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March 30, 2018 by Joseph Fermin 0 Comments

Green Beginnings Helps Boost Testosterone 5 (4)

Green Beginnings Smoothie

Want to try Green Beginnings Smoothie, This straightforward guide takes you from zero to deliciously green in just 5 minutes! I make these things almost every morning as a way to get the tulip-man, and I filled up and ready for the day (and to pack in a few servings of veggies without bothering before 9 am).

Green Beginnings Smoothie Ingredients, The nutrient green appears to be effective in reducing symptoms of acne when ingested regularly.

  • Almond Milk 8 fl oz 262g
  • Apple 1 medium (3″ dia) 182g
  • Avocado 1 fruit, without skin and seed 136g
  • Celery 3 stalk, large (11″-12″ long) 192g
  • Ice 2 cup 252g
  • Lemon ½ fruit (2-3/8″ dia) 42g
  • Spinach 2 cups 60g

Depression, There’s a notable depression reduction treatment and used zinc as an add-on to help improve their symptoms while using anti-depressant medication. Minor improvements in mood and depressive symptoms.

A migraine, Riboflavin (also known as Vitamin B2) appears to reduce the frequency of headaches significantly. It also notably minimizes the intensity of migraines, but the optimal amount isn’t known yet as most studies used 400mg, but one study found similar improvements with just 25mg.

Weight Loss, Subjects who fed more power than baseline energy gained weight without any changes in energy expenditure.

Lower Blood Pressure, Using magnesium shows a significant reduction in blood pressure, assuming one of two conditions. Either the subject is deficient in magnesium already, or the question has a blood pressure of 140/90 or above. A deficiency in magnesium was not a requirement for the items to reduce their blood pressure.

Increase Testosterone, Men taking 3,332 IU of Vitamin D over the course of a year observed an increase in their testosterone levels.

Lower Triglycerides, Subjects with dyslipidemia showed a substantial decrease of triglycerides when given doses of niacin.

testosterone-injections

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March 28, 2018 by Joseph Fermin 0 Comments

Red Velvet Smoothie Helps Boost Testosterone 5 (4)

Red Velvet Smoothie

Red velvet smoothie that tastes as great. It’s called Red Velvet because the tested of the desert-like flavor profile of the cake with the same name.

Red Velvet Smoothie Ingredients, Scrub the beet thoroughly to avoid the taste. You can also peel for better flavors.

  • Almond Milk 8 fl oz 262g
  • Banana 1 large (8″ to 8-7/8″ long) 136g
  • Beet Root 1 beet (2″ dia) 82g
  • Cocoa Powder 2 tbsp 10.8g
  • Date (Medjool) 2 date, pitted 48g
  • Honey 1 tbsp 21g
  • Strawberry 4 medium (1-1/4″ dia) 48g

Depression, symptoms while using anti-depressant medication. Minor improvements in mood and depressive symptoms.

A migraine, Riboflavin (also known as Vitamin B2) appears to reduce a frequency of headaches significantly. It also notably minimizes the intensity of migraines, but the optimal amount isn’t known yet as most studies used 400mg, but one study found similar improvements with just 25mg.

Hair Regrowth, A study noted 100mg of Vitamin E was able to promote hair growth in subjects with alopecia relative to placebo.

Lower Blood Pressure, Using magnesium shows a significant reduction in blood pressure, assuming one of two conditions. Either the subject is deficient in magnesium already, or the question has a blood pressure of 140/90 or above. A deficiency in magnesium was not a requirement for the items to reduce their blood pressure.

Increase Testosterone, Men taking 3,332 IU of Vitamin D over the course of a year observed an increase in their testosterone levels.

Lower Triglycerides, Subjects with dyslipidemia showed a substantial decrease of triglycerides when given doses of niacin.

 

testosterone-injections

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January 30, 2018 by Joseph Fermin 0 Comments

Testosterone Therapy Improves Sexual Interest In Older Men 5 (4)

Testosterone Therapy Improves Sexual Interest in older men, and a controlled study to date finds testosterone can address low libido, erectile dysfunction

Testosterone Therapy Improves Sexual Interest In Older Men, the Older men with low libido and low testosterone levels showed more interest in sex and engaged in the more sexual activity when they underwent testosterone therapy, according to a new study published in the Endocrine Society’s Journal of Clinical Endocrinology & Metabolism.

The study of Testosterone Therapy Improves Sexual Interestis the most significant placebo-trial in older men conducted. The sexual function study is part of the Testosterone Injections Trials, a series of seven studies examining the effectiveness of testosterone therapy in men who are 65 or older, who have low testosterone levels and are experiencing symptoms of low testosterone deficiency. The research is supported primarily by the National Institutes of Health.

Testosterone is an essential a male sex hormone help in maintaining Libido, sex drive, erectile function, and sperm production and much more. The Endocrine Society’s Clinical Practice Guideline recommends using testosterone therapy to treat men with symptoms of androgen deficiency and low testosterone levels.

In the past 50 years, use of injectable testosterone therapy has rapidly expanded among men population. Testosterone levels decline as men age, as early as 30 years old and some men develop low testosterone symptoms.

The placebo-controlled effect and double-blinded trial examined the effect of injectable testosterone therapy on sexual function in a group of 470 men. The men were in the study through 12 academic medical control centers. The participants were at least 65 years old and older, with low testosterone levels, based on the average results of multiple tests.

Testosterone Therapy Improves Sexual Interest, The men treated with injectable testosterone therapy displayed consistent improvement in libido and 10 of the 12 sexual activity measurements, nighttime erections, masturbation, and including frequency of intercourse. In comparison, with men who received the placebo testosterone did not change their responses over the year-long medical study done.

testosterone-injections

 

Testosterone Injections is the most common treatment for men going through andropause. This therapy may provide help and relief from the symptoms and help improve the quality of life in many cases, also lifestyle changes such as increased exercise, stress reduction, and proper nutrition also help.

Testosterone therapy is available in different forms, ask your doctor he will help determine which treatment is best for you.

TESTOSTERONE INJECTIONS: This treatment involves doses of bioidentical (Testosterone Cypionate, Testosterone Enanthate, and Testosterone Propionate).

TESTOSTERONE PATCHES: People who wear a piece containing testosterone receive the hormone through the skin. The patches allow a slow, steady release of testosterone into the bloodstream.

TESTOSTERONE GEL: This treatment is also applied directly to the skin, usually on the arms. Because the gel may transfer to other individuals through skin contact, a person must take care to wash the gel from the hands after each application.

TESTOSTERONE CAPSULES: This is yet another option for testosterone replacement. Men with liver disease, poor liver function, severe heart or kidney disease, or too much calcium in their blood should avoid testosterone capsules.

Follow-up visits with your doctor will be necessary after the initial treatment begins. At follow-up visits, your doctor will check your response to the treatment and make adjustments, if necessary.

