Pituitary Gland – GnRH sent to the pituitary gland where it stimulates the synthesis and release of gonadotropic hormones LH and FSH.
Testis – Gonads carry LH to the testis where they encourage testosterone production through the testicular Leydig cells
Conversion of cholesterol produces testosterone
FSH is crucial for spermatogenesis
Dihydrotestosterone (DHT) is the activated 2% of testosterone is free or unbound, with the remainder bound to SHBG (sex hormone-binding globulin), albumin- and cortisol-binding globulin. Bioavailable testosterone is the testosterone that will not attach to SHBG. Testosterone and DHT act on organs.
Causes development of secondary sexual characteristics
Inhibit secretion of LH and FSH by the pituitary gland, thus stops further testosterone production = negative feedback loop.
There exist androgen receptors in the pituitary and the
hypothalamic neurons that bind to testosterone and signal to stop GnRH release
Homeostasis maintained through this loop – once testosterone stops production, this inhibited secretion stops and GnRH again causes LH and FSH release to produce further testosterone. As men age, they undergo hormonal level changes:
Testosterone decrease
LH and FSH increase
Other hormones that decrease: T3, insulin, growth hormone/insulin-like growth factor 1, stimulating thyroid hormone
Also an increase in SHBG
Dihydrotestosterone levels are unchanged
Estrogen levels unchanged
As men age, the decrease in testosterone paired with the increase in SHBG leads to a decline in free, or bioavailable, testosterone. These hormonal changes start in the 30s and are well established by the 50s.
Testosterone is an essential factor in males, that does more for men than just promote sex drive. Low Testosterone levels decline as a part of healthy aging and are the cause of several physiological changes. Low Testosterone level symptoms include;
1) Reduced Motivation
2) Erectile Dysfunction
3) Loss of Libido or sex drive
4) Fatigue and low energy
5) Increased Cholesterol Levels
6) Memory and Concentration
7) Decreased Muscle Mass
8) Thyroid Dysfunction and more
Since these symptoms are common in low testosterone, physicians will often include hormone levels as part of routine blood work. Normal levels of testosterone are between 300 and 1,000 ng/dL. If a blood test shows that your levels are far below the norm, your doctor may suggest testosterone injections. The treatment is called TRT.
SYMPTOMS OF LOW TESTOSTERONE
Most men naturally start losing testosterone when they hit their 30’s. (low T). Common symptoms of low Testosterone include:
1) Erectile dysfunction (ED)
2) Changes in sex drive
3) Decreased sperm count
4) Depression or anxiety
5) Weight gain
6) Hot flashes
TESTOSTERONE AND DIAGNOSIS
Many men may want to diagnose themselves with a testosterone kit. The problem with self-diagnosis is that many of the symptoms of low Testosterone are healthy parts of aging. So using it for diagnosis isn’t reliable. Our doctor may order testosterone blood test. It is the only way to find out if you have low testosterone.
To get a perfect reading our doctor will take a look at your health history, physical exam and blood test to measure your testosterone levels. You’ll also likely have a test that measures your red blood cell count.
POTENTIAL BENEFITS OF TESTOSTERONE INJECTIONS THERAPY
The purpose of Testosterone Injections Therapy is to help regulate hormone levels and to help address problems related to low Testosterone. For men with low Testosterone, the benefits of these injections can include:
1) Motivation and Memory Loss
2) Sex Drive & Desire
3) Depression and Energy
4) Cholesterol and Osteoporosis
5) Erectile Dysfunction
6) Muscle Mass and Better Sleep
7) Wounds healing & Illness
8) Thyroid Dysfunction and more
TESTOSTERONE CAN HELP WITH FAT AND MUSCLE CHANGES
Men have less body fat than women; This is partly related to testosterone, which regulates the fat in the body and muscle maintenance in your body. You’ll likely also notice an increase in body fat, especially around your midsection.
Your hormones also help regulate muscle growth. So, with low Testosterone, you may feel like you’re losing muscle size or strength.
Testosterone shots regulate fat distribution, but you shouldn’t expect significant weight loss changes from hormone therapy alone, without exercise. As for maintenance of muscle, testosterone therapy has been found to improve increase muscle mass, but not strength.
