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Category: Post Cycle Therapy

May 7, 2019 by admin 0 Comments

Post Cycle Therapy & well-Structured Testosterone Therapy 5 (1)

The Post Cycle Therapy (PCT), and Testosterone Injections Therapy goes hand on hand, Most men embarking on a testosterone injectable therapy replacement protocol are doing so as a result of medical reason or age-related issues that are affecting their life.

Now patients with problems and that face their low testosterone, the related concerns and do not allow fully experience the decline associated with maintaining extended periods of low hormones levels and will usually benefit from comprehensive testosterone therapy.

Note: that the specific drug and dose prescribed will depend on the particular information contained within each patient medical file and medical reason, as well as the individual goals patients.

Example:

  • Day 1. (50–250 mg) of testosterone injection.
  • Day 2. Two estrogen blocker or inhibitor.
  • Day 3. One injectable of an amino acid or vitamin B-vitamin.
  • Day 5. One estrogen blocker or inhibitor by mouth.
  • Day 6. One injection of a (250–800 units) of testosterone secretagogue.
  • Day 7. One estrogen blocker or inhibitor (sometimes two estrogen blockers a week is enough, But depending on the patient file).
  • Day 7. One injection of a (250–800 units) of testosterone secretagogue.

Example: This protocol for a man focused on muscle development (reversing lean muscle loss), Muscle development protocols, also work well in patients that may react to therapy with too much aromatization (estrogen accumulation).

Men are experiencing excessive aromatization and lean muscle depletion who are focused on rebuilding muscle, with Peptides.

Note: that the specific drug and dose prescribed will depend on the particular information contained within each patient medical file, as well as the individual patient goals.

Example:

  • Day 1. (50–150 mg) of a combination of testosterone esters,
    (15–30 units) Sermorelin Peptides before Bedtime.
  • Day 2. Two estrogen blocker or inhibitor,
    (15–30 units) Sermorelin Peptides before Bedtime.
  • Day 3. One injection of an amino acid or B-vitamin,
    (15–30 units) Sermorelin Peptides before Bedtime.
  • Day 4. Combination of (50–150 mg) testosterone esters,
    (15–30 units) Sermorelin Peptides before Bedtime.
  • Day 5. One estrogen blocker or inhibitor by mouth,
    (15–30 units) Sermorelin Peptides before Bedtime.
  • Day 6. One injection of a (250–800 units) of testosterone secretagogue.
  • Day 7. One estrogen blocker or inhibitor (sometimes two estrogen blockers a week is enough, But depending on the patient file).
  • Day 7. One injection of a (250–800 units) of testosterone secretagogue.

This weekly cycle would typically continue for 6–9 months, before a break period in which the body is allowed to normalize and reactivate your natural production.

What is Sermorelin?

Sermorelin is a peptide comprised of the first 29 amino acids of endogenous GH; the sequence is the same as endogenous GHRH. As we age, our body produces less and less of our vital hormones, including GH. Studies have revealed that sermorelin can restore GH RNA concentrations to youthful levels, which subsequently stimulates the production of insulin-like growth factor-1 (IGF-1).

Remember: When you are artificially manipulating your testosterone levels, some other functions of the body stop operating since endogenous testosterone production is shut down because of the presence of high levels of exogenous hormone. You will need Post Cycle Therapy on your break from testosterone therapy.

Break Period: Generally referred to as the Post Cycle Therapy (PCT), consists of medications that are formulated to reactivate the dormant systems that we have not used while your testosterone Injections therapy.

The essential functions that need to reactivate with your
Post Cycle Therapy:

  • FSH (follicle-stimulating hormone): This will stimulate sperm production in the testes.
  • LH (luteinizing hormone): This will stimulate testosterone production in the testes.

The reason why is because estrogen accumulation after extended periods of high testosterone levels, and water retention can cause, decreased libido, and other side effects associated with high estradiol levels from past testosterone therapy.

Well-structured Testosterone Injection Therapy

Following Results:

  • Week One: If you have never received testosterone injections before and are suffering from hypogonadism (clinically low testosterone), you should begin to experience invaluable changes just 3 or 4 days after your first administration. You should sleep better and have more energy.
  • Week Two: Morning erections make a significant comeback! In men with erectile dysfunction problems, morning erections help to determine if their problems stem from a psychological or a physiological problem.
  • Week Three: You will begin to notice a sense of clarity as your cognitive function improves. Your ability to recall information and your articulation will improve. You will suddenly realize that you feel more mentally sharp and able, which will allow you to better cope with stress and pressure.
  • The End of Month One: Your energy levels should be noticeably increased throughout the day.
  • Month Two: The same health manifestations that you were experiencing throughout your first month should continue to develop and improve. Your energy levels should still be increasing, and you should have a stronger “go-getter” attitude.
  • Month Three: There should now be a significant, noticeable difference in your energy level and output. Your workouts will require less effort and will yield quicker, more visible results. The time you need for muscle healing and recuperation after exercise should be reduced.
  • Month Four: By now, your endurance, stamina, exercise potential, and overall performance ability should supersede all your expectations. If you have never been on testosterone therapy before your first program and you have been eating well and exercising from the beginning, you will be surprised at the level of transformation you have experienced. Furthermore, it will be evident that these results and this amount of energy output would not be possible without restoring your testosterone levels to the numbers had in your youth.
  • Month Five: The changes and improvements in your physical performance, ability, and growth will be fantastic. If you were experiencing mental problems such as sadness, depression, anxiety, or even mental fatigue, by now you should notice substantial progress in your ability to deal with unpleasant or challenging scenarios and circumstances. Remember that all the other positive changes you have experienced will also contribute to a sense of self-improvement. This makes you naturally feel better about your progression and growth. More importantly, the physiological changes in brain chemical secretion add to your sense of fulfillment, happiness, and overall well-being.
  • Month Six: All individuals are receiving testosterone experience different effects by six months of therapy. What you experience will also depend on how many cycles of testosterone therapy you have participated in previously. Sometimes, a user’s sense of improvement begins to dwindle or remain stagnant. The body can become used to the type, or ester, of testosterone that is being used if the same therapy is continued for more than 1 or 2 years. Also, because other processes in the body cease to function when testosterone levels are manipulated using testosterone injections, the benefits of therapy begin to diminish and the “feel good” scenarios that were being experienced stopped.

Well-structured Sermorelin Therapy:

Month one:

  • Increased energy
  • Deeper, more restful sleep
  • Improved stamina
  • A more content state of mind

Month Two:

  • Reduced belly fat
  • Improved metabolism
  • The return of some muscle tone
  • Improved skin tone and fewer wrinkles
  • Stronger hair and nails

Month Three:

  • Increased mental focus
  • Improved flexibility and joint health
  • More feelings of drive and ambition
  • Enhanced sex drive and performance

Month Four:

  • Improved mental acuity
  • Better skin elasticity
  • Further improved appearance of the hair and nails
  • Continued weight loss
  • Increased lean muscle mass

Month Five:

  • Continued loss of belly fat
  • Improved skin tone with the reduced appearance of wrinkles
  • Noticeably fuller, healthier hair

Month Six:

  • A 5–10% reduction in body fat, without diet or exercise
  • A 10% increase in lean muscle mass
  • Significantly improved physique
  • Increased vitality dies to organ regrowth (vital organs, including the brain, shrink with age)

March 4, 2019 by Joseph Fermin 0 Comments

What is Luteinizing Hormone (LH) and Testosterone 5 (1)

What is Luteinizing Hormone &
The Productions of Testosterone

If you google the word Luteinizing Hormone or (LH), most of the articles you will find talks about the role of luteinizing hormone in women. There is very no info about the part of Luteinizing Hormone in men. While it may seem like a female hormone due to its role in ovulation, a surge of Luteinizing Hormone is a trigger that causes the ovary to release the egg, in the body. If you’ve been trying to conceive or have a baby your wife, significant other may be monitoring her Luteinizing Hormone levels. If she has trouble with ovulation, your doctor may prescribe medications that help with ovulation.

Many of this medication help stimulate the body to produce more Luteinizing Hormone (LH) and its cousin hormone, Stimulating Follicle Hormone (FSH). If you are not trying to conceive, or get pregnant, she may be on hormonal birth control pills. These pills prevent ovulation by blocking Stimulating Follicle Hormone and Luteinizing Hormone. It is one of the manliest hormones in your body. You can think of Luteinizing Hormone as a tiny drill sergeant that commands the Leydig Cells in the testicle to produce testosterone. When Luteinizing Hormone is present, the Leydig Cells generate Testosterone, when it is not, they don’t. Luteinizing Hormone is commander and chief of your Testosterone and critically crucial for sperm production count, muscle building, and overall sexual health.

Male hormones have a clinical nature to them. Luteinizing Hormone (LH) signals the testicle to produce Testosterone. Testosterone seeps out of the testis and into the bloodstream, where it circulates the body and put to good use. Manly things like growing chest hair, increase muscle and your voice deep are some of the effects.