November 13, 2017 by Joseph Fermin 0 Comments

An Inside Look at Testosterone Injections Therapy 5 (1)

Inside Look Testosterone Injections Therapy

testosterone injections therapyTESTOSTERONE INJECTIONS THERAPY

Testosterone is an essential factor in males, that does more for men than just promote sex drive. Low Testosterone levels decline as a part of healthy aging and are the cause of several physiological changes. Low Testosterone level symptoms include;

1) Reduced Motivation
2) Erectile Dysfunction
3) Loss of Libido or sex drive
4) Fatigue and low energy
5) Increased Cholesterol Levels
6) Memory and Concentration
7) Decreased Muscle Mass
8) Thyroid Dysfunction and more

Since these symptoms are common in low testosterone, physicians will often include hormone levels as part of routine blood work. Normal levels of testosterone are between 300 and 1,000 ng/dL. If a blood test shows that your levels are far below the norm, your doctor may suggest testosterone injections. The treatment is called TRT.

SYMPTOMS OF LOW TESTOSTERONE

Most men naturally start losing testosterone when they hit their 30’s. (low T). Common symptoms of low Testosterone include:

1) Erectile dysfunction (ED)
2) Changes in sex drive
3) Decreased sperm count
4) Depression or anxiety
5) Weight gain
6) Hot flashes

TESTOSTERONE AND DIAGNOSIS

Many men may want to diagnose themselves with a testosterone kit. The problem with self-diagnosis is that many of the symptoms of low Testosterone are healthy parts of aging. So using it for diagnosis isn’t reliable. Our doctor may order testosterone blood test. It is the only way to find out if you have low testosterone.

To get a perfect reading our doctor will take a look at your health history, physical exam and blood test to measure your testosterone levels. You’ll also likely have a test that measures your red blood cell count.

POTENTIAL BENEFITS OF TESTOSTERONE INJECTIONS THERAPY 

The purpose of Testosterone Injections Therapy is to help regulate hormone levels and to help address problems related to low Testosterone. For men with low Testosterone, the benefits of these injections can include:

1)  Motivation and Memory Loss
2)  Sex Drive & Desire
3)  Depression and Energy
4)  Cholesterol and Osteoporosis
5)  Erectile Dysfunction
6)  Muscle Mass and Better Sleep
7)  Wounds healing & Illness
8)  Thyroid Dysfunction and more

TESTOSTERONE CAN HELP WITH FAT AND MUSCLE CHANGES

Men have less body fat than women; This is partly related to testosterone, which regulates the fat in the body and muscle maintenance in your body. You’ll likely also notice an increase in body fat, especially around your midsection.

Your hormones also help regulate muscle growth. So, with low Testosterone, you may feel like you’re losing muscle size or strength.

Testosterone shots regulate fat distribution, but you shouldn’t expect significant weight loss changes from hormone therapy alone, without exercise. As for maintenance of muscle, testosterone therapy has been found to improve increase muscle mass, but not strength.

TESTOSTERONE INJECTIONS THERAPY AND SPERM COUNT

Low sperm count in men is a common side effect of low Testosterone. This problem can make it difficult to get your partner pregnant.

TESTOSTERONE INJECTIONS THERAPY AND THE BOTTOM LINE

Testosterone injections therapy can only be helpful If you just have low Testosterone. If you’re wondering if testosterone is a right choice for you, ask your doctor. They can test you for low Testosterone. Ask your doctors, or Give us a call, if testosterone injections therapy would be a good choice for you.

If you don’t end up having low Testosterone but still feel like your hormone levels might be off, keep in mind that proper Food, Regular exercise, could help you increase testosterone naturally and make you feel better. If that doesn’t help, be sure you contact us for help.

October 25, 2016 by Joseph Fermin 3 Comments

Turmeric Health Benefits 5 (1)

Turmeric and The Health Benefits

Turmeric, Several plants, and their extracts have been reported to have health benefits, and it can be difficult to know what is true. Are all these things as good as they seem? For turmeric, the answer is a resounding yes!

Turmeric is an herbal plant grown in Asia. The roots are used to make the yellow spice turmeric, which is most commonly used in Indian, Pakistani, Bangladeshi, and Iranian cooking. It is the main spice in curries and is also used to color cheese and butter.

Although the health benefits of turmeric have been known for thousands of years in traditional Chinese and Ayurvedic medicine, it has only recently been appreciated in Western medicine. Curcumin is a phenolic curcuminoid that is thought to be responsible for many of the health benefits of turmeric. It has potent and well-characterized antioxidative and anti-inflammatory effects. Read on to learn more about the other ways in which this amazing spice can boost your health.

turmeric

 

Anticancer effects

Cancer development is a highly complex process that involves DNA damage, inflammation, and the disruption of cellular signaling and death pathways. Although the data are preliminary, there is a certain amount of excitement in the oncology community because curcumin can affect several of these pathways to exert anticancer effects.

Specific clinical trials in patients with cancer are ongoing, but the available results suggest that curcumin could be an effective treatment for multiple cancers, including multiple myeloma, head, and neck squamous cell carcinoma, and pancreatic, prostate, breast, colorectal, lung, and oral cancers [1].

 

Cognitive function

An exciting recent discovery is that turmeric could improve cognitive function in elderly individuals. An Australian study published in April 2016 administered placebo control or a form of curcumin to 96 community-dwelling older adults for 1 year. Various cognitive functions were tested before treatment and at 6- and 12-months. Subjects that received placebo exhibited a cognitive decline at 6 months, whereas those that received curcumin did not [2].

Although the Australian study was not definitive, the available data suggest that curcumin could have several anti-Alzheimer’s disease effects such as preventing the production and aggregation of β-amyloid in the brain and also regenerating brain cells [3]. Taken together, these data suggest that the regular intake of turmeric might reduce the aging-associated decline in cognitive function.

 brain-and-boosts

 

Increase testosterone levels

As anyone reading this blog understands, declining testosterone levels during normal aging are associated with several negative effects on health. Recent research has suggested that turmeric might increase testosterone levels in different ways. First, it can help reverse a number of conditions that can contribute to reduced low testosterone production, such as high cholesterol and dysregulated blood sugar.

The anti-oxidative effects of turmeric can also prevent oxidative damage to Leydig cells in the testis, which could, in turn, normalize with testosterone injections. In mice, turmeric could improve fertility by protecting the testes from various stressors [4, 5].

Who knew that eating curry could improve your testosterone levels and fertility!

 

Metabolic diseases

Curcumin exhibits a seemingly endless number of beneficial metabolic effects. For example:

  • It can increase the levels of HDL or good cholesterol and lower the levels of LDL or bad cholesterol [6]. This is important because low HDL levels and high LDL levels are risk factors for metabolic syndrome and type 2 diabetes.
  • It reduces blood glucose levels and improves glucose metabolism in rodent models, suggesting that it could be an effective treatment for diabetes [7].

