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November 13, 2017 by Joseph Fermin 0 Comments

An Inside Look at Testosterone Injections Therapy 0 (0)

Inside Look Testosterone Injections Therapy

testosterone injections therapyTESTOSTERONE INJECTIONS THERAPY

Testosterone is an essential factor in males, that does more for men than just promote sex drive. Low Testosterone levels decline as a part of healthy aging and are the cause of several physiological changes. Low Testosterone level symptoms include;

1) Reduced Motivation
2) Erectile Dysfunction
3) Loss of Libido or sex drive
4) Fatigue and low energy
5) Increased Cholesterol Levels
6) Memory and Concentration
7) Decreased Muscle Mass
8) Thyroid Dysfunction and more

Since these symptoms are common in low testosterone, physicians will often include hormone levels as part of routine blood work. Normal levels of testosterone are between 300 and 1,000 ng/dL. If a blood test shows that your levels are far below the norm, your doctor may suggest testosterone injections. The treatment is called TRT.

SYMPTOMS OF LOW TESTOSTERONE

Most men naturally start losing testosterone when they hit their 30’s. (low T). Common symptoms of low Testosterone include:

1) Erectile dysfunction (ED)
2) Changes in sex drive
3) Decreased sperm count
4) Depression or anxiety
5) Weight gain
6) Hot flashes

TESTOSTERONE AND DIAGNOSIS

Many men may want to diagnose themselves with a testosterone kit. The problem with self-diagnosis is that many of the symptoms of low Testosterone are healthy parts of aging. So using it for diagnosis isn’t reliable. Our doctor may order testosterone blood test. It is the only way to find out if you have low testosterone.

To get a perfect reading our doctor will take a look at your health history, physical exam and blood test to measure your testosterone levels. You’ll also likely have a test that measures your red blood cell count.

POTENTIAL BENEFITS OF TESTOSTERONE INJECTIONS THERAPY 

The purpose of Testosterone Injections Therapy is to help regulate hormone levels and to help address problems related to low Testosterone. For men with low Testosterone, the benefits of these injections can include:

1)  Motivation and Memory Loss
2)  Sex Drive & Desire
3)  Depression and Energy
4)  Cholesterol and Osteoporosis
5)  Erectile Dysfunction
6)  Muscle Mass and Better Sleep
7)  Wounds healing & Illness
8)  Thyroid Dysfunction and more

TESTOSTERONE CAN HELP WITH FAT AND MUSCLE CHANGES

Men have less body fat than women; This is partly related to testosterone, which regulates the fat in the body and muscle maintenance in your body. You’ll likely also notice an increase in body fat, especially around your midsection.

Your hormones also help regulate muscle growth. So, with low Testosterone, you may feel like you’re losing muscle size or strength.

Testosterone shots regulate fat distribution, but you shouldn’t expect significant weight loss changes from hormone therapy alone, without exercise. As for maintenance of muscle, testosterone therapy has been found to improve increase muscle mass, but not strength.

TESTOSTERONE INJECTIONS THERAPY AND SPERM COUNT

Low sperm count in men is a common side effect of low Testosterone. This problem can make it difficult to get your partner pregnant.

TESTOSTERONE INJECTIONS THERAPY AND THE BOTTOM LINE

Testosterone injections therapy can only be helpful If you just have low Testosterone. If you’re wondering if testosterone is a right choice for you, ask your doctor. They can test you for low Testosterone. Ask your doctors, or Give us a call, if testosterone injections therapy would be a good choice for you.

If you don’t end up having low Testosterone but still feel like your hormone levels might be off, keep in mind that proper Food, Regular exercise, could help you increase testosterone naturally and make you feel better. If that doesn’t help, be sure you contact us for help.

July 14, 2016 by admin 3 Comments

Obesity, Low Sex Drive and Testosterone 0 (0)

Weight Affects Testosterone Levels. Symptoms of Sexual Dysfunction Due to Obesity May be Reversible.

