average or high, Cortisol now can become a threat to the new muscle during the new testosterone therapy (“Testosterone correctly suppresses and counteracts Cortisol’s catabolic effects on muscle tissue”). The SHBG (Sex Hormone Binding Globulin) is also a concern here as well, which is a protein that binds to sex hormones Testosterone renders them inactive, essentially ‘handcuffing’ them and preventing them from exerting their effects. SHBG will also usually elevated during the post cycle therapy weeks as a result of the supraphysiological levels of androgens from the new testosterone therapy.

The human body will generally and restore this imbalance of hormones and recover from testosterone levels on its own, over time with no outside assistance or post cycle therapy (PCT), but the studies have demonstrated and shown us that without the intervention of testosterone stimulating agents, this will occur throughout one to four months. Therefore, all testosterone therapy should be concerned with the fastest possible hormonal recovery, assisted and boosted with the use of Testosterone stimulating compounds correctly, also the attempt to allow the body to recover on its own, from a very high probability of long-term endocrine damage to the Hypothalamic Pituitary Testicular Axis (HPTA), whereby the individual will develop-induced hypogonadism to inability the production of proper levels of Testosterone to rest. So therefore paramount that an appropriate post cycle therapy that includes multiple recovery compounds to be utilized to not only restore the (HPTA) function but also to normalize the levels as quickly as possible. To avoid any possible permanent damage, which can take priority over the concern of maintain to the recently gained muscle mass and any other benefits from it.

What Post Cycle Therapy Protocol?

There are many different types of post cycle therapy (PCT) protocols that have overdeveloped over the years; any individual will become extremely confused about how many different opinions exist among the testosterone community, This article will present the best possible and most efficient post cycle therapy protocol valid scientific data, also myths in regards to post cycle therapy (PCT), and outline which post cycle therapy (PCT) protocols should not follow due to recent more advanced developments, as well as contemporary better scientific and medical understandings of how a proper post cycle therapy protocol should work. This point, there still exists very obsolete – and subsequently ineffective – post cycle therapy (PCT) contracts that are still utilized by many testosterone users, and this presents a severe hazard not only for the individual unknowingly using a post cycle therapy.

For example:

There are several therapeutic and safety reasons why you should not continue with testosterone injections indefinitely without giving your body time to normalize to reset. Because of the decline in benefits after six months of a testosterone therapy, the physicians need to regularly incorporate a cleanse therapy post cycle therapy (PCT) in an attempt to reactivate the endocrine in the body, as you increase your testosterone levels using any testosterone therapy, now the levels of testosterone circulating the body will shut down the natural production of your endogenous testosterone; and also increases the production of estrogen in your body, which can lead to a series of undesirable and unwanted side effects in the body. `This means that the synthesis of (LH) luteinizing hormone in your body; this hormone is produced by your brain to stimulate testosterone production. and follicle-stimulating hormone in the body; the hormone produced by your mind to boost sperm production suddenly stops. When Luteinizing Hormone (LH) and Follicle Stimulating Hormone (FSH) levels are no longer detectable, your body will not experience the exceptional health benefits, and energy-optimizing results expected from a testosterone injection program.

Another critical concern for men is testicular atrophy in patients that participate in testosterone therapy and may experience shrinkage of the testes, This occurs as the result of the lack of testosterone, and sperm production has been shut down, in response to the testosterone therapy.

What does post cycle therapy (PCT) consist of, an example?

Your post cycle therapy consists of a testosterone secretagogue to stimulate the secretion of endogenous testosterone from the testes to reignite natural production. The medication mimics the signal from your brain. The Luteinizing Hormone (LH) induce the production of testosterone. An example of a testosterone secretagogue is human chorionic gonadotropin (hCG), which is administered either using sublingual troches or subcutaneous injections once or twice a week during therapy and then on 10–15 consecutive days as part of a post cycle therapy (PCT). Human chorionic gonadotropin (hCG), mimics Luteinizing Hormone (LH) to stimulate testosterone production by the testes. It works by effectively tricking the testes into thinking that they are being instructed to produce testosterone, even though levels are comfortably elevated because of the injectable testosterone therapy. The testosterone production stimulated by human chorionic gonadotropin (hCG) is not sufficient to sustain healthy testosterone levels on its own, but that is not the reason for this supplementation. The purpose is to ensure that the testes remain functioning during therapy to help avoid any shrinkage or atrophy.