 

How to make the most of your turmeric intake

Now you know about just some of the health benefits of turmeric, it is important to understand how to make the most of it. As with all drugs or supplements, the actions of turmeric are limited by its bioavailability, which is defined as the amount that is biologically available to exert its physiological effects. The bioavailability of a drug declines as it is metabolized in the liver, which is a particular concern with any drug or supplement that is administered orally.

One of the best ways to increase the bioavailability of curcumin is to consume turmeric-rich foods with black pepper. Black pepper contains a substance named piperine, which is a potent inhibitor of UDP-glucuronosyltransferase (one of the liver enzymes responsible for drug metabolism) [8]. Indeed, eating even a small amount of piperine with turmeric could increase the bioavailability of turmeric by around 2000% [9].

Curcumin absorption can also be enhanced by consuming turmeric with fats because turmeric is fat-soluble. There are two ways to achieve this: ingest turmeric powder with a healthy fat such as olive oil, or consume natural turmeric root, which contains natural oils that promote its solubility.

Testosterone Injections – Curious about testosterone injections Therapy? Read more about what you can expect from this treatment and contact us for more information (866) 224-5698

References

  1. Gupta, S.C., S. Patchva, and B.B. Aggarwal, Therapeutic Roles of Curcumin: Lessons Learned from Clinical Trials. The AAPS Journal, 2013. 15(1): p. 195-218.
  2. Rainey-Smith, S.R., et al., Curcumin and cognition: a randomised, placebo-controlled, double-blind study of community-dwelling older adults. British Journal of Nutrition, 2016. 115(12): p. 2106-2113.
  3. Goozee, K.G., et al., Examining the potential clinical value of curcumin in the prevention and diagnosis of Alzheimer’s disease. Br J Nutr, 2016. 115(3): p. 449-65.
  4. Lin, C., et al., Curcumin dose-dependently improves spermatogenic disorders induced by scrotal heat stress in mice. Food Funct, 2015. 6(12): p. 3770-7.
  5. Coskun, G., et al., Ameliorating effects of curcumin on nicotine-induced mice testes. Turk J Med Sci, 2016. 46(2): p. 549-60.
  6. Yang, Y.S., et al., Lipid-lowering effects of curcumin in patients with metabolic syndrome: a randomized, double-blind, placebo-controlled trial. Phytother Res, 2014. 28(12): p. 1770-7.
  7. Nabavi, S.F., et al., Curcumin: a natural product for diabetes and its complications. Curr Top Med Chem, 2015. 15(23): p. 2445-55.
  8. Grill, A.E., B. Koniar, and J. Panyam, Co-delivery of natural metabolic inhibitors in a self-microemulsifying drug delivery system for improved oral bioavailability of curcumin. Drug Deliv Transl Res, 2014. 4(4): p. 344-52.
  9. Shoba, G., et al., Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Med, 1998. 64(4): p. 353-6.

August 25, 2016 by admin 3 Comments

Anavar: The Good, The Bad and The Ugly 5 (1)

Pros and Cons of Anavar

Anavar has been around since 1964. It was bought out by Pfizer in 2003. Since then, it has seen a popular reemergence and has been termed the “safest” steroid available. Unfortunately, this is dangerous and brings confusion to the masses whom misleadingly supplement with this compound.

Anavar

We have been receiving many requests for Anavar from patients that have shopped around with other local clinics. Sadly, clinics that, despite the consequential ramifications, opt to sell this controlled substance to their patients. Moreover, they do it under the guise of providing medical treatment, when in fact, this is one of the reasons it was once illegal: there is no real medicinal purpose for Anavar.

  • Anavar is an anabolic steroid.
  • Anavar is not a bio-identical hormone, as is testosterone.
  • Anavar has very little androgenic (testosterone Injections) properties. This is the reason it does not aromatize. Only androgens aromatize.
  • Initially, Anavar was produced to assist patients with lipodystrophy (excessive muscle loss, usually as a result of AIDS).

The Good, The Bad, and The Ugly.
First the Good

  • Because there is no conversion to estrogen with Anavar, blockers nor inhibitors are needed for its use. Estrogen conversion manifest most of the visible side effects men fear from a testosterone therapy program: mood swings, libido loss, water retention, weight gain, etc.
  • Anavar increases anabolism significantly. This allows the muscle to absorb a lot more protein. Being in anabolic state intensifies the muscle building process. Strong, dense muscles develop and are longer lasting than when developed on other steroids.
  • Because Anavar has almost no androgenic properties, it does not cause a swift shutdown of HPTA (the process that invites endogenous low testosterone production)
  • Muscles developed with the aid of Anavar administration are sharper and more cut.
  • Studies have shown Anavar to diminish visceral (stomach area) fat with only moderate exercise. Most impressively, even after discontinuing usage, the subjects kept off the fat. Of course, they were still exercising and minding their caloric intake.
  • Anavar can lubricate joints and assist with joint related pain.

The Bad

  • Want to know the truth behind why Anavar is considered the “safest” or “most mild” anabolic steroid available? In its pharmaceutical form, Anavar comes in 2.5 mg tablets. At that therapeutic dose, even a child could take it without systemic repercussions. There is basically no negative impact on the liver, even if taken on a daily basis.
  • To build significant muscle on Anavar alone, at least 50 mg a day would be needed. At these quantities, arduous taxing of the liver is intense and inevitable.
  • Anavar is a seventeen alpha alkylated. This means it is structured to prevent a breakdown in the liver. This makes the effects of the drug much greater but puts an unimaginably damaging strain on the liver.
  • The required dosage for effective muscle “building” is what makes legitimate medical claims of Anavar’s “mildness” a myth.
  • In a nutshell: With Anavar, what makes it safe, makes it not very effective, and once it becomes effective, it is not very safe.

The Ugly

  • 2.5 mg is the pharmaceutical dosage this brand medication comes in. Patients should be wary of 20 mg to 50 mg tablets. Those are only made through UG laboratories. Patients should require their medication come labeled with their name, the prescribing physician’s name and the providing Laboratories information, including DEA number. This info should be followed up with some quick research on the involved laboratory.
  • Unless you are suffering from acute muscle wasting, there is no medicinal purpose for taking Anavar.
  • Anavar is actually pretty amazing stuff “if you are a bodybuilder willing to administer illegal substances.” It does have the ability to increase strength significantly in a short period of time. However, at the dosages required for effective muscle building, the liver finds itself under constant attack. This program can only be used as a kick-start program.
  • Patients prescribed Anavar under the guise of it being a health supplement should consider very carefully the integrity of the organization they are working with.
  • A “real” Anavar program should not surpass 4 to 6 weeks. Anything beyond that, especially at dosages beyond the 20mg mark, will have impacting effects on the liver.
Real Testosterone Therapy

anavarIn conclusion, Anavar, if abused, is actually the real deal. It then works well to strengthen muscles and build rigid, strong tissue. It might even assist with the loss of stubborn belly fat. Unfortunately, 1) the dosage needed makes it unimaginably toxic to the liver and 2) there is no actual medical use for it and cannot be taken for very long at all. For this reason, unless you are a bodybuilder willing to trade in your future health for accelerated, temporary gains now, Anavar should never be on your radar.

