What Are The Benefits Of Sermorelin?
The Benefits of Sermorelin
Most patients who are interested in participating in sermorelin therapy have educated themselves and understand the more popular HGH therapy program. It is important to understand that sermorelin is also a GH-based therapy.
The primary differences between hGH therapy and sermorelin therapy are described below.
With hGH therapy, the introduction of bioidentical hGH into the bloodstream manipulates the amount of circulating GH. The more hGH is administered, the higher the resulting IGF-1 levels will be. It is important to understand that increasingly high levels of hGH or IGF-1 do not constitute more benefits; on the contrary! You must administer the exact dose determined by your physician based on your medical profile and file characteristics. Excessive doses of hGH could lead to unwanted side effects. If you are currently undergoing hGH therapy and are interested in higher dosages, you should discuss this openly and honestly with your prescribing physician. It is critical that there is an open dialog to ensure that your program is successful and healthy, with little to no negative side effects.
With sermorelin therapy, the introduction of sermorelin into the bloodstream stimulates the production and secretion of endogenous GH from the pituitary gland. If a patient has a well-functioning pituitary gland, then promoting this overproduction of GH will result in health benefits that mirror those of an hGH-based program. Possible benefits of selecting sermorelin over hGH are as follows:
• Endogenous GH production is regulated by a feedback mechanism that shuts down production when circulating levels are too high. Because sermorelin stimulates the production of endogenous GH, the amount of GH released is subject to the same feedback mechanism to prevent levels getting too high and thereby avoiding side effects.
• Because sermorelin induces the production of endogenous GH, the resulting hormone is released in a pulsatile manner, as happens naturally.
• Although it produces results and benefits that mirror those of a traditional hGH protocol, sermorelin therapy can be as much as 50% cheaper than a traditional hGH protocol.
• With hGH therapy, your body stops producing endogenous GH when IGF-1 levels are too high, which can eventually cause atrophy and dysfunction of the pituitary gland, Sermorelin rejuvenates and reactivates the pituitary gland by stimulating the production and secretion of endogenous GH.
Below is a list of just some of the benefits that can be expected from a GH-based therapy such as hGH, sermorelin, or ipamorelin within around 6 months:
• Reduction of body fat around the stomach
• Increased lean muscle mass
• Increased energy
• Increased immune function
• Enhanced sexual performance
• Increased cardiac output
• Improved skin elasticity
• Disappearance of wrinkles
• Reduction in the appearance of cellulite
• Improved vision
• Increased memory retention
• Improved sleep quality
• Increased exercise performance
• Expedited wound healing
• Lower blood pressure
• Reduced cholesterol levels
• Increased bone mass and rigidity
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Sermorelin Peptides & GHRP
Sermorelin Peptides
One of the major roles of many peptides is to function as peptide hormones, which carry signals between cells and glands. These hormones regulate critical physiological processes, including blood sugar, sleep, growth, and much more. They are produced by endocrine glands such as the pituitary, adrenal, pineal, thyroid, and parathyroid glands, the pancreas, testes, and ovaries, as well as the liver, intestines, stomach, adipose tissue, and kidneys. Common peptides hormones include oxytocin, gastrin, bradykinin, hGH, adrenalin, and insulin.
There are several other types of peptide:
• The brain produces neuropeptides, which are found in neural tissue. They are an extension of your neural system throughout the body, meaning that they act as regulators and signals in various processes triggered within the brain. Endorphins are an example of a neuropeptide.
• Alkaloids are peptides that are commonly involved in developing defense mechanisms in small animals, plants, and fungi. Examples include dynorphin, panda mini, and ergotamine.
• Peptides can work as antibiotics to prevent the growth of microorganisms in the body.
GHRPs
Growth hormone-releasing peptides (GHRPs) are a family of synthetic peptides that stimulate GH secretion. Importantly, they have no structural similarity to sermorelin or GHRH; instead, they function via receptors in the pituitary gland and/or hypothalamus. At AAI Rejuvenation Clinic, we compound two different GHRPs (GHRP-2 and GHRP-6) into the sermorelin mixture. The resulting mixtures, sermorelin peptides GHRP2 and sermorelin peptides GHRP6, are particularly potent and effective GH-inducing agents that yield comparable results to typical yet considerably more expensive hGH therapy.
GHRP-2
GHRP-2 is a synthetic analog of the peptide hormone ghrelin. Ghrelin is a small 28 amino acid peptide that is produced by the stomach in response to hunger. It also activates the growth hormone secretagogue receptor (also known as the ghrelin receptor) to stimulate GH production and metabolism. GHRP-2 functions similarly to stimulate the hypothalamus and increase the production of endogenous GH from the pituitary gland; synthesis then slowly drops back to baseline by the third hour after administration. This more closely replicates the pulsatile nature of endogenous GH production, which makes it advantageous and potentially safer compared with synthetic hGH use.