You will also take an anti-estrogen or aromatase inhibitor. For example, Clomid/clomiphene blocks certain types of estrogen from getting to the pituitary and hypothalamus, where it elicits signals that stop testosterone production. Anti-estrogens or aromatase inhibitors also help to reactivate the standard functionality of Luteinizing Hormone (LH) and Follicle Stimulating Hormone (FSH) signaling, while also helping to flush out any residual estrogen that has accumulated during therapy. The estrogen that collects during treatment is responsible for many of the adverse side effects associated with testosterone therapy.

An example of a post cycle therapy (PCT) protocol is as follows (note that the exact drug and dose prescribed will depend on the specific information contained within each patient file, as well as the individual patient goals):

  • 250–800 units of a testosterone secretagogue every day for ten consecutive days
  • One estrogen blocker or antagonist by mouth every day for 10–15 straight days

Without the proper understanding of what is explicitly occurring within the endocrine system during these crucial weeks, as well as a lack of knowledge of which compounds to utilize, what each compound does, and how to properly use them, serious problems can result.

post cycle therapy

The Hypothalamic Pituitary Testicular Axis (HPTA):

The (HPTA), which is an axis interconnected endocrine glands in the body that deals with control the production Testosterone.


Outlined above is a diagram of the Hypothalamic Pituitary Testicular Axis (HPTA), Regulates the body produces the amount of Testosterone at any given time. Every individual is essentially programmed by (DNA) genetics as to maximum Testosterone they will provide.

The Hypothalamic Pituitary Testicular Axis (HPTA) and the functions that undergo a negative feedback loop, and the body will reduce secretion of Testosterone, f have too much Testosterone the body will be detected, known as the negative feedback loop. This controlled by the hypothalamus, which is mostly considered the ‘master’ gland for all endocrine system and the hormonal functions in the body. The negative feedback will loop ultimately in the body to attempt to maintain the hormonal homeostasis, and all endocrine glands operate by way of the negative feedback loop in one way or another in varying degrees, In the case of post cycle therapy, the concern is a negative feedback loop of the (HPTA).

Within the Hypothalamic Pituitary Testicular Axis (HPTA), the concern during post cycle therapy (PCT) is the restoration and regulation of the following five hormones to homeostasis:

  • GnRH (Gonadotropin Releasing Hormone)
  • LH (Luteinizing Hormone)
  • FSH (Follicle Stimulating Hormone)
  • Testosterone production

The Hypothalamic Pituitary Testicular Axis (HPTA), the hypothalamus, which will detect a need for the human body to produce more Testosterone, and will release varying amounts of GnRH, Is a hormone that signals the pituitary gland, to begin the production and release of two essential gonadotropins: Luteinizing Hormone (LH) and Follicle Stimulating Hormone (FSH). Two hormones that work together to start the secretion of Testosterone.

Two primary hormonal factors serve to inhibit, reduce, suppress, or shut down Testosterone production in the Hypothalamic Pituitary Testicular Axis (HPTA):

  • Testosterone Excess
  • Estrogen Excess

Although there exist other hormones that serve to inhibit and suppress Hypothalamic Pituitary Testicular Axis (HPTA) function (such as Progestins and Prolactin), these are the two primary conditional hormones that are of concern. When the hypothalamus detects excess levels of Testosterone and Estrogen in the body (either from the use of exogenous androgens on an testosterone therapy or otherwise), the hypothalamus will act to attempt to restore a balance by essentially doing the opposite of what was previously described. The hypothalamus will reduce or stop its production of GnRH, which halts production of Luteinizing Hormone (LH) and Follicle Stimulating Hormone (FSH), which ultimately reduces or halts production of Testosterone. Until the hypothalamus’ ideal hormonal environment is restored, the output of the various signaling hormones within the (HPTA) will not begin, and this will often require months for the body to do this on its own without the intervention of any Testosterone stimulating agents. The reason as to why the recovery of the (HPTA) naturally takes such a long time should be very clear due to the described workings of the (HPTA).

This fundamental understanding of the mechanisms of the Hypothalamic Pituitary Testicular Axis (HPTA) and negative feedback loop described above is essential to understanding how and why a proper post cycle therapy (PCT) program must be developed and utilized following an testosterone therapy.

