The body undergoes a lot of changes as one ages, which includes the decline of hormones that play a huge role in overall health. Some of the body functions naturally reduce the testosterone levels in the body. Especially when a woman is aging and approaching menopause, they are likely to experience a decline in testosterone, which is normal. When the symptoms of menopause start becoming apparent, Hormone replacement therapy (HRT) is used to address them.
Do Women Need TRT?
Female bodies need testosterone, which they convert into female sex hormones. Women produce enough estrogen and testosterone to last through puberty and young adulthood. While significant amounts of testosterone are produced, it is usually converted into estrogen, the female sex hormone. The primary use of testosterone in women is to maintain good vaginal & menstrual health, enhance sex drive, boost fertility, strengthen bones, and boost breast health.
The standard testosterone levels for women often lie between 15 to 70 ng/dl of blood. When the testosterone levels go below 15 ng/dl, the results might be low sex drive, vaginal dryness, fertility problems, osteoporosis, changes in breast tissues, and irregular/no menstrual periods.
However, high testosterone levels, ie more than 70 ng/dl translate to a condition known as polycystic ovarian syndrome among other effects. This condition negatively impacts monthly periods affecting your ability to ovulate. It is also abbreviated as PCOS and can cause different symptoms like infertility caused by lack of ovulation which makes it difficult to get pregnant. It also associated with skin-related problems like acne, dandruff, oily skin, and dark-patched skin. PCOS can also cause irregular or non-existent periods, miscarriage, infertility, ovarian cysts, and excess hair growth on the toes, back, face, chest, thumbs, and stomach.
Unbalanced testosterone in females affects the general health, so, women need TRT to treat abnormally low testosterone levels in the body.
How to Know When Its For You
The level of testosterone changes throughout the life of a woman. It’s also common for the level to change at different points of the day and during the menstrual cycle. When there is any form of testosterone imbalance the woman’s health is at risk of deterioration. Here are some of the symptoms that can be easily noticed as a sign of low testosterone and a need for TRT treatment.
The weakness of muscles comes with a number of different side effects. You will notice sluggishness and high levels of fatigue. Weak muscles often manifest with age decline, and as time elapses, mundane tasks tend to be hard to accomplish timely.
Sleep patterns tend to change. That may result in irregular resting periods. It may also bring about unwanted weight gain and if experiencing such, you might want to consider TRT which corrects the situation.
Low Sex Drive
While testosterone is known as the ‘male hormone’, it is also present in females. In fact, low testosterone levels might affect how a woman reacts to sexual advances. It might in turn affect her sexual satisfaction. In addition to that, some other sexually related anomalies might arise such as the dryness of the vagina, irregular menstrual cycle, and fertility problems.
Loss Of Bone Density
Testosterone is a key player in the maintenance of the bone structure. Decreased levels usually affect the strength of the bones. It might affect the health of your joints which might result in constant aches.
It is paramount to remember that this area is still being researched. These symptoms might also appear in other ailments. A trained doctor needs to check for other complications before diagnosis. They might look for depression, stress, the transition to menopause, or thyroid disease to ascertain that the symptoms are an indication of low testosterone levels.
To understand testosterone deficiency in a woman’s body, you need to understand some of the causes of low testosterone levels. The two main causes are.
Menopause is the most common cause of low testosterone for women who have advanced in age. During menopause, the functions of the ovaries tend to seize. With the seize in the function it’s quite automatic that the levels of testosterone will significantly drop.
Ovarian And Pituitary Trauma
The level of testosterone may drop for young women if there is an underlying issue with the ovaries or the pituitary gland. The issue might arise from a number of reasons for example during delivery or even an accident.
A less common cause of low testosterone level in women is:
Younger women are the most susceptible to this type of complication. Vitamin deficiencies are usually caused by a number of genetic errors where the body is unable to absorb vitamin b12, zinc, folate, glutamine, and others. Amino acids and vitamins are responsible for the production of testosterones.
Benefits of TRT in Women
Low-T in women also has its implications. However, testosterone replacement therapy has both immediate and long term benefits to the body. Here are some of the immediate benefits.
As you get older the collagen levels tend to get depleted and that results in wrinkling and aging of the skin. Testosterone replacement therapy plays a key role in fighting this sagging of the skin. The presence of testosterone brings back the production of collagen to its former self. After a few visits to the doctor’s office, you might notice brighter and less wrinkly skin.
Improved Mood and Energy
As per the symptoms you have noticed that a low testosterone level comes with a feeling of fatigue and sluggishness. Testosterone replacement therapy tends to push that cloud away. You become more energetic and more zealous than you have been. A balanced level of testosterone in the body tends to bring about a feel-good mood and thwarts the feeling of depression.
As a direct side effect, you can easily notice the thickening of hair follicles so as to stop hair fall out. Do not expect new hair follicles to appear cause that’s impossible. The only thing that happens is that hair growth is stimulated and hair might pop out of follicles that were once unresponsive.
Here are some long term benefits
Balanced Sugar Levels
When the body becomes unresponsive to insulin as a result of unhealthy eating, you are usually at a high risk of getting complications. Testosterone replacement therapy in women tends to alter such body malfunctions. The presence of testosterone helps in making the body more responsive to insulin. Over time the therapy fosters the growth of muscle cells that respond timely to insulin while there is the presence of high sugar levels.
Strengthening of Bones
When the body lacks testosterone the bones tend to lack density and are brittle. This puts a woman’s skeletal structure at a high risk of fractures. Testosterone replacement therapy helps in maintaining the health of the bone cells and enhances bone growth. As a woman continues to age the therapy ensures the bones remain healthy and strong.
Prevention of Heart Disease
Heart diseases affect all ages as opposed to previous ideas that they only affect the old. The healthiness of the heart is always important to avoid any complications within your body. With the continued testosterone replacement therapy the body, in general, tends to regain proper functioning as seen from the previous benefits. When the body has a hormonal balance cardiovascular risks are at all times low.
Regained Sex Drive
With a low libido, most women tend to become frustrated and that affects the interaction with the opposite gender that includes the spouse. Testosterone replacement therapy has proven evidence of changing the levels of your sex drive. It has a positive track record for improving the libido for both men and women alike. For women who are post-menopausal that are facing a lowered level of sex drive, testosterone replacement therapy combined with other hormone therapy tends to bring back the flickering sexual flare. Apart from bringing back the sex drive, sensual satisfaction is also achieved. The dryness of the vagina and other complications are fine-tuned.
Other HRT Options for Women
Just like testosterone, estrogen levels drop when women get to menopause. When experiencing menopausal symptoms, HRT is used. It is also referred to as estrogen replacement therapy, hormone therapy, or menopausal hormone therapy, and is compounded differently depending on the patient’s health. There are different ways of taking HRT as explained below;
The estrogen tablets are common than other methods of HRT and are taken once every day. Some types of estrogen tablets have a somewhat complicated schedule, but most are simple and are taken without food. Two of the unique advantages is that estrogen tablets can be used to reduce the chances of contracting osteoporosis and reduces the likelihood of menopause symptoms.
There are also other forms of estrogen applied directly to the vagina. These are effective for issues such as burning or pain during sex, vaginal dryness, and itchiness. They could come in the form of insertable rings, tablets, or creams and for obvious reasons, they all use different dosing schedules. For instance, creams can be applied a few times a week while vaginal tablets can be used every day before changing the dosing to a few times every week. Vaginal rings, on the other hand, are mostly replaced after a period of three months.
The estrogen patches are worn on the waistline and depending on the dosage, sometimes could be for a week or can be changed once or twice within the week. This is a good alternative if you don’t like taking daily tablets. It might also help avoid some of the side effects that come with using other HRT methods like blood clots and indigestion.
You could also use creams, sprays, and gels for your HRT treatment. Either of these options is rubbed into the skin once a day at specific areas depending on the type. For instance, you might be required to rub it into your wrist, arm, legs, and shoulders, etc.
Another alternative for HRT treatment is implants which are small pellets inserted mostly around your tummy. The pellet releases the hormone into the body and is replaced after it gets depleted, usually after a few months.
HRT Treatment Routines
With the different HRT options, there are two distinct treatment routines for you to consider, sequential or cyclical HRT and continuous combined HRT.
If you are already experiencing menopausal symptoms and you are under the combined treatment routine but still get your periods, then you might need to start cyclical HRT. Monthly HRT is one of the two types of cyclical HRT where you are required to take both estrogen and progestogen. This is usually taken during the final two weeks of your menstrual cycle and is mostly recommended for women with regular periods. The second type of cyclical HRT is the 3-monthly HRT which is taken on a daily basis. You will also need to take it with progestogen for two weeks every three months and is mostly recommended for those women with irregular periods.
Continuous Combined HRT
The combined HRT is best for postmenopausal women. If you haven’t had your periods for about a year, then you are considered a postmenopausal woman. With the combined HRT, you are required to take both estrogen and progestogen on a daily basis.
How to Get Treatment
You are experiencing most or some of the symptoms suggestive of the need for TRT treatment, but do you know where to begin? Your safest and most convenient option would be finding an anti-aging clinic that offers HRT treatment. To get the best treatment, you will need to find a clinic that specializes in your needs.
So, you will be looking for an anti-aging clinic that deals with hormone therapy and other anti-aging treatments. The following are some of the top factors to consider when choosing a clinic for TRT treatment.
Professionalism and Friendly Customer Service
You will be getting your hormone therapy treatment indefinitely, so it is important to find an anti-aging clinic with friendly customer service. After shortlisting the clinics you are interested in, make an inquiry call, or sent an email and pay attention to how they respond to you. Are they kind and willing to answer your questions and take you through the procedure? Bad customer service is a turnoff, so find a place where you will be treated well. In addition to friendly customer service, professionalism is equally important. Is the communication professional, and how presentable is the website?
Check for Reviews
What other patients say about a certain clinic should tell you a lot. Search online for any reviews you can get, and check what people are complaining about or what they highly commend about the clinic. An anti-aging clinic with good reviews and ratings is always a good option. And while it is good to check the good reviews, the bad reviews will also tell you a lot about where they fall short. Also, you can ask your friends and family to recommend any good clinics they know about.
Skill and Experience
Experience and skill matter a lot. They make part of the most important factors to look out for before choosing an anti-aging clinic. Hormone therapy is a delicate kind of treatment, so having a skilled professional do it for you is vital. Also, the amount of experience matters since your provider already knows the common mistakes done during the process and how to avoid them.
Calm and Relaxing Environment
If you are personally visiting the clinic, look for one with a relaxing and calm environment. And even if you are going the online way, then ensure that the process is stress-free. The last thing you would want is to have the treatment abruptly stopped halfway without an explanation or have to deal with very difficult people. This would stress you up, which beats that purpose of the treatment.
You will also want to look for a clinic that offers personalized experiences for you since TRT treatment does not work the same for everybody. Find a clinic offering a personalized approach for TRT treatment. From a customized treatment plan to the expected recovery times, you want to find a clinic run by experts offering nothing but the best anti-aging practices. What’s more, they should be able to provide a detailed consultation before the treatment. You want a deep insight on what the treatment looks like, vague information and a rushed consultation is not going to provide that for you.
Once you decide on the best anti-aging clinic, treatment will likely begin immediately. You already know what your symptoms are, the next phase would be an in-depth consultation and bloodwork carried out. This helps to ascertain your needs and tailor a treatment plan just for you.
After you begin your HRT treatment, keep your doctor updated about any changes and new symptoms you may begin to experience. In addition to your treatment, ensure to maintain a healthy lifestyle as it also goes a long way. From physical fitness to healthy diets and managing bad habits like drinking and smoking. A good TRT treatment combined with a healthy lifestyle will definitely go a long way. Also, the clinic you choose to work with plays a huge role in the overall results you get for TRT treatment. To that end, you might want to consider working with AAI Rejuvenation Clinic which will create a personalized TRT treatment based on your needs in the most reliable and convenient way possible.
Now that you are diagnosed with low-T, the next course of action is starting testosterone therapy. But then it is important to understand the different costs you will incur for the therapy, even though they should be broken down to you when you visit your TRT clinic.
The cost of getting testosterone replacement therapy might differ depending on the medication prescribed, your doctor, your location, method of administration, how severe your symptoms are, how long the treatment will take, and whether/how much coverage you get from your health insurance company.
When you decide to get TRT, you should know exactly what you are paying for, so expect to commit for a long period of time.
That said, here is a quick rundown of how much it will cost you to get testosterone replacement therapy.
