Testosterone is an essential factor in males, that does more for men than just promote sex drive. Low Testosterone levels decline as a part of healthy aging and are the cause of several physiological changes. Low Testosterone level symptoms include;
1) Reduced Motivation
2) Erectile Dysfunction
3) Loss of Libido or sex drive
4) Fatigue and low energy
5) Increased Cholesterol Levels
6) Memory and Concentration
7) Decreased Muscle Mass
8) Thyroid Dysfunction and more
Since these symptoms are common in low testosterone, physicians will often include hormone levels as part of routine blood work. Normal levels of testosterone are between 300 and 1,000 ng/dL. If a blood test shows that your levels are far below the norm, your doctor may suggest testosterone injections. The treatment is called TRT.
SYMPTOMS OF LOW TESTOSTERONE
Most men naturally start losing testosterone when they hit their 30’s. (low T). Common symptoms of low Testosterone include:
1) Erectile dysfunction (ED)
2) Changes in sex drive
3) Decreased sperm count
4) Depression or anxiety
5) Weight gain
6) Hot flashes
TESTOSTERONE AND DIAGNOSIS
Many men may want to diagnose themselves with a testosterone kit. The problem with self-diagnosis is that many of the symptoms of low Testosterone are healthy parts of aging. So using it for diagnosis isn’t reliable. Our doctor may order testosterone blood test. It is the only way to find out if you have low testosterone.
To get a perfect reading our doctor will take a look at your health history, physical exam and blood test to measure your testosterone levels. You’ll also likely have a test that measures your red blood cell count.
POTENTIAL BENEFITS OF TESTOSTERONE INJECTIONS THERAPY
The purpose of Testosterone Injections Therapy is to help regulate hormone levels and to help address problems related to low Testosterone. For men with low Testosterone, the benefits of these injections can include:
1) Motivation and Memory Loss
2) Sex Drive & Desire
3) Depression and Energy
4) Cholesterol and Osteoporosis
5) Erectile Dysfunction
6) Muscle Mass and Better Sleep
7) Wounds healing & Illness
8) Thyroid Dysfunction and more
TESTOSTERONE CAN HELP WITH FAT AND MUSCLE CHANGES
Men have less body fat than women; This is partly related to testosterone, which regulates the fat in the body and muscle maintenance in your body. You’ll likely also notice an increase in body fat, especially around your midsection.
Your hormones also help regulate muscle growth. So, with low Testosterone, you may feel like you’re losing muscle size or strength.
Testosterone shots regulate fat distribution, but you shouldn’t expect significant weight loss changes from hormone therapy alone, without exercise. As for maintenance of muscle, testosterone therapy has been found to improve increase muscle mass, but not strength.
TESTOSTERONE INJECTIONS THERAPY AND SPERM COUNT
Low sperm count in men is a common side effect of low Testosterone. This problem can make it difficult to get your partner pregnant.
TESTOSTERONE INJECTIONS THERAPY AND THE BOTTOM LINE
Testosterone injections therapy can only be helpful If you just have low Testosterone. If you’re wondering if testosterone is a right choice for you, ask your doctor. They can test you for low Testosterone. Ask your doctors, or Give us a call, if testosterone injections therapy would be a good choice for you.
If you don’t end up having low Testosterone but still feel like your hormone levels might be off, keep in mind that proper Food, Regular exercise, could help you increase testosterone naturally and make you feel better. If that doesn’t help, be sure you contact us for help.
The Role of Testosterone, Testosterone therapy is the most important sex hormone that men have. It is responsible for the typical male characteristics and helps maintain sex drive, sperm production, pubic and body hair, muscle, and bone. The brain controls the production of testosterone by the testes.
Low testosterone (also called hypogonadism) can cause:
• A drop in sex drive
• Poor erections
• Low sperm count
• Increased breast tissue
Over time, low testosterone may cause a man to lose body hair, muscle bulk and strength, accumulate body fat, and have weaker bones (osteoporosis), mood changes, less energy and smaller testes.
What causes low testosterone?
Low testosterone can be caused by injury (trauma, castration, radiation or chemotherapy), testicular infection, hormonal disorders (e.g., pituitary tumors or diseases, high levels of prolactin), or other systematic diseases (such as HIV/AIDS, chronic liver and kidney disease, too much body fat, Type 2 Diabetes and associated Diabetes). Some medications and several genetic conditions (Klinefelter syndrome, hemochromatosis, Kallmann syndrome, Prader-Willi syndrome) also can cause low testosterone. Many older men have low testosterone levels and often, the cause is not known.
How is low testosterone diagnosed?
During a physical exam, your doctor will examine body hair, breast size, size and consistency of the testes, scrotum, penis size, and ability to see in all directions. Your doctor will also use blood tests to see if the total testosterone level is within the normal range. This is generally 300 to 1,000 ng/dL but this may differ depending on the laboratory. To diagnose low testosterone you may need more than one early-morning (7 – 10 a.m.) blood test and, sometimes, other tests of the pituitary gland.
The best method will depend on the cause of the problem, the patient’s preference and tolerance, and cost. There are risks with long-term use of any testosterone delivery method for men over 50.