Determining Factors In Difficulty Recovering the Hypothalamic Pituitary Testicular Axis (HPTA):

With testosterone therapy use, there are several different major determining factors in how much difficulty an individual will experience in recovery of their Hypothalamic Pituitary Testicular Axis (HPTA) and endogenous Testosterone function during post cycle therapy (PCT).

They are the following factors, in no particular order of importance:

  • Individual response
  • Type of testosterone(s) used
  • Length of the cycle (degree of testicular desensitization)

Individual response:

Every single individual will respond differently to any chemical, compound, testosterone, food or drug in existence. While some individuals might experience no Hypothalamic Pituitary Testicular Axis (HPTA) suppression or shutdown at all, other individuals might experience severe Hypothalamic Pituitary Testicular Axis (HPTA) suppression and closure to the extent where they might require far more extended periods to ensure full recovery than most. This, like anything else, is a spectrum whereby there are the very ‘lucky’ individuals that recover very quickly and easily on one end of the spectrum, and the ‘unlucky’ individuals that have extreme difficulty recovering during post cycle therapy. In between the two extremes is the average. Once again, this is due to the individual’s genetic programming as to how the Hypothalamic Pituitary Testicular Axis (HPTA) will respond and attempt to maintain homeostasis.

Type of Testosterone Therapy(s) used:

All testosterone therapy exhibit suppression or shutdown of the Hypothalamic Pituitary Testicular Axis (HPTA) through the mechanisms of the negative feedback loop, and there are no exceptions to this. Various testosterone therapy are known as being mildly suppressive, while others are identified as being profoundly suppressive. This is all reliant on multiple different reasons, many of which will not be discussed here. In any case, no matter how mild or severe an testosterone therapy exerts Hypothalamic Pituitary Testicular Axis (HPTA) suppression, all testosterone therapy when utilized for typical cycle lengths of weeks at a time will eventually cause the Hypothalamic Pituitary Testicular Axis (HPTA) to shut down, or at the very least severely suppress its hormonal signal processes.

Length of the cycle degree of testicular desensitization:

This is perhaps the most important and most influential factor. As the range of testosterone therapy use continues, the majority of the Leydig cells of the testes remain dormant and inactive, and the longer these interstitial cells stay dormant and idle, the higher the difficulty is essentially getting these cells to respond to the stimulus of Luteinizing Hormone (LH) and Follicle Stimulating Hormone (FSH) once again. It has been discovered in studies that the issue of recovery of the Leydig cells following testosterone therapy use is not due to a lack of Luteinizing Hormone (LH), but due instead to the desensitization of the Leydig cells to (LH). In one study in which exogenous Testosterone was administered to male test subjects for 21 weeks, Luteinizing Hormone (LH) levels were suppressed shortly after beginning administration. However, at the end of the 21 weeks, Luteinizing Hormone (LH) levels were observed to rise within three weeks once the exogenous Testosterone administration stopped, but Testosterone levels did not arise until many weeks later in most of the test subjects.

Recovery During The Post Cycle Therapy (PCT).

To stimulating hormonal recovery during post cycle therapy, it is essential for individuals to understand that the use of any medication except for a single select one or two is inadequate for hormonal recovery during post cycle therapy (PCT). Ideally, all post cycle therapy programs should be a multi-component post cycle therapy (PCT) program that includes several different compounds that work in tandem with one another to provide the most effective and fastest possible Hypothalamic Pituitary Testicular Axis (HPTA) recovery following an testosterone therapy.

The three categories of compounds are in order of importance:

  • SERMs (Selective Estrogen Receptor Modulators)
  • Aromatase Inhibitors
  • HCG (Human Chorionic Gonadotropin)


Classes of drugs in the SERM category include: Nolvadex (Tamoxifen Citrate), Clomid (Clomiphene Citrate), Raloxifene, and Fareston (Toremifene Citrate). The nature of a SERM is that it exhibits mixed Estrogen agonist and Estrogen antagonist effects on the body. This means that although a SERM might block the effect of Estrogen at the cellular level in specific tissues, it can enhance Estrogenic impacts in other areas of the body. These can be positive effects as well as adverse effects. Nolvadex, for example, exhibits Estrogenic agonistic effects in the liver, which is a positive effect, as its effects here result in a positive change in cholesterol profiles (something desired by many). All SERMs to varying degrees serve to act as an Estrogen antagonist in this area, working to mitigate Estrogen’s effects on breast tissue, reducing or blocking the side effect of gynecomastia. Regarding the impact of SERMs on endogenous Testosterone stimulation, they serve to act as an Estrogen antagonist at the pituitary gland, triggering the release of Luteinizing Hormone (LH) and Follicle Stimulating Hormone (FSH) as a result. Elevated levels of Estrogen in men can and does suppress the output of endogenous Testosterone via the negative feedback loop, leading to hypogonadism. SERMs for this purpose are an essential addition to any post cycle therapy (PCT) protocol and are not to be excluded under any circumstance. Regardless of this, however, the sole focus should not be on SERMs.