Weight affects testosterone levels in men. Aromatization mainly takes place in fat cells. Conclusively, men with more body fat produce more aromatase and, as a result, have higher estrogen levels. Studies also show a correlation between excess body fat and low testosterone production.Weight affects testosterone levels

An in-depth study orchestrated at The Endocrine Society’s 93rd Annual Meeting in Boston made some stunning determinations on how weight affects testosterone levels in men. There, the co-author of the study, Dr. Jean-Paul Thissen, MD, Ph.D. made an impactful statement. He also happened to be a professor at the University of Louvain in Brussels. He said, “Morbidly obese men have a high prevalence of hypotestosteronemia, or low testosterone, and of sexual dysfunction.” He further enlightened, “It is reassuring that these problems are potentially curable by weight loss.”

The test consisted of 75 obese men. From 2007 to 2010, these men had been active patients at an obesity center. The study consisted of having their hormones tested as well as their body composition and body fat measured. Additionally, they were required to fill out a questionnaire designed to help better understand if there was any androgen (male hormone) deficiency. The addressed topics included erectile dysfunction, diminished sex drive and other libido affecting matters. Of these men, 17 of them participated in gastric bypass surgery. They were then reassessed three and twelve months later.

When the assessment was first initiated, of the 75 patients, 54 showed indications they were suffering from testosterone Weight affects testosterone levelsdeficiency. Twenty-seven of those men were clinically diagnosed with low testosterone in men.

The study denoted the higher a man’s body mass index, as well as their waist circumference and body fat percentage, the more depleted their testosterone levels were. Dr. Thissen advocated, “This correlation suggests a potential causal relationship between obesity and low testosterone.”

The seventeen men who underwent gastric bypass surgery lost a group average of approximately 90 lbs. Twelve months later, there had been a significant increase in their natural testosterone production. After the weight loss and the 12 month period, they were considered to be in normal range. This confirmed a reversal of testosterone deficiency, as reported by Dr. Thissen.

Weight affects testosterone levelsWe see in this study that weight affects testosterone levels in men significantly. If you are a man, overweight, in the process of bettering his health, talk to us. We can help you elevate your testosterone levels while you are in the process of losing weight. Not only may it help you with your overall goals, but its positive effects on sexual function, energy levels and overall sense of well-being make it an essential part of any health-focused regimen. Call us. We help you qualify for testosterone therapy and help you address your concerns and goals specifically.

 

Source:
The materials above were sourced from The Endocrine Society. Note: “Materials” may be edited for length and content.

June 27, 2016 by admin 1 Comment

Testosterone Effects on Prostate 0 (0)

Testosterone Effects on Prostate Health.
How That’s Changing.

Testosterone effects on prostate levels and its functionality have always been a delicate topic of conversation. There is a lot of controversy surrounding the different theories on its impact. We have all heard the stories and read the articles where Testosterone injections, or, really any form of testosterone therapy, are allegedly attributed to malignant side effects in the participants. What is most interesting is the notion there actually have not been many studies done focused on that particular reaction to therapy. By this we mean, double-blind, placebo-controlled studies as is the standard of our trusted Food and Drug administration’s qualification process.

  • testosterone effects on prostateWe do not want to give off the impression we share this recently accepted hypothesis, which suggests testosterone effects on prostate health do not necessarily have a correlation. However, it is important to shed light on the fact the medical community and its core beliefs and socially accepted diagnoses often shift, and dramatically. Also, as the world awakens, begins to ask more questions and not accepting the typical status quo, we’ve all become a bit more enlightened to the ways of the world. We’ve learned that big pharma and its main directors don’t necessarily have our health or us at the forefront of their decision-making. Many times profits interfere with factual descriptions and publicly distributed medicinal allocations. We must use discernment when we read data and, dig deeper if it’s a matter of personal importance. Everyone who searches finds…

Particularly men on testosterone therapy, they should do their best research to help them better understand the involved variables. Better understanding of testosterone effects on prostate health can help patients make the best determination, based on their personal considering factors.

A recent study led by researchers at NYU Langone Medical Center denoted men prescribed a minimum of 1 year of testosterone injections replacement therapy demonstrated no additional risk for prostate cancer. One researcher, in particular, Stacy Loeb,testosterone effects on prostate MD, MSc, who happens to be a urologist at NYU Langone Medical Center shared a different notion. She suggests physicians should continue to evaluate prostate cancer risk factors and better understand functionality and future health— such as age over 40, family history of the disease and black ancestry — among men prescribed testosterone therapy. Dr. Loeb said in a corresponding press release, “they should not hesitate to prescribe [testosterone therapy] to appropriate patients for fear of increasing prostate cancer risk.”