Luteinizing Hormone or (LH)

The brain monitors the blood testosterone levels;

  • If they drop too low, it will send a signal to the pituitary gland to send out more Luteinizing Hormone (LH) to kick start testosterone production.
  • If your testosterone is chronically low (as in the case with hypogonadism or Low Testosterone), the brain will respond by increasing the level of Luteinizing Hormone (LH).
  • If testosterone is chronically higher (as in the case with using testosterone therapy, other performance enhancers or steroids), the brain will shut down production of Luteinizing Hormone (LH). When testosterone therapy is stopped, without post-therapy, men can experience a “crash” as Testosterone levels plummet, but with a post-therapy, the brain lags in re-starting the machinery to generate Luteinizing Hormone.

Getting Tested:

To measure Luteinizing Hormone (LH) levels, you will need to get blood work in a hormone clinic done. Because, doctors will order blood to estimate a panel of hormones which usually includes Stimulating Follicle Hormone, Luteinizing Hormone, Testosterone, Estrogen and They may also add Estrodial, Prolactin which will provide additional information into the insight into your hormonal health and a physical to know your body composition.

In a typical day, Luteinizing Hormone (LH) and Testosterone levels cycle from high to low. When getting blood work done to measure hormone levels, it is important to note the time of day that the analysis was performed to understand the values better.

Testosterone naturally will peak first thing in the morning (partially responsible for morning “wood”). For this reason, doctors prefer to regulate hormones between 8-10am to get a snapshot of your hormone panel profile when Testosterone level is likely to be highest.

When preparing for a Luteinizing Hormone test and to sure your doctor is aware of a few things like:

  • Current Prescription Taking: Current or past use of testosterone therapy. (If you are using anything at the gym or in supplements stores and you aren’t quite sure), you should bring it with your doctor about the appointment.
  • The Use Of Marijuana or THC: It may decrease the number of hormones levels, including Luteinizing Hormone.
  • Medical Radioactive Tracer: This can interfere with the test
  • Normal levels Luteinizing Hormone Range For Adult Males: 1–10 mIU/mL.

They are different labs report different reference ranges, and based on the exact way that they perform the blood work test. From a review of various lab reports, Values lower than 1.0 or higher than 10.0 typically indicate some problem.

For average men, Luteinizing Hormone (LH) typically falls somewhere between 4-7mIU/mL with drops and surges (about 6) throughout the day. Values below 4 and above seven may be considered borderline, and are useful to look at when compared to other hormones, particularly Testosterone and Prolactin.

In the studies that we have reviewed and found that these types of conditions have shown, and can significant drops in testosterone levels and minimal effect in Luteinizing Hormone (LH). Occasionally, Luteinizing Hormone may show up a little low, but often it is entirely in the normal range.

Therefore, low testosterone levels accompanied with normal Luteinizing Hormone (LH) levels often indicate the cause of Low Testosterone can tremendously help to diagnose the condition and also help to create a game plan for treating the cause while managing symptoms of low Testosterone.untitled-design-16

Whats the Causes of high Luteinizing Hormone in Men?

If Luteinizing Hormone (LH) is high and testosterone is low. Then some damage is causing the testicle, or the pituitary gland is trying to compensate by going into overdrive and flooding the balls. With extra Luteinizing Hormone in hopes that it will encourage higher Testosterone production. In cases like this, Luteinizing Hormone levels are often off the charts high sometimes double or triple the average values.

Common causes for this include:

  • Chromosome Abnormalities: Such as Klinefelter’s syndrome
  • Childhood Problems: Such as testicle or testicular torsion, The injury that causes significant damage to testicular tissue
  • Viral Infection: (most commonly mumps) that damages the testis.
  • Radiation exposure or chemotherapy
  • Testicular cancer
  • Borderline High Luteinizing Hormone (LH) levels

Medications or untreated autoimmune disorders can cause slightly elevated Luteinizing Hormone (LH) levels (8.0 – 10.0 range). Some studies have linked Celiac’s Disease with elevated somewhat Luteinizing Hormone (LH). Men with the untreated disease can have moderately high Luteinizing Hormone levels, that usually return to normal upon starting a gluten-free diet.

What causes low Luteinizing Hormone in Men?

The most common reason for Luteinizing Hormone deficiency in men is the use of external androgens (testosterone, other performance enhancers or non-medication). External androgens can trick the brain into thinking the body is producing naturally high levels of testosterone which low down production of luteinizing hormone (LH) and consequently natural testosterone production.

The second most common cause of low Luteinizing Hormone (LH) levels is a health issue, and can directly impact the function of the pituitary in the brain, Most common causes of the pituitary malfunction can include genetic conditions, such as Prader-Willi Syndrome or Kallman’s Syndrome and can cause other problems like:

  • Pituitary tumors (cancerous and benign)
  • Hyperprolactinemia
  • Head trauma
  • Various Medications
  • Auto-immune disorders
  • Borderline low Luteinizing Hormone (LH) results

Luteinizing Hormone levels in the 1.0 – some things can cause 3.0 range. Like, reduce temporarily imbalance hormones: such as overtraining, endurance. They are significantly under or overweight Alcohol consumption spikes in insulin medications or other drugs. High-stress Chronic conditions: that can cause hormone imbalance: such as diabetes, insulin resistance, various auto-immune disorders and can create borderline or low levels of Luteinizing Hormone (LH).

 

January 28, 2019 by Joseph Fermin 0 Comments

The importance of Testosterone Post Cycle Therapy? 0 (0)

Why Is Testosterone
Post Cycle Therapy Is Need It?

Why is Post Cycle Therapy (PCT) is perhaps the most critical aspect of testosterone use? The concept of the post cycle therapy (PCT), did not exist before the late 1980s, and 1990s and the mechanisms by which testosterone affected, the body were not wholly understood during the 1950s, 1960s, and 1970s.

This period were doctors, scientists, and testosterone injections users were only beginning to learn about the dynamics of testosterone and how they affect the endocrine system. We believed and understood since the beginning of testosterone injections use, the administration of testosterone resulted in triggering the body’s negative loop of the (HPTA) Hypothalamic Pituitary Testicular Axis. That endogenous Testosterone production would result become suppressed and shut down. The, unfortunately, is during the early periods of testosterone use between the 1950s and 1990, there was limited access to the compounds or knowledge or effectively.

Today it is a very different story. Now scientific and medical understanding of bio-identical testosterone use has soared exponentially since the old ‘golden era’ days of looking young and testosterone therapy use in athletics. Countless developments of beneficial compounds for hormonal recovery after testosterone therapy use, alongside the increased scientific and medical knowledge, has enabled testosterone use and its associated endocrine disruptions. The proper knowledge on how to recover the body’s from Hypothalamic Pituitary Testicular Axis (HPTA). Through post cycle therapy (PCT), we can not only emerge from their testosterone therapy while holding on to almost all of their benefits, but they can also increase the chances upwards to 90 percent or higher range of emerging with a fully healthy (HPTA).

Following the use of exogenous testosterone injections, the majority of users will experience what has been a hormonal crash or post cycle therapy crash, which is a physical environment in which key hormones essential is has been suppressed or shut down. The critical hormones in question are Luteinizing Hormone (LH), Follicle Stimulating Hormone (FSH), and subsequently (and are most importantly), for our natural testosterone. The Luteinizing Hormone (LH), and the Follicle Stimulating Hormone (FSH), known as phototropism. These hormones increase Testosterone secretion. Also alongside low levels of these hormones, to balance the essential hormones that have been thrown off balance, whereby Testosterone levels will be small, and most of the time, depending on the factors, estrogen levels will be higher than usual, and levels of Cortisol a steroid hormone that destroys muscle tissue. With the testosterone levels low and Cortisol levels in the average or high, Cortisol now can become a threat to the new muscle during the new testosterone therapy (“Testosterone correctly suppresses and counteracts Cortisol’s catabolic effects on muscle tissue”). The SHBG (Sex Hormone Binding Globulin) is also a concern here as well, which is a protein that binds to sex hormones Testosterone renders them inactive, essentially ‘handcuffing’ them and preventing them from exerting their effects. SHBG will also usually elevated during the post cycle therapy weeks as a result of the supraphysiological levels of androgens from the new testosterone therapy.

The human body will generally and restore this imbalance of hormones and recover from testosterone levels on its own, over time with no outside assistance or post cycle therapy (PCT), but the studies have demonstrated and shown us that without the intervention of testosterone stimulating agents, this will occur throughout one to four months. Therefore, all testosterone therapy should be concerned with the fastest possible hormonal recovery, assisted and boosted with the use of Testosterone stimulating compounds correctly, also the attempt to allow the body to recover on its own, from a very high probability of long-term endocrine damage to the Hypothalamic Pituitary Testicular Axis (HPTA), whereby the individual will develop-induced hypogonadism to inability the production of proper levels of Testosterone to rest. So therefore paramount that an appropriate post cycle therapy that includes multiple recovery compounds to be utilized to not only restore the (HPTA) function but also to normalize the levels as quickly as possible. To avoid any possible permanent damage, which can take priority over the concern of maintain to the recently gained muscle mass and any other benefits from it.

What Post Cycle Therapy Protocol?

There are many different types of post cycle therapy (PCT) protocols that have overdeveloped over the years; any individual will become extremely confused about how many different opinions exist among the testosterone community, This article will present the best possible and most efficient post cycle therapy protocol valid scientific data, also myths in regards to post cycle therapy (PCT), and outline which post cycle therapy (PCT) protocols should not follow due to recent more advanced developments, as well as contemporary better scientific and medical understandings of how a proper post cycle therapy protocol should work. This point, there still exists very obsolete – and subsequently ineffective – post cycle therapy (PCT) contracts that are still utilized by many testosterone users, and this presents a severe hazard not only for the individual unknowingly using a post cycle therapy.