Aromatase Inhibitors:

These are compounds such as Aromasin (Exemestane), Arimidex (Anastrozole), and Letrozole (Femara). Rather than block the activity of Estrogen at the cellular level in different tissues, aromatase inhibitors (AIs) serve to lower total circulating Estrogen levels in the body by way of inhibiting the aromatase enzyme, which is the enzyme responsible for the conversion of androgens into Estrogen. The transformation of androgens into Estrogen results in excess Estrogen levels, which, as explained earlier in this article, will trigger the negative feedback loop leading to suppression of Testosterone production. By way of lowering total circulating blood plasma Estrogen levels, AIs will positively engage the negative feedback loop and result in the release of Luteinizing Hormone (LH) and Follicle Stimulating Hormone (FSH) for the manufacture and secretion of more Testosterone. This is mainly due to the hypothalamus realizing that circulating. Estrogen levels are too low and will attempt to increase circulating levels of Testosterone for a portion of the Testosterone secreted to be able to become aromatized into Estrogen to restore the hormonal balance. The other importance of aromatase inhibitors is the ability to mitigate the Estrogenic effects of human chorionic gonadotropin (HCG), which will be explained shortly. It is important to note, however, that the majority of aromatase inhibitors do not comply very well with SERMs such as Nolvadex, and those particular choices should be made in regards as to which AI is used during post cycle therapy (PCT).


Human Chorionic Gonadotropin is, for the most part, synthetic Luteinizing Hormone (LH). It is a protein hormone manufactured in high amounts by pregnant females that contains a protein subunit that is 100% identical to Luteinizing Hormone (LH), and therefore when administered to men, it will mimic the action of Luteinizing Hormone (LH) in target tissues, such as the testes. What results is an increase in Testosterone production via stimulation of the Leydig cells by human chorionic gonadotropin (HCG). Human chorionic gonadotropin (HCG) should never be utilized alone, as its nature as a gonadotropin will itself trigger a negative feedback loop whereby once human chorionic gonadotropin (HCG) is used, the pituitary gland will halt output of Luteinizing Hormone (LH) until human chorionic gonadotropin (HCG) use has discontinued. Therefore, human chorionic gonadotropin (HCG) must be utilized with a SERM and especially an aromatase inhibitor, as human chorionic gonadotropin (HCG) has demonstrated to increase aromatase activity in the testes, resulting in rising Estrogen levels.

Putting Them Together:

The reader may be wondering which compounds to select of the three categories listed, and how to use them properly. The answer lies in understanding the properties of each and, in interpreting these properties, how to use them efficiently and appropriately.

Human chorionic gonadotropin (HCG):

The first item to be examined will be human chorionic gonadotropin (HCG). The majority of testosterone therapy users from the 1960s – mid-1980s did not even utilize any compounds for hormonal recovery, and the term post cycle therapy (PCT) did not even exist at that time. When the use of human chorionic gonadotropin (HCG) became increasingly popular (circa 1980), it was the only compound utilized. Since then, the medical and scientific understanding of such things has increased exponentially, and there should be no reason for any informed and adequately educated individual to utilize human chorionic gonadotropin (HCG) on its own for post cycle therapy (PCT). When used in conjunction with one of the other two categories of compounds (an AI and a SERM), the dynamics change considerably.

It has been mentioned already that much of the difficulty in recovering the Hypothalamic Pituitary Testicular Axis (HPTA) following an testosterone therapy is the result of Leydig cell desensitization. Human chorionic gonadotropin (HCG) is necessarily an analog of Luteinizing Hormone (LH), and the testes after a prolonged testosterone therapy would be as equally desensitized to human chorionic gonadotropin (HCG) as they are to Luteinizing Hormone (LH). The human body, however, produces Luteinizing Hormone (LH) amounts on its own that is far too inefficient for proper and rapid Testosterone production. The body’s natural increase of Luteinizing Hormone (LH) and Follicle Stimulating Hormone (FSH), evidenced by the study referenced earlier in which it was not until three weeks when Luteinizing Hormone (LH) levels only began to reach the standard physiological measurements following the cessation of Testosterone. Therefore, the body’s natural Luteinizing Hormone (LH) production does not provide a high enough dose for stimulation, nor an immediate stimulus to the tests required for the initial increase in Testosterone needed during the post cycle therapy weeks.