If you are looking for a supplement to take to maximize your masculine efficiency while ensuring a health-enjoying, long, quality life in the future, consider learning more about a bio-identical Testosterone replacement protocol.

Again, if you are considering bettering your health, changing your physique, improving your sex life and libido, consider a bio-identical testosterone replacement program. We can provide you the same type of testosterone your body produces. Of course, there is still the potential for side effects but, because it is bio-identical, your body is more receptive to it and you can continue therapy safely for many years. Most importantly, our doctors are experts in the art of Testosterone replacement therapy. We make sure our patients have all the required counterparts to their therapy to ensure better keeping unwanted side effects out of the picture.

A properly administered testosterone injection program can reignite the fire you have lost. It may sound intense, but the results of revitalizing the male body are unparalleled and near impossible to denote. It is simply a reawakening of life; a happier, more efficient life.

Testosterone Therapy Information

July 18, 2016 by admin 1 Comment

Acai Berries 5 (1)

Acai Berries ~ The Antioxidant Powerhouse

acai berriesAcai Berries have one of the highest antioxidant values of any other known food at the moment. They have been studied and noted to be an effective COX-2 inhibitor and anti-inflammatory. These details are based on testing that was recorded in Gainesville, FL in April of 2006. [1]

There was also a study conducted by the Journal of Agricultural and Food Chemistry in January of 2006. This publication denoted extract from Acai berries triggered a self-destruct response in up to 86% of leukemia cells tested. Stephen Talcott elaborated on details. He is an assistant professor at the University of Florida’s Institute of Food and Agricultural Sciences. [2] The great news about Acai berries is anyone can eat them. Even diabetics and cancer patients can enjoy them because acai berries have no sugar content.

  • The health benefits of Acai berries are one of the highest of all the fruits in Anthocyanins levels. It barely trails behind the purple sweet potato overall. These high levels of Anthocyanins are also thought to help lower cholesterol.
  • The anthocyanins appear to prevent lipid peroxidation and the accumulation of deposits on arterial walls. One great way to enjoy these benefits is by purchasing Acai Powder.

You can find this by doing a simple Google search. There is a trusted brand we recommend you consider. It has no affiliation to AAI clinics, however, after careful review, use and comparison, acai berriesthe Sambazon, USDA Organic Powder were one of the top choices. Make sure to purchase “Pure Açai without sugar”.

Some powders are diluted and/or cut with sugar or soy lecithin. Extracts that are not produced by the highest quality standards lose co-factors and the “whole plant effect”. A properly prepared Acai powder always ensures that the powder is delicately processed using a non-thermal drying process to protect the integrity of the molecular structure. If you can get your hands on 100% Pure Organic Acai powder or the frozen pulp itself (i.e. no agave sweetener or other fruit juice or soy lecithin blended in to dilute the effects), definitely go for that.

acai berriesAnthocyanin:
• More powerful than beta-carotene.
• High vibration purple pigments – healing phytochemical that promotes anti-aging.
• In Greek, Anthos means Flower & Kyanos, which means Deep blue.acai berries

Açai berries:
• 10 times the antioxidants as grapes.
• 2 times the antioxidants of blueberries.

 

If you are interested in any information about this topic or interested in injectable testosterone, testosterone blood level testing or any testosterone therapy related inquiries, please contact us. In less than 5 minutes we can tell you what you need to qualify for any of our Testosterone injections protocols.

Case Studies

[1] Schuass, AG and others “Antioxidant capacity and other bioactivities of the freeze-dried Amazonian palm berry, Euterpe oleraceous mart. (acai)” j. Agric Food Chem., 2006 54 (22) 8604-10 1

[2] Del Pozo-Insfran D, Percival SS, Talcott ST. “Açai (Euterpe oleracea Mart.) polyphenolics in their glycoside and aglycone forms induce apoptosis of HL-60 leukemia cells.” J Agric Food Chem. 2006 Feb 22;54(4):1222-9

 

AAI Rejuvenation Clinic

 

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February 4, 2016 by admin 1 Comment

Testosterone Enanthate Description 5 (1)

Testosterone Enanthate Description

Testosterone Enanthate Injection, USP provides Testosterone Enanthate Description, USP, a derivative of the primary endogenous androgen testosterone, for intramuscular administration. In their active form, androgens have a 17-beta-hydroxy group. Esterification of the 17-beta-hydroxy group increases the duration of action of testosterone; hydrolysis to free testosterone occurs in vivo. Each mL of sterile, colorless to pale yellow, solution provides 200 mg Testosterone Enanthate, USP in sesame oil with 5 mg chlorobutanol (chloral derivative) as a preservative.

Testosterone Enanthate, USP is designated chemically as androst-4-en-3-one, 17-[(1-oxoheptyl)-oxy]-, (17β)-. Structural formula:
Testosterone Enanthate – Clinical Pharmacology


Endogenous androgens are responsible for the normal growth and development of the male sex organs and for maintenance of secondary sex characteristics. These effects include growth and maturation of prostate, seminal vesicles, penis, and scrotum; development of male hair distribution, such as beard, pubic, chest, and axillary hair; laryngeal enlargement; vocal chord thickening; alterations in body musculature; and fat distribution.

Androgens also cause retention of nitrogen, sodium, potassium, and phosphorus, and decreased urinary excretion of calcium. Androgens have been reported to increase protein anabolism and decrease protein catabolism. Nitrogen balance is improved only when there is sufficient intake of calories and protein.

Slideshow: Breast Cancer Therapy: Right On Target Breast Cancer Therapy: Right On Target
Androgens are responsible for the growth spurt of adolescence and for the eventual termination of linear growth which is brought about by fusion of the epiphyseal growth centers. In children, exogenous androgens accelerate linear growth rates but may cause a disproportionate advancement in bone maturation. Use over long periods may result in fusion of the epiphyseal growth centers and termination of the growth process. Androgens have been reported to stimulate the production of red blood cells by enhancing the production of erythropoietic stimulating factor.

During exogenous administration of androgens, endogenous testosterone release is inhibited through feedback inhibition of pituitary luteinizing hormone (LH). At large doses of exogenous androgens, spermatogenesis may also be suppressed through feedback inhibition of pituitary follicle stimulating hormone (FSH).

There is a lack of substantial evidence that androgens are effective in fractures, surgery, convalescence, and functional uterine bleeding.

PHARMACOKINETICS
Testosterone injections esters are less polar than free testosterone. Testosterone esters in oil injected intramuscularly are absorbed slowly from the lipid phase; thus Testosterone Enanthate can be given at intervals of two to four weeks.