Before the therapy starts, there are a few required tests and other things that will make part of the overall costs. These are done to help customize the treatment plan because all individuals are different and have different needs.
Here are the startup costs to expect when you decide to get TRT. Keep in mind every clinic charges different rates. This is only meant to be an overview of potential costs.
Blood work is vital when it comes to determining the level of testosterone in the body. The process includes two separate assessments which include total testosterone and free testosterone. The free testosterone test is used to determine the amount of testosterone not bound to proteins. On the other hand, the total testosterone test is used to measure comprehensive testosterone levels in the body, both the free testosterone as well as the amount attached to proteins to aid with the transportation of the hormone in the bloodstream.
Your treatment is customized to your special needs which is why different blood tests are done, to ensure that all those needs are addressed. It also helps to establish the severity of your symptoms and which approach to use for treatment. The cost of getting blood work done could range anything from $100- $200, but with the financial help of your insurance company, it could cost less. If your insurer can cover the cost, then it helps to gauge where you are financially before starting therapy.
A physical exam before your testosterone therapy is used to determine how healthy you are, which aids in creating a treatment plan unique to only you. This cost could be covered by your insurer, after proof of a need from your medical care provider. If covered by insurance, the cost will vary depending on the insurance plan and the provider. While most of the treatment methods are used to increase testosterone levels rather than restore then, the therapy might be a lifetime, so, you’d be advantaged to get financial aid from your insurance cover.
On the downside, not everyone has a health insurance cover, and even those with it sometimes end up paying out of pocket for different reasons. For instance, if you are still showing symptoms but your testosterone levels have not reached the amount used to establish a need for your insurer, then they may not payout.
On the brighter side, getting testosterone replacement therapy comes at very reasonable prices that won’t hurt your pocket, often between $50- $200.
During the physical exam, you might be required to fill out health questionnaires regarding your medical history and any issues about your health, if any. A review is done to establish the glaring risks for the likelihood of any diseases that can be avoided, as well as pinpointing existing problem areas.
When a possible health concern is discovered, the matter is brought to your attention and a few changes on your lifestyle and medication might be made for your treatment so that you may attain better health.
Your TRT doctor will need to review your blood work results before coming up with a treatment plan for you. Does the blood work show any risks for the possibilities of certain conditions or illnesses? How will different treatments work for you? Are you healthy? This is important, and the cost usually ranges between $100-$200.
Your TRT health care provider is going to personalize a treatment plan suitable just for you and your needs.
Also, this is usually done more often than not after your testosterone therapy begins. You might have to get more blood work done to assess your current health position and how effective the therapy is, in order to make any changes to the treatment plan if necessary.
When it comes to TRT, normally you will have a stack of things you take. Some clinics charge monthly, some bi-monthly, and some can sell in bulk.
You will usually start with:
You will be put on one of three types of testosterone, cypionate or ethanate are the most popular. If you have no health insurance cover, cypionate might cost you an approximate of $110 for a little over a month’s supply.
However, if you have a health insurance cover, the cost will be definitely lower. This cost is usually determined by your insurer’s guidelines. To prove that you have low-T, they may request you to take two different testosterone tests before 10 am. If the results turn out positive, then approved TRT replacement can begin, and this may cost about $30.
Another alternative treatment is Androgel which costs as much as $300-$500 for one month’s supply if you pay without insurance. But with an insurance cover, you might pay as little as $30 for the same amount of Androgel.
So, take advantage of the many insurance companies that offer partial coverage for TRT costs. You might have to pay out of your pocket, but this is going to come in hand in the long run. If you don’t know how or where to begin, discuss with your TRT physician for advice on how to get compensated by your insurer.
You’d be surprised by how easy it is to get insurance for your TRT because a lot of health insurance companies provide coverage for the same provided there is proof of a need. The amount covered will not be the same for all health insurance providers, it will differ depending on your health plan and other policy-specific factors such as the deductible, etc.
Diagnosis from your TRT doctor or some conditions might not prevent your approval from the health insurance provider. For instance, if you have had a prostatectomy before, you might not need to undergo tests to check for low-T.
Because of testosterone injections, your doctor may choose to put you on HCG which is used to sustain the natural function of the testicles. This is because the treatment is linked to shrinkage and prevention of the natural production of the testicles. Hence, HCG is used to prevent this occurrence while boosting fertility.
As one ages and gains more weight, their body converts testosterone into estradiol. This estradiol is regarded as the “bad estrogen” which is mostly linked to problems with the prostate, erectile issues, and gynecomastia. While the production of estradiol is more harmful than good, aromatase, an enzyme complex, speeds it up. Aromatase plays the role of changing testosterone into the bad estrogen, estradiol.
To that end, once aromatase inhibitors are introduced to the body, they bind with the aromatase in order to weaken it. Aromatase is usually present in fat cells in the male body, and as they increase in size, so does the estradiol. This causes a decline in testosterone levels.
The bone mineral intensity in men is determined by estradiol in the body, hence low levels are associated with osteoporosis and bone loss in elderly men. Low amounts of estradiol are also linked to erectile dysfunction, reduced sex drive, and increased fat.
Through the administration of the aromatase inhibitor, the levels of estradiol are decreased. As a result, testosterone, LH, and the follicle-stimulating hormone (FSH) are elevated. As such, aromatase inhibitors are mostly used to increase the amount of testosterone for men with low-T.
The average cost is about $250 monthly, while some clinics can charge up to $500 for the same products. As you dial in, these things may be tweaked in quantity.
Blood work will have to be done regularly to monitor your levels, things like your hematocrit need to be watched, so do your hormones in order to Dial you in.
Collectively, here is what you can expect to pay every year for testosterone replacement therapy if you don’t have insurance coverage;
Blood work-$100-$200 + Physical exam-$50-$200 + Consult-$100-$200 as one off or occasional costs, and monthly you’re looking at Testosterone-$110 + Aromatase inhibitor-on average $250= $610-$960
Annually TRT costs can range between $2,400-$5,000 depending on what protocol you’re on and what clinic you work with.
However, if you have health insurance coverage, then you would definitely pay lower than that.
Keep in mind that is a small price to pay when you consider the impact it will have on your life, your work, and your overall health. In fact, most people say that TRT is an investment that has a tremendous ROI because your professional life will benefit as a result.
Work With AAI
Work with a group of professionals from AAI and get the best customer service to the end of your TRT journey. AAI clinic offers a cost-effective solution to TRT, we work with you to get the plan you need. You not only get top-notch services but also value for your money.
The internet has made it very easy to get nearly everything you need from anywhere in the world. With a good internet connection and a phone/tablet or laptop, you can comfortably buy TRT online from your house. There are lots of reliable and genuine hormone replacement therapy clinics that are accessible online. And the process is not that complicated, you are only required to follow a few simple steps then have your medication delivered at your doorstep.
On the downside, buying online does not guarantee safety since you are buying from strangers, and this begs the question, how and where do you buy TRT online? The last thing you want to do is to get scammed or end up with fake and/or illegal testosterone in your hands. When browsing for a reliable source, look out for red flags such as unprofessional-looking websites and pay attention to how they answer your questions or handle your situation.
You will find a lot of misleading websites with vague information about reversing symptoms of testosterone deficiency which makes it hard to make a decision on where to buy. Any good hormone replacement and the anti-aging clinic will provide you with ample information about TRT so if you have more questions than answers then it might not be the best place to buy.
Mostly, buying TRT online does not require you to visit the clinic, so it might be hard to set apart genuine and professional providers from fake ones. But, a clinic that offers diagnostic testing a consultation, and a proper treatment plan is worth considering.
Can You Buy TRT Online?
Yes, you can! After discovering you have symptoms of low-T, the next step is finding a solution. And since online buying has been made easy, you are presented with different options for you to make a choice. However, you have to know that there is a right and wrong way of buying TRT online. If anything just offers you a way to “add to cart” you want to run the other way as those are probably either fake or tainted products sold by illegal means. There is an official way of doing things, let’s talk about both.
The Wrong Way
The last thing you want is to get shoddy services for your testosterone replacement therapy and worse, lose your hard-earned money to internet cons. When buying TRT online, don’t just google random websites that claim to have real testosterone but don’t require you to do anything else but put in your credit card information. This is a major red flag that should tell you whether they are authentic or not. Don’t just rush into paying for products you know nothing about or for a treatment plan that has not been well-broken down for you.
What’s more, when you buy TRT online the wrong way, you risk getting contaminated or false products, this is a very dangerous route for your health. There is more that goes into TRT and every approach is uniquely tailored because it is not a one-size-fits-all. If you exhibit the symptoms of low-T, blood tests and a medical exam are vital in determining your treatment plan.
Also, you need an expert to breakdown the whole process and point you in the right direction. Most of these unprofessional and illegal websites that you might fall prey to don’t have an operating license and they market counterfeit products that are a hazard to your health. You will also likely receive poor quality patient care without an expert to walk you through the whole process.
In the end, you lose money buying products that will do more harm than good to your body. But when you take the time to understand how the process works, then it will be easy to know how and where to purchase TRT online.
The Right Way
On the other hand, you can get TRT through a completely legit online and telephone process. The best way to buy TRT online is to work with a telemedicine testosterone clinic. You will not be prompted to quickly fill your card details before your health and testosterone levels are accessed. Everything is done remotely, and you have an expert to guide you through the whole process.
A reliable nationwide telemedicine clinic will be able to schedule your blood work, medical exam, and get you on a therapy program from anywhere in the country. For convenience purposes, they can either send you a home kit or schedule an appointment with a lab near you, whichever you are most comfortable with. They also have seasoned physicians assigned to work with you throughout the process. In addition, exceptional patient service and support are essential.
TRT is not a one-time event, it is a step-by-step process made to leave you feeling and looking good. When you find a good telemedicine testosterone clinic and decide to begin therapy, this is the process to expect.
Once you find a good clinic online to buy TRT, consult with your doctor, and discuss your symptoms with them. Since you don’t need to visit the clinic in person, your doctor will schedule an unrushed meeting over the phone. The symptoms you present to them will help to determine your needs for testosterone replacement therapy.
They will inform you of everything about TRT and what the protocol is made of. You also get to know how long the process will take and its benefits for someone diagnosed with testosterone deficiency. Also, during your first consultation, you can also get answers to all your questions like how much the therapy will cost you, etc. Don’t hesitate to ask about anything about the therapy at this stage.
A medical exam is conducted to assess your health and to establish if you are suitable for Testosterone Replacement Therapy. This may include evaluating your medical history and filling out a medical form issued by the clinic. When evaluating your medical history, your doctor will ask you different questions revolving around some of the symptoms of low-T you have. For instance, history of head trauma, cranial surgery, infection and injury to your testicles, irradiation or chemotherapy, medication use, family history of diseases associated with testosterone deficiency, and so on.
Getting blood work done
After you discuss your symptoms of low-T with your doctor and get a medical examination, blood tests including a full blood panel are done to determine how much testosterone is in your body. This also includes your red and white blood cell count as well as other biomarkers. This is done to help establish the cause of your symptoms and your health in general. A single type of testosterone test can be used to scan for low-T but both total testosterone tests and SHBG tests are done to give a larger perspective of the levels and if TRT will be beneficial to you.
And sometimes, the blood work might need to be redone in order to confirm the measurements of the treatment. You don’t require any special preparations to get your blood work done and you also won’t be required to visit for it to get done.
Follow up consultation
The process also includes a consultation with your doctor to follow up on the blood work. This follow up consultation is important for the diagnosis and to set expectations for what your treatment protocol will be like. If not all tests had been initially done, then more tests might be done to aid further diagnosis. The follow-up care plan remains even after therapy starts because the doctor will need to monitor your health.
Coming up with a treatment plan
TRT does not work the same for everybody with low-T and related symptoms. Every decision made towards the treatment should be personalized, as your signs and symptoms play a huge role in determining what type of testosterone therapy you need. So, a treatment plan will be made based on factors including the blood work done, the medical exam, your age, and so on. Also, when you start the therapy, you will need to regularly follow up with your doctor to check for the testosterone levels in the blood.
For instance, the dosage for your treatment might need to be decreased should the blood cell count get very high. Perhaps the mode of administration you are currently using is no longer working for you, then your doctor will need to revise this. Your needs might change over time, and your current treatment might not work towards your therapy goals, so monitoring and doctor review is important to ensure the longterm goal is achieved. TRT is a serious decision that you should make only after your doctor advises you to do so.