In their research to better understand testosterone injections effects on prostate health, Dr. Loeb and her contemporaries collected data from close to 25 million medical files on a group of men. These men were enumerated in the National Prostate Cancer Register and Prescribed Drug Register in Sweden.

  • testosterone effects on prostateThey were able to classify 38,570 men diagnosed with prostate cancer between 2009 and 2012. Of these men, 284 received testosterone therapy treatments prior to their prostate tissue diagnosis. These numbers were then compared to the results of 192,838 men who showed no development of cancer in the prostate. Most interestingly, 1,378 of those men had been on testosterone therapy.
  • Multivariable examination helped conclude no significant association between any kind of testosterone injections replacement therapy and prostate cancer risk (OR = 1.03; 95% CI, 0.9-1.17). In fact, the results suggested a 35% increase in low-risk prostate cancer occurrence after the commencement of a testosterone therapy regimen (OR = 1.35; 95% CI, 1.16-1.56). Results also showed a lower risk of aggressive disease among men who used testosterone injections replacement therapy for more than a year (OR = 0.5; 95% CI, 0.37-0.67).

testosterone effects on prostateFrom this analysis, the demarcations indicating the lessened potential for testosterone injections therapy to have a negative side effect on the prostate are significantly prominent. Testosterone injections effects on prostate health and blood testing levels shown to have little to no association. That being said, until the concrete information has changed the national standard on this widespread opinion, AAI Rejuvenation Clinic will continue to supplement each one of our therapies with the necessary medicinal requirements currently utilized to maintain possible, unwanted side effects from interfering with a successful testosterone therapy treatment. If you have any questions or comments related to this subject, please fill out our short contact form and someone will reach you within 24 hours. Make sure to leave your phone number. You can also call us directly by dialing:

Testosterone Therapy Information

March 21, 2016 by admin 0 Comments

Testosterone from a clinic? Why go that route if there are cheaper options? 0 (0)

Testosterone from a clinic, Why? It’s cheaper online or at the gym!

Testosterone from the clinic

Testosterone from a clinic sounds great but, if you’ve  done a little research online, you’d have found much better pricing on different online sources than what the doctor is telling you. Moreover, they deliver right to your front door. It’s a no-brainer, right?

For a lot of people that begin testosterone therapy after a long run of having low testosterone levels, the new amounts of testosterone floating through their bloodstream creates almost a euphoric life experience. The problem is the fact that our testosterone recedes at such a slow pace the transition is actually seamless. All of a sudden, you just “remember” being this person that you are currently not. It’s great stuff testosterone, for people that are depleted naturally or starting to deplete.

So, what’s the problem?

Unfortunately, the cost of doing a proper, healthy testosterone program under the supervision and monitor of a specialized Testosterone from a clinic
hormone replacement physician isn’t an economically feasible option for a lot of people that could genuinely benefit from the alternative. This means, for many, obtaining Testosterone from a clinic and trusted source is just not a possibility, so they think.

So, what do they do?

They hop online and try to find alternatives. What people don’t understand is, we live in a very different time. Gone are the Testosterone from a clinicdays when only the elite of organizations was able to finance fancy websites, packaging, advertising, marketing, medication labeling and delivery systems. No sir. The internet and its resourceful means for acquisition have all of the above available to any savvy (anyone) sitting in their home-office-garage, taking phone calls in his underwear, pretending to be 3 different departments while a batch of Testosterone injections is just about ready to be extracted from his bath tub only to be bottled before shipment, which is expected at 5 pm later that afternoon. The sad part is unless you did some deeper research, you’d probably never know the difference. More importantly, you’d never know what you are actually injecting into your body when you are not obtaining your testosterone from a clinic you can research and get to know.

Maybe the example above is a little bit colorful but don’t be mislead into believing it’s exaggerated or a fabrication of any sort. It’s actually a growing concern and the issue is that men that are on testosterone therapy, for the most part, don’t talk about it. So, if something happens… no one knows why and if they found out, there is no way to trace it back to the supplier.

Why should I be concerned?