Possible Risks of Testosterone Treatment:
1) A high red blood cell count 2) Occasional stopping of breathing during sleep (sleep apnea) 3) An increase in prostate enlargement or prostate cancer growth 4) Fluid build-up (rarely) 5) Breast enlargement 6) Acne
African American men and men over 40 years of age who have close relatives with prostate cancer and all men over 50 years of age should be carefully monitored for prostate cancer during testosterone treatment. Men with breast cancer or known or suspected prostate cancer should not receive testosterone therapy.
What should you do with this information?
The Role of Testosterone, If you have symptoms, talk with a specialist. Be open with your doctor about your medical history, all prescription and nonprescription drugs you are now taking sexual problems, and any major changes in your life. If you would like more information about hormone replacement therapy, click here and complete our short contact form. One of our Clinical Assistants would be happy to explain your options.
Testosterone Injections – Curious about testosterone injections Therapy? Read more about what you can expect from this treatment and contact us for more information (866) 224-5698.
Hormones and Stress in the holiday season are upon us! Although this can a wonderful time filled with love and laughter, it can also significantly increase the day-to-day stresses experienced by many people; this can easily turn into chronic stress. Did you know that chronic stress can have a significant impact on your normal hormonal responses? Read on to learn more about the effects stress can have on your body and what you can do about it.
The Hormones and Stress feeling that we all know so well is part of the body’s normal response to a real or perceived threat. However, your body does not differentiate between serious physical threats and “normal” pressures, and so a heavy workload or demands from your family can build up over time and have a detrimental effect on your health.
The stress response is commonly known as the “fight or flight” response, and it begins in the brain. When a stress is perceived, the amygdala sends a signal to the hypothalamus, which activates the sympathetic nervous system and triggers the release of adrenaline from the adrenal glands into the bloodstream. Adrenaline then accelerates the heartbeat to pump more blood to the muscles in preparation for “flight.” In addition, the pulse, blood pressure, and breathing rate all increase to enhance the amount of oxygen inhaled. Other senses, such as sight and hearing, become sharper.
The Normal Stress Response
During the second phase of the stress response, the hypothalamus releases corticotropin-releasing hormone (CRH), which stimulates the release of adrenocorticotropic hormone (ACTH). ACTH then stimulates the release of cortisol from the adrenal glands, which ensures that the body remains on “high alert.” Cortisol levels remain elevated until the threat passes; the stress response is then shut down once the brain perceives that the threat is no longer there (http://www.health.harvard.edu/staying-healthy/understanding-the-stress-response).
The Effects of Stress
Prolonged periods of stress prevent the shut-down of the normal stress response because the body remains on high-alert and producing cortisol. The long-term exposure to cortisol and other Hormones and Stress has a number of negative effects throughout the body, including:
In the respiratory system, the accelerated breathing rate could lead to asthma or panic attacks (http://www.apa.org/helpcenter/stress-body.aspx).
In the cardiovascular system, prolonged periods of an elevated heart rate and increased blood pressure can increase the risk of cardiovascular disease, heart attack, and stroke.
In the liver, the increased levels of cortisol stimulate the production of glucose in anticipation of increased energy demands. Such prolonged exposure to elevated blood glucose levels might increase the risk of metabolic syndrome and type 2 diabetes.
Some animal studies have suggested that chronic stress can reduce testosterone levels and sperm production and maturation in men; it can even lead to erectile dysfunction and impotence.
In women, chronic stress can lead to an irregular menstrual cycle, worsened premenstrual syndrome symptoms, and reduced libido.
Stress can also dampen theimmune system.
Emotionally, stress can affect your sleep, increase irritability, anxiety, and depression, and reduce concentration.
How to Reduce the Effects of Stress
There is no need to worry: there is a lot you can do to counteract the natural stress responses that occur at this time of year. It is important to understand what makes you stressed, as well as what makes you relax. For example, there are several lifestyle changes that can help reduce stress (http://www.webmd.com/balance/stress-management/stress-management-relieving-stress):
Take time out to do something you enjoy
Express your feelings
Use relaxation techniques such as meditation
Exercise regularly; exercise is one of the best ways of reducing stress
Because many of the symptoms of chronic stress are also associated with low hormones, such as sleep loss, fatigue, and low testosterone levels, we recommend getting your Hormones and Stress levels checked if you experience any prolonged, unusual or unexplained stress. At AAI Clinic, we can measure your Hormones, Testosterone Injections, and Stress and make recommendations regarding any hormone replacement therapy or supplements that could alleviate your stress-related symptoms.
Testosterone Injections – Curious about testosterone injections Therapy? Read more about what you can expect from this treatment and contact us for more information (866) 224-LowT (5698)
Golbidi, S., J.C. Frisbee, and I. Laher, Chronic stress impacts the cardiovascular system: animal models and clinical outcomes. Am J Physiol Heart Circ Physiol, 2015. 308(12): p. H1476-98.
Bergmann, N., F. Gyntelberg, and J. Faber, The appraisal of chronic stress and the development of the metabolic syndrome: a systematic review of prospective cohort studies. Endocr Connect, 2014. 3(2): p. R55-80.
Kalaitzidou, I., et al., Stress management and erectile dysfunction: a pilot comparative study. Andrologia, 2014. 46(6): p. 698-702.
Gannon, L., et al., Perimenstrual symptoms: relationships with chronic stress and selected lifestyle variables. Behav Med, 1989. 15(4): p. 149-59.