TESTOSTERONE INJECTIONS THERAPY AND SPERM COUNT
Low sperm count in men is a common side effect of low Testosterone. This problem can make it difficult to get your partner pregnant.
TESTOSTERONE INJECTIONS THERAPY AND THE BOTTOM LINE
Testosterone injections therapy can only be helpful If you just have low Testosterone. If you’re wondering if testosterone is a right choice for you, ask your doctor. They can test you for low Testosterone. Ask your doctors, or Give us a call, if testosterone injections therapy would be a good choice for you.
If you don’t end up having low Testosterone but still feel like your hormone levels might be off, keep in mind that proper Food, Regular exercise, could help you increase testosterone naturally and make you feel better. If that doesn’t help, be sure you contact us for help.
Right around the age of 30, most men experience a significant “shift” in their lives. They can’t tell what it is. They can’t quite put their finger on it. All they know is, something has “changed”. Usually, men attribute it to being “tired” from working so hard, keeping up with the kids and maintaining their household. The supposition is, “if I can only get one good nights rest, I’ll be all better the next day,” but that day never comes. (*) Individual Results May Vary & Are Not Guaranteed
Durian is a species of fruit that is native to Southeast Asia. Every species of Durian is made up of 5% fat. The glycemic index of this fruit is 44, which happens to be lower than a papaya’s. This is mainly due to the oil slowing down its sugar-burn time.
• Durian tastes like custard ice-cream.
• Maximum serving should be no more than 100g a day.
• Only has about 25g of fat.
• Sugar propels yellow phytochemicals and rich sulfur into the cell walls to be absorbed.
• One of the very few fruits with high in B vitamins.
• 4g of fiber.
• A special power to heal and cleanse stomach if eaten before any other food.
• Two types of Durian: Canary yellow and cream.
• Species known as D 22 has a better flavor and 25% more saturated fats (Palmitic acid) than other types.
• Durian’s fat content level is 50% Omega– 9 Oleic acid, classified as an “Organoleptic Oil”. It is also found an avocado, olive oil and virtually all tree nuts.
• Durian has less saturated fat than 1-tablespoon of butter.
Healthy Stomach, Calm Mind
Durian contains high levels of Tryptophan. When consumed on an empty stomach it has a significant boosting effect on serotonin. Tryptophan is an amino acid (bioavailable fruit protein) that helps make a brain neurotransmitter of higher consciousness.
Tryptophan incites the body’s production of Serotonin, which promotes a calm, content state of mind. The more serotonin a person has in their body, the happier they feel.
Durian also helps with the production of the hormone Melatonin.
Serotonin and melatonin are both hormones that manage emotions.
This combination can help relieve:
~ Anxiousness
~ Sleeplessness
~ Depressive disorders
Tyrosine, an amino acid that, on its own, assists with relieving stress and sleeping disorders, is also found in Durian.
Durian is a nitric oxide (NO) enhancer. It has a phytochemical called Harmaline, a well-documented MAO inhibitor.
An elevated body warmth may be experienced after consuming Durian resulting from its rare spectrum of amino acids that
combine with some intense, Naturals sugars. This helps fats and minerals to be delivered to your brain instantly. Some reference it comparable to a euphoric rush. Bear in mind, this happens only when eaten on an empty stomach.
Urine may smell like durian as one detoxifies, similar to asparagus.
Durian contains sulfur, which produces a very strong smell. However, for the same reason, it has impressive detoxifying superpowers. Sulfur is the third most abundant mineral in our body and liver glutathione needs sulfur to become active and detoxify.
Durian Has:
• Yellow lutein for the eyes
• Smooth fatty substances
• Divine sweet taste to explore.
• Properties for better digestion (Thiamin – 61%)
• Properties to normalize blood sugar levels (Manganese – 39%)
• Properties to help fight emotional instability (Vitamin B6 – 38%)
• Properties to help evade and relieve constipation (Fiber – 37%)
• Protection for future healthy bones (Potassium – 30%)
• Properties for migraine alleviation (Riboflavin – 29%)
• Thyroid protecting properties (Copper – 25%)
• Properties to help promote a healthy pregnancy (Folate – 22%)
• Properties to help relax muscles and nerves (Magnesium -18%)
• Properties to help fight the development of anemia (Folate)
• Properties that Promote healthy gums and teeth (Phosphorous)
• Vitamins essential to the body. (mainly iron, dietary fiber, potassium, vitamin C, and vitamin B complex.