Why this is the best bet
When you buy TRT online, the therapy process should be a breeze and you don’t have to worry about dealing with unethical individuals or counterfeit medication. Working with a telemedicine testosterone clinic has a lot of perks listed below.
The Authenticity of the Medication
One of the biggest worries for patients when buying TRT online is whether the medication is approved by the relevant bodies and if it is safe to use. You will find a lot of websites online advertising testosterone, but that does not mean that they are harmless. When buying TRT online, ensure that it is from a licensed hormone replacement treatment or anti-aging clinic.
When you choose to work with a telemedicine testosterone clinic, then you are assured of authentic medication that is made in a reputable pharmacy. You don’t have to worry about fake, harmful products from phony websites that may have serious side effects on you. You get to buy high-grade medication from the pharmacies with a high reputation they are working with.
Also, you are guaranteed of high-quality care with the right telemedicine testosterone clinic. From the beginning of the therapy to the end, it is important to have a physician in charge. So, you can’t just buy over-the-counter medication and do the process all by yourself. Once your treatment plan is made, you will need an expert to work closely with you and monitor your progress throughout the entire time.
You will need to regularly consult with your doctor to ensure that they give you the right prescriptions depending on your progress. Also, testosterone therapy is not something you want to do blindly as more blood tests will be required in the future for your doctor’s review. This could aid in adjusting the dosage and means of administration of the treatment when things change in the future.
Another major perk of buying TRT online is that it gives you the freedom to get therapy regardless of your location. You don’t have to keep on booking appointments to see your physician at the clinic when you need to get blood work done or when you need to consult a few things with them. Buying online allows you to go through the entire process, including taking blood tests and consultations without having to physically be in the clinic. You just need to ensure that you’ve picked the right clinic with a system that makes it hassle-free to get the TRT.
There is nothing as more convenient as buying TRT online and having everything shipped to your house for administration. From home kits for the tests required to the medication you require. You give out your address and everything you need is delivered to where you are. So if your clinic is a few states away or if you have other pressing commitments, you can still comfortably get the therapy when you need it.
Work with AAI
AAI Rejuvenation Clinic is one of the best anti-aging clinics online to buy TRT from. Professionalism is one of our top priorities, so you can be assured of having experienced personnel walk with you throughout the whole therapy. From consultation to taking the medical exam, blood work, and treatment plan, all services are delivered professionally. You also receive authentic medication from credible pharmacies as well as a treatment approach customized just for you. What’s more, our telemedicine services allow you to get the whole process done from the comfort of your home as well as getting your medicine shipped to your location.
Low testosterone levels in the body are usually a result of a medical condition or a decline in age. Also known as low-T, a decline in testosterone in the body has different symptoms including depression, low energy levels, irritability, poor muscle mass and bone health, and bad cardiac health. Testosterone replacement therapy, also abbreviated as TRT is a type of hormone therapy used to treat low-T.
The testosterone preparation methods have advanced over time with the present-day ones including IM injections, oral, subcutaneous, transdermal, and buccal. They all have different dosage, formulations, safety profiles, and ways of administration that have also changed over the course of the years. With the introduction of more delivery systems, newer ones have been used to serve as alternatives for the more established ones.
In fact, the use of testosterone replacement therapy has tripled over the past couple of years, and although most people get the treatment without a clear reason, 75% of the men who receive the treatment have their testosterone levels checked before they start the process.
As the popularity of testosterone therapy increases, doctor and patient awareness has equally increased and this has skyrocketed the use of TRT globally. While men have been the most common recipients of TRT, there has been a gradual shift especially because of the increasing number of transgender patients. Hence, this has significantly impacted the growth and rampant use of different testosterone treatments.
How to Get Testosterone Replacement Therapy
There are wrong and right ways to go about getting testosterone replacement therapy, let’s dive into how to get it the right way.
Go to Your Doctor
One way of getting testosterone replacement therapy is through your doctor. Perhaps you have been exhibiting symptoms of low-T, you could consult with your doctor who will prescribe a testosterone treatment for you. While getting TRT through your doctor might seem like the right thing to do, some people report that doctors simply don’t understand their symptoms, and tell them they are “in range.” Oftentimes, doctors follow reference ranges for testosterone that are usually reduced overtime and span many age groups. So your doctor may tell you you’re in “normal testosterone range” even when you are experiencing low-T symptoms and with very low testosterone levels. This can mean that you are in range as an 80-year-old when your actual age is in the ’40s, which can lead to many men who aren’t getting the treatment they should get,
Go to an Anti-aging Clinic
An anti-aging clinic is a clinic that specializes in providing anti-aging treatments that are usually surgical or non-surgical. As opposed to getting TRT from a general practitioner, an anti-aging clinic specifically work with patients who need hormone therapy and have doctors who are experts in it working with them and with you. Since their services are narrowed down to hormone therapy and different anti-aging solutions, you can be sure of getting top-notch treatment.
Process of Getting TRT with Clinic
Once you choose a clinic of your choice for testosterone treatment, there are a few steps involved. From consulting an expert to getting your treatment plan, all the steps are important in establishing the kind of treatment you will need. That said, below is the simple process of getting TRT through a clinic.
During your first appointment, your doctor will identify your potential needs for therapy. And during the consultation, you become aware of the different methods of treatment that your clinic is comfortable and knowledgeable with. It is during the consultation that you will also learn more about how TRT works and exactly what it does. You need to also inquire about the side effects of the treatment if any, and what to expect once therapy begins. Above all, you want to begin building an honest and trustworthy relationship with your provider.
You will also be required to undergo a medical exam before you are placed for therapy. This may also include filling out your medical history form about your symptoms, supplements, and medications prescribed to you, as well as your final goal for the testosterone replacement therapy. The medical exam gives your provider clarity on your health which makes it easy to start in the right direction.
Blood work is also done to ascertain whether your red blood cell count, prostate-specific antigen, blood lipids, and other pertinent markers lie in a healthy range. The blood test is made up of two hormone panels that show Free Testosterone and Total Testosterone. After blood work, your provider can use your unique profile to come up with an optimization protocol.
Follow up Consultation
You also need a follow-up consultation to review blood work and determine the way forward for your treatment. The blood work results are vital when it comes to effective and safe prescriptions.
Your blood work is used to determine the right treatment plan for you. A good clinic will layout your options and customized therapy protocol. Once the treatment begins, there is a need for blood tests every year for the purposes of keeping tabs on the testosterone levels but it is okay to take more blood tests along the way if you want to for regular checkups.
Medicine Shipped to Your House
Medication commences immediately after a treatment plan is established and customized for your needs. Your provider will ship medicine to your house which is convenient.
How Long Does the Process Take?
Often you can start therapy within one to two weeks time depending on how quickly you can get through the requirements. On the other hand, the onset and the period of the effects of TRT will differ depending on the dose and type of medication you use. The effects of the treatment will be gradual and results might start showing as early as a few weeks into the treatment or up to after six months.
Changes in sexual interests and desires often take between 3 weeks steadying at the 6th week which is similar to the onset of the effects on depressive moods which peak between 18-30 weeks. Effects on muscle strength, fat mass, and lean body mass start showing between 12-16 weeks and plateau 6-12 months while those on bone start manifesting at 6 months up until 3 years. Effects on inflammation are usually detectable after 3-12 weeks and those of quality life between 3-4 weeks with extended maximal benefits.
How to Pick a Good Clinic?
When you decide to have TRT from a clinic, how do you ensure that you pick the right clinic? The treatment might have serious side effects but with the right clinic, your doctor should be able to come up with a treatment that reduces side effects and other ramifications linked to it. Your provider should also walk with you throughout the journey and guide you. Hence, below are a few tips to consider when choosing a clinic for your TRT.
They have a doctor and work with reputable pharmacies
A lot of clinics today are run by quacks who have zero training and expertise on what they market themselves for. You don’t want to fall victim to unprofessional individuals, so always look for a clinic with a qualified TRT doctor. The experience and reputation of your doctor play a huge role in the success of the treatment. Also, you want to ensure that your preferred clinic has collaborations with reputable pharmacies. This is because there are a lot of counterfeit drugs, so if they are working with questionable or unheard of pharmacies, then consider looking for other options. The more reputable(positive) the pharmacies your clinic work with, the easier it is to trust them.
They require blood work and exam
Before deciding the specific type of treatment, blood work and exam will need to be carried out to establish how low your testosterone levels are. Symptoms might be apparent but carrying out the blood work and exam is important in diagnosing low-T ie, testosterone deficiency. So, when looking for a TRT clinic, confirm first before proceeding with the treatment.
They have nationwide reach
You also don’t want to be limited because of your location, so you want to be able to access TRT services from anywhere. A lot of patients end up missing out on the treatment because a lot of clinics don’t have nationwide reach. The best way you could avoid this limitation is to find a clinic with telemedicine services. This way, you can receive treatment remotely regardless of where you are in the country.
They don’t require you to come in for injections
When picking out a clinic for your testosterone replacement treatment, you want to choose one that does not require you to go into the office for injections. This treatment is going to take a while, so you want the convenience to be on the top of your list before deciding on which clinic to choose. Going to the clinic for injections every time can be a hassle, but finding a clinic that offers delivery services can make the whole process painless.
Different TRT Options
One of the biggest perks of testosterone replacement treatment is that it can be done in different ways. So this gives you different options to choose from if you are not comfortable with one method. To that end, here are different TRT options you might want to consider.
Testosterone injections can either be made under the skin or in a muscle. While you or a family member can learn to give the injection, some of the injections, especially deep intermuscular ones, will have to be given by your doctor’s office and they may exhibit significant side effects.
Testosterone can also be introduced into the body through cream application. You will be required to rub the cream into your skin, and depending on the type of cream or gel you are using the area may vary from the upper arm, shoulder, and the front or inner thigh. The testosterone is then absorbed into the body, so showering unless a few hours have lapsed should be avoided. On the downside, the medication can be transferred to another person in case of skin-to-skin contact, and the area of skin might get irritated after application.
TRT is also administered through pellets surgically implanted under the skin. The procedure requires an incision, and the testosterone-infused pellets have to be implanted every three to six months. They are usually buried inside the soft tissues where the testosterone is slowly released into the bloodstreams.
Benefits of TRT
TRT started mainly as a treatment for low testosterone as a result of a medical condition and other various gains for patients. Here are some of the benefits of getting TRT.
Boosts Muscle Mass
TRT helps to increase strength, endurance, and muscle size while decreasing the fat in various parts of the body. Hence, testosterone replacement therapy combined with healthy physical exercise goes a long way to improving muscle mass.
Enhances Bone Health
With a decline in age, the testosterone levels also drop which leads to a decrease in bone density and strength. This often results in a high risk of osteoporosis, fractures, and breaks as time goes by. Bone mineral intensity, increased mobility, and support are some of the significant improvements of TRT.
Boosts Moods and Energy Levels
Another benefit of TRT is that it boosts moods, as well as raising energy levels. Low levels of testosterone in men have been linked with low energy levels and moods, especially in their old age.
The onset of cardiovascular disease is also associated with testosterone levels in the body, as low testosterone increases the risk of cardiovascular diseases and problems. Research has proved that men with high testosterone levels have low levels of triglycerides, insulin, and systolic blood pressure, and increased high-density lipoprotein cholesterol. All these are linked to good cardiovascular health.
Boosts Sexual Drive
Low testosterone count translates to low libido and sex drive in men. This also affects the quality of erections, as well as the ability to get and maintain them. One way to restore your sexual drive is through testosterone replacement treatment.
Work With AAI!
If you are looking to get testosterone replacement therapy, then you might want to consider working with AAI Rejuvenation Clinic. AAI Rejuvenation Clinic is made up of professionals dedicated to providing a personalized solution to your needs. Our approach also includes continuous support and monitoring to ensure that your health and wellness goals are achieved. Additionally, working with AAI is convenient as you won’t have to make endless trips to the clinic thanks to their concierge-like services that get everything you need to be delivered to you. In a nutshell, AAI clinics’ services are fashioned to leave you feeling and looking better!
*Please consult with a medical professional about any information provided in this article.
Thymosin stimulates the development of T-cells. Throughout your childhood years, growing up, your white blood cells, called lymphocytes, pass through the thymus, where they transformed into T-cells.