Golkar, A., et al., The Influence of Work-Related Chronic Stress on the Regulation of Emotion and on Functional Connectivity in the Brain. PLoS ONE, 2014. 9(9): p. e104550.
Today’s media is full of reports about so-called “superfoods.” While most of these reports are based on some level of fact, misrepresentation or poor interpretation of medical and scientific findings often leads to misinformation and sensational yet misleading headlines. A prime example of this is raw cacao. The health benefits of raw cacao are astounding; however, this, unfortunately, does not necessarily mean that eating a bar of milk chocolate each day will have the same effects. Read on to learn more about the ways in which raw cacao can improve your health and how to take full advantage.
What is Raw Cacao?
Cacao-based products are made from cacao beans and include cacao powder, nibs, paste, and butter.
When purchasing raw cacao products such as powder, it is important to understand the differences between raw cacao powder and the more common cocoa powder. Raw cacao powder is very pure. It is made from raw, unroasted cocoa beans via a process known as cold pressing, which removes the fat in the form of cacao butter; much of the bean and nutrients remain intact.
Cacao is one of the best sources of flavonoids (which are potent antioxidants) available, which means that it has huge health benefits. It is also rich in protein, cholesterol-free and monounsaturated fats, fiber, natural carbohydrates, and minerals (including zinc, iron, potassium, magnesium, copper, manganese, and calcium).
Cocoa powder is produced in a similar way to cacao powder, except that it undergoes high-temperature processing during production. Although it retains significant health benefits, the high temperatures used to destroy some of the nutritional value. As cocoa undergoes further processing to make reduced-strength dark chocolate and milk chocolate, increasing amounts of the nutrients are removed. Therefore, raw cacao powder, cocoa powder, or very strong dark chocolate are recommended for optimal health benefits.
Many people are at an increased risk of cardiovascular events as they age. The good news is that the consumption of certain foods can help reduce this risk. Cocoa-based products can have significant beneficial effects on the cardiovascular system by reducing cardiovascular risk and atherosclerosis, improving circulation, lowering the levels of LDL (bad) and increasing the levels of HDL (good) cholesterol, and reducing blood pressure. Many of these effects are caused by the anti-inflammatory and antioxidant properties of the flavonoids.
Cacao- and cocoa-based products can reduce hypertension. For example, the Cocoa, Cognition, and Aging (CoCoA) Study was performed in 90 elderly individuals who received cocoa-based drinks with high, medium, or low flavonoid content. Blood pressure was reduced significantly in patients that received high- or medium-content cocoa compared with those that received low flavonoid cocoa . The subjects also exhibited improved insulin resistance and reduced lipid peroxidation.
Cardiovascular function. A recent study assessed vascular stiffness in healthy younger (<35) and older (50–80) men who drank cocoa or a control drink twice a day for two weeks. The subjects who drank cocoa exhibited significantly improved cardiovascular function, as measured by improved endothelial function, blood pressure, and vascular stiffness . A second similar study confirmed these effects and also indicated that the consumption of high-flavonoid chocolate improved platelet aggregation (an indicator of the ability of the blood to form clots) compared with low flavonoid chocolate .
Cholesterol. Several studies have investigated the ability of cocoa and cacao to improve cholesterol. For example, consuming 400 g cocoa powder with 500 ml skimmed milk per day increased HDL and lowered LDL cholesterol levels in elderly subjects at high risk of cardiovascular disease . Similar observations were made in young healthy and hypercholesterolemic subjects  and in elderly healthy individuals .
The available data suggest that cocoa and cacao could help protect against cognitive decline in aging individuals.
In the same CoCoA study described above, subjects that received cocoa with a high or medium flavonoid content had significant improvements in two different measures of cognitive function: a trail making test and a verbal fluency test. The improvements were greatest in the high flavonoid vs. the intermediate flavonoid group. However, there were no improvements in the mini-mental state evaluation among groups .
Cocoa and cacao might also protect against dementia and related diseases such as Alzheimer’s disease .
The risk of metabolic diseases often increases as we age, and conditions such as diabetes and obesity are associated with reduced mortality. Luckily, cocoa could help reduce the risk of these conditions and their symptoms. Possibly the most important metabolic effect of cocoa is its ability to improve insulin sensitivity. In one study, subjects received dark or white chocolate (with high and zero flavonoid content, respectively), and insulin sensitivity was assessed using glucose tolerance tests and the quantitative insulin sensitivity check index. Dark, but not white, chocolate significantly improved both measures of insulin sensitivity and reduced blood pressure .
The symptoms of many aging-related diseases have been linked to reduced hormone levels over time. Therefore, improving natural hormone production can reduce the symptoms of many aging-related diseases. Cocoa can have beneficial effects on the production of several hormones.
Stress hormones. We all know that nice, relaxed feeling that occurs when we eat a delicious, rich piece of dark chocolate. It turns out that there is a physiological reason for this! Cocoa can potently inhibit the release of the stress hormone cortisol. Healthy men aged 20–50 who consumed a single piece of dark chocolate had a significantly reduced response to a psychosocial stressor. These effects were caused by inhibiting the release of the stress hormones cortisol and epinephrine from the adrenal gland .
So, there you have it! Cocoa really is a super-food. It is not only delicious but, when eaten in unprocessed forms, it has significant health benefits.