Durian Also Has:
• Properties that lower cholesterol (Omega’s and fatty acids)
• Blood Detoxification properties (Sulfur)
• Properties to help build muscles.
• Properties to help Improve sexual function.
• Anti-inflammatory properties.
• Antioxidant Activity.
• Mosquito repellent potential (Husk)
• Properties to encourage stronger immune system (antioxidant, vitamin-rich)
• Better energy promoting properties
• Properties to Promote healthy skin (Vitamin C – 80%)
• Properties to help prevent premature aging (antioxidant and vitamin-rich, and detoxifies blood)
• Natural sleeping pills affect (Promotes release of Serotonin and Melatonin)
• Properties to help with preventing cancer, diabetes, heart disease and inhibit tumor growth (specific phytosterol ingredients)
• Cognitive function aiding properties
• Properties for avoiding Morning Sickness.
• Properties to help alleviate stress (Serotonin, Melatonin)
• Properties for a Strong protection from harmful effects of free radicals. (Intense combination of amino acids)
Testosterone Injections – Curious about testosterone injections Therapy? Read more about what you can expect from this treatment and contact us for more information (866) 224-5698
If you are interested in more information or would like to know about the requirement for qualifying for hGH, testosterone therapy or any other hormone-related program, please fill out our short form or call us at:
Testosterone Cypionate Description injection for intramuscular injection contains Testosterone Cypionate which is the oil-soluble 17 (beta)- cyclopentyl propionate ester of the androgenic hormone testosterone. Testosterone Cypionate is a white or creamy white crystalline powder, odorless or nearly so and stable in air. It is insoluble in water, freely soluble in alcohol, chloroform, dioxane, ether, and soluble in vegetable oils. The chemical name for Testosterone Cypionate is androst-4-en-3-one,17-(3-cyclopentyl-1-oxopropoxy)-, (17β)-. Its molecular formula is C27H40O3, and the molecular weight 412.61.
The structural formula is represented below:
Testosterone Cypionate injection, USP is available in two strengths, 100 mg/mL and 200 mg/mL Testosterone Cypionate, USP.
Endogenous androgens are responsible for normal growth and development of the male sex organs and for maintenance of secondary sex characteristics. These effects include growth and maturation of the prostate, seminal vesicles, penis, and scrotum; development of male hair distribution, such as beard, pubic, chest, and axillary hair; laryngeal enlargement, vocal cord thickening, and alterations in body musculature and fat distribution. Drugs in this class also cause retention of nitrogen, sodium, potassium, and phosphorous, and decreased urinary excretion of calcium. Androgens have been reported to increase protein anabolism and decrease protein catabolism. Nitrogen balance is improved only when there is sufficient intake of calories and protein.
Androgens are responsible for the growth spurt of adolescence and for eventual termination of linear growth, brought about by fusion of the epiphyseal growth centers. In children, exogenous androgens accelerate linear growth rates but may cause a disproportionate advancement in bone maturation. Use over long periods may result in fusion of the epiphyseal growth centers and termination of the growth process. Androgens have been reported to stimulate the production of red blood cells by enhancing production of erythropoietic stimulation factor.
During exogenous administration of androgens, endogenous testosterone release is inhibited through feedback inhibition of pituitary luteinizing hormone (LH). At large doses of exogenous androgens, spermatogenesis may also be suppressed through feedback inhibition of pituitary follicle stimulating hormone (FSH).
There is a lack of substantial evidence that androgens are effective in fractures, surgery, convalescence, and functional uterine bleeding.
Pharmacokinetics
Testosterone esters are less polar than free testosterone. Testosterone esters in oil injected intramuscularly are absorbed slowly from the lipid phase; thus, Testosterone Cypionate can be given at intervals of two to four weeks.
Testosterone in plasma is 98 percent bound to a specific testosterone-estradiol binding globulin, and about 2 percent is free. Generally, the amount of this sex-hormone binding globulin in the plasma will determine the distribution of testosterone between free and bound forms, and the free testosterone concentration will determine its half-life.