Once T-cells have fully matured in the thymus, they migrate to the lymph nodes (groups of immune system t-cells) throughout the body, where they aid the immune system in helping fighting disease. Also, some lymphocytes, regardless if they reside in the lymph nodes or thymus in the body, can develop into cancers, also (known as Hodgkin disease, and non-Hodgkin lymphomas), and can also be harmful to the cell.
Though the thymus gland is only active until puberty as we grow, the endocrine and the lymphatic gland plays a significant role in the body of your long-term body health.
Enhances the function of specific immune cells called T-cells and dendritic cells. Help eradicate unhealthy cells and stop the infection or cancer growth. Exhibits antibacterial, antifungal properties, and Suppresses tumor growth.
The thymus is a tiny gland in the body organ behind the breastbone that plays a vital role in the immune system and the endocrine system. The thymus begins to atrophy (decay) during puberty, its effect in “training” the T lymphocytes to fight infections and even cancer in the body.
The Anatomy of the Body
The thymus gland lies in the chest in the body, directly behind the breastbone (sternum), and in front of the heart in the area between the lungs called the anterior mediastinum. Sometimes, however, the thymus gland is found in another (ectopic) location, such as in the neck, the thyroid gland, or on the lung’s (the pleura) near the area where the blood vessels and bronchi enter the lungs.
It is named the thymus due to its shape being similar to that of a thyme leaf—pyramid-shaped with two lobes. The two portions of the thymus are broken down into lobules. These lobules have an outer cortex occupied by immature T lymphocytes, and an inner medulla occupied by mature T lymphocytes.
It is considered a lymphoid organ (an organ of the immune system) similar to the tonsils, adenoids, and spleen.
Cells of the Thymus
Several different cell types are present within the thymus gland:
Epithelial cells: cells that line body surfaces and cavities
Kulchitsky cells: cells that are the hormone-producing cells of the thymus or neuroendocrine cells
Thymocytes: cells that become mature T lymphocytes
The thymus gland is also home to some macrophages. Macrophages are known as the “garbage trucks” of the immune system because they eat foreign matter. Dendritic cells and a few B lymphocytes (the types of lymphocytes that produce antibodies) also reside in the thymus.
Interestingly, the thymus gland also contains some myoid (muscle-like) cells.
Changes With Age
The thymus gland is large in infants, but after infancy, it grows and reaches its maximum size during puberty. After puberty, the thymus gland shrinks and becomes replaced mainly with fat.
The gland is tiny in older adults, but can sometimes atrophy prematurely in response to severe stress. The term used to describe the atrophy of the thymus gland with age is “thymic involution.”
The thymus gland is very active from before birth until puberty. It functions as both a lymphatic organ and an endocrine organ (an organ of the endocrine system that produces hormones). To understand the role the thymus gland plays in immunity, it’s helpful to first distinguish between T lymphocytes and B lymphocytes.
T-Cells vs. B-Cells
T-cells (also known as T lymphocytes or thymus-derived lymphocytes) mature in the thymus gland and play a central role in cell-mediated immunity, meaning the batteries themselves are active in fighting off foreign invaders such as bacteria, viruses, cancer cells, and more.
In contrast, B lymphocytes are part of the humoral immune system and produce antibodies directed at specific invaders.
T-Cell Training Ground
As part of the adaptive immune system, the thymus can be thought of as the T lymphocytes’ training ground. During childhood, immature T-cells (called progenitor cells) originate in the bone marrow travel via the bloodstream to the thymus gland, where they mature and differentiate into specialized T-cells.
Types of T-Cells
T-cells in the thymus differentiate into three primary types.
Cytotoxic T-cells. The word cytotoxic means “to kill.” These cells are responsible for directly killing infected cells.
Helper T-cells. These cells are responsible for producing antibodies by B-cells and activating other types of T-cells to address a foreign invader.
Regulatory T-cells. These cells function as “police.” They suppress both B-cells and other T-cells.
Positive and Negative Selection
The immature T-cells that leave the bone marrow enter the thymus in the cortex (known as the thymus). During “training,” these cells are taught to recognize antigens associated with foreign cells and matter in a positive selection process. Cells are positively for usefulness.
Once the T-cells have learned to recognize specific pathogens, they travel to the medulla to undergo “negative selection.” In the medulla, the mature T-cells introduced to the body’s antigens. Since T-cells that would react with the body’s antigens could attack a person’s cells, they eliminated. T-cells negatively selected for autoimmunity, and these self-attacking cells either die or turn into regulatory cells.
Not all T-cells make it through this selection process, and only around 2% eventually make it through positive and negative selection.
The survivors exposed to hormones produced by the thymus gland complete their maturation before being released to do their job (circulating in the bloodstream or waiting in the lymph nodes for foreign invaders).
The thymus gland produces several hormones, including:
Thymopoietin and thymulin which are hormones that assist in the process where T-cells differentiate into different types
Thymosin, which accentuates the immune response as well as stimulating pituitary hormones such as growth hormone
Thymic humoral factor, which acts similarly to thymosin, but increases the immune response to viruses in particular
The thymus gland may produce small amounts of hormones produced in other areas of the body, such as melatonin and insulin. Cells in the thymus gland (such as epithelial cells) also have receptors through which other hormones can regulate its function.
The mature T-cells derived have a few significant roles.
T-cells are part of the adaptive immune system, in which each T-cell has trained to recognize a particular antigen. When exposed to a foreign cell, cytotoxic T-cells lock onto the battery and kill it with assistance from the helper and regulatory T-cells, It will also be referred to as cell-mediated immunity, as it involves the use of immune cells to fight infections.
In general, T-cells barricaded in the cortex of the thymus, so they do not become sensitized to the body’s cells. However, the process of adverse selection in the medulla used to get rid of cells that accidentally have become sensitized to “self.
This function helps prevent the development of autoimmune disorders, which are medical conditions in which the body attacks its tissues rather than foreign invaders. If the thymus gland removed early in life, a person could develop one of these disorders.
In recent years it’s been determined that aging isn’t merely a process in which the body wears out, but is an active process. In other words, we designed to age. The involution of the thymus gland may be a form of programmed aging, with the complexity (beginning around age 60) being the trigger for the deterioration of the immune system with age.
This decrease is immunity resulting from thymus involution can increase the risk of infections and reduce the response to vaccines.
Several studies have looked at methods to delay the atrophy of the thymus with hopes of slowing the aging process. Early studies suggest that calorie restriction may slow the atrophy, but the research is still in its infancy.
Diseases and Disorders
Some several diseases and disorders can affect the thymus gland, ranging from genetic disorders that are evident at birth to cancers that are most common in older adults. These disorders can lead to problems with immunity and autoimmunity, such as myasthenia gravis4 and hypogammaglobulinemia.
Hypoplasia/Aplasia of the Thymus
The developmental disorder called DiGeorge syndrome is an uncommon condition marked by a significant reduction or absence of thymus function. Caused by a gene mutation, and children with the disease will have severe immunodeficiency, a high risk of infections, and hypoparathyroidism.
Thymic Follicular Hyperplasia
Enlargement (hyperplasia) of lymphoid follicles in the thymus gland often seen in autoimmune diseases such as myasthenia gravis, Graves’ disease, and lupus.
On their own, thymic cysts are often an incidental finding, but they can be important because they sometimes hide cancer (thymoma or lymphoma).
Tumors of the Thymus Gland
Thymomas are tumors that arise in thymic epithelial cells of the thymus gland and may be benign (usually harmless) or malignant (cancerous). They may occur in the usual location of the thymus gland in the mediastinum and in other regions where the thymus gland sometimes located, such as the neck, thyroid gland, or lungs. Other tumors that may occur in the thymus include thymic lymphomas, germ cell tumors, and carcinoids.
The symptoms of thymomas may be related to the tumor’s location in the chest (such as shortness of breath). Still, these tumors may also be discovered due to paraneoplastic syndromes associated with cancer. There are several of these types of conditions.
Myasthenia Gravis (MG). The autoimmune condition myasthenia gravis occurs in roughly 25% of people with thymomas, but may also occur with thymic hyperplasia. MG is an autoimmune neuromuscular disease caused by problems in communication between nerves and muscles. It characterized by profound weakness of muscles (both in the extremities and respiratory muscles—this can lead to breathing problems).
Pure Red Cell Aplasia. This condition is a rare autoimmune disorder in which T-cells are directed against red blood cells’ precursors, leading to severe anemia. It occurs in roughly 5% of people with thymomas.
Hypogammaglobulinemia. Hypogammaglobulinemia (low levels of antibodies) occurs in approximately 10% of people with thymomas.
Thymomas may also cause a condition referred to as thymoma-associated multiorgan autoimmunity. This condition is similar to the rejection seen in some people who have had organ transplants (graft vs. host disease). In this case, the thymic tumor produces T-cells that attack a person’s body.
Surgery to remove the thymus gland may be done for several reasons. One is for congenital heart surgery. A congenital heart condition is a congenital disability of the heart. Due to the location of the thymus gland, surgeons must remove to gain access to the center in infants.
Another common reason for this surgery is for a person with thymic cancer. Also, myasthenia gravis (MG) is another condition treated with thymectomy. When the thymus gland removed, roughly 60% of people with myasthenia gravis achieved remission.
However, it can take months to years for these effects to be apparent with myasthenia gravis. When used for MG, surgery usually done between puberty and middle age to avoid the potential consequences of removing the thymus gland earlier.
Consequences of Thymus Removal
The thymus gland provides a critical role in cell-mediated immunity. Fortunately, a significant part of this benefit occurs before birth (the T-cells formed during development in the uterus are long-lasting).
However, there are potential consequences of removal early in life, like when the thymus is removed during heart surgery in infants. It appears that early dismissal can increase the risk of developing infections. The development of autoimmune diseases (such as autoimmune thyroid disease), the risk of atopic disease (allergies, asthma, and eczema), and possibly the risk of cancer, like T-cells, perform a vital role in preventing cancer.
There is also some evidence that thymus removal may be associated with premature aging of the immune system.
The thymus gland is a tiny gland that virtually disappears with age but plays a vital role in immunity and autoimmunity for a person’s lifetime. As changes in the thymus gland have linked with the aging of the immune system, and such virus-like COVID-19, researchers study ways to delay the atrophy. Since many autoimmune diseases have increased significantly in recent years, more will likely learn about the proper health of this gland in the future.
The Post Cycle Therapy (PCT), and Testosterone Injections Therapy goes hand on hand, Most men embarking on a testosterone injectable therapy replacement protocol are doing so as a result of medical reason or age-related issues that are affecting their life.
Now patients with problems and that face their low testosterone, the related concerns and do not allow fully experience the decline associated with maintaining extended periods of low hormones levels and will usually benefit from comprehensive testosterone therapy.
Note: that the specific drug and dose prescribed will depend on the particular information contained within each patient medical file and medical reason, as well as the individual goals patients.
Day 1. (50–250 mg) of testosterone injection.
Day 2. Two estrogen blocker or inhibitor.
Day 3. One injectable of an amino acid or vitamin B-vitamin.
Day 5. One estrogen blocker or inhibitor by mouth.
Day 6. One injection of a (250–800 units) of testosterone secretagogue.
Day 7. One estrogen blocker or inhibitor (sometimes two estrogen blockers a week is enough, But depending on the patient file).
Day 7. One injection of a (250–800 units) of testosterone secretagogue.
Example: This protocol for a man focused on muscle development (reversing lean muscle loss), Muscle development protocols, also work well in patients that may react to therapy with too much aromatization (estrogen accumulation).
Men are experiencing excessive aromatization and lean muscle depletion who are focused on rebuilding muscle, with Peptides.
Note: that the specific drug and dose prescribed will depend on the particular information contained within each patient medical file, as well as the individual patient goals.
Day 1. (50–150 mg) of a combination of testosterone esters, (15–30 units) Sermorelin Peptides before Bedtime.
Day 2. Two estrogen blocker or inhibitor, (15–30 units) Sermorelin Peptides before Bedtime.
Day 3. One injection of an amino acid or B-vitamin, (15–30 units) Sermorelin Peptides before Bedtime.
Day 4. Combination of (50–150 mg) testosterone esters, (15–30 units) Sermorelin Peptides before Bedtime.
Day 5. One estrogen blocker or inhibitor by mouth, (15–30 units) Sermorelin Peptides before Bedtime.
Day 6. One injection of a (250–800 units) of testosterone secretagogue.
Day 7. One estrogen blocker or inhibitor (sometimes two estrogen blockers a week is enough, But depending on the patient file).