Here are some key facts about GHRP-2:
• GHRP-2 (also known as pralmorelin or KP 102) is a synthetic hexapeptide GHRP that acts on the hypothalamus and pituitary gland to stimulate GH secretion; it also has a slight stimulatory effect on prolactin, ACTH, and cortisol secretion.
• GHRP-2 is an hGH secretagogue; it effectively stimulates the secretion of endogenous hGH. GH promotes lean body mass and reduces adiposity (fat mass).
• It has a short half-life of 5–30 minutes.
• GHRP-2 is a second generation GHRP. It is much more effective at stimulating GH production than GHRP-6.
• Because it stimulates GH production, GHRP-2 also increases IGF-1 levels. Even greater results are achieved when it is used in combination with sermorelin.
• Unlike ghrelin and GHRP-6, GHRP-2 does not affect the appetite and is not lipogenic. This means that it does not induce fat storage.
GHRP6
GHRP-6 is a hexapeptide synthetic analog of met-enkephalin, which is an endogenous opioid growth factor; however, GHRP-6 does not exhibit opioid activity. GHRP-6 works similarly to GHRP-2; however, it is a first-generation GHRP that does not induce GH levels as strongly as GHRP-2. Instead, it promotes food intake by stimulating hunger and helps increase energy metabolism; therefore, it is good for patients that need to increase their food intake.
Here are some key facts about GHRP-6:
• GHRP-6 is most commonly used for the treatment of GH deficiency, as well as eating disorders.
• GHRPs act synergistically with GHRH, which is related to sermorelin, to stimulate larger releases of GH.
• GHRP-6, the first GHRP, was developed in the 1980s. It became the first member of a class of drugs called GH secretagogues because of its potent ability to stimulate GH secretion.
• GHRP-6 acts on the ghrelin receptor in both the pituitary and hypothalamus in both a time- and dose-dependent manner.
Combination Treatment With Sermorelin and GHRPS
Both GHRP-2 and GHRP-6 bring great benefits to a sermorelin protocol. They are effective for treating the age-related decline in GH levels when used in combination with sermorelin.
When used with an equal dose of GHRH, GHRPs create a 3-hour pulse of GH that is double the amplitude of 8 IU of synthetic GH, resulting in:
• Increased energy
• Improved sleep
• An increased lean body mass
• A reduced body fat mass
• Increased collagen production
• An enhanced healing capacity
These factors not only make it more effective, but also a safer and healthier alternative to exogenous GH.
When considering GH therapy, personal preference and characteristics are always the determining factors. However, a sermorelin plus GHRP combination is a wonderful option to allow you to get back your vitality and youth.
Contact us at your earliest convenience so we can give you more information about how HGH therapy and/or sermorelin therapy can make a difference to your health. We look forward to helping you decide which replacement therapy is best for you. AAI Rejuvenation Clinic’s anti-aging professionals are your personal resource to help you extend your life and get more from it.
Sermorelin Injection – Curious about Benefits of Sermorelin Therapy? Read more about what you can expect from this treatment and contact us for more information (866) 224-5698
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Sermorelin Peptides GHRP and Benefits of HGH Sermorelin peptides GHRP and benefits of hGH are undeniable. However, when using injectable exogenous HGH (GH not produced naturally by our body) our bodies go from producing low amounts of GH to essentially producing no GH. The reason this occurs is that the body becomes completely dependent on the exogenous hGH. As incredible as it is to have higher levels of GH in your body, it’s extremely important to cater to the health of your pituitary gland to ensure long-term health and positive results. So how do you get your pituitary gland to start working again? More importantly, how do you get it to work harder and more efficiently for an individual your age or with your particular abnormal pituitary condition? This is a job for Sermorelin peptide GHRP peptides.
Sermorelin
- Sermorelin peptides (GHRH) is a bio-identical hormone that has recently been genetically engineered to stimulate the secretion of Growth Hormone releasing hormone from the hypothalamus. GHRH is a peptide that contains the first 29 amino acids of the 191 in GH. It is GHRH that stimulates your pituitary gland to release GH. As we age, hormone production in the pituitary gland declines. It has been proven that HGRH can restore the production levels of the pituitary causing significant elevation of IGF-1.
Peptides
- – One of the major functions of peptides is to work as hormones because these are a specific type of peptide responsible for carrying signals between cells and glands. These peptides will control blood sugar regulation, sleep, and other body functions. They are created by the liver, intestine, stomach, kidneys and endocrine glands. Common peptides found in hormones include oxytocins, gastrins, bradykinins, human growth hormone and insulin.
- – The brain produces neuropeptides, which you find in neural tissue. They are an extension of your neuro system throughout your body, meaning that they act as regulators and signals in various processes triggered from locations within the brain. One example of neuropeptides would be endorphins.
- – Alkaloids are another type of peptide and they are commonly involved in developing defense mechanisms in small animals, plants, and fungi. Examples of these peptides include dynorphin, panda mini, and ergotamine.
- – When peptides work as antibiotics, they prevent microorganisms from growing within the body. This is an example of using peptides side effects to kill bacteria that cause diseases as antibiotics are commonly used in medicine.