Testosterone Injections – Curious about testosterone injections Therapy? Read more about what you can expect from this treatment and contact us for more information (866) 224-5698
 D. Mastroiacovo, C. Kwik-Uribe, D. Grassi, S. Necozione, A. Raffaele, L. Pistacchio, R. Righetti, R. Locale, M.C. Lechiara, C. Marini, C. Ferri, G. Desideri, Cocoa flavanol consumption improves cognitive function, blood pressure control, and metabolic profile in elderly subjects: the Cocoa, Cognition, and Aging (CoCoA) Study–a randomized controlled trial, The American journal of clinical nutrition, 101 (2015) 538-548.
 C. Heiss, R. Sansone, H. Karimi, M. Krabbe, D. Schuler, A. Rodriguez-Mateos, T. Kraemer, M.M. Cortese-Krott, G.G. Kuhnle, J.P. Spencer, H. Schroeter, M.W. Marx, M. Kelm, Impact of cocoa flavanol intake on age-dependent vascular stiffness in healthy men: a randomized, controlled, double-masked trial, Age (Dordrecht, Netherlands), 37 (2015) 9794.
 G. Rull, Z.N. Mohd-Zain, J. Shiel, M.H. Lundberg, D.J. Collier, A. Johnston, T.D. Warner, R. Corder, Effects of high flavanol dark chocolate on cardiovascular function and platelet aggregation, Vascular Pharmacology, 71 (2015) 70-78.
 N. Khan, M. Monagas, C. Andres-Lacueva, R. Casas, M. Urpi-Sarda, R.M. Lamuela-Raventos, R. Estruch, Regular consumption of cocoa powder with milk increases HDL cholesterol and reduces oxidized LDL levels in subjects at high-risk of cardiovascular disease, Nutrition, metabolism, and cardiovascular diseases : NMCD, 22 (2012) 1046-1053.
 S. Martinez-Lopez, B. Sarria, J.L. Sierra-Cinos, L. Goya, R. Mateos, L. Bravo, Realistic intake of a flavanol-rich soluble cocoa product increases HDL-cholesterol without inducing anthropometric changes in healthy and moderately hypercholesterolemic subjects, Food & function, 5 (2014) 364-374.
 N. Neufingerl, Y.E. Zebregs, E.A. Schuring, E.A. Trautwein, Effect of cocoa and theobromine consumption on serum HDL-cholesterol concentrations: a randomized controlled trial, The American journal of clinical nutrition, 97 (2013) 1201-1209.
 L. Dubner, J. Wang, L. Ho, L. Ward, G.M. Pasinetti, Recommendations for Development of New Standardized Forms of Cocoa Breeds and Cocoa Extract Processing for the Prevention of Alzheimer’s Disease: Role of Cocoa in Promotion of Cognitive Resilience and Healthy Brain Aging, Journal of Alzheimer’s disease : JAD, 48 (2015) 879-889.
 D. Grassi, C. Lippi, S. Necozione, G. Desideri, C. Ferri, Short-term administration of dark chocolate is followed by a significant increase in insulin sensitivity and a decrease in blood pressure in healthy persons, The American journal of clinical nutrition, 81 (2005) 611-614.
 C.D. Hunt, P.E. Johnson, J. Herbel, L.K. Mullen, Effects of dietary zinc depletion on seminal volume and zinc loss, serum testosterone concentrations, and sperm morphology in young men, The American journal of clinical nutrition, 56 (1992) 148-157.
 P.H. Wirtz, R. von Kanel, R.E. Meister, A. Arpagaus, S. Treichler, U. Kuebler, S. Huber, U. Ehlert, Dark chocolate intake buffers stress reactivity in humans, Journal of the American College of Cardiology, 63 (2014) 2297-2299.
Anavar has been around since 1964. It was bought out by Pfizer in 2003. Since then, it has seen a popular reemergence and has been termed the “safest” steroid available. Unfortunately, this is dangerous and brings confusion to the masses whom misleadingly supplement with this compound.
We have been receiving many requests for Anavar from patients that have shopped around with other local clinics. Sadly, clinics that, despite the consequential ramifications, opt to sell this controlled substance to their patients. Moreover, they do it under the guise of providing medical treatment, when in fact, this is one of the reasons it was once illegal: there is no real medicinal purpose for Anavar.
Anavar has very little androgenic (testosterone Injections) properties. This is the reason it does not aromatize. Only androgens aromatize.
Initially, Anavar was produced to assist patients with lipodystrophy (excessive muscle loss, usually as a result of AIDS).
The Good, The Bad, and The Ugly. First the Good
Because there is no conversion to estrogen with Anavar, blockers nor inhibitors are needed for its use. Estrogen conversion manifest most of the visible side effects men fear from a testosterone therapy program: mood swings, libido loss, water retention, weight gain, etc.
Anavar increases anabolism significantly. This allows the muscle to absorb a lot more protein. Being in anabolic state intensifies the muscle building process. Strong, dense muscles develop and are longer lasting than when developed on other steroids.
Because Anavar has almost no androgenic properties, it does not cause a swift shutdown of HPTA (the process that invites endogenous low testosterone production)
Muscles developed with the aid of Anavar administration are sharper and more cut.
Studies have shown Anavar to diminish visceral (stomach area) fat with only moderate exercise. Most impressively, even after discontinuing usage, the subjects kept off the fat. Of course, they were still exercising and minding their caloric intake.