Testosterone in plasma is 98 percent bound to a specific testosterone-estradiol binding globulin, and about two percent is free. Generally, the amount of this sex-hormone binding globulin (SHBG) in the plasma will determine the distribution of testosterone between free and bound forms, and the free testosterone concentration will determine its half-life.

About 90 percent of a dose of testosterone Therapy is excreted in the urine as glucuronic and sulfuric acid conjugates of testosterone and its metabolites; about six percent of a dose is excreted in the feces, mostly in the unconjugated form. Inactivation of testosterone occurs primarily in the liver. Testosterone is metabolized to various 17-keto steroids through two different pathways. There are considerable variations of the half-life of testosterone as reported in the literature, ranging from 10 to 100 minutes.

In responsive tissues, the activity of testosterone appears to depend on reduction to dihydrotestosterone (DHT), which binds to cytosol receptor proteins. The steroid-receptor complex is transported to the nucleus where it initiates transcription events and cellular changes related to androgen action.

Indications and Usage for Testosterone Enanthate

Males

Testosterone Enanthate Injection, USP is indicated for replacement therapy in conditions associated with a deficiency or absence of endogenous testosterone.

Primary hypogonadism (congenital or acquired) – Testicular failure due to cryptorchidism, bilateral torsion, orchitis, vanishing testis syndrome, or orchidectomy.

Hypogonadotropic hypogonadism (congenital or acquired) –  Gonadotropin or luteinizing hormone‑releasing hormone (LHRH) deficiency, or pituitary-hypothalamic injury from tumors, trauma, or radiation. (Appropriate adrenal cortical and thyroid hormone replacement therapy are still necessary, however, and are actually of primary importance.)

If the above conditions occur prior to puberty, androgen replacement therapy will be needed during the adolescent years for development of secondary sexual characteristics. Prolonged androgen treatment will be required to maintain sexual characteristics in these and other males who develop testosterone deficiency after puberty.

Safety and efficacy of Testosterone Enanthate Injection, USP in men with “age-related hypogonadism” (also referred to as “late-onset hypogonadism”) have not been established.

Delayed pubertyTestosterone Enanthate Injection, USP may be used to stimulate puberty in carefully selected males with clearly delayed puberty. This patient usually have a familial pattern of delayed puberty that is not secondary to a pathological disorder; puberty is expected to occur spontaneously at a relatively late date. Brief treatment with conservative doses may occasionally be justified in these patients if they do not respond to psychological support. The potential adverse effect on bone maturation should be discussed with the Patient and parents prior to androgen administration. An X-ray of the hand and wrist to determine bone age should be obtained every six months to assess the effect of treatment on the epiphyseal centers (see Warnings).

Females

Metastatic mammary cancerTestosterone Enanthate Injection, USP may be used secondarily in women with advancing inoperable metastatic (skeletal) mammary cancer who are one to five years postmenopausal. Primary goals of therapy in these women include ablation of the ovaries. Other methods of counteracting estrogen activity are adrenalectomy, hypophysectomy, and/or antiestrogen therapy. This treatment has also been used in premenopausal women with breast cancer who have benefited from oophorectomy and are considered to have a hormone-responsive tumor. Judgment concerning androgen therapy should be made by an oncologist with expertise in this field.

Contraindications

Androgens are contraindicated in men with carcinomas of the breast or with known or suspected carcinomas of the prostate and in women who are or may become pregnant. When administered to pregnant women, androgens cause virilization of the external genitalia of the female fetus. This virilization includes clitoromegaly, abnormal vaginal development, and fusion of genital folds to form a scrotal-like structure. The degree of masculinization is related to the amount of drug given and the age of the fetus and is most likely to occur in the female fetus when the drugs are given in the first trimester. If the patient becomes pregnant while taking androgens, she should be apprised of the potential hazard to the fetus.

This preparation is also contraindicated in patients with a history of hypersensitivity to any of its components.

Warnings

In patients with breast cancer and in immobilized patients, androgen therapy may cause hypercalcemia by stimulating osteolysis. In patients with cancer, hypercalcemia may indicate progression of bony metastasis. If hypercalcemia occurs, the drug should be discontinued and appropriate measures instituted.

Prolonged use of high doses of androgens has been associated with the development of peliosis hepatis and hepatic neoplasms including hepatocellular carcinoma (see PRECAUTIONS, Carcinogenesis). Peliosis hepatis can be a life-threatening or fatal complication.

If cholestatic hepatitis with jaundice appears or if liver function tests become abnormal, the androgen should be discontinued and the etiology should be determined. Drug-induced jaundice is reversible when the medication is discontinued.

Geriatric patients treated with androgens may be at an increased risk for the development of prostatic hypertrophy and prostatic carcinoma.

There have been postmarketing reports of venous thromboembolic events, including deep vein thrombosis (DVT) and pulmonary embolism (PE), in patients using Testosterone Enanthate Description products, such as Testosterone Enanthate injection. Evaluate patients who report symptoms of pain, edema, warmth, and erythema in the lower extremity for DVT and those who present with acute shortness of breath for PE. If a venous thromboembolic event is suspected, discontinue treatment with Testosterone Enanthate injection and initiate appropriate workup and management.

Long term clinical safety trials have not been conducted to assess the cardiovascular outcomes of testosterone replacement therapy in men. To date, epidemiologic studies and randomized controlled trials have been inconclusive for determining the risk of major adverse cardiovascular events (MACE), such as non-fatal myocardial infarction, non-fatal stroke, and cardiovascular death, with the use of Testosterone Enanthate Description, compared to non-use. Some studies, but not all, have reported an increased risk of MACE in association with the use of testosterone replacement therapy in men. Patients should be informed of this possible risk when deciding whether to use or to continue to use Testosterone Enanthate injection.

Due to sodium and water retention, edema with or without congestive heart failure may be a serious complication in patients with preexisting cardiac, renal, or hepatic disease. In addition to discontinuation of the drug, diuretic therapy may be required. If the administration of Testosterone Enanthate Description is restarted, a lower dose should be used.

Gynecomastia frequently develops and occasionally persists in patients being treated for hypogonadism.

Androgen therapy should be used cautiously in healthy males with delayed puberty. The effect on bone maturation should be monitored by assessing the bone age of the wrist and hand every six months. In children, androgen treatment may accelerate bone maturation without producing a compensatory gain in linear growth. This adverse effect may result in compromised adult stature. The younger the child the greater the risk of compromising final mature height.

Precautions

General

Women should be observed for signs of virilization (deepening of the voice, hirsutism, acne, clitoromegaly, and menstrual irregularities). Discontinuation of drug therapy at the time of evidence of mild virilism is necessary to prevent irreversible virilization. Such virilization is usual following androgen use at high doses and is not prevented by concomitant use of estrogens. A decision may be made by the patient and the physician that some virilization will be tolerated during treatment for breast carcinoma.

