What is Sermorelin?
Sermorelin is a growth hormone-releasing hormone (GHRH) analog that functions as a growth hormone (GH) secretagogue. This means that it stimulates the production and secretion of endogenous GH from the hypothalamus in the same way as endogenous GHRH.
Sermorelin is a peptide comprised of the first 29 amino acids of endogenous GH; the sequence is the same as endogenous GHRH. As we age, our body produces less and less of our vital hormones, including GH. Studies have revealed that sermorelin can restore GH RNA concentrations to youthful levels, which subsequently stimulates the production of insulin-like growth factor-1 (IGF-1).
How Will the Sermorelin My Physician Describes Arrive?
Depending on how your physician designs your protocol, your sermorelin will come in a multi-dose injectable vial. Each vial contains a powder disc that contains sermorelin acetate. The amount of drug in the disc will determine the potency of the dose, which will vary according to your physician’s recommendations for an effective and safe therapy. The vial is vacuum-sealed by the pharmacy for your protection and to preserve the hormone peptide. You will also receive a bottle of bacteriostatic water for each vial of sermorelin Injections, which you will use to reconstitute the drug before injection. Sermorelin therapy is also available in an oral preparation. Of course, all administration and storage instructions will be provided with your prescription. We also offer sermorelin/ipamorelin combination treatments. Ipamorelin is a peptide that activates the GH secretagogue receptor and function as a GH secretagogue.
Sermorelin at AAI Rejuvenation Clinic
The specialty pharmacies that we partner with allow us to offer our patients the convenience of being prescribed medication that does not need to be refrigerated. Sermorelin needs to be administered every day and, depending on the protocol, sometimes several times a day. This can be complicated for many patients, who are always on the go. Our sermorelin and combination sermorelin/ipamorelin products never require refrigeration, which makes it easy and convenient for you.
How Do I Take Sermorelin?
Sermorelin is injected subcutaneously into the body fat using a very small needle, similar to what a diabetic may use to inject insulin. Injections are initially prescribed daily and are then decreased in frequency over time.
There is no specific time of day that you should administer your therapy. Some patients find it beneficial to take it at bedtime because both sermorelin and GHRH can induce deep, restful sleep, which is linked to the increased pulsatile secretion of GH from the pituitary in the brain. However, other patients find that the increased GH release stimulates mental activity and thereby reduces sleep quality. Therefore, you should administer the drug when it works best for you.
How Do You Measure the Effectiveness of Sermorelin?
Due to the pulsatile nature of endogenous hGH secretion, a single blood draw is not sufficient to accurately measure its concentrations. In contrast, IGF-1 levels remain stable throughout the day; therefore, IGF-1 is considered a more stable and accurate measure of GH production. The physicians at AAI Rejuvenation Clinic specialize in assisting patients to understand how they are affected by and benefit from their treatment program. Aside from measuring the effectiveness of therapy by changes in the symptoms and physical appearance and measurements, frequent blood analyses are the most accurate way to ensure that your treatment protocol remains safe and effective.
Several things should be expected from a properly administered program. Remember that sermorelin is another form of GH therapy; therefore, the list of benefits and side effects is the same as what you’d expect from hGH therapy.
Initially, patients on GHRH therapy could expect the following:
- • Improved sleep within the first few weeks of therapy – most patients at least notice an increase in sleep quality.
- • Increased energy levels.
- • Improved mood.
- • After 3–6 months of therapy, patients start reporting noticeable or significant body changes, such as an increase in muscle tone and a leaner physique.
- • Over time, patients will also notice a significant improvement in skin tone and health.
If you are interested in learning more or have any questions, you are welcome to fill out our contact form and someone will get to you within 24 business hours.