Day 7. One injection of a (250–800 units) of testosterone secretagogue.
This weekly cycle would typically continue for 6–9 months, before a break period in which the body is allowed to normalize and reactivate your natural production.
What is Sermorelin?
Sermorelin is a peptide comprised of the first 29 amino acids of endogenous GH; the sequence is the same as endogenous GHRH. As we age, our body produces less and less of our vital hormones, including GH. Studies have revealed that sermorelin can restore GH RNA concentrations to youthful levels, which subsequently stimulates the production of insulin-like growth factor-1 (IGF-1).
Remember: When you are artificially manipulating your testosterone levels, some other functions of the body stop operating since endogenous testosterone production is shut down because of the presence of high levels of exogenous hormone. You will need Post Cycle Therapy on your break from testosterone therapy.
Break Period: Generally referred to as the Post Cycle Therapy (PCT), consists of medications that are formulated to reactivate the dormant systems that we have not used while your testosterone Injections therapy.
The essential functions that need to reactivate with your Post Cycle Therapy:
FSH (follicle-stimulating hormone): This will stimulate sperm production in the testes.
LH (luteinizing hormone): This will stimulate testosterone production in the testes.
The reason why is because estrogen accumulation after extended periods of high testosterone levels, and water retention can cause, decreased libido, and other side effects associated with high estradiol levels from past testosterone therapy.
Well-structured Testosterone Injection Therapy
Week One: If you have never received testosterone injections before and are suffering from hypogonadism (clinically low testosterone), you should begin to experience invaluable changes just 3 or 4 days after your first administration. You should sleep better and have more energy.
Week Two: Morning erections make a significant comeback! In men with erectile dysfunction problems, morning erections help to determine if their problems stem from a psychological or a physiological problem.
Week Three: You will begin to notice a sense of clarity as your cognitive function improves. Your ability to recall information and your articulation will improve. You will suddenly realize that you feel more mentally sharp and able, which will allow you to better cope with stress and pressure.
The End of Month One: Your energy levels should be noticeably increased throughout the day.
Month Two: The same health manifestations that you were experiencing throughout your first month should continue to develop and improve. Your energy levels should still be increasing, and you should have a stronger “go-getter” attitude.
Month Three: There should now be a significant, noticeable difference in your energy level and output. Your workouts will require less effort and will yield quicker, more visible results. The time you need for muscle healing and recuperation after exercise should be reduced.
Month Four: By now, your endurance, stamina, exercise potential, and overall performance ability should supersede all your expectations. If you have never been on testosterone therapy before your first program and you have been eating well and exercising from the beginning, you will be surprised at the level of transformation you have experienced. Furthermore, it will be evident that these results and this amount of energy output would not be possible without restoring your testosterone levels to the numbers had in your youth.
Month Five: The changes and improvements in your physical performance, ability, and growth will be fantastic. If you were experiencing mental problems such as sadness, depression, anxiety, or even mental fatigue, by now you should notice substantial progress in your ability to deal with unpleasant or challenging scenarios and circumstances. Remember that all the other positive changes you have experienced will also contribute to a sense of self-improvement. This makes you naturally feel better about your progression and growth. More importantly, the physiological changes in brain chemical secretion add to your sense of fulfillment, happiness, and overall well-being.
Month Six: All individuals are receiving testosterone experience different effects by six months of therapy. What you experience will also depend on how many cycles of testosterone therapy you have participated in previously. Sometimes, a user’s sense of improvement begins to dwindle or remain stagnant. The body can become used to the type, or ester, of testosterone that is being used if the same therapy is continued for more than 1 or 2 years. Also, because other processes in the body cease to function when testosterone levels are manipulated using testosterone injections, the benefits of therapy begin to diminish and the “feel good” scenarios that were being experienced stopped.
Deeper, more restful sleep
A more content state of mind
Reduced belly fat
The return of some muscle tone
Improved skin tone and fewer wrinkles
Stronger hair and nails
Increased mental focus
Improved flexibility and joint health
More feelings of drive and ambition
Enhanced sex drive and performance
Improved mental acuity
Better skin elasticity
Further improved appearance of the hair and nails
Continued weight loss
Increased lean muscle mass
Continued loss of belly fat
Improved skin tone with the reduced appearance of wrinkles
Noticeably fuller, healthier hair
A 5–10% reduction in body fat, without diet or exercise
A 10% increase in lean muscle mass
Significantly improved physique
Increased vitality dies to organ regrowth (vital organs, including the brain, shrink with age)
What is Follicle Stimulating Hormone (FSH), is one of the gonadotrophic hormones, and the other being a Luteinizing Hormone (LH). The pituitary gland releases both into the bloodstream and body, and Follicle Stimulating Hormone (FSH) is one of the hormones essential for the development function of women’s ovaries and men’s testes. In women, Follicle Stimulating Hormone (FSH) stimulates the growth in the ovary before the release of an egg from one follicle to the ovulation. It also increases estradiol production. In men, Stimulating Follicle Hormone (FSH) acts on the Sertoli cells of the testes to stimulate sperm production (spermatogenesis).
How is Follicle Stimulating Hormone (FSH) control?
The release of Follicle Stimulating Hormone (FSH) is regulated by the levels of some circulating hormones released by the ovaries and testes. This system is called the hypothalamic–pituitary–gonadal axis. The gonadotropin-releasing hormone is published in the hypothalamus and the receptors in the anterior pituitary gland to stimulate both the synthesis release of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The released Follicle Stimulating Hormone (FSH) is carried in the bloodstream, where it binds to receptors in the testes and the ovaries. Using this mechanism Follicle Stimulating Hormone (FSH), along with Luteinizing Hormone (LH), can control the functions of the ovaries and testes.
In women, when hormone levels are deficient, and it has complication the menstrual cycle, this is sensed by nerve cells in the hypothalamus. These cells produce the more gonadotrophin-releasing hormone, which in turn stimulates the pituitary gland to produce more Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH), and release these into the bloodstream. The rise in Follicle Stimulating Hormone (FSH) and stimulates the growth of the follicle in the ovary, and the cells of the follicles produce increasing amounts of estradiol. In turn, this production of these hormones is sensed by the hypothalamus, and pituitary gland and less gonadotrophin-releasing hormone and Follicle Stimulating Hormone (FSH) will be released, However, as the follicle grows, and more and more estrogen is produced from the follicles, it simulates a surge in luteinizing hormone (LH) and Follicle Stimulating Hormone (FSH), which stimulates the released egg from a mature follicle – ovary.
During women menstrual cycle, there is a rise the Follicle Stimulating Hormone (FSH) secretion in the first half of the period and stimulates follicular growth in the ovary, after ovulation, each month the ruptured follicle forms and Corpus luteum that produces high levels of progesterone. This inhibits the release of stimulating Follicle Stimulating Hormone (FSH), and towards the end of the cycle the Corpus luteum breaks down, and progesterone production decreases. The next menstrual period begins when Follicle Stimulating Hormone (FSH) starts the production again, and get back to normal…
Now In men, the production of Follicle Stimulating Hormone (FSH) is regulated by levels of testosterone and inhibin, both produced by the testes. Follicle Stimulating Hormone (FSH) regulates testosterone levels and when this rise they are sensed by nerve cells in the hypothalamus so that gonadotropin-releasing hormone secretion and consequently Follicle Stimulating Hormone (FSH) is decreased. The opposite occurs when testosterone levels drop. This is known as a ‘Negative Feedback in the body’ control so that the production of testosterone remains steady. But the sensed by cells in the anterior pituitary gland rather than the hypothalamus.
What happens if you have too much Follicle Stimulating Hormone (FSH)?
Most often, and raised levels of Follicle Stimulating Hormone (FSH) are a sign of malfunction in the ovary or testis. If the gonads fail to create enough estrogen, testosterone and inhibit, the right feedback control of Follicle Stimulating Hormone (FSH) production from the pituitary gland is lost, and the levels of both Follicle Stimulating Hormone (FSH) will rise. This condition is called hypogonadotropic-hypogonadism and is associated with primary ovarian failure or testicular failure. This is seen in states such as Klinefelter’s syndrome in men and Turner syndrome in women.
In women, Follicle Stimulating Hormone (FSH) levels also start to rise naturally in women around the menopausal period, reflecting a reduction in the function of the ovaries and decline of estrogen and progesterone production.
There are rare pituitary conditions that can raise the levels of Follicle Stimulating Hormone (FSH) in the bloodstream. This overwhelms the regular negative feedback and can cause ovarian hyperstimulation syndrome in women ovaries.
Symptoms: This includes enlarging of the ovaries and potentially dangerous accumulation of fluid in the abdomen, and triggered the rise in ovarian steroid output. Which leads to pain and other problems in the pelvic area of the body.
What happens if don’t produce enough Follicle Stimulating Hormone (FSH)?
In women, lack of Follicle-Stimulating-Hormone (FSH) leads to incomplete development in puberty o poor ovarian function (ovarian failure), and In this situation ovarian follicles do not grow properly and do not release in the egg, thus leading to infertility. Since levels of Follicle-Stimulating-Hormone (FSH) in the bloodstream are low, this condition is called hypogonadotropic-hypogonadism. This condition is called Kallman’s syndrome, which is associated with a reduced sense of smell.
Sufficient Follicle-Stimulating-Hormone (FSH), this action is also needed for proper sperm production in men, in case of complete absence of Follicle Stimulating in men, and the lack of puberty and infertility due no production of sperm is called (azoospermia). Partial Follicle-Stimulating-Hormone (FSH) deficiency in young men, can also cause delayed puberty and low sperm production, called (oligozoospermia), but fathering a child may still be possible. Follicle-Stimulating-Hormone (FSH) occurs after puberty; there will be a similar loss of fertility…
What is Luteinizing Hormone &
The Productions of Testosterone
If you google the word Luteinizing Hormone or (LH), most of the articles you will find talks about the role of luteinizing hormone in women. There is very no info about the part of Luteinizing Hormone in men. While it may seem like a female hormone due to its role in ovulation, a surge of Luteinizing Hormone is a trigger that causes the ovary to release the egg, in the body. If you’ve been trying to conceive or have a baby your wife, significant other may be monitoring her Luteinizing Hormone levels. If she has trouble with ovulation, your doctor may prescribe medications that help with ovulation.
Many of this medication help stimulate the body to produce more Luteinizing Hormone (LH) and its cousin hormone, Stimulating Follicle Hormone (FSH). If you are not trying to conceive, or get pregnant, she may be on hormonal birth control pills. These pills prevent ovulation by blocking Stimulating Follicle Hormone and Luteinizing Hormone. It is one of the manliest hormones in your body. You can think of Luteinizing Hormone as a tiny drill sergeant that commands the Leydig Cells in the testicle to produce testosterone. When Luteinizing Hormone is present, the Leydig Cells generate Testosterone, when it is not, they don’t. Luteinizing Hormone is commander and chief of your Testosterone and critically crucial for sperm production count, muscle building, and overall sexual health.
Male hormones have a clinical nature to them. Luteinizing Hormone (LH) signals the testicle to produce Testosterone. Testosterone seeps out of the testis and into the bloodstream, where it circulates the body and put to good use. Manly things like growing chest hair, increase muscle and your voice deep are some of the effects.
The brain monitors the blood testosterone levels;
If they drop too low, it will send a signal to the pituitary gland to send out more Luteinizing Hormone (LH) to kick start testosterone production.
If your testosterone is chronically low (as in the case with hypogonadism or Low Testosterone), the brain will respond by increasing the level of Luteinizing Hormone (LH).
If testosterone is chronically higher (as in the case with using testosterone therapy, other performance enhancers or steroids), the brain will shut down production of Luteinizing Hormone (LH). When testosterone therapy is stopped, without post-therapy, men can experience a “crash” as Testosterone levels plummet, but with a post-therapy, the brain lags in re-starting the machinery to generate Luteinizing Hormone.
To measure Luteinizing Hormone (LH) levels, you will need to get blood work in a hormone clinic done. Because, doctors will order blood to estimate a panel of hormones which usually includes Stimulating Follicle Hormone, Luteinizing Hormone, Testosterone, Estrogen and They may also add Estrodial, Prolactin which will provide additional information into the insight into your hormonal health and a physical to know your body composition.
In a typical day, Luteinizing Hormone (LH) and Testosterone levels cycle from high to low. When getting blood work done to measure hormone levels, it is important to note the time of day that the analysis was performed to understand the values better.