Because androgens may alter serum cholesterol concentration, caution should be used when administering these drugs to patients with a history of myocardial infarction or coronary artery disease. Serial determinations of serum cholesterol should be made and therapy adjusted accordingly. A causal relationship between myocardial infarction and hypercholesterolemia has not been established.

Information for Patients

Male adolescent patients receiving androgens for delayed puberty should have bone development checked every six months.

The physician should instruct patients to report any of the following side effects of androgens:

Adult or adolescent males – too frequent or persistent erections of the penis.

Women – hoarseness, acne, changes in menstrual periods, or more facial hair.

All patients – any nausea, vomiting, changes in skin color, or ankle swelling.

Geriatric Use

Clinical studies of Testosterone Enanthate Description did not include sufficient numbers of subjects, aged 65 and older, to determine whether they respond differently from younger subjects. Testosterone replacement is not indicated in geriatric patients who have age‑related hypogonadism only (“andropause‘) because there are insufficient safety and efficacy information to support such use. Current studies do not assess whether Testosterone Enanthate Description uses increased risks of prostate cancer, prostate hyperplasia, and cardiovascular disease in the geriatric population.

Intramuscular Administration

When properly given, injections of Testosterone Enanthate Description are well tolerated. Care should be taken to slowly inject the preparation deeply into the gluteal muscle, being sure to follow the usual precautions for intramuscular administration, such as the avoidance of intravascular injection. There have been rare post-marketing reports of transient reactions involving urge to cough, coughing fits, and respiratory distress immediately after the injection of Testosterone Enanthate Description, an oil-based depot preparation (see DOSAGE AND ADMINISTRATION).

Laboratory Tests

Women with disseminated breast carcinoma should have frequent determination of urine and serum calcium levels during the course of androgen therapy (see WARNINGS).

Periodic (every six months) X-ray examinations of bone age should be made during treatment of pre-pubertal males to determine the rate of bone maturation and the effects of androgen therapy on the epiphyseal centers.

Hemoglobin and hematocrit should be checked periodically for polycythemia in patients who are receiving high doses of androgens.

Drug Interactions

When administered concurrently, the following drugs may interact with androgens:

Anticoagulants, oral – C-17 substituted derivatives of Testosterone Enanthate Description, such as methandrostenolone, have been reported to decrease the anticoagulant requirement. Patients receiving oral anticoagulant therapy require close monitoring especially when androgens are started or stopped.

Antidiabetic drugs and insulin – In diabetic patients, the metabolic effects of androgens may decrease blood glucose and insulin requirements.

ACTH and corticosteroids – Enhanced tendency toward edema. Use caution when giving these drugs together, especially in patients with the hepatic or cardiac disease.

Oxyphenbutazone – Elevated serum levels of oxyphenbutazone may result.

Drug/Laboratory Test Interferences

Androgens may decrease levels of thyroxine-binding globulin, resulting in decreased total T4 serum levels and increased resin uptake of T3 and T4. Free thyroid hormone levels remain unchanged, however, and there is no clinical evidence of thyroid dysfunction.

Carcinogenesis

Testosterone Enanthate Description has been tested by subcutaneous injection and implantation in mice and rats. The implant induced cervical-uterine tumors in mice, which metastasized in some cases. There is suggestive evidence that injection of Testosterone Enanthate Description into some strains of female mice increases their susceptibility to hepatoma. Testosterone Enanthate Description is also known to increase the number of tumors and decrease the degree of differentiation of chemically induced carcinomas of the liver in rats.

There are rare reports of hepatocellular carcinoma in patients receiving long-term therapy with androgens in high doses. Withdrawal of the drugs did not lead to regression of the tumors in all cases.

Geriatric patients treated with androgens may be at an increased risk for the development of prostatic hypertrophy and prostatic carcinoma.

Pregnancy: Teratogenic Effects

Category X (see CONTRAINDICATIONS).

Nursing Mothers

It is not known whether androgens are excreted in human milk. Because many drugs are excreted in human milk and because of the potential for serious adverse reactions in nursing infants from androgens, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.

Pediatric Use

Androgen therapy should be used very cautiously in pediatric patients and only by specialists who are aware of the adverse effects on bone maturation. Skeletal maturation must be monitored every six months by an X-ray of the hand and wrist (see INDICATIONS AND USAGE and WARNINGS).

Adverse Reactions

Endocrine and Urogenital, Female – The most common side effects of androgen therapy are amenorrhea and other menstrual irregularities, inhibition of gonadotropin secretion, and virilization, including deepening of the voice and clitoral enlargement. The latter usually is not reversible after androgens are discontinued. When administered to a pregnant woman, androgens cause virilization of the external genitalia of the female fetus.

Male – Gynecomastia, and excessive frequency and duration of penile erections. Oligospermia may occur at high dosages (see CLINICAL PHARMACOLOGY).

Skin and Appendages – Hirsutism, male pattern baldness, and acne.

Cardiovascular Disorders – Myocardial infarction, stroke.

Fluid and Electrolyte Disturbances – Retention of sodium, chloride, water, potassium, calcium (see warnings), and inorganic phosphates.

Gastrointestinal – Nausea, cholestatic jaundice, alterations in liver function tests; rarely, hepatocellular neoplasms, peliosis hepatis (see WARNINGS).

Hematologic – Suppression of clotting factors II, V, VII, and X; bleeding in patients on concomitant anticoagulant therapy; polycythemia.

Nervous System – Increased or decreased libido, headache, anxiety, depression, and generalized paresthesia.

Metabolic – Increased serum cholesterol.

Vascular Disorders – venous thromboembolism

Miscellaneous – Rarely, anaphylactoid reactions; inflammation and pain at injection site.

Testosterone Therapy Information

What Is Testosterone?

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causes of Low Testosterone

Low Testosterone in Men

Low Testosterone in Women

Low Testosterone

Testosterone Cypionate

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February 4, 2016 by admin 0 Comments

Testosterone Cypionate Description 5 (1)

Testosterone Cypionate description injections

Testosterone Cypionate Description injection for intramuscular injection contains Testosterone Cypionate which is the oil-soluble 17 (beta)- cyclopentyl propionate ester of the androgenic hormone testosterone. Testosterone Cypionate is a white or creamy white crystalline powder, odorless or nearly so and stable in air. It is insoluble in water, freely soluble in alcohol, chloroform, dioxane, ether, and soluble in vegetable oils. The chemical name for Testosterone Cypionate is androst-4-en-3-one,17-(3-cyclopentyl-1-oxopropoxy)-, (17β)-. Its molecular formula is C27H40O3, and the molecular weight 412.61.

The structural formula is represented below:

Testosterone Cypionate injection, USP is available in two strengths, 100 mg/mL and 200 mg/mL Testosterone Cypionate, USP.