- – The peptide can help support our body. This is because when peptide chains become long enough, it will form proteins, which are used as building blocks of animal and human bodies. Keratin is a perfect example as this protein is in human nails and hair and animal claws, hooves, scales, feathers, and horns. Collagen is another protein created from peptides and is found in bones, tooth enamel, ligaments, and tendons.
GHRP’s
- GHRP’s are a small family of peptides acting in the hypophyseal portal system to release Growth Hormone (GH). There are two main forms of GHRP, which will be depicted further below, that are compounded into the Sermorelin Peptides GHRP mixture. The end result, Sermorelin GHRP2 or Sermorelin GHRP6, is an especially potent and effective Growth Hormone inducing agent that can generate comparable results to a typical, yet considerably more costly, hGH therapy protocol.
GHRP2
- Growth-Hormone-Releasing-Peptide-Two (GHRP2) is a synthetic ghrelin analogue. It stimulates the hypothalamus and critically increases the natural production of Growth Hormone (GH) from the pituitary gland, which slowly drops back to baseline levels by the third hour after administration. This more closely replicates the natural pulse of GH in the human body, giving it an advantage over synthetic HGH use
– GHRP-2 (also known as KP 102) is a synthetic hexapeptide Growth Hormone Releasing Peptide (GHRP) which acts on the hypothalamus and the pituitary gland to release growth hormone with a slight stimulatory effect on Prolactin, ACTH, and Cortisol levels.
– GHRP-2 is considered to be a true hGH secretagogue, meaning that it stimulates the body’s own secretion of hGH. Human Growth hormone has been shown in studieshttps://www.aaiclinics.com/treatments/hgh-therapy/what-is-human-growth-hormone/ to promote lean body mass and reduce adiposity (fat).
– GHRP2 has demonstrated that it is very effective at stimulating GH production in research test subjects.
– It has a short half-life with peak concentrations occurring around 15 minutes and not longer than 60 minutes after administration.
– GHRP-2 is a 2nd generation GHRP just behind GHRP-6. Compared to GHRP-6, GHRP-2 is considered to be much more superior in terms of growth hormone stimulation because over longer periods of time it maintains maximum elevations in Growth Hormone.
– GHRP-2 has shown to increase IGF-1 levels (Insulin-like Growth Factor-1), and even greater results happen when used with Sermorelin Peptides GHRP (Growth Hormone Releasing Hormone – GHRH). It has a short half-life with peak concentrations occurring around 15 minutes but not longer than 60 minutes. The response of natural physiologic system includes the increase in levels of calcium ion influx alongside with increased release of growth hormones in response to the high-amplitude pulsation from the GHRP-2.
– GHRP-2 and other ghrelin analogues increase the number of somatotropes involved in the GH pulse by inhibiting somatostatin, GHRH increases the pulse amplitude per pituitary cell or somatotrope by other means.
-Unlike ghrelin, GHRP-2 is not lipogenic which means that it does not induce fat storage. Although ghrelin plays a large role in hunger, GHRP-2 as an analog of ghrelin does not increase appetite significantly.
GHRP6
- Growth-Hormone-Releasing-Peptide-Six (GHRP6) is a Growth Hormone (GH) secretagogue. The Peptide GHRP-6 works similarly to GHRP-2, however, it is a Hexapeptide that promotes food intake by stimulating hunger and helps increase energy metabolism.
– Growth Hormone Releasing Peptides, similar to GHRP-6, are most commonly used for the treatment of Growth Hormone (GH) deficiencies, eating disorders, etc.
– Researchers discovered that those GH-Releasing Peptides (specifically GHRP-6 & GHRP-2) followed a mode of action, which bound them to and was mediated through receptors different from those for GHRH.
– Researchers discovered that these GH-Releasing Peptides acted synergistically with the natural human Growth Hormone Releasing Hormone (GHRH), which is related to Sermorelin Peptides GHRP, in both laboratory animals and humans to produce large releases of Growth Hormone.
– In the 1980s, the first highly potent GH-Releasing peptide, GHRP-6, was developed. Due to a strong GH release response from the peptide, it became the first member of a class called Growth Hormone Secretagogues.
– GHRP-6 is believed to be acting naturally on both pituitary and hypothalamic sites (Fairhall et al. 1995). In a time-dependent and dose-dependent manner, the primary pituitary cells of rats were demonstrated on.
- Both GHRP-2 and GHRP-6 have great benefit and potential. Studies have shown them to be effective in treating age-related GH decline when used in combination with Sermorelin (GHRH).
– GHRP’s when used in equal dosages of GHRH creates a 3-hour pulse of GH that is double the amplitude of 8IU of synthetic GH, resulting in:
a) increased energy
b) improved sleep
c) increased lean body mass
d) decreased body fat
e) increased collagen production and
f) increased healing capability.
These factors not only make it more effective but actually a healthier substitute to Exogenous Growth Hormone.