Anavar can lubricate joints and assist with joint related pain.
Want to know the truth behind why Anavar is considered the “safest” or “most mild” anabolic steroid available? In its pharmaceutical form, Anavar comes in 2.5 mg tablets. At that therapeutic dose, even a child could take it without systemic repercussions. There is basically no negative impact on the liver, even if taken on a daily basis.
To build significant muscle on Anavar alone, at least 50 mg a day would be needed. At these quantities, arduous taxing of the liver is intense and inevitable.
Anavar is a seventeen alpha alkylated. This means it is structured to prevent a breakdown in the liver. This makes the effects of the drug much greater but puts an unimaginably damaging strain on the liver.
The required dosage for effective muscle “building” is what makes legitimate medical claims of Anavar’s “mildness” a myth.
In a nutshell: With Anavar, what makes it safe, makes it not very effective, and once it becomes effective, it is not very safe.
2.5 mg is the pharmaceutical dosage this brand medication comes in. Patients should be wary of 20 mg to 50 mg tablets. Those are only made through UG laboratories. Patients should require their medication come labeled with their name, the prescribing physician’s name and the providing Laboratories information, including DEA number. This info should be followed up with some quick research on the involved laboratory.
Unless you are suffering from acute muscle wasting, there is no medicinal purpose for taking Anavar.
Anavar is actually pretty amazing stuff “if you are a bodybuilder willing to administer illegal substances.” It does have the ability to increase strength significantly in a short period of time. However, at the dosages required for effective muscle building, the liver finds itself under constant attack. This program can only be used as a kick-start program.
Patients prescribed Anavar under the guise of it being a health supplement should consider very carefully the integrity of the organization they are working with.
A “real” Anavar program should not surpass 4 to 6 weeks. Anything beyond that, especially at dosages beyond the 20mg mark, will have impacting effects on the liver.
Real Testosterone Therapy
In conclusion, Anavar, if abused, is actually the real deal. It then works well to strengthen muscles and build rigid, strong tissue. It might even assist with the loss of stubborn belly fat. Unfortunately, 1) the dosage needed makes it unimaginably toxic to the liver and 2) there is no actual medical use for it and cannot be taken for very long at all. For this reason, unless you are a bodybuilder willing to trade in your future health for accelerated, temporary gains now, Anavar should never be on your radar.
If you are looking for a supplement to take to maximize your masculine efficiency while ensuring a health-enjoying, long, quality life in the future, consider learning more about a bio-identical Testosterone replacement protocol.
Again, if you are considering bettering your health, changing your physique, improving your sex life and libido, consider a bio-identical testosterone replacement program. We can provide you the same type of testosterone your body produces. Of course, there is still the potential for side effects but, because it is bio-identical, your body is more receptive to it and you can continue therapy safely for many years. Most importantly, our doctors are experts in the art of Testosterone replacement therapy. We make sure our patients have all the required counterparts to their therapy to ensure better keeping unwanted side effects out of the picture.
A properly administered testosterone injection program can reignite the fire you have lost. It may sound intense, but the results of revitalizing the male body are unparalleled and near impossible to denote. It is simply a reawakening of life; a happier, more efficient life.
Testosterone Effects on Prostate Health.
How That’s Changing.
Testosterone effects on prostate levels and its functionality have always been a delicate topic of conversation. There is a lot of controversy surrounding the different theories on its impact. We have all heard the stories and read the articles where Testosterone injections, or, really any form of testosterone therapy, are allegedly attributed to malignant side effects in the participants. What is most interesting is the notion there actually have not been many studies done focused on that particular reaction to therapy. By this we mean, double-blind, placebo-controlled studies as is the standard of our trusted Food and Drug administration’s qualification process.
We do not want to give off the impression we share this recently accepted hypothesis, which suggests testosterone effects on prostate health do not necessarily have a correlation. However, it is important to shed light on the fact the medical community and its core beliefs and socially accepted diagnoses often shift, and dramatically. Also, as the world awakens, begins to ask more questions and not accepting the typical status quo, we’ve all become a bit more enlightened to the ways of the world. We’ve learned that big pharma and its main directors don’t necessarily have our health or us at the forefront of their decision-making. Many times profits interfere with factual descriptions and publicly distributed medicinal allocations. We must use discernment when we read data and, dig deeper if it’s a matter of personal importance. Everyone who searches finds…
Particularly men on testosterone therapy, they should do their best research to help them better understand the involved variables. Better understanding of testosterone effects on prostate health can help patients make the best determination, based on their personal considering factors.
A recent study led by researchers at NYU Langone Medical Center denoted men prescribed a minimum of 1 year of testosterone injections replacement therapy demonstrated no additional risk for prostate cancer. One researcher, in particular, Stacy Loeb, MD, MSc, who happens to be a urologist at NYU Langone Medical Center shared a different notion. She suggests physicians should continue to evaluate prostate cancer risk factors and better understand functionality and future health— such as age over 40, family history of the disease and black ancestry — among men prescribed testosterone therapy. Dr. Loeb said in a corresponding press release, “they should not hesitate to prescribe [testosterone therapy] to appropriate patients for fear of increasing prostate cancer risk.”