Human chorionic gonadotropin (HCG), utilized in a specific manner during the first 1 – 2 weeks of post cycle therapy (PCT) at a dose of 100-1,500IU every 2 days, is what allows the individual to provide the testes with a high dose to provide them with a ‘shock’ effect, and sustain this shock effect on the Leydig cells of the testes for a sustained period of the first 1 – 2 weeks of post cycle therapy. Studies have demonstrated the incredible effectiveness of human chorionic gonadotropin (HCG) for this purpose, it been suggested that human chorionic gonadotropin (HCG) therapy is utilized to treat low testosterone and hypogonadism. Following this line of thought, the other two compounds (the SERM and the AI) are to be used as supportive compounds for human chorionic gonadotropin (HCG) use in this 1 – 2 week period, and after human chorionic gonadotropin (HCG) is discontinued early on in post cycle therapy (PCT), only the SERM is to be used in order to carry along the hormonal recovery process.

In spite of the good news in regards to the ability for human chorionic gonadotropin (HCG) to assist in hormonal recovery, there are still two remaining issues to be addressed:

  • The fact that human chorionic gonadotropin (HCG) causes increased production of aromatase, leading to increased Estrogen levels.
  • Following the discontinuation of human chorionic gonadotropin (HCG), the body is left with very little endogenous Luteinizing Hormone (LH), and Follicle Stimulating Hormone (FSH) production due to the exogenous administration of human chorionic gonadotropin (HCG).

Aromatase Inhibitors:

Aromasin (Exemestane) Above All Else The first of the two remaining issues to be addressed will be the fact that human chorionic gonadotropin (HCG) will trigger increases in testicular aromatase expression, and result in Estrogen increases in the body. It should also be noted that it will cause an increase in testicular progesterone levels. Estrogen rising is, of course, undesirable during post cycle therapy (PCT), as it has already been explained that Estrogen will trigger suppression of endogenous Testosterone production, and there is no doubt that any individual wishes to encounter Estrogenic side effects during post cycle therapy (PCT) either.

Therefore, the option here is to include an aromatase inhibitor. However, there exists a big problem in regards to the other two of the three major aromatase inhibitors (Arimidex and Letrozole). The issue is the fact that in a post cycle therapy (PCT) program that includes the use of SERMs such as Nolvadex and Clomid, which are known as essential components to a post cycle therapy (PCT) program, Arimidex and Letrozole have direct negative interactions with Nolvadex. The problem here is that Arimidex (or Letrozole) and Nolvadex both directly counteract one another. One study has demonstrated that when Arimidex is utilized with Nolvadex, Nolvadex will decrease the blood plasma concentration of Arimidex (as well as Letrozole, another commonly used aromatase inhibitor). The conclusion here is that the use of Arimidex or Letrozole with Nolvadex together is a terrible idea and may work together in a post cycle therapy (PCT) protocol. Aromasin completely circumvents this problem, as it has been demonstrated to have no interactions what so ever with Nolvadex, unlike the other two aromatase above inhibitors. In one study, Aromasin displayed no such reduced effectiveness or any reduced blood plasma levels when utilized with Nolvadex.

The other benefit of selecting Aromasin over all other AIs is the fact that Aromasin has demonstrated in several studies to impact cholesterol profiles in a negative manner far less than other aromatase inhibitors have, wherein one particular review on cancer patients, 24 weeks of Aromasin (Exemestane) administration held no impact on cholesterol profiles. Some other studies have also demonstrated a nil effect on cholesterol profiles from the use of Aromasin. Although there have also been some studies that have shown a negative impact on cholesterol profiles resultant from Aromasin use, it is evident that there is not as a significant or as a negatively impacting effect from Aromasin on cholesterol as other aromatase inhibitor.