The truth is, there actually are some places abroad that sell medication that is essentially real and it is cheaper. It’s not only Testosterone from the clinictestosterone from a clinic here in the U.S.A. that you can get injectable testosterone from, especially if you are basing it solely on price. You know the old saying, though… You get what you pay for.

  • How are you going to verify that the medication is real?
  • Company reviews can be made up and strategized.
  • If you don’t have your regulated American search options for inquiry, how and whom are you going to trust to control where that medication is coming from?
  • How can you verify it was created in sterile conditions?
  • How can you verify the quality of the material that was used and where it came from?
  • Can you ask for a certificate of authenticity to verify the efficacy percentage of the medication your about to inject into your body?
  • If something bad happened, is there anybody from that organization to contact?
  • Do you get to talk to the doctor that prescribed your medication, or any physician that works directly under him/her?
  • Again, what if something happened?!? – We have to think further than our eyes can see.

What to look out for?

  • Is the only payment the Western Union or western union-like? Big red flag! That means, once they have your money, that’s it. There is no tracing that person. Cross your fingers.
  • Can you ask for the name of the prescribing physician?
  • Are you allowed to or requested to speak with your prescribing physician or any physician that works directly under him/her, as is legally required in this wonderful, standardized country of ours.
  • If a website has in small print “Not for human consumption” but they are selling everything you want to buy, they are completely eliminating themselves from any possible legal repercussions after any adverse reactions you may experience.
  • Can you ask for details of the pharmacy?
  • What’s the pharmacy’s DEA number?
  • Does the organization have a Bricks and Mortar establishment? An actual, patient-seeing location?

Testosterone from a clinicBe very vigilant. Think about your health. The thing is we men for the most part only contemplate about the now. Immediate gratification. When we want what we want, we are perfectly ok with wearing blinders. The issue is that with the rise in popularity regarding the incredible, incomparable benefits of testosterone therapy, a lot of guys are self-diagnosing, not doing research and basing their medication acquisition source on the best bargain they can obtain.

Well, in case this article is about you and you haven’t done your research related to these hormone therapy mills, the events that are happening to ‘haggling-with-their-health-patients’ range from multistate fungal meningitis outbreaks to bacterial infections of the eye resulting in permanent vision loss. Also, contaminated dispensing mechanisms and products are leading to all kinds of unfortunate bacterial infections.

Make sure you do your research. Don’t hurt yourself to save a few dollars. Try to do your best to obtain testosterone from a clinic that you have researched and trust. At AAI Rejuvenation Clinic, you can do all the research you want and will find that we are the right choice for anyone looking to participate in an effective, regulated hormone replacement program. Even if you don’t want to do business with us now, please feel free to contact us and pick our brains. You will never reach a ‘sales person’. That is not what we do here.

We hope to hear from you. You can fill out our Medical History Form and be reached within the next 24 business hours or, if you want to reach us immediately, you can speak with one of our friendly Wellness Advisors by dialing:

Testosterone Therapy Information

What Is Testosterone?

Testosterone Therapy Info

Testosterone Injections

symptoms of Low Testosterone

causes of Low Testosterone

Low Testosterone in Men

Low Testosterone in Women

Low Testosterone

Testosterone Cypionate

Testosterone Propionate

Testosterone Enanthate

Testosterone Patches

Testosterone Gels

Testosterone Boosters

Side Effects of Testosterone

March 9, 2016 by admin 1 Comment

Cure for the Common Cold 0 (0)

Common cold: Healing Foods Series

Cure for the

The cure for the common cold, flu, and other infections. It would be magnificent to be able to knock out a creeping cold. Not only does it make us feel horrid but it also disrupts our lives. Sad to say it, nowadays, we actually don’t have time to be sick.

Thank goodness for our immune systems. Without you even being aware, there is a constant war inside your body: Your immune system against all other systemic degrading impurities, which are constantly invading our bodies no matter how clean of a person we are.

Cure for the Common Cold

We must do everything in our power to keep our immune systems strong. Potent! If we are constantly vigilant to do the correct things in our lives to keep our immune system healthy, we can rest assured that other key areas of our health will inadvertently follow suit.

For now, there is no 100% guaranteed cure for the common cold but being able to give an authentic boost to your immune system in the early stages of a cold, flu or infection, can really do wonders to reduce the healing time and severity of the symptoms. Many times, all your immune system needed to be was a little boost and you’ll actually knock the cold or flu right out of you.