For example:

There are several therapeutic and safety reasons why you should not continue with testosterone injections indefinitely without giving your body time to normalize to reset. Because of the decline in benefits after six months of a testosterone therapy, the physicians need to regularly incorporate a cleanse therapy post cycle therapy (PCT) in an attempt to reactivate the endocrine in the body, as you increase your testosterone levels using any testosterone therapy, now the levels of testosterone circulating the body will shut down the natural production of your endogenous testosterone; and also increases the production of estrogen in your body, which can lead to a series of undesirable and unwanted side effects in the body. `This means that the synthesis of (LH) luteinizing hormone in your body; this hormone is produced by your brain to stimulate testosterone production. and follicle-stimulating hormone in the body; the hormone produced by your mind to boost sperm production suddenly stops. When Luteinizing Hormone (LH) and Follicle Stimulating Hormone (FSH) levels are no longer detectable, your body will not experience the exceptional health benefits, and energy-optimizing results expected from a testosterone injection program.

Another critical concern for men is testicular atrophy in patients that participate in testosterone therapy and may experience shrinkage of the testes, This occurs as the result of the lack of testosterone, and sperm production has been shut down, in response to the testosterone therapy.

What does post cycle therapy (PCT) consist of, an example?

Your post cycle therapy consists of a testosterone secretagogue to stimulate the secretion of endogenous testosterone from the testes to reignite natural production. The medication mimics the signal from your brain. The Luteinizing Hormone (LH) induce the production of testosterone. An example of a testosterone secretagogue is human chorionic gonadotropin (hCG), which is administered either using sublingual troches or subcutaneous injections once or twice a week during therapy and then on 10–15 consecutive days as part of a post cycle therapy (PCT). Human chorionic gonadotropin (hCG), mimics Luteinizing Hormone (LH) to stimulate testosterone production by the testes. It works by effectively tricking the testes into thinking that they are being instructed to produce testosterone, even though levels are comfortably elevated because of the injectable testosterone therapy. The testosterone production stimulated by human chorionic gonadotropin (hCG) is not sufficient to sustain healthy testosterone levels on its own, but that is not the reason for this supplementation. The purpose is to ensure that the testes remain functioning during therapy to help avoid any shrinkage or atrophy.

You will also take an anti-estrogen or aromatase inhibitor. For example, Clomid/clomiphene blocks certain types of estrogen from getting to the pituitary and hypothalamus, where it elicits signals that stop testosterone production. Anti-estrogens or aromatase inhibitors also help to reactivate the standard functionality of Luteinizing Hormone (LH) and Follicle Stimulating Hormone (FSH) signaling, while also helping to flush out any residual estrogen that has accumulated during therapy. The estrogen that collects during treatment is responsible for many of the adverse side effects associated with testosterone therapy.

An example of a post cycle therapy (PCT) protocol is as follows (note that the exact drug and dose prescribed will depend on the specific information contained within each patient file, as well as the individual patient goals):

  • 250–800 units of a testosterone secretagogue every day for ten consecutive days
  • One estrogen blocker or antagonist by mouth every day for 10–15 straight days

Without the proper understanding of what is explicitly occurring within the endocrine system during these crucial weeks, as well as a lack of knowledge of which compounds to utilize, what each compound does, and how to properly use them, serious problems can result.

post cycle therapy

The Hypothalamic Pituitary Testicular Axis (HPTA):

The (HPTA), which is an axis interconnected endocrine glands in the body that deals with control the production Testosterone.

Post-Cycle-therapy:

Outlined above is a diagram of the Hypothalamic Pituitary Testicular Axis (HPTA), Regulates the body produces the amount of Testosterone at any given time. Every individual is essentially programmed by (DNA) genetics as to maximum Testosterone they will provide.

The Hypothalamic Pituitary Testicular Axis (HPTA) and the functions that undergo a negative feedback loop, and the body will reduce secretion of Testosterone, f have too much Testosterone the body will be detected, known as the negative feedback loop. This controlled by the hypothalamus, which is mostly considered the ‘master’ gland for all endocrine system and the hormonal functions in the body. The negative feedback will loop ultimately in the body to attempt to maintain the hormonal homeostasis, and all endocrine glands operate by way of the negative feedback loop in one way or another in varying degrees, In the case of post cycle therapy, the concern is a negative feedback loop of the (HPTA).

Within the Hypothalamic Pituitary Testicular Axis (HPTA), the concern during post cycle therapy (PCT) is the restoration and regulation of the following five hormones to homeostasis:

  • GnRH (Gonadotropin Releasing Hormone)
  • LH (Luteinizing Hormone)
  • FSH (Follicle Stimulating Hormone)
  • Testosterone production

The Hypothalamic Pituitary Testicular Axis (HPTA), the hypothalamus, which will detect a need for the human body to produce more Testosterone, and will release varying amounts of GnRH, Is a hormone that signals the pituitary gland, to begin the production and release of two essential gonadotropins: Luteinizing Hormone (LH) and Follicle Stimulating Hormone (FSH). Two hormones that work together to start the secretion of Testosterone.

Two primary hormonal factors serve to inhibit, reduce, suppress, or shut down Testosterone production in the Hypothalamic Pituitary Testicular Axis (HPTA):

  • Testosterone Excess
  • Estrogen Excess

Although there exist other hormones that serve to inhibit and suppress Hypothalamic Pituitary Testicular Axis (HPTA) function (such as Progestins and Prolactin), these are the two primary conditional hormones that are of concern. When the hypothalamus detects excess levels of Testosterone and Estrogen in the body (either from the use of exogenous androgens on an testosterone therapy or otherwise), the hypothalamus will act to attempt to restore a balance by essentially doing the opposite of what was previously described. The hypothalamus will reduce or stop its production of GnRH, which halts production of Luteinizing Hormone (LH) and Follicle Stimulating Hormone (FSH), which ultimately reduces or halts production of Testosterone. Until the hypothalamus’ ideal hormonal environment is restored, the output of the various signaling hormones within the (HPTA) will not begin, and this will often require months for the body to do this on its own without the intervention of any Testosterone stimulating agents. The reason as to why the recovery of the (HPTA) naturally takes such a long time should be very clear due to the described workings of the (HPTA).

This fundamental understanding of the mechanisms of the Hypothalamic Pituitary Testicular Axis (HPTA) and negative feedback loop described above is essential to understanding how and why a proper post cycle therapy (PCT) program must be developed and utilized following an testosterone therapy.

Determining Factors In Difficulty Recovering the Hypothalamic Pituitary Testicular Axis (HPTA):

With testosterone therapy use, there are several different major determining factors in how much difficulty an individual will experience in recovery of their Hypothalamic Pituitary Testicular Axis (HPTA) and endogenous Testosterone function during post cycle therapy (PCT).

They are the following factors, in no particular order of importance:

  • Individual response
  • Type of testosterone(s) used
  • Length of the cycle (degree of testicular desensitization)

Individual response:

Every single individual will respond differently to any chemical, compound, testosterone, food or drug in existence. While some individuals might experience no Hypothalamic Pituitary Testicular Axis (HPTA) suppression or shutdown at all, other individuals might experience severe Hypothalamic Pituitary Testicular Axis (HPTA) suppression and closure to the extent where they might require far more extended periods to ensure full recovery than most. This, like anything else, is a spectrum whereby there are the very ‘lucky’ individuals that recover very quickly and easily on one end of the spectrum, and the ‘unlucky’ individuals that have extreme difficulty recovering during post cycle therapy. In between the two extremes is the average. Once again, this is due to the individual’s genetic programming as to how the Hypothalamic Pituitary Testicular Axis (HPTA) will respond and attempt to maintain homeostasis.

Type of Testosterone Therapy(s) used:

All testosterone therapy exhibit suppression or shutdown of the Hypothalamic Pituitary Testicular Axis (HPTA) through the mechanisms of the negative feedback loop, and there are no exceptions to this. Various testosterone therapy are known as being mildly suppressive, while others are identified as being profoundly suppressive. This is all reliant on multiple different reasons, many of which will not be discussed here. In any case, no matter how mild or severe an testosterone therapy exerts Hypothalamic Pituitary Testicular Axis (HPTA) suppression, all testosterone therapy when utilized for typical cycle lengths of weeks at a time will eventually cause the Hypothalamic Pituitary Testicular Axis (HPTA) to shut down, or at the very least severely suppress its hormonal signal processes.

Length of the cycle degree of testicular desensitization:

This is perhaps the most important and most influential factor. As the range of testosterone therapy use continues, the majority of the Leydig cells of the testes remain dormant and inactive, and the longer these interstitial cells stay dormant and idle, the higher the difficulty is essentially getting these cells to respond to the stimulus of Luteinizing Hormone (LH) and Follicle Stimulating Hormone (FSH) once again. It has been discovered in studies that the issue of recovery of the Leydig cells following testosterone therapy use is not due to a lack of Luteinizing Hormone (LH), but due instead to the desensitization of the Leydig cells to (LH). In one study in which exogenous Testosterone was administered to male test subjects for 21 weeks, Luteinizing Hormone (LH) levels were suppressed shortly after beginning administration. However, at the end of the 21 weeks, Luteinizing Hormone (LH) levels were observed to rise within three weeks once the exogenous Testosterone administration stopped, but Testosterone levels did not arise until many weeks later in most of the test subjects.