In their research to better understand testosterone injections effects on prostate health, Dr. Loeb and her contemporaries collected data from close to 25 million medical files on a group of men. These men were enumerated in the National Prostate Cancer Register and Prescribed Drug Register in Sweden.
They were able to classify 38,570 men diagnosed with prostate cancer between 2009 and 2012. Of these men, 284 received testosterone therapy treatments prior to their prostate tissue diagnosis. These numbers were then compared to the results of 192,838 men who showed no development of cancer in the prostate. Most interestingly, 1,378 of those men had been on testosterone therapy.
Multivariable examination helped conclude no significant association between any kind of testosterone injections replacement therapy and prostate cancer risk (OR = 1.03; 95% CI, 0.9-1.17). In fact, the results suggested a 35% increase in low-risk prostate cancer occurrence after the commencement of a testosterone therapy regimen (OR = 1.35; 95% CI, 1.16-1.56). Results also showed a lower risk of aggressive disease among men who used testosterone injections replacement therapy for more than a year (OR = 0.5; 95% CI, 0.37-0.67).
From this analysis, the demarcations indicating the lessened potential for testosterone injections therapy to have a negative side effect on the prostate are significantly prominent. Testosterone injections effects on prostate health and blood testing levels shown to have little to no association. That being said, until the concrete information has changed the national standard on this widespread opinion, AAI Rejuvenation Clinic will continue to supplement each one of our therapies with the necessary medicinal requirements currently utilized to maintain possible, unwanted side effects from interfering with a successful testosterone therapy treatment. If you have any questions or comments related to this subject, please fill out our short contact form and someone will reach you within 24 hours. Make sure to leave your phone number. You can also call us directly by dialing:
Testosterone Cypionate Description injection for intramuscular injection contains Testosterone Cypionate which is the oil-soluble 17 (beta)- cyclopentyl propionate ester of the androgenic hormone testosterone. Testosterone Cypionate is a white or creamy white crystalline powder, odorless or nearly so and stable in air. It is insoluble in water, freely soluble in alcohol, chloroform, dioxane, ether, and soluble in vegetable oils. The chemical name for Testosterone Cypionate is androst-4-en-3-one,17-(3-cyclopentyl-1-oxopropoxy)-, (17β)-. Its molecular formula is C27H40O3, and the molecular weight 412.61.
The structural formula is represented below:
Testosterone Cypionate injection, USP is available in two strengths, 100 mg/mL and 200 mg/mL Testosterone Cypionate, USP.
Endogenous androgens are responsible for normal growth and development of the male sex organs and for maintenance of secondary sex characteristics. These effects include growth and maturation of the prostate, seminal vesicles, penis, and scrotum; development of male hair distribution, such as beard, pubic, chest, and axillary hair; laryngeal enlargement, vocal cord thickening, and alterations in body musculature and fat distribution. Drugs in this class also cause retention of nitrogen, sodium, potassium, and phosphorous, and decreased urinary excretion of calcium. Androgens have been reported to increase protein anabolism and decrease protein catabolism. Nitrogen balance is improved only when there is sufficient intake of calories and protein.
Androgens are responsible for the growth spurt of adolescence and for eventual termination of linear growth, brought about by fusion of the epiphyseal growth centers. In children, exogenous androgens accelerate linear growth rates but may cause a disproportionate advancement in bone maturation. Use over long periods may result in fusion of the epiphyseal growth centers and termination of the growth process. Androgens have been reported to stimulate the production of red blood cells by enhancing production of erythropoietic stimulation factor.
During exogenous administration of androgens, endogenous testosterone release is inhibited through feedback inhibition of pituitary luteinizing hormone (LH). At large doses of exogenous androgens, spermatogenesis may also be suppressed through feedback inhibition of pituitary follicle stimulating hormone (FSH).
There is a lack of substantial evidence that androgens are effective in fractures, surgery, convalescence, and functional uterine bleeding.
Testosterone esters are less polar than free testosterone. Testosterone esters in oil injected intramuscularly are absorbed slowly from the lipid phase; thus, Testosterone Cypionate can be given at intervals of two to four weeks.
Testosterone in plasma is 98 percent bound to a specific testosterone-estradiol binding globulin, and about 2 percent is free. Generally, the amount of this sex-hormone binding globulin in the plasma will determine the distribution of testosterone between free and bound forms, and the free testosterone concentration will determine its half-life.
About 90 percent of a dose of testosterone injections is excreted in the urine as glucuronic and sulfuric acid conjugates of testosterone and its metabolites; about 6 percent of a dose is excreted in the feces, mostly in the unconjugated form. Inactivation of testosterone occurs primarily in the liver. Testosterone therapy is metabolized to various 17-keto steroids through two different pathways.
The half-life of Testosterone Cypionate, when injected intramuscularly, is approximately eight days.
In many tissues, the activity of testosterone therapy appears to depend on reduction to dihydrotestosterone, which binds to cytosol receptor proteins. The steroid-receptor complex is transported to the nucleus where it initiates transcription events and cellular changes related to androgen action.
Indications and Usage for Testosterone Cypionate description
Testosterone Cypionate description injection is indicated for replacement therapy in the male in conditions associated with symptoms of deficiency or absence of endogenous testosterone.
Primary hypogonadism (congenital or acquired)-testicular failure due to cryptorchidism, bilateral torsion, orchitis, vanishing testis syndrome; or orchidectomy.