Each mL of the 100 mg/mL solution contains:

Testosterone Cypionate……………………………………………………………………. 100 mg
Benzyl benzoate ……………………………………………………………………………… 0.1 mL
Cottonseed oil ………………………………………………………………………………… 736 mg
Benzyl alcohol (as preservative)………………………………………………………… 9.45 mg

Each mL of the 200 mg/mL solution contains:

Testosterone Cypionate……………………………………………………………………. 200 mg
Benzyl benzoate………………………………………………………………………………. 0.2 mL
Cottonseed oil………………………………………………………………………………… 560 mg

Benzyl alcohol (as preservative)………………………………………………………… 9.45 mg

Testosterone Cypionate – Clinical Pharmacology

Endogenous androgens are responsible for normal growth and development of the male sex organs and for maintenance of secondary sex characteristics. These effects include growth and maturation of the prostate, seminal vesicles, penis, and scrotum; development of male hair distribution, such as beard, pubic, chest, and axillary hair; laryngeal enlargement, vocal cord thickening, and alterations in body musculature and fat distribution. Drugs in this class also cause retention of nitrogen, sodium, potassium, and phosphorous, and decreased urinary excretion of calcium. Androgens have been reported to increase protein anabolism and decrease protein catabolism. Nitrogen balance is improved only when there is sufficient intake of calories and protein.

Androgens are responsible for the growth spurt of adolescence and for eventual termination of linear growth, brought about by fusion of the epiphyseal growth centers. In children, exogenous androgens accelerate linear growth rates but may cause a disproportionate advancement in bone maturation. Use over long periods may result in fusion of the epiphyseal growth centers and termination of the growth process. Androgens have been reported to stimulate the production of red blood cells by enhancing production of erythropoietic stimulation factor.

During exogenous administration of androgens, endogenous testosterone release is inhibited through feedback inhibition of pituitary luteinizing hormone (LH). At large doses of exogenous androgens, spermatogenesis may also be suppressed through feedback inhibition of pituitary follicle stimulating hormone (FSH).

There is a lack of substantial evidence that androgens are effective in fractures, surgery, convalescence, and functional uterine bleeding.

Pharmacokinetics

Testosterone esters are less polar than free testosterone. Testosterone esters in oil injected intramuscularly are absorbed slowly from the lipid phase; thus, Testosterone Cypionate can be given at intervals of two to four weeks.

Testosterone in plasma is 98 percent bound to a specific testosterone-estradiol binding globulin, and about 2 percent is free. Generally, the amount of this sex-hormone binding globulin in the plasma will determine the distribution of testosterone between free and bound forms, and the free testosterone concentration will determine its half-life.

About 90 percent of a dose of testosterone injections is excreted in the urine as glucuronic and sulfuric acid conjugates of testosterone and its metabolites; about 6 percent of a dose is excreted in the feces, mostly in the unconjugated form. Inactivation of testosterone occurs primarily in the liver. Testosterone therapy is metabolized to various 17-keto steroids through two different pathways.

The half-life of Testosterone Cypionate, when injected intramuscularly, is approximately eight days.

In many tissues, the activity of testosterone therapy appears to depend on reduction to dihydrotestosterone, which binds to cytosol receptor proteins. The steroid-receptor complex is transported to the nucleus where it initiates transcription events and cellular changes related to androgen action.

Indications and Usage for Testosterone Cypionate description

Testosterone Cypionate description injection is indicated for replacement therapy in the male in conditions associated with symptoms of deficiency or absence of endogenous testosterone.

  • Primary hypogonadism (congenital or acquired)-testicular failure due to cryptorchidism, bilateral torsion, orchitis, vanishing testis syndrome; or orchidectomy.
  • Hypogonadotropic hypogonadism (congenital or acquired): gonadotropin or LHRH deficiency, or pituitary-hypothalamic injury from tumors, trauma, or radiation.

Safety and efficacy of Testosterone Cypionate description in men with “age-related hypogonadism” (also referred to as “late-onset hypogonadism”) have not been established.

Contraindications

  1. Known hypersensitivity to the drug
  2. Males with carcinoma of the breast
  3. Males with known or suspected carcinoma of the prostate gland
  4. Women who are or who may become pregnant
  5. Patients with serious cardiac, hepatic or renal disease

Warnings

Hypercalcemia may occur in immobilized patients. If this occurs, the drug should be discontinued.

Prolonged use of high doses of androgens (principally the 17-α alkyl-androgens) has been associated with the development of hepatic adenomas, hepatocellular carcinoma, and peliosis hepatis —all potentially life-threatening complications.

Geriatric patients treated with androgens may be at an increased risk of developing prostatic hypertrophy and prostatic carcinoma although conclusive evidence to support this concept is lacking.

There have been postmarketing reports of venous thromboembolic events, including deep vein thrombosis (DVT) and pulmonary embolism (PE), in patients using testosterone products, such as Testosterone Cypionate description. Evaluate patients who report symptoms of pain, edema, warmth, and erythema in the lower extremity for DVT and those who present with acute shortness of breath for PE. If a venous thromboembolic event is suspected, discontinue treatment with Testosterone Cypionate description and initiate appropriate workup and management.

Long term clinical safety trials have not been conducted to assess the cardiovascular outcomes of testosterone replacement therapy in men. To date, epidemiologic studies and randomized controlled trials have been inconclusive for determining the risk of major adverse cardiovascular events (MACE), such as non-fatal myocardial infarction, non-fatal stroke, and cardiovascular death, with the use of testosterone compared to non-use. Some studies, but not all, have reported an increased risk of MACE in association with the use of testosterone replacement therapy in men. Patients should be informed of this possible risk when deciding whether to use or to continue to use Testosterone Cypionate description.

Edema, with or without congestive heart failure, may be a serious complication in patients with preexisting cardiac, renal or hepatic disease.

Gynecomastia may develop and occasionally persists in patients being treated for hypogonadism.

The preservative benzyl alcohol has been associated with serious adverse events, including the “gasping syndrome”, and death in pediatric patients. Although normal therapeutic doses of this product ordinarily deliver amounts of benzyl alcohol that are substantially lower than those reported in association with the “gasping syndrome”, the minimum amount of benzyl alcohol at which toxicity may occur is not known. The risk of benzyl alcohol toxicity depends on the quantity administered and the hepatic capacity to detoxify the chemical. Premature and low-birth weight infants may be more likely to develop toxicity.

Androgen therapy should be used cautiously in healthy males with delayed puberty. The effect on bone maturation should be monitored by assessing the bone age of the wrist and hand every 6 months. In children, androgen treatment may accelerate bone maturation without producing a compensatory gain in linear growth. This adverse effect may result in compromised adult stature. The younger the child the greater the risk of compromising final mature height.

This drug has not been shown to be safe and effective for the enhancement of athletic performance. Because of the potential risk of serious adverse health effects, this drug should not be used for such purpose.