About 90 percent of a dose of testosterone injections is excreted in the urine as glucuronic and sulfuric acid conjugates of testosterone and its metabolites; about 6 percent of a dose is excreted in the feces, mostly in the unconjugated form. Inactivation of testosterone occurs primarily in the liver. Testosterone therapy is metabolized to various 17-keto steroids through two different pathways.
The half-life of Testosterone Cypionate, when injected intramuscularly, is approximately eight days.
In many tissues, the activity of testosterone therapy appears to depend on reduction to dihydrotestosterone, which binds to cytosol receptor proteins. The steroid-receptor complex is transported to the nucleus where it initiates transcription events and cellular changes related to androgen action.
Indications and Usage for Testosterone Cypionate description
Testosterone Cypionate description injection is indicated for replacement therapy in the male in conditions associated with symptoms of deficiency or absence of endogenous testosterone.
Primary hypogonadism (congenital or acquired)-testicular failure due to cryptorchidism, bilateral torsion, orchitis, vanishing testis syndrome; or orchidectomy.
Hypogonadotropic hypogonadism (congenital or acquired): gonadotropin or LHRH deficiency, or pituitary-hypothalamic injury from tumors, trauma, or radiation.
Safety and efficacy of Testosterone Cypionate description in men with “age-related hypogonadism” (also referred to as “late-onset hypogonadism”) have not been established.
Contraindications
Known hypersensitivity to the drug
Males with carcinoma of the breast
Males with known or suspected carcinoma of the prostate gland
Women who are or who may become pregnant
Patients with serious cardiac, hepatic or renal disease
Warnings
Hypercalcemia may occur in immobilized patients. If this occurs, the drug should be discontinued.
Prolonged use of high doses of androgens (principally the 17-α alkyl-androgens) has been associated with the development of hepatic adenomas, hepatocellular carcinoma, and peliosis hepatis —all potentially life-threatening complications.
Geriatric patients treated with androgens may be at an increased risk of developing prostatic hypertrophy and prostatic carcinoma although conclusive evidence to support this concept is lacking.
There have been postmarketing reports of venous thromboembolic events, including deep vein thrombosis (DVT) and pulmonary embolism (PE), in patients using testosterone products, such as Testosterone Cypionate description. Evaluate patients who report symptoms of pain, edema, warmth, and erythema in the lower extremity for DVT and those who present with acute shortness of breath for PE. If a venous thromboembolic event is suspected, discontinue treatment with Testosterone Cypionate description and initiate appropriate workup and management.
Long term clinical safety trials have not been conducted to assess the cardiovascular outcomes of testosterone replacement therapy in men. To date, epidemiologic studies and randomized controlled trials have been inconclusive for determining the risk of major adverse cardiovascular events (MACE), such as non-fatal myocardial infarction, non-fatal stroke, and cardiovascular death, with the use of testosterone compared to non-use. Some studies, but not all, have reported an increased risk of MACE in association with the use of testosterone replacement therapy in men. Patients should be informed of this possible risk when deciding whether to use or to continue to use Testosterone Cypionate description.
Edema, with or without congestive heart failure, may be a serious complication in patients with preexisting cardiac, renal or hepatic disease.
Gynecomastia may develop and occasionally persists in patients being treated for hypogonadism.
The preservative benzyl alcohol has been associated with serious adverse events, including the “gasping syndrome”, and death in pediatric patients. Although normal therapeutic doses of this product ordinarily deliver amounts of benzyl alcohol that are substantially lower than those reported in association with the “gasping syndrome”, the minimum amount of benzyl alcohol at which toxicity may occur is not known. The risk of benzyl alcohol toxicity depends on the quantity administered and the hepatic capacity to detoxify the chemical. Premature and low-birth weight infants may be more likely to develop toxicity.
Androgen therapy should be used cautiously in healthy males with delayed puberty. The effect on bone maturation should be monitored by assessing the bone age of the wrist and hand every 6 months. In children, androgen treatment may accelerate bone maturation without producing a compensatory gain in linear growth. This adverse effect may result in compromised adult stature. The younger the child the greater the risk of compromising final mature height.