Try these little mixtures the next time you are not feeling well or realize you need that little extra immune boost. These may not be an immediate cure for the common cold but, watch and see how much quicker you will feel better and how much your symptoms will be reduced.

Stage One: You will do this immediately after the first signs of any cold, flu, virus or infection.

  • 1 ‘Wellness Fizz’ effervescent tablet dissolved in 8oz of water every 3 hours (look up online. It’s a fantastic product – Amazon has it)
  • 2 droppers every hour of ‘Echinacea Supreme, Extra Strength’. (you want the one by Gia Herbs. We also found it on Amazon)
  • 6 drops of Oregano Oil (do your research. It’s a godsend) every 4 hours. Make sure it has a high Carvacrol level but, no more than 70%. More than 70% compromises other key ingredients so, don’t be misled.

Stage Two: Eat Correctly with STRICT discipline. (SWEETS LOWER IMMUNITY)

  • 3 raw garlic cloves with lots of ginger, in a smoothie with pear. (contains antiviral caffeic acid)Cure for the Common Cold
  • Blend 1 onion, 6oz of water and add a little honey – take two tablespoons every hour
  • Make a 9 Clove Garlic Pesto (recipe online. Use organic ingredients) and use it at meals
  • Add lots of onion to your meals.

Stage Three: Healing from the outside in. You can rotate between the following two options.

  • Garlic Gauze Foot Pads: AWESOME to turn up anti-viral powers while you sleep:
    ~ Dice 10 cloves of organic garlic into tiny pieces (do not mash).
    ~ Place on the surface of two gauze pads.
    ~ Coat the soles of your feet with olive oil so the garlic doesn’t irritate
    ~ Affix the garlic pads to the soles of your feet with gauze tape and
    cover with socks. Leave on overnight.
  • 100% Pure Tea Tree Oil:
    ~ Rubbed on your back, neck, and bottom of your feet before bed. Tea Tree Oil has been used successfully by doctors dealing wit MRSA, it’s so powerful.

By now, our readers know that the root of our therapies is hormone therapies such as Testosterone Therapy, HGH Therapy, Sermorelin Therapy and many others. Our point is to always try to inculcate the fact that if your hormones are low, your immune system is low. If you are a man, you absolutely need testosterone injections in order to feel and be healthy. The ladies need a combination of their three essential hormones checked (Estrogen, Progesterone, and Testosterone) to ensure their wellbeing. Both sexes will age prematurely if Human Growth Hormone levels are low and, you know age is cruel to the immune system.

If you have any questions about our cure for the common cold or with to try to qualify for therapy, kindly reach out to us by filling out our Medical History Form to be contacted within 24 business hours. If you wish to speak with someone right away.

February 10, 2016 by admin 0 Comments

Is Testosterone Therapy Preventive Medicine? 0 (0)

Is Testosterone Therapy Preventive Medicine?

testosterone therapy preventive medicine

Is Testosterone therapy preventive medicine? This is a very fair question. We hear of so many pro’s and cons but, is there an actual medical need for testosterone. Is Testosterone therapy preventive medicine or, where does it rank in terms of the necessity for the male body?

It could be said that testosterone is what makes men, men. It gives them:

  • their characteristic deep voices
  • larger muscles
  • facial and body hair, distinguishing them from women.

It also:

  • stimulates the growth of the genitals at puberty
  • plays a role in sperm production
  • fuels libido
  • contributes to normal erections
  • fosters the production of red blood cells
  • boosts mood
  • aids cognition

Over time, the testicular “machinery” that makes testosterone gradually becomes less effective, and testosterone levels start to fall, by about 1% a year, beginning in the 40s. As men get into their 50s, 60s, and beyond, they may start to have signs and symptoms of low testosterone such as:

  • lower sex drive and sense of vitality
  • erectile dysfunction
  • decreased energy
  • reduced muscle mass and bone density
  • and even anemia, to name a few.

Taken together, these signs and symptoms are often called hypogonadism (“hypo” meaning low functioning and “gonadism” referring to the testicles). Researchers estimate that the condition affects anywhere from two to six million men in the United States. Yet it is an underdiagnosed problem, with only about 5% of those affected receiving treatment.