Hypogonadotropic hypogonadism (congenital or acquired): gonadotropin or LHRH deficiency, or pituitary-hypothalamic injury from tumors, trauma, or radiation.
Safety and efficacy of Testosterone Cypionate description in men with “age-related hypogonadism” (also referred to as “late-onset hypogonadism”) have not been established.
Known hypersensitivity to the drug
Males with carcinoma of the breast
Males with known or suspected carcinoma of the prostate gland
Women who are or who may become pregnant
Patients with serious cardiac, hepatic or renal disease
Hypercalcemia may occur in immobilized patients. If this occurs, the drug should be discontinued.
Prolonged use of high doses of androgens (principally the 17-α alkyl-androgens) has been associated with the development of hepatic adenomas, hepatocellular carcinoma, and peliosis hepatis —all potentially life-threatening complications.
Geriatric patients treated with androgens may be at an increased risk of developing prostatic hypertrophy and prostatic carcinoma although conclusive evidence to support this concept is lacking.
There have been postmarketing reports of venous thromboembolic events, including deep vein thrombosis (DVT) and pulmonary embolism (PE), in patients using testosterone products, such as Testosterone Cypionate description. Evaluate patients who report symptoms of pain, edema, warmth, and erythema in the lower extremity for DVT and those who present with acute shortness of breath for PE. If a venous thromboembolic event is suspected, discontinue treatment with Testosterone Cypionate description and initiate appropriate workup and management.
Long term clinical safety trials have not been conducted to assess the cardiovascular outcomes of testosterone replacement therapy in men. To date, epidemiologic studies and randomized controlled trials have been inconclusive for determining the risk of major adverse cardiovascular events (MACE), such as non-fatal myocardial infarction, non-fatal stroke, and cardiovascular death, with the use of testosterone compared to non-use. Some studies, but not all, have reported an increased risk of MACE in association with the use of testosterone replacement therapy in men. Patients should be informed of this possible risk when deciding whether to use or to continue to use Testosterone Cypionate description.
Edema, with or without congestive heart failure, may be a serious complication in patients with preexisting cardiac, renal or hepatic disease.
Gynecomastia may develop and occasionally persists in patients being treated for hypogonadism.
The preservative benzyl alcohol has been associated with serious adverse events, including the “gasping syndrome”, and death in pediatric patients. Although normal therapeutic doses of this product ordinarily deliver amounts of benzyl alcohol that are substantially lower than those reported in association with the “gasping syndrome”, the minimum amount of benzyl alcohol at which toxicity may occur is not known. The risk of benzyl alcohol toxicity depends on the quantity administered and the hepatic capacity to detoxify the chemical. Premature and low-birth weight infants may be more likely to develop toxicity.
Androgen therapy should be used cautiously in healthy males with delayed puberty. The effect on bone maturation should be monitored by assessing the bone age of the wrist and hand every 6 months. In children, androgen treatment may accelerate bone maturation without producing a compensatory gain in linear growth. This adverse effect may result in compromised adult stature. The younger the child the greater the risk of compromising final mature height.
This drug has not been shown to be safe and effective for the enhancement of athletic performance. Because of the potential risk of serious adverse health effects, this drug should not be used for such purpose.
Patients with benign prostatic hypertrophy may develop acute urethral obstruction. Priapism or excessive sexual stimulation may develop. Oligospermia may occur after prolonged administration or excessive dosage. If any of these effects appear, the androgen should be stopped and if restarted, a lower dosage should be utilized.
Testosterone Cypionate description should not be used interchangeably with testosterone propionate description because of differences in duration of action.
Testosterone Cypionate description is not for intravenous use.
Information for Patients
Patients should be instructed to report any of the following: nausea, vomiting, changes in skin color, ankle swelling, too frequent or persistent erections of the penis.
Hemoglobin and hematocrit levels (to detect polycythemia) should be checked periodically in patients receiving long-term androgen administration.
Serum cholesterol may increase during androgen therapy.
Androgens may increase sensitivity to oral anticoagulants. The dosage of the anticoagulant may require a reduction in order to maintain satisfactory therapeutic hypoprothrombinemia.
Concurrent administration of oxyphenbutazone and androgens may result in elevated serum levels of oxyphenbutazone.
In diabetic patients, the metabolic effects of androgens may decrease blood glucose and, therefore, insulin requirements.
Drug/Laboratory Test Interferences
Androgens may decrease levels of thyroxine-binding globulin, resulting in decreased total T4 serum levels and increased resin uptake of T3 and T4. Free thyroid hormone levels remain unchanged, however, and there is no clinical evidence of thyroid dysfunction.
Testosterone has been tested by subcutaneous injection and implantation in mice and rats. The implant induced cervical-uterine tumors in mice, which metastasized in some cases. There is suggestive evidence that injection of testosterone into some strains of female mice increases their susceptibility to hepatoma. Testosterone is also known to increase the number of tumors and decrease the degree of differentiation of chemically induced carcinomas of the liver in rats.
There are rare reports of hepatocellular carcinoma in patients receiving long-term therapy with androgens in high doses. Withdrawal of the drugs did not lead to regression of the tumors in all cases.
Geriatric patients treated with androgens may be at an increased risk of developing prostatic hypertrophy and prostatic carcinoma although conclusive evidence to support this concept is lacking.