Recovery During The Post Cycle Therapy (PCT).

To stimulating hormonal recovery during post cycle therapy, it is essential for individuals to understand that the use of any medication except for a single select one or two is inadequate for hormonal recovery during post cycle therapy (PCT). Ideally, all post cycle therapy programs should be a multi-component post cycle therapy (PCT) program that includes several different compounds that work in tandem with one another to provide the most effective and fastest possible Hypothalamic Pituitary Testicular Axis (HPTA) recovery following an testosterone therapy.

The three categories of compounds are in order of importance:

  • SERMs (Selective Estrogen Receptor Modulators)
  • Aromatase Inhibitors
  • HCG (Human Chorionic Gonadotropin)

SERMs:

Classes of drugs in the SERM category include: Nolvadex (Tamoxifen Citrate), Clomid (Clomiphene Citrate), Raloxifene, and Fareston (Toremifene Citrate). The nature of a SERM is that it exhibits mixed Estrogen agonist and Estrogen antagonist effects on the body. This means that although a SERM might block the effect of Estrogen at the cellular level in specific tissues, it can enhance Estrogenic impacts in other areas of the body. These can be positive effects as well as adverse effects. Nolvadex, for example, exhibits Estrogenic agonistic effects in the liver, which is a positive effect, as its effects here result in a positive change in cholesterol profiles (something desired by many). All SERMs to varying degrees serve to act as an Estrogen antagonist in this area, working to mitigate Estrogen’s effects on breast tissue, reducing or blocking the side effect of gynecomastia. Regarding the impact of SERMs on endogenous Testosterone stimulation, they serve to act as an Estrogen antagonist at the pituitary gland, triggering the release of Luteinizing Hormone (LH) and Follicle Stimulating Hormone (FSH) as a result. Elevated levels of Estrogen in men can and does suppress the output of endogenous Testosterone via the negative feedback loop, leading to hypogonadism. SERMs for this purpose are an essential addition to any post cycle therapy (PCT) protocol and are not to be excluded under any circumstance. Regardless of this, however, the sole focus should not be on SERMs.

Aromatase Inhibitors:

These are compounds such as Aromasin (Exemestane), Arimidex (Anastrozole), and Letrozole (Femara). Rather than block the activity of Estrogen at the cellular level in different tissues, aromatase inhibitors (AIs) serve to lower total circulating Estrogen levels in the body by way of inhibiting the aromatase enzyme, which is the enzyme responsible for the conversion of androgens into Estrogen. The transformation of androgens into Estrogen results in excess Estrogen levels, which, as explained earlier in this article, will trigger the negative feedback loop leading to suppression of Testosterone production. By way of lowering total circulating blood plasma Estrogen levels, AIs will positively engage the negative feedback loop and result in the release of Luteinizing Hormone (LH) and Follicle Stimulating Hormone (FSH) for the manufacture and secretion of more Testosterone. This is mainly due to the hypothalamus realizing that circulating. Estrogen levels are too low and will attempt to increase circulating levels of Testosterone for a portion of the Testosterone secreted to be able to become aromatized into Estrogen to restore the hormonal balance. The other importance of aromatase inhibitors is the ability to mitigate the Estrogenic effects of human chorionic gonadotropin (HCG), which will be explained shortly. It is important to note, however, that the majority of aromatase inhibitors do not comply very well with SERMs such as Nolvadex, and those particular choices should be made in regards as to which AI is used during post cycle therapy (PCT).

HCG:

Human Chorionic Gonadotropin is, for the most part, synthetic Luteinizing Hormone (LH). It is a protein hormone manufactured in high amounts by pregnant females that contains a protein subunit that is 100% identical to Luteinizing Hormone (LH), and therefore when administered to men, it will mimic the action of Luteinizing Hormone (LH) in target tissues, such as the testes. What results is an increase in Testosterone production via stimulation of the Leydig cells by human chorionic gonadotropin (HCG). Human chorionic gonadotropin (HCG) should never be utilized alone, as its nature as a gonadotropin will itself trigger a negative feedback loop whereby once human chorionic gonadotropin (HCG) is used, the pituitary gland will halt output of Luteinizing Hormone (LH) until human chorionic gonadotropin (HCG) use has discontinued. Therefore, human chorionic gonadotropin (HCG) must be utilized with a SERM and especially an aromatase inhibitor, as human chorionic gonadotropin (HCG) has demonstrated to increase aromatase activity in the testes, resulting in rising Estrogen levels.

Putting Them Together:

The reader may be wondering which compounds to select of the three categories listed, and how to use them properly. The answer lies in understanding the properties of each and, in interpreting these properties, how to use them efficiently and appropriately.

Human chorionic gonadotropin (HCG):

The first item to be examined will be human chorionic gonadotropin (HCG). The majority of testosterone therapy users from the 1960s – mid-1980s did not even utilize any compounds for hormonal recovery, and the term post cycle therapy (PCT) did not even exist at that time. When the use of human chorionic gonadotropin (HCG) became increasingly popular (circa 1980), it was the only compound utilized. Since then, the medical and scientific understanding of such things has increased exponentially, and there should be no reason for any informed and adequately educated individual to utilize human chorionic gonadotropin (HCG) on its own for post cycle therapy (PCT). When used in conjunction with one of the other two categories of compounds (an AI and a SERM), the dynamics change considerably.

It has been mentioned already that much of the difficulty in recovering the Hypothalamic Pituitary Testicular Axis (HPTA) following an testosterone therapy is the result of Leydig cell desensitization. Human chorionic gonadotropin (HCG) is necessarily an analog of Luteinizing Hormone (LH), and the testes after a prolonged testosterone therapy would be as equally desensitized to human chorionic gonadotropin (HCG) as they are to Luteinizing Hormone (LH). The human body, however, produces Luteinizing Hormone (LH) amounts on its own that is far too inefficient for proper and rapid Testosterone production. The body’s natural increase of Luteinizing Hormone (LH) and Follicle Stimulating Hormone (FSH), evidenced by the study referenced earlier in which it was not until three weeks when Luteinizing Hormone (LH) levels only began to reach the standard physiological measurements following the cessation of Testosterone. Therefore, the body’s natural Luteinizing Hormone (LH) production does not provide a high enough dose for stimulation, nor an immediate stimulus to the tests required for the initial increase in Testosterone needed during the post cycle therapy weeks.

Human chorionic gonadotropin (HCG), utilized in a specific manner during the first 1 – 2 weeks of post cycle therapy (PCT) at a dose of 100-1,500IU every 2 days, is what allows the individual to provide the testes with a high dose to provide them with a ‘shock’ effect, and sustain this shock effect on the Leydig cells of the testes for a sustained period of the first 1 – 2 weeks of post cycle therapy. Studies have demonstrated the incredible effectiveness of human chorionic gonadotropin (HCG) for this purpose, it been suggested that human chorionic gonadotropin (HCG) therapy is utilized to treat low testosterone and hypogonadism. Following this line of thought, the other two compounds (the SERM and the AI) are to be used as supportive compounds for human chorionic gonadotropin (HCG) use in this 1 – 2 week period, and after human chorionic gonadotropin (HCG) is discontinued early on in post cycle therapy (PCT), only the SERM is to be used in order to carry along the hormonal recovery process.

In spite of the good news in regards to the ability for human chorionic gonadotropin (HCG) to assist in hormonal recovery, there are still two remaining issues to be addressed:

  • The fact that human chorionic gonadotropin (HCG) causes increased production of aromatase, leading to increased Estrogen levels.
  • Following the discontinuation of human chorionic gonadotropin (HCG), the body is left with very little endogenous Luteinizing Hormone (LH), and Follicle Stimulating Hormone (FSH) production due to the exogenous administration of human chorionic gonadotropin (HCG).

Aromatase Inhibitors:

Aromasin (Exemestane) Above All Else The first of the two remaining issues to be addressed will be the fact that human chorionic gonadotropin (HCG) will trigger increases in testicular aromatase expression, and result in Estrogen increases in the body. It should also be noted that it will cause an increase in testicular progesterone levels. Estrogen rising is, of course, undesirable during post cycle therapy (PCT), as it has already been explained that Estrogen will trigger suppression of endogenous Testosterone production, and there is no doubt that any individual wishes to encounter Estrogenic side effects during post cycle therapy (PCT) either.

Therefore, the option here is to include an aromatase inhibitor. However, there exists a big problem in regards to the other two of the three major aromatase inhibitors (Arimidex and Letrozole). The issue is the fact that in a post cycle therapy (PCT) program that includes the use of SERMs such as Nolvadex and Clomid, which are known as essential components to a post cycle therapy (PCT) program, Arimidex and Letrozole have direct negative interactions with Nolvadex. The problem here is that Arimidex (or Letrozole) and Nolvadex both directly counteract one another. One study has demonstrated that when Arimidex is utilized with Nolvadex, Nolvadex will decrease the blood plasma concentration of Arimidex (as well as Letrozole, another commonly used aromatase inhibitor). The conclusion here is that the use of Arimidex or Letrozole with Nolvadex together is a terrible idea and may work together in a post cycle therapy (PCT) protocol. Aromasin completely circumvents this problem, as it has been demonstrated to have no interactions what so ever with Nolvadex, unlike the other two aromatase above inhibitors. In one study, Aromasin displayed no such reduced effectiveness or any reduced blood plasma levels when utilized with Nolvadex.