Studies have shown that testosterone-replacement therapy may offer a wide range of benefits for men with hypogonadism, including improved libido, mood, cognition, muscle mass, bone density, and red blood cell production.

Taking into account some of the scientific facts delineated above, its simple to see how maintaining healthy testosterone levels can help in preventing accelerated aging. If maintaining healthy testosterone levels is reflected in a patient maintaining their vigor, strength, sexual interest and functionality and positive attitude, then it should be deemed preventive medicine. We think we can say “yes”. Testosterone therapy is preventive medicine.

Consider the fact that Testosterone is an incomparable antioxidant to the heart and its proven to maintain and aid in brain health. Not only do these points make testosterone out to be preventive medicine, it proves it an invaluable aspect of a male’s anti-aging regimen. No matter how well off all your other hormones are, as a male, if your testosterone is low, you are just simply not your normal self… and you can feel it. Call us at your earliest convenience so we can help you determine your testosterone levels. We even have

You can also reach us by filling out our Medical History Form. Upon completion, you can expect a contact within 24 business hours from one of our expert Wellness Advisors. Take advantage, testosterone therapy preventive medicine is our area of expertise. Let us share more life-transforming fact as they would affect you specifically. Contact us now.

 

testosterone-injections

 

Testosterone Injections is the most common treatment for men going through andropause. This therapy may provide help and relief from the symptoms and help improve the quality of life in many cases, also lifestyle changes such as increased exercise, stress reduction, and proper nutrition also help.

Testosterone therapy is available in different forms, ask your doctor he will help determine which treatment is best for you.

TESTOSTERONE INJECTIONS: This treatment involves doses of bioidentical (Testosterone Cypionate, Testosterone Enanthate, and Testosterone Propionate).

TESTOSTERONE PATCHES: People who wear a piece containing testosterone receive the hormone through the skin. The patches allow a slow, steady release of testosterone into the bloodstream.

TESTOSTERONE GEL: This treatment is also applied directly to the skin, usually on the arms. Because the gel may transfer to other individuals through skin contact, a person must take care to wash the gel from the hands after each application.

TESTOSTERONE CAPSULES: This is yet another option for testosterone replacement. Men with liver disease, poor liver function, severe heart or kidney disease, or too much calcium in their blood should avoid testosterone capsules.

Follow-up visits with your doctor will be necessary after the initial treatment begins. At follow-up visits, your doctor will check your response to the treatment and make adjustments, if necessary.

February 4, 2016 by admin 0 Comments

Testosterone Cypionate Description 0 (0)

Testosterone Cypionate description injections

Testosterone Cypionate Description injection for intramuscular injection contains Testosterone Cypionate which is the oil-soluble 17 (beta)- cyclopentyl propionate ester of the androgenic hormone testosterone. Testosterone Cypionate is a white or creamy white crystalline powder, odorless or nearly so and stable in air. It is insoluble in water, freely soluble in alcohol, chloroform, dioxane, ether, and soluble in vegetable oils. The chemical name for Testosterone Cypionate is androst-4-en-3-one,17-(3-cyclopentyl-1-oxopropoxy)-, (17β)-. Its molecular formula is C27H40O3, and the molecular weight 412.61.

The structural formula is represented below:

Testosterone Cypionate injection, USP is available in two strengths, 100 mg/mL and 200 mg/mL Testosterone Cypionate, USP.

Each mL of the 100 mg/mL solution contains:

Testosterone Cypionate……………………………………………………………………. 100 mg
Benzyl benzoate ……………………………………………………………………………… 0.1 mL
Cottonseed oil ………………………………………………………………………………… 736 mg
Benzyl alcohol (as preservative)………………………………………………………… 9.45 mg

Each mL of the 200 mg/mL solution contains:

Testosterone Cypionate……………………………………………………………………. 200 mg
Benzyl benzoate………………………………………………………………………………. 0.2 mL
Cottonseed oil………………………………………………………………………………… 560 mg

Benzyl alcohol (as preservative)………………………………………………………… 9.45 mg

Testosterone Cypionate – Clinical Pharmacology

Endogenous androgens are responsible for normal growth and development of the male sex organs and for maintenance of secondary sex characteristics. These effects include growth and maturation of the prostate, seminal vesicles, penis, and scrotum; development of male hair distribution, such as beard, pubic, chest, and axillary hair; laryngeal enlargement, vocal cord thickening, and alterations in body musculature and fat distribution. Drugs in this class also cause retention of nitrogen, sodium, potassium, and phosphorous, and decreased urinary excretion of calcium. Androgens have been reported to increase protein anabolism and decrease protein catabolism. Nitrogen balance is improved only when there is sufficient intake of calories and protein.