Pregnancy Category X. (See CONTRAINDICATIONS)
Benzyl alcohol can cross the placenta. See WARNINGS.
Testosterone Cypionate description is not recommended for use in nursing mothers.
Safety and effectiveness in pediatric patients below the age of 12 years have not been established.
The following adverse reactions in the male have occurred with some androgens:
Endocrine and urogenital: Gynecomastia and excessive frequency and duration of penile erections. Oligospermia may occur at high dosages.
Skin and Appendages: Hirsutism, male pattern of baldness, seborrhea, and acne.
You can’t read anything about testosterone therapy without it being followed up with a warning about prostate issues and even prostate cancer. It was common knowledge that if you participated in Testosterone therapy, then you were ultimately going to suffer from prostate issues. Testosterone therapy has represented as a proverbial pact with the devil, by trading short-term sexual and physical rewards for the ultimate development of malignant cancer.
For the longest time, the medical community theorized that testosterone replacement therapy increased one’s risk of prostate cancer. Now, physician, Harvard-based Abraham Morgentaler, MD, FACS, has shown this theory to be inaccurate. Contrary to the notion that restoring testosterone to youthful levels is somehow risky, Dr. Morgentaler meticulously shows that there is also an increased risk of prostate cancer in aging men with low testosterone. This exact information about the dangers of declining testosterone levels was detailed quite a while back, actually, by the Life Extension Foundation.
In his book, Dr. Morgentaler details how a medical myth can be accepted by the medical community, and furthermore, by the masses, it could take years, even decades for that misinformation to be reestablished. For instance, the establishment’s misconception about testosterone and prostate cancer, which has condemned millions of aging men to suffer degenerative diseases caused by dwindling testosterone levels until just a few years ago. It was almost universally believed that Testosterone protocols would lead to some degree of increased risk of prostate issues or even cancer. Fortunately, this belief has been shown to be incorrect, and medical opinion has begun to shift quite dramatically, with good evidence that testosterone therapy is quite safe for the prostate. There is even now a growing concern that low testosterone is a risk for prostate cancer rather than high testosterone.
The very origin of the idea that Testosterone therapy causes prostate cancer is a fantastic story involving Nobel Prize winners, medical breakthroughs, and a critical paradox that took two-thirds of a century to solve.
The relationship of testosterone to prostate cancer has undergone a significant re-evaluation, and all recent evidence has reinforced the position that testosterone therapy is safe for the prostate.
The advantage of living in the 21st century is that you don’t have to take any information at face value. You should always take the time to complete your own research and investigate the information that you are being served as fast. We are fortunate that we live in a time where we can take charge and find answers and details to information we would not have had access to 10 years ago. Especially taking into account how contradicting and negative most of the information regarding the health of your prostate and testosterone therapy. It’s imperative that you take this outdated idea and do your own research.
Imagine if you are living in the fog of low testosterone based on misinformation. How devastating would it be to find out that your knowledge base was completely inaccurate? How would you feel to know that the past decade you could have felt better, looked better or been better?
Don’t let that happen to you. At AAI, we process comprehensive panels to ensure that you are healthy enough to undergo hormone therapy and keep unwanted side effects at bay. Furthermore, we schedule periodic follow-ups, based on your program, to check and see how your hormones are progressing while on therapy, to ensure your dosage is just right for you throughout the duration of your program.
Call us for more information or fill out the Medical History Form located in our header.
We look forward to hearing from you.
Testosterone Injections is the most common treatment for men going through andropause. This therapy may provide help and relief from the symptoms and help improve the quality of life in many cases, also lifestyle changes such as increased exercise, stress reduction, and proper nutrition also help.
Testosterone therapy is available in different forms, ask your doctor he will help determine which treatment is best for you.
TESTOSTERONE INJECTIONS: This treatment involves doses of bioidentical (Testosterone Cypionate, Testosterone Enanthate, and Testosterone Propionate).
TESTOSTERONE PATCHES: People who wear a piece containing testosterone receive the hormone through the skin. The patches allow a slow, steady release of testosterone into the bloodstream.
TESTOSTERONE GEL: This treatment is also applied directly to the skin, usually on the arms. Because the gel may transfer to other individuals through skin contact, a person must take care to wash the gel from the hands after each application.
TESTOSTERONE CAPSULES: This is yet another option for testosterone replacement. Men with liver disease, poor liver function, severe heart or kidney disease, or too much calcium in their blood should avoid testosterone capsules.
Follow-up visits with your doctor will be necessary after the initial treatment begins. At follow-up visits, your doctor will check your response to the treatment and make adjustments, if necessary.
**NOTE** The content contained in this blog is subject to interpretation and is the opinion of the content writer. We do not claim it to be fact. We encourage you to consult a medical doctor before taking any prescribed medications or supplements.
The influence of testosterone towards sexual function and libido isn’t emphasized enough. Even though it is implicated in study after study, the need for all persons to have their testosterone therapy levels properly balanced is essential. It’s an intricate part of a properly functioning endocrine system, which is critical for feeling healthy. Testosterone injections are among the most potent of libido-enhancing agents known to mankind. Testosterone therapy is effective in raising a person’s testosterone levels. This can certainly have a positive, “rising” effect on the desire for sexual contact.