Finally, in addition to these benefits from Aromasin, it is evident that Aromasin holds the ability to increase Testosterone levels in males as demonstrated by studies. For example, one particularly notable study selected 12 healthy young male test subjects, and were administered random Aromasin doses of 25mg and 50mg for a 10 day period, and not only was Estrogen suppressed by a significant amount (38%), but Testosterone levels in the test subjects were observed to have increased by an incredible 60%.

Following these details, Aromasin would be the best possible aromatase inhibitor of choice to combat the increased aromatase activity caused by human chorionic gonadotropin (HCG). Therefore, Aromasin would then be utilized at a full 25mg daily dose, and only while human chorionic gonadotropin (HCG) is used. Once human chorionic gonadotropin (HCG) is discontinued, Aromasin too should be halted.

The only following issue to cover now is that of stimulating and maintaining proper endogenous Luteinizing Hormone (LH) release to carry recovery along until the body can become self-sufficient once again.

Nolvadex and Clomid: 

The question is often asked among the testosterone therapy using community: Clomid or Nolvadex? Which one for post cycle therapy (PCT)?

First of all, the best possible addition to human chorionic gonadotropin (HCG) in a post cycle therapy (PCT) protocol is Nolvadex (Tamoxifen Citrate), as studies have demonstrated that human chorionic gonadotropin (HCG) and Nolvadex utilized together have exhibited a remarkable synergistic effect in terms of stimulating endogenous Testosterone production and that Nolvadex will actually work to block the desensitization effect on the Leydig cells of the testes caused by high doses of human chorionic gonadotropin (HCG). This is very important because just as too little Luteinizing Hormone (LH) secretion for extended periods can cause desensitization to gonadotropins, too much gonadotropin stimulation (in the form of human chorionic gonadotropin (HCG) or otherwise) will likewise create a desensitization effect.

Secondly, Nolvadex on an mg for mg basis is far more effective than Clomid in stimulating endogenous Testosterone production, as well as being a more cost-effective choice than Clomid itself. Studies have demonstrated that 150mg of Clomid (Clomiphene Citrate) administered daily raised endogenous Testosterone levels of 10 healthy males by approximately 150%, while incidentally, 20mg of Nolvadex (Tamoxifen Citrate) daily raised endogenous Testosterone levels by the same amount. It is very evident here that Clomid is very useful for this purpose, but Nolvadex seems to be a more cost-effective choice seeing as though it is more effective than Clomid when compared mg for mg. The benefits of Nolvadex over Clomid do not end there – Clomid, although it does exhibit Estrogen antagonist effects at the pituitary gland as Nolvadex does, actually shows Estrogen agonist effects there too. What this means is that Clomid will work in varying degrees as an Estrogen at the pituitary gland, triggering the negative feedback loop and reducing the output of Testosterone stimulating gonadotropins Luteinizing Hormone (LH) and Follicle Stimulating Hormone (FSH). This is a severe problem during post cycle therapy, which is a period in which individuals are trying to recover their Hypothalamic Pituitary Testicular Axis (HPTA) function rather than halt it even further. Ideally, one would want a SERM that exhibits almost 100% Estrogen antagonistic effects on the pituitary gland, and Nolvadex is the perfect choice for this.

When it comes to the dosing aspect of Nolvadex, The standard dose for post cycle therapy (PCT) and for stimulating the release of GnRH (Gonadotropin Releasing Hormone), Luteinizing Hormone (LH), Follicle Stimulating Hormone (FSH), and ultimately Testosterone is that of a single Nolvadex dose of 20 – 40mg daily. In all studies involving Nolvadex doses used to stimulate endogenous Testosterone production, only 20 – 40mg daily of Nolvadex was utilized, and it has been shown that doubling the dose to 40mg or any higher will not produce any significant difference in endogenous Testosterone secretion. The only reason why many elects to utilize 40mg daily of Nolvadex for the first 1-2 weeks of a post cycle therapy (PCT) program is to achieve optimal peak blood plasma levels quicker to ensure Hypothalamic Pituitary Testicular Axis (HPTA) recovery faster.

The ideal post cycle therapy protocol for 4 – 6 weeks Total post cycle therapy (PCT) time (depending on the recovery ability of the individual):

01) Weeks 1 – 2:

  • human chorionic gonadotropin at 1000iu/E2D.
  • Aromasin (Exemestane) at 25mg/day.
  • Nolvadex (Tamoxifen Citrate) at 40mg/day.

02) Weeks 2 – 6:

  • Nolvadex or (Tamoxifen Citrate).