The other benefit of selecting Aromasin over all other AIs is the fact that Aromasin has demonstrated in several studies to impact cholesterol profiles in a negative manner far less than other aromatase inhibitors have, wherein one particular review on cancer patients, 24 weeks of Aromasin (Exemestane) administration held no impact on cholesterol profiles. Some other studies have also demonstrated a nil effect on cholesterol profiles from the use of Aromasin. Although there have also been some studies that have shown a negative impact on cholesterol profiles resultant from Aromasin use, it is evident that there is not as a significant or as a negatively impacting effect from Aromasin on cholesterol as other aromatase inhibitor.

Finally, in addition to these benefits from Aromasin, it is evident that Aromasin holds the ability to increase Testosterone levels in males as demonstrated by studies. For example, one particularly notable study selected 12 healthy young male test subjects, and were administered random Aromasin doses of 25mg and 50mg for a 10 day period, and not only was Estrogen suppressed by a significant amount (38%), but Testosterone levels in the test subjects were observed to have increased by an incredible 60%.

Following these details, Aromasin would be the best possible aromatase inhibitor of choice to combat the increased aromatase activity caused by human chorionic gonadotropin (HCG). Therefore, Aromasin would then be utilized at a full 25mg daily dose, and only while human chorionic gonadotropin (HCG) is used. Once human chorionic gonadotropin (HCG) is discontinued, Aromasin too should be halted.

The only following issue to cover now is that of stimulating and maintaining proper endogenous Luteinizing Hormone (LH) release to carry recovery along until the body can become self-sufficient once again.

Nolvadex and Clomid: 

The question is often asked among the testosterone therapy using community: Clomid or Nolvadex? Which one for post cycle therapy (PCT)?

First of all, the best possible addition to human chorionic gonadotropin (HCG) in a post cycle therapy (PCT) protocol is Nolvadex (Tamoxifen Citrate), as studies have demonstrated that human chorionic gonadotropin (HCG) and Nolvadex utilized together have exhibited a remarkable synergistic effect in terms of stimulating endogenous Testosterone production and that Nolvadex will actually work to block the desensitization effect on the Leydig cells of the testes caused by high doses of human chorionic gonadotropin (HCG). This is very important because just as too little Luteinizing Hormone (LH) secretion for extended periods can cause desensitization to gonadotropins, too much gonadotropin stimulation (in the form of human chorionic gonadotropin (HCG) or otherwise) will likewise create a desensitization effect.

Secondly, Nolvadex on an mg for mg basis is far more effective than Clomid in stimulating endogenous Testosterone production, as well as being a more cost-effective choice than Clomid itself. Studies have demonstrated that 150mg of Clomid (Clomiphene Citrate) administered daily raised endogenous Testosterone levels of 10 healthy males by approximately 150%, while incidentally, 20mg of Nolvadex (Tamoxifen Citrate) daily raised endogenous Testosterone levels by the same amount. It is very evident here that Clomid is very useful for this purpose, but Nolvadex seems to be a more cost-effective choice seeing as though it is more effective than Clomid when compared mg for mg. The benefits of Nolvadex over Clomid do not end there – Clomid, although it does exhibit Estrogen antagonist effects at the pituitary gland as Nolvadex does, actually shows Estrogen agonist effects there too. What this means is that Clomid will work in varying degrees as an Estrogen at the pituitary gland, triggering the negative feedback loop and reducing the output of Testosterone stimulating gonadotropins Luteinizing Hormone (LH) and Follicle Stimulating Hormone (FSH). This is a severe problem during post cycle therapy, which is a period in which individuals are trying to recover their Hypothalamic Pituitary Testicular Axis (HPTA) function rather than halt it even further. Ideally, one would want a SERM that exhibits almost 100% Estrogen antagonistic effects on the pituitary gland, and Nolvadex is the perfect choice for this.

When it comes to the dosing aspect of Nolvadex, The standard dose for post cycle therapy (PCT) and for stimulating the release of GnRH (Gonadotropin Releasing Hormone), Luteinizing Hormone (LH), Follicle Stimulating Hormone (FSH), and ultimately Testosterone is that of a single Nolvadex dose of 20 – 40mg daily. In all studies involving Nolvadex doses used to stimulate endogenous Testosterone production, only 20 – 40mg daily of Nolvadex was utilized, and it has been shown that doubling the dose to 40mg or any higher will not produce any significant difference in endogenous Testosterone secretion. The only reason why many elects to utilize 40mg daily of Nolvadex for the first 1-2 weeks of a post cycle therapy (PCT) program is to achieve optimal peak blood plasma levels quicker to ensure Hypothalamic Pituitary Testicular Axis (HPTA) recovery faster.

The ideal post cycle therapy protocol for 4 – 6 weeks Total post cycle therapy (PCT) time (depending on the recovery ability of the individual):

01) Weeks 1 – 2:

  • human chorionic gonadotropin at 1000iu/E2D.
  • Aromasin (Exemestane) at 25mg/day.
  • Nolvadex (Tamoxifen Citrate) at 40mg/day.

02) Weeks 2 – 6:

  • Nolvadex or (Tamoxifen Citrate).

Additional and Optional, Vitamins, Supplements, Compounds to Aid During post cycle therapy (PCT), Aside from the principal components discussed, various other parts are mostly optional, but still very useful for hormonal recovery of the Hypothalamic Pituitary Testicular Axis (HPTA) during the post cycle therapy weeks.

Vitamin B12 Health Benefits, There has been a lot of controversy over whether or not there is indeed a benefit from taking B12 supplements. Some doctors suggest that as long as a person is not vegan (though probiotics in the gut can produce some B12), they are probably getting sufficient B12 from the basic foods they are ingesting.

vitamin b12

Let us reference some studies:

There is documented research from the Framingham Study suggesting that 40% of all people are deficient in B12. The American Journal of Clinical Nutrition researched in 2009, and they published a study suggesting close to 6% of U.S. and U.K. residents over the age of 60 are B12 deficient. Another 20% were referenced as “marginal status.”

Vitamin B12 Health Benefits has the most multifaceted and prevalent chemical structure of all vitamins. One area where it differentiates from other vitamins is in the fact that it’s the only vitamin that contains a metal commonly referred to as Cobalamin, which is also a universal term for all the various compounds that may have some B12 properties in it.

B12 can improve energy by aiding in thyroid function and cellular methylation, That being said, B12 is not only useful in supporting healthy energy levels. It is unequivocally essential to life and whole existence. People deficient in B12 will suffer from serious health issues if the problem is not addressed.

What role B12 plays in the following human biological processes:

  • Nerve and brain regeneration
  • Adrenal gland support
  • Male and female reproductive health
  • Nutrient absorption
  • Red blood cell formation
  • Cellular energy
  • Memory recall
  • DNA synthesis

Here are some of the risks associated depleted B12 levels are:

  • Pernicious anemia
  • Migraine headaches
  • Macular degeneration
  • Tinnitus
  • Fatigue (adrenal fatigue and CFS)
  • Multiple sclerosis
  • Memory loss
  • Neuropathy
  • Anemia
  • Asthma
  • Shingles
  • Kidney disease
  • Depression

November 13, 2017 by Joseph Fermin 0 Comments

An Inside Look at Testosterone Injections Therapy 0 (0)

Inside Look Testosterone Injections Therapy

testosterone injections therapyTESTOSTERONE INJECTIONS THERAPY

Testosterone is an essential factor in males, that does more for men than just promote sex drive. Low Testosterone levels decline as a part of healthy aging and are the cause of several physiological changes. Low Testosterone level symptoms include;

1) Reduced Motivation
2) Erectile Dysfunction
3) Loss of Libido or sex drive
4) Fatigue and low energy
5) Increased Cholesterol Levels
6) Memory and Concentration
7) Decreased Muscle Mass
8) Thyroid Dysfunction and more

Since these symptoms are common in low testosterone, physicians will often include hormone levels as part of routine blood work. Normal levels of testosterone are between 300 and 1,000 ng/dL. If a blood test shows that your levels are far below the norm, your doctor may suggest testosterone injections. The treatment is called TRT.

SYMPTOMS OF LOW TESTOSTERONE

Most men naturally start losing testosterone when they hit their 30’s. (low T). Common symptoms of low Testosterone include:

1) Erectile dysfunction (ED)
2) Changes in sex drive
3) Decreased sperm count
4) Depression or anxiety
5) Weight gain
6) Hot flashes

TESTOSTERONE AND DIAGNOSIS

Many men may want to diagnose themselves with a testosterone kit. The problem with self-diagnosis is that many of the symptoms of low Testosterone are healthy parts of aging. So using it for diagnosis isn’t reliable. Our doctor may order testosterone blood test. It is the only way to find out if you have low testosterone.

To get a perfect reading our doctor will take a look at your health history, physical exam and blood test to measure your testosterone levels. You’ll also likely have a test that measures your red blood cell count.