Testosterone naturally will peak first thing in the morning (partially responsible for morning “wood”). For this reason, doctors prefer to regulate hormones between 8-10am to get a snapshot of your hormone panel profile when Testosterone level is likely to be highest.
When preparing for a Luteinizing Hormone test and to sure your doctor is aware of a few things like:
Current Prescription Taking: Current or past use of testosterone therapy. (If you are using anything at the gym or in supplements stores and you aren’t quite sure), you should bring it with your doctor about the appointment.
The Use Of Marijuana or THC: It may decrease the number of hormones levels, including Luteinizing Hormone.
Medical Radioactive Tracer: This can interfere with the test
Normal levels Luteinizing Hormone Range For Adult Males: 1–10 mIU/mL.
They are different labs report different reference ranges, and based on the exact way that they perform the blood work test. From a review of various lab reports, Values lower than 1.0 or higher than 10.0 typically indicate some problem.
For average men, Luteinizing Hormone (LH) typically falls somewhere between 4-7mIU/mL with drops and surges (about 6) throughout the day. Values below 4 and above seven may be considered borderline, and are useful to look at when compared to other hormones, particularly Testosterone and Prolactin.
In the studies that we have reviewed and found that these types of conditions have shown, and can significant drops in testosterone levels and minimal effect in Luteinizing Hormone (LH). Occasionally, Luteinizing Hormone may show up a little low, but often it is entirely in the normal range.
Therefore, low testosterone levels accompanied with normal Luteinizing Hormone (LH) levels often indicate the cause of Low Testosterone can tremendously help to diagnose the condition and also help to create a game plan for treating the cause while managing symptoms of low Testosterone.
Whats the Causes of high Luteinizing Hormone in Men?
If Luteinizing Hormone (LH) is high and testosterone is low. Then some damage is causing the testicle, or the pituitary gland is trying to compensate by going into overdrive and flooding the balls. With extra Luteinizing Hormone in hopes that it will encourage higher Testosterone production. In cases like this, Luteinizing Hormone levels are often off the charts high sometimes double or triple the average values.
Common causes for this include:
Chromosome Abnormalities: Such as Klinefelter’s syndrome
Childhood Problems: Such as testicle or testicular torsion, The injury that causes significant damage to testicular tissue
Viral Infection: (most commonly mumps) that damages the testis.
Radiation exposure or chemotherapy
Borderline High Luteinizing Hormone (LH) levels
Medications or untreated autoimmune disorders can cause slightly elevated Luteinizing Hormone (LH) levels (8.0 – 10.0 range). Some studies have linked Celiac’s Disease with elevated somewhat Luteinizing Hormone (LH). Men with the untreated disease can have moderately high Luteinizing Hormone levels, that usually return to normal upon starting a gluten-free diet.
What causes low Luteinizing Hormone in Men?
The most common reason for Luteinizing Hormone deficiency in men is the use of external androgens (testosterone, other performance enhancers or non-medication). External androgens can trick the brain into thinking the body is producing naturally high levels of testosterone which low down production of luteinizing hormone (LH) and consequently natural testosterone production.
The second most common cause of low Luteinizing Hormone (LH) levels is a health issue, and can directly impact the function of the pituitary in the brain, Most common causes of the pituitary malfunction can include genetic conditions, such as Prader-Willi Syndrome or Kallman’s Syndrome and can cause other problems like:
Pituitary tumors (cancerous and benign)
Borderline low Luteinizing Hormone (LH) results
Luteinizing Hormone levels in the 1.0 – some things can cause 3.0 range. Like, reduce temporarily imbalance hormones: such as overtraining, endurance. They are significantly under or overweight Alcohol consumption spikes in insulin medications or other drugs. High-stress Chronic conditions: that can cause hormone imbalance: such as diabetes, insulin resistance, various auto-immune disorders and can create borderline or low levels of Luteinizing Hormone (LH).
Why Is Testosterone
Post Cycle Therapy Is Need It?
Why is Post Cycle Therapy (PCT) is perhaps the most critical aspect of testosterone use? The concept of the post cycle therapy (PCT), did not exist before the late 1980s, and 1990s and the mechanisms by which testosterone affected, the body were not wholly understood during the 1950s, 1960s, and 1970s.
This period were doctors, scientists, and testosterone injections users were only beginning to learn about the dynamics of testosterone and how they affect the endocrine system. We believed and understood since the beginning of testosterone injections use, the administration of testosterone resulted in triggering the body’s negative loop of the (HPTA) Hypothalamic Pituitary Testicular Axis. That endogenous Testosterone production would result become suppressed and shut down. The, unfortunately, is during the early periods of testosterone use between the 1950s and 1990, there was limited access to the compounds or knowledge or effectively.
Today it is a very different story. Now scientific and medical understanding of bio-identical testosterone use has soared exponentially since the old ‘golden era’ days of looking young and testosterone therapy use in athletics. Countless developments of beneficial compounds for hormonal recovery after testosterone therapy use, alongside the increased scientific and medical knowledge, has enabled testosterone use and its associated endocrine disruptions. The proper knowledge on how to recover the body’s from Hypothalamic Pituitary Testicular Axis (HPTA). Through post cycle therapy (PCT), we can not only emerge from their testosterone therapy while holding on to almost all of their benefits, but they can also increase the chances upwards to 90 percent or higher range of emerging with a fully healthy (HPTA).
Following the use of exogenous testosterone injections, the majority of users will experience what has been a hormonal crash or post cycle therapy crash, which is a physical environment in which key hormones essential is has been suppressed or shut down. The critical hormones in question are Luteinizing Hormone (LH), Follicle Stimulating Hormone (FSH), and subsequently (and are most importantly), for our natural testosterone. The Luteinizing Hormone (LH), and the Follicle Stimulating Hormone (FSH), known as phototropism. These hormones increase Testosterone secretion. Also alongside low levels of these hormones, to balance the essential hormones that have been thrown off balance, whereby Testosterone levels will be small, and most of the time, depending on the factors, estrogen levels will be higher than usual, and levels of Cortisol a steroid hormone that destroys muscle tissue. With the testosterone levels low and Cortisol levels in the average or high, Cortisol now can become a threat to the new muscle during the new testosterone therapy (“Testosterone correctly suppresses and counteracts Cortisol’s catabolic effects on muscle tissue”). The SHBG (Sex Hormone Binding Globulin) is also a concern here as well, which is a protein that binds to sex hormones Testosterone renders them inactive, essentially ‘handcuffing’ them and preventing them from exerting their effects. SHBG will also usually elevated during the post cycle therapy weeks as a result of the supraphysiological levels of androgens from the new testosterone therapy.
The human body will generally and restore this imbalance of hormones and recover from testosterone levels on its own, over time with no outside assistance or post cycle therapy (PCT), but the studies have demonstrated and shown us that without the intervention of testosterone stimulating agents, this will occur throughout one to four months. Therefore, all testosterone therapy should be concerned with the fastest possible hormonal recovery, assisted and boosted with the use of Testosterone stimulating compounds correctly, also the attempt to allow the body to recover on its own, from a very high probability of long-term endocrine damage to the Hypothalamic Pituitary Testicular Axis (HPTA), whereby the individual will develop-induced hypogonadism to inability the production of proper levels of Testosterone to rest. So therefore paramount that an appropriate post cycle therapy that includes multiple recovery compounds to be utilized to not only restore the (HPTA) function but also to normalize the levels as quickly as possible. To avoid any possible permanent damage, which can take priority over the concern of maintain to the recently gained muscle mass and any other benefits from it.
What Post Cycle Therapy Protocol?
There are many different types of post cycle therapy (PCT) protocols that have overdeveloped over the years; any individual will become extremely confused about how many different opinions exist among the testosterone community, This article will present the best possible and most efficient post cycle therapy protocol valid scientific data, also myths in regards to post cycle therapy (PCT), and outline which post cycle therapy (PCT) protocols should not follow due to recent more advanced developments, as well as contemporary better scientific and medical understandings of how a proper post cycle therapy protocol should work. This point, there still exists very obsolete – and subsequently ineffective – post cycle therapy (PCT) contracts that are still utilized by many testosterone users, and this presents a severe hazard not only for the individual unknowingly using a post cycle therapy.
There are several therapeutic and safety reasons why you should not continue with testosterone injections indefinitely without giving your body time to normalize to reset. Because of the decline in benefits after six months of a testosterone therapy, the physicians need to regularly incorporate a cleanse therapy post cycle therapy (PCT) in an attempt to reactivate the endocrine in the body, as you increase your testosterone levels using any testosterone therapy, now the levels of testosterone circulating the body will shut down the natural production of your endogenous testosterone; and also increases the production of estrogen in your body, which can lead to a series of undesirable and unwanted side effects in the body. `This means that the synthesis of (LH) luteinizing hormone in your body; this hormone is produced by your brain to stimulate testosterone production. and follicle-stimulating hormone in the body; the hormone produced by your mind to boost sperm production suddenly stops. When Luteinizing Hormone (LH) and Follicle Stimulating Hormone (FSH) levels are no longer detectable, your body will not experience the exceptional health benefits, and energy-optimizing results expected from a testosterone injection program.
Another critical concern for men is testicular atrophy in patients that participate in testosterone therapy and may experience shrinkage of the testes, This occurs as the result of the lack of testosterone, and sperm production has been shut down, in response to the testosterone therapy.
What does post cycle therapy (PCT) consist of, an example?
Your post cycle therapy consists of a testosterone secretagogue to stimulate the secretion of endogenous testosterone from the testes to reignite natural production. The medication mimics the signal from your brain. The Luteinizing Hormone (LH) induce the production of testosterone. An example of a testosterone secretagogue is human chorionic gonadotropin (hCG), which is administered either using sublingual troches or subcutaneous injections once or twice a week during therapy and then on 10–15 consecutive days as part of a post cycle therapy (PCT). Human chorionic gonadotropin (hCG), mimics Luteinizing Hormone (LH) to stimulate testosterone production by the testes. It works by effectively tricking the testes into thinking that they are being instructed to produce testosterone, even though levels are comfortably elevated because of the injectable testosterone therapy. The testosterone production stimulated by human chorionic gonadotropin (hCG) is not sufficient to sustain healthy testosterone levels on its own, but that is not the reason for this supplementation. The purpose is to ensure that the testes remain functioning during therapy to help avoid any shrinkage or atrophy.
You will also take an anti-estrogen or aromatase inhibitor. For example, Clomid/clomiphene blocks certain types of estrogen from getting to the pituitary and hypothalamus, where it elicits signals that stop testosterone production. Anti-estrogens or aromatase inhibitors also help to reactivate the standard functionality of Luteinizing Hormone (LH) and Follicle Stimulating Hormone (FSH) signaling, while also helping to flush out any residual estrogen that has accumulated during therapy. The estrogen that collects during treatment is responsible for many of the adverse side effects associated with testosterone therapy.
An example of a post cycle therapy (PCT) protocol is as follows (note that the exact drug and dose prescribed will depend on the specific information contained within each patient file, as well as the individual patient goals):
250–800 units of a testosterone secretagogue every day for ten consecutive days
One estrogen blocker or antagonist by mouth every day for 10–15 straight days
Without the proper understanding of what is explicitly occurring within the endocrine system during these crucial weeks, as well as a lack of knowledge of which compounds to utilize, what each compound does, and how to properly use them, serious problems can result.
The Hypothalamic Pituitary Testicular Axis (HPTA):
The (HPTA), which is an axis interconnected endocrine glands in the body that deals with control the production Testosterone.
Outlined above is a diagram of the Hypothalamic Pituitary Testicular Axis (HPTA), Regulates the body produces the amount of Testosterone at any given time. Every individual is essentially programmed by (DNA) genetics as to maximum Testosterone they will provide.
The Hypothalamic Pituitary Testicular Axis (HPTA) and the functions that undergo a negative feedback loop, and the body will reduce secretion of Testosterone, f have too much Testosterone the body will be detected, known as the negative feedback loop. This controlled by the hypothalamus, which is mostly considered the ‘master’ gland for all endocrine system and the hormonal functions in the body. The negative feedback will loop ultimately in the body to attempt to maintain the hormonal homeostasis, and all endocrine glands operate by way of the negative feedback loop in one way or another in varying degrees, In the case of post cycle therapy, the concern is a negative feedback loop of the (HPTA).