Androgens are responsible for the growth spurt of adolescence and for eventual termination of linear growth, brought about by fusion of the epiphyseal growth centers. In children, exogenous androgens accelerate linear growth rates but may cause a disproportionate advancement in bone maturation. Use over long periods may result in fusion of the epiphyseal growth centers and termination of the growth process. Androgens have been reported to stimulate the production of red blood cells by enhancing production of erythropoietic stimulation factor.

During exogenous administration of androgens, endogenous testosterone release is inhibited through feedback inhibition of pituitary luteinizing hormone (LH). At large doses of exogenous androgens, spermatogenesis may also be suppressed through feedback inhibition of pituitary follicle stimulating hormone (FSH).

There is a lack of substantial evidence that androgens are effective in fractures, surgery, convalescence, and functional uterine bleeding.

Pharmacokinetics

Testosterone esters are less polar than free testosterone. Testosterone esters in oil injected intramuscularly are absorbed slowly from the lipid phase; thus, Testosterone Cypionate can be given at intervals of two to four weeks.

Testosterone in plasma is 98 percent bound to a specific testosterone-estradiol binding globulin, and about 2 percent is free. Generally, the amount of this sex-hormone binding globulin in the plasma will determine the distribution of testosterone between free and bound forms, and the free testosterone concentration will determine its half-life.

About 90 percent of a dose of testosterone injections is excreted in the urine as glucuronic and sulfuric acid conjugates of testosterone and its metabolites; about 6 percent of a dose is excreted in the feces, mostly in the unconjugated form. Inactivation of testosterone occurs primarily in the liver. Testosterone therapy is metabolized to various 17-keto steroids through two different pathways.

The half-life of Testosterone Cypionate, when injected intramuscularly, is approximately eight days.

In many tissues, the activity of testosterone therapy appears to depend on reduction to dihydrotestosterone, which binds to cytosol receptor proteins. The steroid-receptor complex is transported to the nucleus where it initiates transcription events and cellular changes related to androgen action.

Indications and Usage for Testosterone Cypionate description

Testosterone Cypionate description injection is indicated for replacement therapy in the male in conditions associated with symptoms of deficiency or absence of endogenous testosterone.

  • Primary hypogonadism (congenital or acquired)-testicular failure due to cryptorchidism, bilateral torsion, orchitis, vanishing testis syndrome; or orchidectomy.
  • Hypogonadotropic hypogonadism (congenital or acquired): gonadotropin or LHRH deficiency, or pituitary-hypothalamic injury from tumors, trauma, or radiation.

Safety and efficacy of Testosterone Cypionate description in men with “age-related hypogonadism” (also referred to as “late-onset hypogonadism”) have not been established.

Contraindications

  1. Known hypersensitivity to the drug
  2. Males with carcinoma of the breast
  3. Males with known or suspected carcinoma of the prostate gland
  4. Women who are or who may become pregnant
  5. Patients with serious cardiac, hepatic or renal disease

Warnings

Hypercalcemia may occur in immobilized patients. If this occurs, the drug should be discontinued.

Prolonged use of high doses of androgens (principally the 17-α alkyl-androgens) has been associated with the development of hepatic adenomas, hepatocellular carcinoma, and peliosis hepatis —all potentially life-threatening complications.

Geriatric patients treated with androgens may be at an increased risk of developing prostatic hypertrophy and prostatic carcinoma although conclusive evidence to support this concept is lacking.

There have been postmarketing reports of venous thromboembolic events, including deep vein thrombosis (DVT) and pulmonary embolism (PE), in patients using testosterone products, such as Testosterone Cypionate description. Evaluate patients who report symptoms of pain, edema, warmth, and erythema in the lower extremity for DVT and those who present with acute shortness of breath for PE. If a venous thromboembolic event is suspected, discontinue treatment with Testosterone Cypionate description and initiate appropriate workup and management.