POTENTIAL BENEFITS OF TESTOSTERONE INJECTIONS THERAPY 

The purpose of Testosterone Injections Therapy is to help regulate hormone levels and to help address problems related to low Testosterone. For men with low Testosterone, the benefits of these injections can include:

1)  Motivation and Memory Loss
2)  Sex Drive & Desire
3)  Depression and Energy
4)  Cholesterol and Osteoporosis
5)  Erectile Dysfunction
6)  Muscle Mass and Better Sleep
7)  Wounds healing & Illness
8)  Thyroid Dysfunction and more

TESTOSTERONE CAN HELP WITH FAT AND MUSCLE CHANGES

Men have less body fat than women; This is partly related to testosterone, which regulates the fat in the body and muscle maintenance in your body. You’ll likely also notice an increase in body fat, especially around your midsection.

Your hormones also help regulate muscle growth. So, with low Testosterone, you may feel like you’re losing muscle size or strength.

Testosterone shots regulate fat distribution, but you shouldn’t expect significant weight loss changes from hormone therapy alone, without exercise. As for maintenance of muscle, testosterone therapy has been found to improve increase muscle mass, but not strength.

TESTOSTERONE INJECTIONS THERAPY AND SPERM COUNT

Low sperm count in men is a common side effect of low Testosterone. This problem can make it difficult to get your partner pregnant.

TESTOSTERONE INJECTIONS THERAPY AND THE BOTTOM LINE

Testosterone injections therapy can only be helpful If you just have low Testosterone. If you’re wondering if testosterone is a right choice for you, ask your doctor. They can test you for low Testosterone. Ask your doctors, or Give us a call, if testosterone injections therapy would be a good choice for you.

If you don’t end up having low Testosterone but still feel like your hormone levels might be off, keep in mind that proper Food, Regular exercise, could help you increase testosterone naturally and make you feel better. If that doesn’t help, be sure you contact us for help.

August 25, 2016 by admin 3 Comments

Anavar: The Good, The Bad and The Ugly 0 (0)

Pros and Cons of Anavar

Anavar has been around since 1964. It was bought out by Pfizer in 2003. Since then, it has seen a popular reemergence and has been termed the “safest” steroid available. Unfortunately, this is dangerous and brings confusion to the masses whom misleadingly supplement with this compound.

Anavar

We have been receiving many requests for Anavar from patients that have shopped around with other local clinics. Sadly, clinics that, despite the consequential ramifications, opt to sell this controlled substance to their patients. Moreover, they do it under the guise of providing medical treatment, when in fact, this is one of the reasons it was once illegal: there is no real medicinal purpose for Anavar.

  • Anavar is an anabolic steroid.
  • Anavar is not a bio-identical hormone, as is testosterone.
  • Anavar has very little androgenic (testosterone Injections) properties. This is the reason it does not aromatize. Only androgens aromatize.
  • Initially, Anavar was produced to assist patients with lipodystrophy (excessive muscle loss, usually as a result of AIDS).

The Good, The Bad, and The Ugly.
First the Good

  • Because there is no conversion to estrogen with Anavar, blockers nor inhibitors are needed for its use. Estrogen conversion manifest most of the visible side effects men fear from a testosterone therapy program: mood swings, libido loss, water retention, weight gain, etc.
  • Anavar increases anabolism significantly. This allows the muscle to absorb a lot more protein. Being in anabolic state intensifies the muscle building process. Strong, dense muscles develop and are longer lasting than when developed on other steroids.
  • Because Anavar has almost no androgenic properties, it does not cause a swift shutdown of HPTA (the process that invites endogenous low testosterone production)
  • Muscles developed with the aid of Anavar administration are sharper and more cut.
  • Studies have shown Anavar to diminish visceral (stomach area) fat with only moderate exercise. Most impressively, even after discontinuing usage, the subjects kept off the fat. Of course, they were still exercising and minding their caloric intake.
  • Anavar can lubricate joints and assist with joint related pain.

The Bad

  • Want to know the truth behind why Anavar is considered the “safest” or “most mild” anabolic steroid available? In its pharmaceutical form, Anavar comes in 2.5 mg tablets. At that therapeutic dose, even a child could take it without systemic repercussions. There is basically no negative impact on the liver, even if taken on a daily basis.
  • To build significant muscle on Anavar alone, at least 50 mg a day would be needed. At these quantities, arduous taxing of the liver is intense and inevitable.
  • Anavar is a seventeen alpha alkylated. This means it is structured to prevent a breakdown in the liver. This makes the effects of the drug much greater but puts an unimaginably damaging strain on the liver.
  • The required dosage for effective muscle “building” is what makes legitimate medical claims of Anavar’s “mildness” a myth.
  • In a nutshell: With Anavar, what makes it safe, makes it not very effective, and once it becomes effective, it is not very safe.

The Ugly

  • 2.5 mg is the pharmaceutical dosage this brand medication comes in. Patients should be wary of 20 mg to 50 mg tablets. Those are only made through UG laboratories. Patients should require their medication come labeled with their name, the prescribing physician’s name and the providing Laboratories information, including DEA number. This info should be followed up with some quick research on the involved laboratory.
  • Unless you are suffering from acute muscle wasting, there is no medicinal purpose for taking Anavar.
  • Anavar is actually pretty amazing stuff “if you are a bodybuilder willing to administer illegal substances.” It does have the ability to increase strength significantly in a short period of time. However, at the dosages required for effective muscle building, the liver finds itself under constant attack. This program can only be used as a kick-start program.
  • Patients prescribed Anavar under the guise of it being a health supplement should consider very carefully the integrity of the organization they are working with.
  • A “real” Anavar program should not surpass 4 to 6 weeks. Anything beyond that, especially at dosages beyond the 20mg mark, will have impacting effects on the liver.
Real Testosterone Therapy

anavarIn conclusion, Anavar, if abused, is actually the real deal. It then works well to strengthen muscles and build rigid, strong tissue. It might even assist with the loss of stubborn belly fat. Unfortunately, 1) the dosage needed makes it unimaginably toxic to the liver and 2) there is no actual medical use for it and cannot be taken for very long at all. For this reason, unless you are a bodybuilder willing to trade in your future health for accelerated, temporary gains now, Anavar should never be on your radar.

If you are looking for a supplement to take to maximize your masculine efficiency while ensuring a health-enjoying, long, quality life in the future, consider learning more about a bio-identical Testosterone replacement protocol.

Again, if you are considering bettering your health, changing your physique, improving your sex life and libido, consider a bio-identical testosterone replacement program. We can provide you the same type of testosterone your body produces. Of course, there is still the potential for side effects but, because it is bio-identical, your body is more receptive to it and you can continue therapy safely for many years. Most importantly, our doctors are experts in the art of Testosterone replacement therapy. We make sure our patients have all the required counterparts to their therapy to ensure better keeping unwanted side effects out of the picture.

A properly administered testosterone injection program can reignite the fire you have lost. It may sound intense, but the results of revitalizing the male body are unparalleled and near impossible to denote. It is simply a reawakening of life; a happier, more efficient life.

Testosterone Therapy Information

February 4, 2016 by admin 0 Comments

Testosterone Cypionate Description 0 (0)

Testosterone Cypionate description injections

Testosterone Cypionate Description injection for intramuscular injection contains Testosterone Cypionate which is the oil-soluble 17 (beta)- cyclopentyl propionate ester of the androgenic hormone testosterone. Testosterone Cypionate is a white or creamy white crystalline powder, odorless or nearly so and stable in air. It is insoluble in water, freely soluble in alcohol, chloroform, dioxane, ether, and soluble in vegetable oils. The chemical name for Testosterone Cypionate is androst-4-en-3-one,17-(3-cyclopentyl-1-oxopropoxy)-, (17β)-. Its molecular formula is C27H40O3, and the molecular weight 412.61.

The structural formula is represented below:

Testosterone Cypionate injection, USP is available in two strengths, 100 mg/mL and 200 mg/mL Testosterone Cypionate, USP.

Each mL of the 100 mg/mL solution contains:

Testosterone Cypionate……………………………………………………………………. 100 mg
Benzyl benzoate ……………………………………………………………………………… 0.1 mL
Cottonseed oil ………………………………………………………………………………… 736 mg
Benzyl alcohol (as preservative)………………………………………………………… 9.45 mg

Each mL of the 200 mg/mL solution contains:

Testosterone Cypionate……………………………………………………………………. 200 mg
Benzyl benzoate………………………………………………………………………………. 0.2 mL
Cottonseed oil………………………………………………………………………………… 560 mg

Benzyl alcohol (as preservative)………………………………………………………… 9.45 mg

Testosterone Cypionate – Clinical Pharmacology

Endogenous androgens are responsible for normal growth and development of the male sex organs and for maintenance of secondary sex characteristics. These effects include growth and maturation of the prostate, seminal vesicles, penis, and scrotum; development of male hair distribution, such as beard, pubic, chest, and axillary hair; laryngeal enlargement, vocal cord thickening, and alterations in body musculature and fat distribution. Drugs in this class also cause retention of nitrogen, sodium, potassium, and phosphorous, and decreased urinary excretion of calcium. Androgens have been reported to increase protein anabolism and decrease protein catabolism. Nitrogen balance is improved only when there is sufficient intake of calories and protein.