Within the Hypothalamic Pituitary Testicular Axis (HPTA), the concern during post cycle therapy (PCT) is the restoration and regulation of the following five hormones to homeostasis:
GnRH (Gonadotropin Releasing Hormone)
LH (Luteinizing Hormone)
FSH (Follicle Stimulating Hormone)
The Hypothalamic Pituitary Testicular Axis (HPTA), the hypothalamus, which will detect a need for the human body to produce more Testosterone, and will release varying amounts of GnRH, Is a hormone that signals the pituitary gland, to begin the production and release of two essential gonadotropins: Luteinizing Hormone (LH) and Follicle Stimulating Hormone (FSH). Two hormones that work together to start the secretion of Testosterone.
Two primary hormonal factors serve to inhibit, reduce, suppress, or shut down Testosterone production in the Hypothalamic Pituitary Testicular Axis (HPTA):
Although there exist other hormones that serve to inhibit and suppress Hypothalamic Pituitary Testicular Axis (HPTA) function (such as Progestins and Prolactin), these are the two primary conditional hormones that are of concern. When the hypothalamus detects excess levels of Testosterone and Estrogen in the body (either from the use of exogenous androgens on an testosterone therapy or otherwise), the hypothalamus will act to attempt to restore a balance by essentially doing the opposite of what was previously described. The hypothalamus will reduce or stop its production of GnRH, which halts production of Luteinizing Hormone (LH) and Follicle Stimulating Hormone (FSH), which ultimately reduces or halts production of Testosterone. Until the hypothalamus’ ideal hormonal environment is restored, the output of the various signaling hormones within the (HPTA) will not begin, and this will often require months for the body to do this on its own without the intervention of any Testosterone stimulating agents. The reason as to why the recovery of the (HPTA) naturally takes such a long time should be very clear due to the described workings of the (HPTA).
This fundamental understanding of the mechanisms of the Hypothalamic Pituitary Testicular Axis (HPTA) and negative feedback loop described above is essential to understanding how and why a proper post cycle therapy (PCT) program must be developed and utilized following an testosterone therapy.
Determining Factors In Difficulty Recovering the Hypothalamic Pituitary Testicular Axis (HPTA):
With testosterone therapy use, there are several different major determining factors in how much difficulty an individual will experience in recovery of their Hypothalamic Pituitary Testicular Axis (HPTA) and endogenous Testosterone function during post cycle therapy (PCT).
They are the following factors, in no particular order of importance:
Type of testosterone(s) used
Length of the cycle (degree of testicular desensitization)
Every single individual will respond differently to any chemical, compound, testosterone, food or drug in existence. While some individuals might experience no Hypothalamic Pituitary Testicular Axis (HPTA) suppression or shutdown at all, other individuals might experience severe Hypothalamic Pituitary Testicular Axis (HPTA) suppression and closure to the extent where they might require far more extended periods to ensure full recovery than most. This, like anything else, is a spectrum whereby there are the very ‘lucky’ individuals that recover very quickly and easily on one end of the spectrum, and the ‘unlucky’ individuals that have extreme difficulty recovering during post cycle therapy. In between the two extremes is the average. Once again, this is due to the individual’s genetic programming as to how the Hypothalamic Pituitary Testicular Axis (HPTA) will respond and attempt to maintain homeostasis.
Type of Testosterone Therapy(s) used:
All testosterone therapy exhibit suppression or shutdown of the Hypothalamic Pituitary Testicular Axis (HPTA) through the mechanisms of the negative feedback loop, and there are no exceptions to this. Various testosterone therapy are known as being mildly suppressive, while others are identified as being profoundly suppressive. This is all reliant on multiple different reasons, many of which will not be discussed here. In any case, no matter how mild or severe an testosterone therapy exerts Hypothalamic Pituitary Testicular Axis (HPTA) suppression, all testosterone therapy when utilized for typical cycle lengths of weeks at a time will eventually cause the Hypothalamic Pituitary Testicular Axis (HPTA) to shut down, or at the very least severely suppress its hormonal signal processes.
Length of the cycle degree of testicular desensitization:
This is perhaps the most important and most influential factor. As the range of testosterone therapy use continues, the majority of the Leydig cells of the testes remain dormant and inactive, and the longer these interstitial cells stay dormant and idle, the higher the difficulty is essentially getting these cells to respond to the stimulus of Luteinizing Hormone (LH) and Follicle Stimulating Hormone (FSH) once again. It has been discovered in studies that the issue of recovery of the Leydig cells following testosterone therapy use is not due to a lack of Luteinizing Hormone (LH), but due instead to the desensitization of the Leydig cells to (LH). In one study in which exogenous Testosterone was administered to male test subjects for 21 weeks, Luteinizing Hormone (LH) levels were suppressed shortly after beginning administration. However, at the end of the 21 weeks, Luteinizing Hormone (LH) levels were observed to rise within three weeks once the exogenous Testosterone administration stopped, but Testosterone levels did not arise until many weeks later in most of the test subjects.
Recovery During The Post Cycle Therapy (PCT).
To stimulating hormonal recovery during post cycle therapy, it is essential for individuals to understand that the use of any medication except for a single select one or two is inadequate for hormonal recovery during post cycle therapy (PCT). Ideally, all post cycle therapy programs should be a multi-component post cycle therapy (PCT) program that includes several different compounds that work in tandem with one another to provide the most effective and fastest possible Hypothalamic Pituitary Testicular Axis (HPTA) recovery following an testosterone therapy.
The three categories of compounds are in order of importance:
SERMs (Selective Estrogen Receptor Modulators)
HCG (Human Chorionic Gonadotropin)
Classes of drugs in the SERM category include: Nolvadex (Tamoxifen Citrate), Clomid (Clomiphene Citrate), Raloxifene, and Fareston (Toremifene Citrate). The nature of a SERM is that it exhibits mixed Estrogen agonist and Estrogen antagonist effects on the body. This means that although a SERM might block the effect of Estrogen at the cellular level in specific tissues, it can enhance Estrogenic impacts in other areas of the body. These can be positive effects as well as adverse effects. Nolvadex, for example, exhibits Estrogenic agonistic effects in the liver, which is a positive effect, as its effects here result in a positive change in cholesterol profiles (something desired by many). All SERMs to varying degrees serve to act as an Estrogen antagonist in this area, working to mitigate Estrogen’s effects on breast tissue, reducing or blocking the side effect of gynecomastia. Regarding the impact of SERMs on endogenous Testosterone stimulation, they serve to act as an Estrogen antagonist at the pituitary gland, triggering the release of Luteinizing Hormone (LH) and Follicle Stimulating Hormone (FSH) as a result. Elevated levels of Estrogen in men can and does suppress the output of endogenous Testosterone via the negative feedback loop, leading to hypogonadism. SERMs for this purpose are an essential addition to any post cycle therapy (PCT) protocol and are not to be excluded under any circumstance. Regardless of this, however, the sole focus should not be on SERMs.
These are compounds such as Aromasin (Exemestane), Arimidex (Anastrozole), and Letrozole (Femara). Rather than block the activity of Estrogen at the cellular level in different tissues, aromatase inhibitors (AIs) serve to lower total circulating Estrogen levels in the body by way of inhibiting the aromatase enzyme, which is the enzyme responsible for the conversion of androgens into Estrogen. The transformation of androgens into Estrogen results in excess Estrogen levels, which, as explained earlier in this article, will trigger the negative feedback loop leading to suppression of Testosterone production. By way of lowering total circulating blood plasma Estrogen levels, AIs will positively engage the negative feedback loop and result in the release of Luteinizing Hormone (LH) and Follicle Stimulating Hormone (FSH) for the manufacture and secretion of more Testosterone. This is mainly due to the hypothalamus realizing that circulating. Estrogen levels are too low and will attempt to increase circulating levels of Testosterone for a portion of the Testosterone secreted to be able to become aromatized into Estrogen to restore the hormonal balance. The other importance of aromatase inhibitors is the ability to mitigate the Estrogenic effects of human chorionic gonadotropin (HCG), which will be explained shortly. It is important to note, however, that the majority of aromatase inhibitors do not comply very well with SERMs such as Nolvadex, and those particular choices should be made in regards as to which AI is used during post cycle therapy (PCT).
Human Chorionic Gonadotropin is, for the most part, synthetic Luteinizing Hormone (LH). It is a protein hormone manufactured in high amounts by pregnant females that contains a protein subunit that is 100% identical to Luteinizing Hormone (LH), and therefore when administered to men, it will mimic the action of Luteinizing Hormone (LH) in target tissues, such as the testes. What results is an increase in Testosterone production via stimulation of the Leydig cells by human chorionic gonadotropin (HCG). Human chorionic gonadotropin (HCG) should never be utilized alone, as its nature as a gonadotropin will itself trigger a negative feedback loop whereby once human chorionic gonadotropin (HCG) is used, the pituitary gland will halt output of Luteinizing Hormone (LH) until human chorionic gonadotropin (HCG) use has discontinued. Therefore, human chorionic gonadotropin (HCG) must be utilized with a SERM and especially an aromatase inhibitor, as human chorionic gonadotropin (HCG) has demonstrated to increase aromatase activity in the testes, resulting in rising Estrogen levels.
Putting Them Together:
The reader may be wondering which compounds to select of the three categories listed, and how to use them properly. The answer lies in understanding the properties of each and, in interpreting these properties, how to use them efficiently and appropriately.
Human chorionic gonadotropin (HCG):
The first item to be examined will be human chorionic gonadotropin (HCG). The majority of testosterone therapy users from the 1960s – mid-1980s did not even utilize any compounds for hormonal recovery, and the term post cycle therapy (PCT) did not even exist at that time. When the use of human chorionic gonadotropin (HCG) became increasingly popular (circa 1980), it was the only compound utilized. Since then, the medical and scientific understanding of such things has increased exponentially, and there should be no reason for any informed and adequately educated individual to utilize human chorionic gonadotropin (HCG) on its own for post cycle therapy (PCT). When used in conjunction with one of the other two categories of compounds (an AI and a SERM), the dynamics change considerably.
It has been mentioned already that much of the difficulty in recovering the Hypothalamic Pituitary Testicular Axis (HPTA) following an testosterone therapy is the result of Leydig cell desensitization. Human chorionic gonadotropin (HCG) is necessarily an analog of Luteinizing Hormone (LH), and the testes after a prolonged testosterone therapy would be as equally desensitized to human chorionic gonadotropin (HCG) as they are to Luteinizing Hormone (LH). The human body, however, produces Luteinizing Hormone (LH) amounts on its own that is far too inefficient for proper and rapid Testosterone production. The body’s natural increase of Luteinizing Hormone (LH) and Follicle Stimulating Hormone (FSH), evidenced by the study referenced earlier in which it was not until three weeks when Luteinizing Hormone (LH) levels only began to reach the standard physiological measurements following the cessation of Testosterone. Therefore, the body’s natural Luteinizing Hormone (LH) production does not provide a high enough dose for stimulation, nor an immediate stimulus to the tests required for the initial increase in Testosterone needed during the post cycle therapy weeks.
Human chorionic gonadotropin (HCG), utilized in a specific manner during the first 1 – 2 weeks of post cycle therapy (PCT) at a dose of 100-1,500IU every 2 days, is what allows the individual to provide the testes with a high dose to provide them with a ‘shock’ effect, and sustain this shock effect on the Leydig cells of the testes for a sustained period of the first 1 – 2 weeks of post cycle therapy. Studies have demonstrated the incredible effectiveness of human chorionic gonadotropin (HCG) for this purpose, it been suggested that human chorionic gonadotropin (HCG) therapy is utilized to treat low testosterone and hypogonadism. Following this line of thought, the other two compounds (the SERM and the AI) are to be used as supportive compounds for human chorionic gonadotropin (HCG) use in this 1 – 2 week period, and after human chorionic gonadotropin (HCG) is discontinued early on in post cycle therapy (PCT), only the SERM is to be used in order to carry along the hormonal recovery process.
In spite of the good news in regards to the ability for human chorionic gonadotropin (HCG) to assist in hormonal recovery, there are still two remaining issues to be addressed:
The fact that human chorionic gonadotropin (HCG) causes increased production of aromatase, leading to increased Estrogen levels.
Following the discontinuation of human chorionic gonadotropin (HCG), the body is left with very little endogenous Luteinizing Hormone (LH), and Follicle Stimulating Hormone (FSH) production due to the exogenous administration of human chorionic gonadotropin (HCG).