This drug has not been shown to be safe and effective for the enhancement of athletic performance. Because of the potential risk of serious adverse health effects, this drug should not be used for such purpose.
Precautions
General
Patients with benign prostatic hypertrophy may develop acute urethral obstruction. Priapism or excessive sexual stimulation may develop. Oligospermia may occur after prolonged administration or excessive dosage. If any of these effects appear, the androgen should be stopped and if restarted, a lower dosage should be utilized.
Testosterone Cypionate description should not be used interchangeably with testosterone propionate description because of differences in duration of action.
Testosterone Cypionate description is not for intravenous use.
Information for Patients
Patients should be instructed to report any of the following: nausea, vomiting, changes in skin color, ankle swelling, too frequent or persistent erections of the penis.
Laboratory Tests
Hemoglobin and hematocrit levels (to detect polycythemia) should be checked periodically in patients receiving long-term androgen administration.
Serum cholesterol may increase during androgen therapy.
Drug Interactions
Androgens may increase sensitivity to oral anticoagulants. The dosage of the anticoagulant may require a reduction in order to maintain satisfactory therapeutic hypoprothrombinemia.
Concurrent administration of oxyphenbutazone and androgens may result in elevated serum levels of oxyphenbutazone.
In diabetic patients, the metabolic effects of androgens may decrease blood glucose and, therefore, insulin requirements.
Drug/Laboratory Test Interferences
Androgens may decrease levels of thyroxine-binding globulin, resulting in decreased total T4 serum levels and increased resin uptake of T3 and T4. Free thyroid hormone levels remain unchanged, however, and there is no clinical evidence of thyroid dysfunction.
Carcinogenesis
Animal data
Testosterone has been tested by subcutaneous injection and implantation in mice and rats. The implant induced cervical-uterine tumors in mice, which metastasized in some cases. There is suggestive evidence that injection of testosterone into some strains of female mice increases their susceptibility to hepatoma. Testosterone is also known to increase the number of tumors and decrease the degree of differentiation of chemically induced carcinomas of the liver in rats.
Human data
There are rare reports of hepatocellular carcinoma in patients receiving long-term therapy with androgens in high doses. Withdrawal of the drugs did not lead to regression of the tumors in all cases.
Geriatric patients treated with androgens may be at an increased risk of developing prostatic hypertrophy and prostatic carcinoma although conclusive evidence to support this concept is lacking.
Pregnancy
Teratogenic Effects
Pregnancy Category X. (See CONTRAINDICATIONS)
Benzyl alcohol can cross the placenta. See WARNINGS.
Nursing Mothers
Testosterone Cypionate description is not recommended for use in nursing mothers.
Pediatric Use
Safety and effectiveness in pediatric patients below the age of 12 years have not been established.
Adverse Reactions
The following adverse reactions in the male have occurred with some androgens:
Endocrine and urogenital: Gynecomastia and excessive frequency and duration of penile erections. Oligospermia may occur at high dosages.
Skin and Appendages: Hirsutism, male pattern of baldness, seborrhea, and acne.
Fluid and electrolyte disturbances: Retention of sodium, chloride, water, potassium, calcium, and inorganic phosphates.
Gastrointestinal: Nausea, cholestatic jaundice, alterations in liver function tests, rarely hepatocellular neoplasms and peliosis hepatis (see WARNINGS).
Hematologic: Suppression of clotting factors II, V, VII, and X, bleeding in patients on concomitant anticoagulant therapy, and polycythemia.
Nervous system: Increased or decreased libido, headache, anxiety, depression, and generalized paresthesia.
Allergic: Hypersensitivity, including skin manifestations and anaphylactoid reactions.
Vascular Disorders: venous thromboembolism
Miscellaneous: Inflammation and pain at the site of intramuscular testosterone injection.
The influence of testosterone towards sexual function and libido isn’t emphasized enough. Even though it is implicated in study after study, the need for all persons to have their testosterone therapy levels properly balanced is essential. It’s an intricate part of a properly functioning endocrine system, which is critical for feeling healthy. Testosterone injections are among the most potent of libido-enhancing agents known to mankind. Testosterone therapy is effective in raising a person’s testosterone levels. This can certainly have a positive, “rising” effect on the desire for sexual contact.