Additional and Optional, Vitamins, Supplements, Compounds to Aid During post cycle therapy (PCT), Aside from the principal components discussed, various other parts are mostly optional, but still very useful for hormonal recovery of the Hypothalamic Pituitary Testicular Axis (HPTA) during the post cycle therapy weeks.

Vitamin B12 Health Benefits, There has been a lot of controversy over whether or not there is indeed a benefit from taking B12 supplements. Some doctors suggest that as long as a person is not vegan (though probiotics in the gut can produce some B12), they are probably getting sufficient B12 from the basic foods they are ingesting.

vitamin b12

Let us reference some studies:

There is documented research from the Framingham Study suggesting that 40% of all people are deficient in B12. The American Journal of Clinical Nutrition researched in 2009, and they published a study suggesting close to 6% of U.S. and U.K. residents over the age of 60 are B12 deficient. Another 20% were referenced as “marginal status.”

Vitamin B12 Health Benefits has the most multifaceted and prevalent chemical structure of all vitamins. One area where it differentiates from other vitamins is in the fact that it’s the only vitamin that contains a metal commonly referred to as Cobalamin, which is also a universal term for all the various compounds that may have some B12 properties in it.

B12 can improve energy by aiding in thyroid function and cellular methylation, That being said, B12 is not only useful in supporting healthy energy levels. It is unequivocally essential to life and whole existence. People deficient in B12 will suffer from serious health issues if the problem is not addressed.

What role B12 plays in the following human biological processes:

  • Nerve and brain regeneration
  • Adrenal gland support
  • Male and female reproductive health
  • Nutrient absorption
  • Red blood cell formation
  • Cellular energy
  • Memory recall
  • DNA synthesis

Here are some of the risks associated depleted B12 levels are:

  • Pernicious anemia
  • Migraine headaches
  • Macular degeneration
  • Tinnitus
  • Fatigue (adrenal fatigue and CFS)
  • Multiple sclerosis
  • Memory loss
  • Neuropathy
  • Anemia
  • Asthma
  • Shingles
  • Kidney disease
  • Depression

December 14, 2018 by Joseph Fermin 0 Comments

What is Ibutamoren MK-677 and The Benefits 5 (5)

What is Ibutamoren MK-677 and The Benefits

Ibutamoren MK-677 and the all-news online and forums are talking about Ibutamoren and for the properties to help athletes recover faster and used by those patients wishing to increase their growth hormone. However, clinical studies of this compound Ibutamoren are relative, So far, Ibutamoren (also known as MK-677), and promotes the secretion of the growth hormone (GH), and increases insulin-like growth factor (IGF-1) Levels.

Ibutamoren MK-677 increases the growth hormone levels by mimicking the action of the hormone ghrelin and binding the ghrelin receptors (GHSR) in the brain. The activated (GHSR) stimulates growth hormone release from the brain, (GHSR) found in brain regions that control appetite, mood, pleasure, biological rhythms, memory, and cognition. Therefore, we can expect ibutamoren MK-677 may also affect these functions. The clinical studies describe only the effects ibutamoren MK-677 has on appetite.

The great thing about ibutamoren MK-677 increases with little or no efforts the growth hormone levels. Also, help such as cortisol levels: cortisol help suppress the immune system to heal faster and impairs the learning and memory.

Uses Of Ibutamoren MK-677

Ibutamoren MK-677

Building Muscle:

Ibutamoren MK-677 is frequently used as an anabolic substance, to increase lean body mass, and create muscle. It is orally active also and can be taken once a day. These are all full benefits compared to other growth hormone stimulators.

As previously mentioned, ibutamoren MK-677 increases growth hormone levels and the (IGF-1). Both growth hormone and (IGF-1), and it help increase muscle mass, muscle strength, and reduce body fat In obese patients, a two-month treatment (DB-RCT) with ibutamoren MK-677 increased lean mass, and transiently increased basal metabolic rate (BMR).

Muscle Wasting and Strength:

In a study done (DB-RCT) in eight patients healthy volunteers and where food-deprived, and ibutamoren MK-677 reversed the diet-induced protein loss and helped with the muscle wasting patients. In a study 123 elderly patients with hip fracture, ibutamoren improved gait speed, muscle strength and reduced the number of falls (RCT).