Androgens are responsible for the growth spurt of adolescence and for eventual termination of linear growth, brought about by fusion of the epiphyseal growth centers. In children, exogenous androgens accelerate linear growth rates but may cause a disproportionate advancement in bone maturation. Use over long periods may result in fusion of the epiphyseal growth centers and termination of the growth process. Androgens have been reported to stimulate the production of red blood cells by enhancing production of erythropoietic stimulation factor.

During exogenous administration of androgens, endogenous testosterone release is inhibited through feedback inhibition of pituitary luteinizing hormone (LH). At large doses of exogenous androgens, spermatogenesis may also be suppressed through feedback inhibition of pituitary follicle stimulating hormone (FSH).

There is a lack of substantial evidence that androgens are effective in fractures, surgery, convalescence, and functional uterine bleeding.

Pharmacokinetics

Testosterone esters are less polar than free testosterone. Testosterone esters in oil injected intramuscularly are absorbed slowly from the lipid phase; thus, Testosterone Cypionate can be given at intervals of two to four weeks.

Testosterone in plasma is 98 percent bound to a specific testosterone-estradiol binding globulin, and about 2 percent is free. Generally, the amount of this sex-hormone binding globulin in the plasma will determine the distribution of testosterone between free and bound forms, and the free testosterone concentration will determine its half-life.

About 90 percent of a dose of testosterone injections is excreted in the urine as glucuronic and sulfuric acid conjugates of testosterone and its metabolites; about 6 percent of a dose is excreted in the feces, mostly in the unconjugated form. Inactivation of testosterone occurs primarily in the liver. Testosterone therapy is metabolized to various 17-keto steroids through two different pathways.

The half-life of Testosterone Cypionate, when injected intramuscularly, is approximately eight days.

In many tissues, the activity of testosterone therapy appears to depend on reduction to dihydrotestosterone, which binds to cytosol receptor proteins. The steroid-receptor complex is transported to the nucleus where it initiates transcription events and cellular changes related to androgen action.

Indications and Usage for Testosterone Cypionate description

Testosterone Cypionate description injection is indicated for replacement therapy in the male in conditions associated with symptoms of deficiency or absence of endogenous testosterone.

  • Primary hypogonadism (congenital or acquired)-testicular failure due to cryptorchidism, bilateral torsion, orchitis, vanishing testis syndrome; or orchidectomy.
  • Hypogonadotropic hypogonadism (congenital or acquired): gonadotropin or LHRH deficiency, or pituitary-hypothalamic injury from tumors, trauma, or radiation.

Safety and efficacy of Testosterone Cypionate description in men with “age-related hypogonadism” (also referred to as “late-onset hypogonadism”) have not been established.

Contraindications

  1. Known hypersensitivity to the drug
  2. Males with carcinoma of the breast
  3. Males with known or suspected carcinoma of the prostate gland
  4. Women who are or who may become pregnant
  5. Patients with serious cardiac, hepatic or renal disease

Warnings

Hypercalcemia may occur in immobilized patients. If this occurs, the drug should be discontinued.

Prolonged use of high doses of androgens (principally the 17-α alkyl-androgens) has been associated with the development of hepatic adenomas, hepatocellular carcinoma, and peliosis hepatis —all potentially life-threatening complications.

Geriatric patients treated with androgens may be at an increased risk of developing prostatic hypertrophy and prostatic carcinoma although conclusive evidence to support this concept is lacking.

There have been postmarketing reports of venous thromboembolic events, including deep vein thrombosis (DVT) and pulmonary embolism (PE), in patients using testosterone products, such as Testosterone Cypionate description. Evaluate patients who report symptoms of pain, edema, warmth, and erythema in the lower extremity for DVT and those who present with acute shortness of breath for PE. If a venous thromboembolic event is suspected, discontinue treatment with Testosterone Cypionate description and initiate appropriate workup and management.

Long term clinical safety trials have not been conducted to assess the cardiovascular outcomes of testosterone replacement therapy in men. To date, epidemiologic studies and randomized controlled trials have been inconclusive for determining the risk of major adverse cardiovascular events (MACE), such as non-fatal myocardial infarction, non-fatal stroke, and cardiovascular death, with the use of testosterone compared to non-use. Some studies, but not all, have reported an increased risk of MACE in association with the use of testosterone replacement therapy in men. Patients should be informed of this possible risk when deciding whether to use or to continue to use Testosterone Cypionate description.

Edema, with or without congestive heart failure, may be a serious complication in patients with preexisting cardiac, renal or hepatic disease.

Gynecomastia may develop and occasionally persists in patients being treated for hypogonadism.

The preservative benzyl alcohol has been associated with serious adverse events, including the “gasping syndrome”, and death in pediatric patients. Although normal therapeutic doses of this product ordinarily deliver amounts of benzyl alcohol that are substantially lower than those reported in association with the “gasping syndrome”, the minimum amount of benzyl alcohol at which toxicity may occur is not known. The risk of benzyl alcohol toxicity depends on the quantity administered and the hepatic capacity to detoxify the chemical. Premature and low-birth weight infants may be more likely to develop toxicity.

Androgen therapy should be used cautiously in healthy males with delayed puberty. The effect on bone maturation should be monitored by assessing the bone age of the wrist and hand every 6 months. In children, androgen treatment may accelerate bone maturation without producing a compensatory gain in linear growth. This adverse effect may result in compromised adult stature. The younger the child the greater the risk of compromising final mature height.

This drug has not been shown to be safe and effective for the enhancement of athletic performance. Because of the potential risk of serious adverse health effects, this drug should not be used for such purpose.

Precautions

General

Patients with benign prostatic hypertrophy may develop acute urethral obstruction. Priapism or excessive sexual stimulation may develop. Oligospermia may occur after prolonged administration or excessive dosage. If any of these effects appear, the androgen should be stopped and if restarted, a lower dosage should be utilized.

Testosterone Cypionate description should not be used interchangeably with testosterone propionate description because of differences in duration of action.

Testosterone Cypionate description is not for intravenous use.

Information for Patients

Patients should be instructed to report any of the following: nausea, vomiting, changes in skin color, ankle swelling, too frequent or persistent erections of the penis.

Laboratory Tests

Hemoglobin and hematocrit levels (to detect polycythemia) should be checked periodically in patients receiving long-term androgen administration.

Serum cholesterol may increase during androgen therapy.

Drug Interactions

Androgens may increase sensitivity to oral anticoagulants. The dosage of the anticoagulant may require a reduction in order to maintain satisfactory therapeutic hypoprothrombinemia.

Concurrent administration of oxyphenbutazone and androgens may result in elevated serum levels of oxyphenbutazone.

In diabetic patients, the metabolic effects of androgens may decrease blood glucose and, therefore, insulin requirements.

Drug/Laboratory Test Interferences

Androgens may decrease levels of thyroxine-binding globulin, resulting in decreased total T4 serum levels and increased resin uptake of T3 and T4. Free thyroid hormone levels remain unchanged, however, and there is no clinical evidence of thyroid dysfunction.

Carcinogenesis

Animal data

Testosterone has been tested by subcutaneous injection and implantation in mice and rats. The implant induced cervical-uterine tumors in mice, which metastasized in some cases. There is suggestive evidence that injection of testosterone into some strains of female mice increases their susceptibility to hepatoma. Testosterone is also known to increase the number of tumors and decrease the degree of differentiation of chemically induced carcinomas of the liver in rats.

Human data

There are rare reports of hepatocellular carcinoma in patients receiving long-term therapy with androgens in high doses. Withdrawal of the drugs did not lead to regression of the tumors in all cases.

Geriatric patients treated with androgens may be at an increased risk of developing prostatic hypertrophy and prostatic carcinoma although conclusive evidence to support this concept is lacking.

Pregnancy

Teratogenic Effects

Pregnancy Category X. (See CONTRAINDICATIONS)

Benzyl alcohol can cross the placenta. See WARNINGS.

Nursing Mothers

Testosterone Cypionate description is not recommended for use in nursing mothers.

Pediatric Use

Safety and effectiveness in pediatric patients below the age of 12 years have not been established.

Adverse Reactions

The following adverse reactions in the male have occurred with some androgens:

Endocrine and urogenital: Gynecomastia and excessive frequency and duration of penile erections. Oligospermia may occur at high dosages.

Skin and Appendages: Hirsutism, male pattern of baldness, seborrhea, and acne.

Cardiovascular Disorders – myocardial infarction, stroke

Fluid and electrolyte disturbances: Retention of sodium, chloride, water, potassium, calcium, and inorganic phosphates.

Gastrointestinal: Nausea, cholestatic jaundice, alterations in liver function tests, rarely hepatocellular neoplasms and peliosis hepatis (see WARNINGS).

Hematologic: Suppression of clotting factors II, V, VII, and X, bleeding in patients on concomitant anticoagulant therapy, and polycythemia.

Nervous system: Increased or decreased libido, headache, anxiety, depression, and generalized paresthesia.

Allergic: Hypersensitivity, including skin manifestations and anaphylactoid reactions.

Vascular Disorders: venous thromboembolism

Miscellaneous: Inflammation and pain at the site of intramuscular testosterone injection.