Precautions

General

Patients with benign prostatic hypertrophy may develop acute urethral obstruction. Priapism or excessive sexual stimulation may develop. Oligospermia may occur after prolonged administration or excessive dosage. If any of these effects appear, the androgen should be stopped and if restarted, a lower dosage should be utilized.

Testosterone Cypionate description should not be used interchangeably with testosterone propionate description because of differences in duration of action.

Testosterone Cypionate description is not for intravenous use.

Information for Patients

Patients should be instructed to report any of the following: nausea, vomiting, changes in skin color, ankle swelling, too frequent or persistent erections of the penis.

Laboratory Tests

Hemoglobin and hematocrit levels (to detect polycythemia) should be checked periodically in patients receiving long-term androgen administration.

Serum cholesterol may increase during androgen therapy.

Drug Interactions

Androgens may increase sensitivity to oral anticoagulants. The dosage of the anticoagulant may require a reduction in order to maintain satisfactory therapeutic hypoprothrombinemia.

Concurrent administration of oxyphenbutazone and androgens may result in elevated serum levels of oxyphenbutazone.

In diabetic patients, the metabolic effects of androgens may decrease blood glucose and, therefore, insulin requirements.

Drug/Laboratory Test Interferences

Androgens may decrease levels of thyroxine-binding globulin, resulting in decreased total T4 serum levels and increased resin uptake of T3 and T4. Free thyroid hormone levels remain unchanged, however, and there is no clinical evidence of thyroid dysfunction.

Carcinogenesis

Animal data

Testosterone has been tested by subcutaneous injection and implantation in mice and rats. The implant induced cervical-uterine tumors in mice, which metastasized in some cases. There is suggestive evidence that injection of testosterone into some strains of female mice increases their susceptibility to hepatoma. Testosterone is also known to increase the number of tumors and decrease the degree of differentiation of chemically induced carcinomas of the liver in rats.

Human data

There are rare reports of hepatocellular carcinoma in patients receiving long-term therapy with androgens in high doses. Withdrawal of the drugs did not lead to regression of the tumors in all cases.

Geriatric patients treated with androgens may be at an increased risk of developing prostatic hypertrophy and prostatic carcinoma although conclusive evidence to support this concept is lacking.

Pregnancy

Teratogenic Effects

Pregnancy Category X. (See CONTRAINDICATIONS)

Benzyl alcohol can cross the placenta. See WARNINGS.

Nursing Mothers

Testosterone Cypionate description is not recommended for use in nursing mothers.

Pediatric Use

Safety and effectiveness in pediatric patients below the age of 12 years have not been established.

Adverse Reactions

The following adverse reactions in the male have occurred with some androgens:

Endocrine and urogenital: Gynecomastia and excessive frequency and duration of penile erections. Oligospermia may occur at high dosages.

Skin and Appendages: Hirsutism, male pattern of baldness, seborrhea, and acne.

Cardiovascular Disorders – myocardial infarction, stroke

Fluid and electrolyte disturbances: Retention of sodium, chloride, water, potassium, calcium, and inorganic phosphates.

Gastrointestinal: Nausea, cholestatic jaundice, alterations in liver function tests, rarely hepatocellular neoplasms and peliosis hepatis (see WARNINGS).

Hematologic: Suppression of clotting factors II, V, VII, and X, bleeding in patients on concomitant anticoagulant therapy, and polycythemia.

Nervous system: Increased or decreased libido, headache, anxiety, depression, and generalized paresthesia.

Allergic: Hypersensitivity, including skin manifestations and anaphylactoid reactions.

Vascular Disorders: venous thromboembolism

Miscellaneous: Inflammation and pain at the site of intramuscular testosterone injection.

Testosterone Therapy Information

January 6, 2016 by admin 0 Comments

What is Testosterone-Cypionate? 5 (1)

Testosterone-Cypionate the form of testosterone provided most often in testosterone therapy. It’s a specific form of testosterone, slightly different than what human bodies produce on their own, but for reasons essential to its administration to the body. To maximize the benefits of male hormone therapy, testosterone Cypionate is one of the types of testosterone a person can inject or get in a gel. There are very specific reasons why this form of testosterone is most popular for therapy.

Testosterone is the substance produced in human bodies that regulate the expression of male characteristics. It also promotes healing and mental well-being. It’s a relatively small organic molecule that isn’t a protein or peptide-like HGH, but instead is very similar to cholesterol or Vitamin E; it’s a hydrocarbon ring, an oil-soluble type of substance. It travels to all parts of the body through the blood. In males, it’s produced by specific cells in the testicles, triggered by signals from the brain, which also travel through the blood. The amount of testosterone in a man’s blood correlates directly with the masculine traits he exhibits, i.e., being hairy, being strong, and having physical and mental energy.

The human body produces a natural form of testosterone.

When humans produce testosterone in their body, the specific type of testosterone that’s produced is just plain testosterone. No additional fragment is stuck to it, as in the case of testosterone-Cypionate where what’s called a Cypionate moiety is stuck to one end of the testosterone molecule.  Technically, human bodies don’t produce the Cypionate form, but doses of testosterone injections are taken in the Cypionate form as opposed to just plain testosterone by itself.

what is testosterone cypionate used if the body doesn’t make that form?

When testosterone-Cypionate is administered in the form of a gel or injection, the body converts the Cypionate form into plain testosterone. There are enzymes called esterases that target the connection between the Cypionate moiety and the testosterone molecule, breaking off the Cypionate from testosterone, leaving plain testosterone in the form that the body uses it. These esterases yield the same molecule of testosterone the body produces. This is why testosterone-Cypionate is referred to as bio-identical testosterone, putting it into the body is essentially equivalent to increasing what the body has made at one time and is already capable of using, natural testosterone in the form the body uses it.

A time-release effect provides stable hormone levels.

The reason the Cypionate form is administered, as opposed to just plain testosterone, is to provide a time-release type of effect. Making the molecule more oil-soluble tends to stabilize the blood levels of free testosterone, releasing more gradually over time. If free testosterone were injected directly, we’d observe a peak in its blood concentration immediately after injection followed by a rapid decrease thereafter. By injecting the Cypionate form, more of the testosterone gets absorbed by the body’s fatty tissue to be released more gradually over time. It gets dissolved into the blood more slowly, and the blood concentrations of testosterone Therapy resemble a more stable pattern useful for therapy. Instead of having to get multiple injections daily, with testosterone-Cypionate you can instead space out injections on the order of weeks.

As we discussed in our previous blog post about the different forms of testosterone, testosterone-Cypionate is only one out of several that are included in therapeutic doses. The dosage and forms that are prescribed to anti-aging patients differ from patient to patient. Whatever form is prescribed, it’s important to follow dosage instructions as precisely as possible. Both the form and the dosage times are chosen together to provide the most stable, consistent hormone levels possible, getting the most benefits with the least side effects.