Aromasin (Exemestane) Above All Else The first of the two remaining issues to be addressed will be the fact that human chorionic gonadotropin (HCG) will trigger increases in testicular aromatase expression, and result in Estrogen increases in the body. It should also be noted that it will cause an increase in testicular progesterone levels. Estrogen rising is, of course, undesirable during post cycle therapy (PCT), as it has already been explained that Estrogen will trigger suppression of endogenous Testosterone production, and there is no doubt that any individual wishes to encounter Estrogenic side effects during post cycle therapy (PCT) either.
Therefore, the option here is to include an aromatase inhibitor. However, there exists a big problem in regards to the other two of the three major aromatase inhibitors (Arimidex and Letrozole). The issue is the fact that in a post cycle therapy (PCT) program that includes the use of SERMs such as Nolvadex and Clomid, which are known as essential components to a post cycle therapy (PCT) program, Arimidex and Letrozole have direct negative interactions with Nolvadex. The problem here is that Arimidex (or Letrozole) and Nolvadex both directly counteract one another. One study has demonstrated that when Arimidex is utilized with Nolvadex, Nolvadex will decrease the blood plasma concentration of Arimidex (as well as Letrozole, another commonly used aromatase inhibitor). The conclusion here is that the use of Arimidex or Letrozole with Nolvadex together is a terrible idea and may work together in a post cycle therapy (PCT) protocol. Aromasin completely circumvents this problem, as it has been demonstrated to have no interactions what so ever with Nolvadex, unlike the other two aromatase above inhibitors. In one study, Aromasin displayed no such reduced effectiveness or any reduced blood plasma levels when utilized with Nolvadex.
The other benefit of selecting Aromasin over all other AIs is the fact that Aromasin has demonstrated in several studies to impact cholesterol profiles in a negative manner far less than other aromatase inhibitors have, wherein one particular review on cancer patients, 24 weeks of Aromasin (Exemestane) administration held no impact on cholesterol profiles. Some other studies have also demonstrated a nil effect on cholesterol profiles from the use of Aromasin. Although there have also been some studies that have shown a negative impact on cholesterol profiles resultant from Aromasin use, it is evident that there is not as a significant or as a negatively impacting effect from Aromasin on cholesterol as other aromatase inhibitor.
Finally, in addition to these benefits from Aromasin, it is evident that Aromasin holds the ability to increase Testosterone levels in males as demonstrated by studies. For example, one particularly notable study selected 12 healthy young male test subjects, and were administered random Aromasin doses of 25mg and 50mg for a 10 day period, and not only was Estrogen suppressed by a significant amount (38%), but Testosterone levels in the test subjects were observed to have increased by an incredible 60%.
Following these details, Aromasin would be the best possible aromatase inhibitor of choice to combat the increased aromatase activity caused by human chorionic gonadotropin (HCG). Therefore, Aromasin would then be utilized at a full 25mg daily dose, and only while human chorionic gonadotropin (HCG) is used. Once human chorionic gonadotropin (HCG) is discontinued, Aromasin too should be halted.
The only following issue to cover now is that of stimulating and maintaining proper endogenous Luteinizing Hormone (LH) release to carry recovery along until the body can become self-sufficient once again.
Nolvadex and Clomid:
The question is often asked among the testosterone therapy using community: Clomid or Nolvadex? Which one for post cycle therapy (PCT)?
First of all, the best possible addition to human chorionic gonadotropin (HCG) in a post cycle therapy (PCT) protocol is Nolvadex (Tamoxifen Citrate), as studies have demonstrated that human chorionic gonadotropin (HCG) and Nolvadex utilized together have exhibited a remarkable synergistic effect in terms of stimulating endogenous Testosterone production and that Nolvadex will actually work to block the desensitization effect on the Leydig cells of the testes caused by high doses of human chorionic gonadotropin (HCG). This is very important because just as too little Luteinizing Hormone (LH) secretion for extended periods can cause desensitization to gonadotropins, too much gonadotropin stimulation (in the form of human chorionic gonadotropin (HCG) or otherwise) will likewise create a desensitization effect.
Secondly, Nolvadex on an mg for mg basis is far more effective than Clomid in stimulating endogenous Testosterone production, as well as being a more cost-effective choice than Clomid itself. Studies have demonstrated that 150mg of Clomid (Clomiphene Citrate) administered daily raised endogenous Testosterone levels of 10 healthy males by approximately 150%, while incidentally, 20mg of Nolvadex (Tamoxifen Citrate) daily raised endogenous Testosterone levels by the same amount. It is very evident here that Clomid is very useful for this purpose, but Nolvadex seems to be a more cost-effective choice seeing as though it is more effective than Clomid when compared mg for mg. The benefits of Nolvadex over Clomid do not end there – Clomid, although it does exhibit Estrogen antagonist effects at the pituitary gland as Nolvadex does, actually shows Estrogen agonist effects there too. What this means is that Clomid will work in varying degrees as an Estrogen at the pituitary gland, triggering the negative feedback loop and reducing the output of Testosterone stimulating gonadotropins Luteinizing Hormone (LH) and Follicle Stimulating Hormone (FSH). This is a severe problem during post cycle therapy, which is a period in which individuals are trying to recover their Hypothalamic Pituitary Testicular Axis (HPTA) function rather than halt it even further. Ideally, one would want a SERM that exhibits almost 100% Estrogen antagonistic effects on the pituitary gland, and Nolvadex is the perfect choice for this.
When it comes to the dosing aspect of Nolvadex, The standard dose for post cycle therapy (PCT) and for stimulating the release of GnRH (Gonadotropin Releasing Hormone), Luteinizing Hormone (LH), Follicle Stimulating Hormone (FSH), and ultimately Testosterone is that of a single Nolvadex dose of 20 – 40mg daily. In all studies involving Nolvadex doses used to stimulate endogenous Testosterone production, only 20 – 40mg daily of Nolvadex was utilized, and it has been shown that doubling the dose to 40mg or any higher will not produce any significant difference in endogenous Testosterone secretion. The only reason why many elects to utilize 40mg daily of Nolvadex for the first 1-2 weeks of a post cycle therapy (PCT) program is to achieve optimal peak blood plasma levels quicker to ensure Hypothalamic Pituitary Testicular Axis (HPTA) recovery faster.
The ideal post cycle therapy protocol for 4 – 6 weeks Total post cycle therapy (PCT) time (depending on the recovery ability of the individual):
01) Weeks 1 – 2:
human chorionic gonadotropin at 1000iu/E2D.
Aromasin (Exemestane) at 25mg/day.
Nolvadex (Tamoxifen Citrate) at 40mg/day.
02) Weeks 2 – 6:
Nolvadex or (Tamoxifen Citrate).
Additional and Optional, Vitamins, Supplements, Compounds to Aid During post cycle therapy (PCT), Aside from the principal components discussed, various other parts are mostly optional, but still very useful for hormonal recovery of the Hypothalamic Pituitary Testicular Axis (HPTA) during the post cycle therapy weeks.
Vitamin B12 Health Benefits, There has been a lot of controversy over whether or not there is indeed a benefit from taking B12 supplements. Some doctors suggest that as long as a person is not vegan (though probiotics in the gut can produce some B12), they are probably getting sufficient B12 from the basic foods they are ingesting.
Let us reference some studies:
There is documented research from the Framingham Study suggesting that 40% of all people are deficient in B12. The American Journal of Clinical Nutrition researched in 2009, and they published a study suggesting close to 6% of U.S. and U.K. residents over the age of 60 are B12 deficient. Another 20% were referenced as “marginal status.”
Vitamin B12 Health Benefits has the most multifaceted and prevalent chemical structure of all vitamins. One area where it differentiates from other vitamins is in the fact that it’s the only vitamin that contains a metal commonly referred to as Cobalamin, which is also a universal term for all the various compounds that may have some B12 properties in it.
B12 can improve energy by aiding in thyroid function and cellular methylation, That being said, B12 is not only useful in supporting healthy energy levels. It is unequivocally essential to life and whole existence. People deficient in B12 will suffer from serious health issues if the problem is not addressed.
What role B12 plays in the following human biological processes:
Nerve and brain regeneration
Adrenal gland support
Male and female reproductive health
Red blood cell formation
Here are some of the risks associated depleted B12 levels are:
Ibutamoren MK-677 and the all-news online and forums are talking about Ibutamoren and for the properties to help athletes recover faster and used by those patients wishing to increase their growth hormone. However, clinical studies of this compound Ibutamoren are relative, So far, Ibutamoren (also known as MK-677), and promotes the secretion of the growth hormone (GH), and increases insulin-like growth factor (IGF-1) Levels.
Ibutamoren MK-677 increases the growth hormone levels by mimicking the action of the hormone ghrelin and binding the ghrelin receptors (GHSR) in the brain. The activated (GHSR) stimulates growth hormone release from the brain, (GHSR) found in brain regions that control appetite, mood, pleasure, biological rhythms, memory, and cognition. Therefore, we can expect ibutamoren MK-677 may also affect these functions. The clinical studies describe only the effects ibutamoren MK-677 has on appetite.
The great thing about ibutamoren MK-677 increases with little or no efforts the growth hormone levels. Also, help such as cortisol levels: cortisol help suppress the immune system to heal faster and impairs the learning and memory.
Uses Of Ibutamoren MK-677
Ibutamoren MK-677 is frequently used as an anabolic substance, to increase lean body mass, and create muscle. It is orally active also and can be taken once a day. These are all full benefits compared to other growth hormone stimulators.
As previously mentioned, ibutamoren MK-677 increases growth hormone levels and the (IGF-1). Both growth hormone and (IGF-1), and it help increase muscle mass, muscle strength, and reduce body fat In obese patients, a two-month treatment (DB-RCT) with ibutamoren MK-677 increased lean mass, and transiently increased basal metabolic rate (BMR).
Muscle Wasting and Strength:
In a study done (DB-RCT) in eight patients healthy volunteers and where food-deprived, and ibutamoren MK-677 reversed the diet-induced protein loss and helped with the muscle wasting patients. In a study 123 elderly patients with hip fracture, ibutamoren improved gait speed, muscle strength and reduced the number of falls (RCT).
Bone Density and Healing:
Growth hormone (GH) increases bone healing and eventually bone density. Now because of the increased turnover in treated patients with growth hormone. Patients under the therapy over (1 year) to see the bone density increase, and in 24 volunteers with healthy obese patients, ibutamoren MK-677 increased the bone turnover (DB-RCT).
The study on 187 elderly Patients, Ibutamoren MK-677, increased bone building, measured by osteocalcin on bone turnover in multiple studies (3 DB-RCTs). In one study (DB-RCT), In 292 women patients with post-menopausal. Ibutamoren MK-677 has increased bone mineral density which helps improve bone strength and prevent osteoporosis and more.
Better Quality Sleep Duration:
A study on (DB-PCT) showed that in both younger and elderly patients, ibutamoren MK-677 improved sleep quality and Rapid Eye Movement (REM), and sleep duration, apart from scientific studies done, there have been many reports, across various forums online.
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Growth Hormone Secretion (GHS) and muscle mass both decline around mid-puberty throughout life, In a study with 65 senior men and women (DB-RCT), THE daily ibutamoren MK-677 increased Growth Hormones and (IGF-1) levels without serious adverse effects. Now the (IGF-1) is known to have beneficial effects on longevity.
Memory Enhancement Effects:
Ibutamoren MK 677 increases (IGF-1), which is known to enhance memory and learning, Ibutamoren MK-677 also increases (REM) sleep duration and quality. Understand that sleep is essential for proper cognitive function, A study (DB-multicenter) questioned the association of low (IGF-1) and Alzheimer’s, and whether ibutamoren MK 677 could be of help. However, in this study, ibutamoren MK-677 was ineffective at slowing the progression of Alzheimer’s in Patients.
Growth Hormone Deficiency:
Ibutamoren MK 677 can increase growth hormone, (IGF-1), levels in children with growth hormone deficiency. Furthermore, these effects change the concentrations of prolactin, triiodothyronine (T3), thyroxine (T4), thyrotropin, glucose, cortisol, and insulin.
In severe men with GH deficiency Ibutamoren MK 677 increased (IGF-1) and growth hormone, with no changes in cortisol, PRL, and thyroid hormone levels. However, insulin and glucose increased (DB-RCT). Tissue Regeneration and Wound Healing:
Growth hormone (GH) increases tissue regeneration and wound healing so that ibutamoren MK 677 may help with these. There are individual reports of ibutamoren being helpful, but scientific studies are lacking.