Bone Density and Healing:

Growth hormone (GH) increases bone healing and eventually bone density. Now because of the increased turnover in treated patients with growth hormone. Patients under the therapy over (1 year) to see the bone density increase, and in 24 volunteers with healthy obese patients, ibutamoren MK-677 increased the bone turnover (DB-RCT).

The study on 187 elderly Patients, Ibutamoren MK-677, increased bone building, measured by osteocalcin on bone turnover in multiple studies (3 DB-RCTs). In one study (DB-RCT), In 292 women patients with post-menopausal. Ibutamoren MK-677 has increased bone mineral density which helps improve bone strength and prevent osteoporosis and more.

Better Quality Sleep Duration:

A study on (DB-PCT) showed that in both younger and elderly patients, ibutamoren MK-677 improved sleep quality and Rapid Eye Movement (REM), and sleep duration, apart from scientific studies done, there have been many reports, across various forums online.

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Longevity Benefits:

Growth Hormone Secretion (GHS) and muscle mass both decline around mid-puberty throughout life, In a study with 65 senior men and women (DB-RCT), THE daily ibutamoren MK-677 increased Growth Hormones and (IGF-1) levels without serious adverse effects. Now the (IGF-1) is known to have beneficial effects on longevity.

Memory Enhancement Effects:

Ibutamoren MK 677 increases (IGF-1), which is known to enhance memory and learning, Ibutamoren MK-677 also increases (REM) sleep duration and quality. Understand that sleep is essential for proper cognitive function, A study (DB-multicenter) questioned the association of low (IGF-1) and Alzheimer’s, and whether ibutamoren MK 677 could be of help. However, in this study, ibutamoren MK-677 was ineffective at slowing the progression of Alzheimer’s in Patients.

Growth Hormone Deficiency:

Ibutamoren MK 677 can increase growth hormone, (IGF-1), levels in children with growth hormone deficiency. Furthermore, these effects change the concentrations of prolactin, triiodothyronine (T3), thyroxine (T4), thyrotropin, glucose, cortisol, and insulin.

In severe men with GH deficiency Ibutamoren MK 677 increased (IGF-1) and growth hormone, with no changes in cortisol, PRL, and thyroid hormone levels. However, insulin and glucose increased (DB-RCT).

Tissue Regeneration and Wound Healing:

Growth hormone (GH) increases tissue regeneration and wound healing so that ibutamoren MK 677 may help with these. There are individual reports of ibutamoren being helpful, but scientific studies are lacking.

December 11, 2018 by Joseph Fermin 0 Comments

AAI Clinics Receives 2018 Best of Health Consultant 5 (5)

Health Consultant Press Release:


Anti Aging Rejuvenation Clinic (AAI Clinics) Receives 2018 Best of Plantation, Award Program Honors the Achievement.

AAI Clinics, aai rejuvenation clinic, Health Consultant

PLANTATION December 4, 2018 — Anti Aging Rejuvenation Clinic has been selected for 2018 Best of Plantation Award in the Health Consultant category by the Plantation Award Program.

Each year, the Plantation Award Program identifies companies that we believe have achieved exceptional marketing success in their local community and business category. These are local companies that enhance the positive image of small business through service to their customers and our community. These exceptional companies help make the Plantation area a great place to live, work and play.

Various sources of information were gathered and analyzed to choose the winners in each category. The 2018 Plantation Award Program focuses on quality, not quantity. Winners are determined based on the information gathered both internally by the Plantation Award Program and data provided by third parties.

AAI has made the qualification process simple. The initial step in getting started is to fill out the medical history form on our website. This will give the physician a more detailed view of your unique history to align with your goals. You will be assigned a physician trained wellness advisor within minutes of filling out this form. Our advisors will then walk you through setting up a physical examination and a comprehensive lab test within your desired zip code. We are available to answer any questions you may have and can be reached at 1-866-AAI-Low-T or 1-866-224-5698

About Plantation Award Program

The Plantation Award Program is an annual awards program honoring the achievements and accomplishments of local businesses throughout the Plantation area. Recognition is given to those companies that have shown the ability to use their best practices and implemented programs to generate competitive advantages and long-term value.

The Plantation Award Program was established to recognize the best of local businesses in our community. Our organization works exclusively with local business owners, trade groups, professional associations, and other business advertising and marketing groups. Our mission is to recognize the small business community’s contributions to the U.S. economy.

SOURCE: Plantation Award Program

Plantation Award Program
Email: PublicRelations@local-recognition.net

URL: https://www.aaiclinics.com