Testosterone Therapy Information

September 21, 2015 by Joseph Fermin 1 Comment

L-Carnitine Health Benefits 0 (0)

L-Carnitine Health Benefits

  • Fat Burner: L-Carnitine is to the human body what a turbo mechanism is a high-performance automobile. It’s an essential amino acid with vitamin-like qualities for optimum fat burning.
  • Muscle builder: Supplementing with l-Carnitine can help increase strength and heavier weights eventually mean a better-defined physique.
  • Bone Mass: Slows down the bone loss process and improves bone microstructural properties by decreasing bone turnover.
  • Improves Cardio system: L-Carnitine is vital for maintaining a healthy cardiovascular system and can be used along with conventional treatment for angina to reduce the needs for medicine and improve the ability of those with angina to exercise without chest pain or discomfort.
  • Male infertility: Helps improve both sperm count and quality of sperm.
  • Type II Diabetes: Helps diabetics by increasing glucose oxidation, glucose storage, as well as glucose uptake.
  • Immune System: Serves as an antioxidant that can help prevent damage done to your healthy cells by free radicals. This can help you out when you have a cold or are dealing with various seasonal allergies and/or training.
  • Brain Function: Helps protect the brain from both age-related and stress-related damage, which helps it function longer and better.

L-Carnitine Health Benefits

This medication is usually compounded with other amino acids in an effort to maximize the benefits and end results. However, when it’s administered on its own, it’s usually in an effort to use the medication to stimulate weight loss. The patient’s prescribing physician will determine the exact dosage and protocol.

Typically, on its own, L-Carnitine Health Benefits is administered on a daily basis or, at least every other day. If it’s compounded with other amino acids or formulations, then the protocol can vastly vary.

Our L-Carnitine Health Benefits comes in 10ml vials and does not need to be stored in a refrigerated unit. As long as it is kept in a cool, dry spot there should be no issues with its efficacy.

**NOTE**  The content contained in this blog is subject to interpretation and is the opinion of the content writer.  We do not claim it to be fact.  We encourage you to consult a medical doctor before taking any prescribed medications or supplements.

August 28, 2015 by admin 0 Comments

Jeff used hormone therapy and stopped gaining weight. 5 (1)

How someone used hormone therapy to control the effects of aging.

Jeff Harrington started noticing he was getting overweight around his 48th birthday. He always worked out 2 to 3 times a week for about an hour. He got into this workout habit in college and stuck to it pretty loyally, wearing out sneakers like there’s no tomorrow. He loved getting to spend time at the gym.  He especially enjoyed the benefits it had given him compared to his friends who didn’t work out as much, referring to them as “slackers”.

Lately, though, he had begun to start feeling like a slacker himself. He had begun to gain weight, particularly around his stomach. His six-packs abs had begun to turn into one big belly and started getting in his way when he bent over. He found himself missing days at the gym. It made him call himself a slacker; he was angry at himself about it.

(more…)

August 27, 2015 by Joseph Fermin 0 Comments

Do you Know You Hormone Levels? Weight Gain 5 (1)

Do you Know You Hormone Levels? Weight Gain

Once we hit age 30, it’s all downhill for the body’s hormone levels. The lean body mass (LBM) of our organs starts to decrease, while the adipose mass, or fat mass, increases. Between the ages of 30 thru 75, the liver, kidneys, brain and pancreas atrophy by 30% on average. In men between the ages of 40 thru 80, the LBM declines about 5% per decade and in women by 2.5% per decade. Meanwhile, during this same period, the body fat in both sexes is increasing. By the late 30s, men are starting to gain fat in the abdomen. Men between the ages of 30 thru 70 don’t gain weight, but women’s mass shrinks by 30% and the fat expand by 50%. Women, as they age mainly, accumulate fat on their hips and as menopause starts, the belly rolls begin.

These changes aren’t part of the aging process, but a threat to health and longevity, according to gerontologist. First, the amount of aerobic power is directly connected to the amount of LBM. Second, this shrinkage of the vital organs means that they cannot do their jobs as well, whether it is the heart pumping, the muscles lifting, or the kidneys clearing metabolic wastes from the blood. Third, as the abdominal fat rises, so does the risk for heart attack, hypertension, and diabetes.

In one study by St. Thomas’ Hospital in London, of 24 adults with Human Growth Hormone (HGH) deficiency, half the group was put on Human Growth Hormone Levels and the other half was given a placebo. At the end of the six-month period, the hormone treated group had no change in weight. But they had lost an average of 12.5 pounds of fat and gained an average of 12.1 pounds of lean body mass, which is mostly muscle. The increase in their lean body mass was 10.8%. The bodies became sleeker and more tapered, as shown by the significant decrease in their waist to hip ratio. Although this study was conducted on patients with pituitary diseases, the researchers note that recombinant Human Growth Hormone Levels reduces fat mass by about 20%, which suggests that growth hormone has a regulatory effect on fat mass in normal adults.

The fact that Human Growth Hormone was the reason for these changes could clearly be seen when this clinical research stopped giving the Human Growth Hormone. The men’s bodies fast forwarded to old-age. And if that weren’t proof enough, consider the fate of the untreated controls. At the same time that the treated man was morphing into younger versions of themselves, the untreated control group was careening downhill, their lean body mass and organs shrinking by an average of 2.5 – 4.5% a year.

HGH therapy does have a shapeshifting effect on the body. Here at AAI Rejuvenation Clinic, our intention is to structure comprehensive blood panel testing, to help create a personalized program to fit your specific body and its needs. Please fill out our medical history form or contact us directly to speak with one of our wellness advisors who is knowledgeable on hormone replacement therapies. Call today! Begin to take charge of your life and make sure that you are enjoying this existence to the fullest.

**NOTE**  The content contained in this blog is subject to interpretation and is the opinion of the content writer.  We do not claim it to be fact.  We encourage you to consult a medical doctor before taking any prescribed medications or supplements.

HGH Therapy Information

July 27, 2015 by Joseph Fermin 2 Comments

Can a Change in Hormones Cause Chronic Fatigue? 5 (1)

Could The Hormone explain
Your Chronic Fatigue?

Men experience a slow, yet steady decline in testosterone as they age. The continued loss of this male sex hormone is sometimes referred to as male menopause or andropause. Similar to female menopause, hormonal changes come with a number of undeniable symptoms, including Chronic Fatigue. These changes are not easy to accept or notice, however, they can have a gradual, crippling feeling.

Testosterone injections play a vital role in the body’s immune response. As testosterone levels decline, the body compensates by redistributing energy and resources to the immune system. This takes a considerable toll on energy levels resulting in testosterone-related Chronic Fatigue.

Additionally, another potential relationship between free testosterone and Chronic Fatigue is sleep disruption. It isn’t uncommon for a drop in testosterone levels to cause sleep disruptions in men and women. Testosterone is naturally released into the body in different periods throughout the day. However, it is mainly produced at night when you sleep. Usually, most production occurs approximately 3 hours into your sleep cycle. You probably get little to no quality sleep if you are suffering from low testosterone. Sleep deprivation causes your natural along with all the vigorous attributions associated with it.

The loss of energy, lack of sleep, Chronic Fatigue and other symptoms linked with diminishing testosterone levels is not something you have to incorporate into your lifestyle. Fortunately, this can be improved. Here at AAI, we delve deeper into each of our patient’s history, goals, and lifestyle. We recognize that everyone is a unique individual and our bodies work differently. AAI takes this into account when we develop and organize your profile and pharmaceutical protocol. There is no one size fits all remedy. A thorough evaluation of your blood work will reveal areas of focus, signs of potential health concerns, as well as ailments you may be experiencing. Testosterone replacement therapy in conjunction with supplemental pharmaceuticals can drastically increase energy levels and reduce Chronic Fatigue. Testosterone Therapy has also been proven to improve mood, bone density, strengthen the immune system, reduce body fat, improve muscle mass, and reduce feelings of depression.

Like any use of medication, testosterone replacement therapy does not come without risks. Before injectable Testosterone replacement therapy is started, you must complete our Medical History Form, Blood Work, and Physical Examination in order to rule out any possible contradictions to Testosterone therapy. Blood Work is essential in determining your free testosterone levels. This process can be facilitated close to your home. At AAI, we feel it is imperative to continue to monitor hormone levels throughout the duration of your treatment. We have implemented various programs to help facilitate those follow up’s. You do not have to schedule an appointment to go to a lab to have blood drawn for these follow-ups. We provide you with a 7-day mouth swab kit. This provides our physician with data over a consecutive 7- day period of time for remarkable accuracy. It assures you are getting the most out of your therapy and that any required adjustments are made accordingly. This is essential to ensure that you are enjoying all the benefits that you wanted and deserve your testosterone therapy while avoiding any potential health risks.

**NOTE**  The content contained in this blog is subject to interpretation and is the opinion of the content writer.  We do not claim it to be fact.  We encourage you to consult a medical doctor before taking any prescribed medications or supplements.

At AAI Rejuvenation Clinic, we advise anyone to think seriously about beginning Hormone treatment if there is no medical need for it. However, we will take every precaution to ensure that you read all the positive benefits from your program by providing the latest at-home hormonal mouth-swab testing. This will ensure we are continually monitoring your progress and aware of any negative side effects. Fill out the Medical History Form or call us at (866) 224-5698