Long term clinical safety trials have not been conducted to assess the cardiovascular outcomes of testosterone replacement therapy in men. To date, epidemiologic studies and randomized controlled trials have been inconclusive for determining the risk of major adverse cardiovascular events (MACE), such as non-fatal myocardial infarction, non-fatal stroke, and cardiovascular death, with the use of testosterone compared to non-use. Some studies, but not all, have reported an increased risk of MACE in association with the use of testosterone replacement therapy in men. Patients should be informed of this possible risk when deciding whether to use or to continue to use Testosterone Cypionate description.

Edema, with or without congestive heart failure, may be a serious complication in patients with preexisting cardiac, renal or hepatic disease.

Gynecomastia may develop and occasionally persists in patients being treated for hypogonadism.

The preservative benzyl alcohol has been associated with serious adverse events, including the “gasping syndrome”, and death in pediatric patients. Although normal therapeutic doses of this product ordinarily deliver amounts of benzyl alcohol that are substantially lower than those reported in association with the “gasping syndrome”, the minimum amount of benzyl alcohol at which toxicity may occur is not known. The risk of benzyl alcohol toxicity depends on the quantity administered and the hepatic capacity to detoxify the chemical. Premature and low-birth weight infants may be more likely to develop toxicity.

Androgen therapy should be used cautiously in healthy males with delayed puberty. The effect on bone maturation should be monitored by assessing the bone age of the wrist and hand every 6 months. In children, androgen treatment may accelerate bone maturation without producing a compensatory gain in linear growth. This adverse effect may result in compromised adult stature. The younger the child the greater the risk of compromising final mature height.

This drug has not been shown to be safe and effective for the enhancement of athletic performance. Because of the potential risk of serious adverse health effects, this drug should not be used for such purpose.

Precautions

General

Patients with benign prostatic hypertrophy may develop acute urethral obstruction. Priapism or excessive sexual stimulation may develop. Oligospermia may occur after prolonged administration or excessive dosage. If any of these effects appear, the androgen should be stopped and if restarted, a lower dosage should be utilized.

Testosterone Cypionate description should not be used interchangeably with testosterone propionate description because of differences in duration of action.

Testosterone Cypionate description is not for intravenous use.

Information for Patients

Patients should be instructed to report any of the following: nausea, vomiting, changes in skin color, ankle swelling, too frequent or persistent erections of the penis.

Laboratory Tests

Hemoglobin and hematocrit levels (to detect polycythemia) should be checked periodically in patients receiving long-term androgen administration.

Serum cholesterol may increase during androgen therapy.

Drug Interactions

Androgens may increase sensitivity to oral anticoagulants. The dosage of the anticoagulant may require a reduction in order to maintain satisfactory therapeutic hypoprothrombinemia.

Concurrent administration of oxyphenbutazone and androgens may result in elevated serum levels of oxyphenbutazone.

In diabetic patients, the metabolic effects of androgens may decrease blood glucose and, therefore, insulin requirements.

Drug/Laboratory Test Interferences

Androgens may decrease levels of thyroxine-binding globulin, resulting in decreased total T4 serum levels and increased resin uptake of T3 and T4. Free thyroid hormone levels remain unchanged, however, and there is no clinical evidence of thyroid dysfunction.

Carcinogenesis

Animal data

Testosterone has been tested by subcutaneous injection and implantation in mice and rats. The implant induced cervical-uterine tumors in mice, which metastasized in some cases. There is suggestive evidence that injection of testosterone into some strains of female mice increases their susceptibility to hepatoma. Testosterone is also known to increase the number of tumors and decrease the degree of differentiation of chemically induced carcinomas of the liver in rats.

Human data

There are rare reports of hepatocellular carcinoma in patients receiving long-term therapy with androgens in high doses. Withdrawal of the drugs did not lead to regression of the tumors in all cases.

Geriatric patients treated with androgens may be at an increased risk of developing prostatic hypertrophy and prostatic carcinoma although conclusive evidence to support this concept is lacking.

Pregnancy

Teratogenic Effects

Pregnancy Category X. (See CONTRAINDICATIONS)

Benzyl alcohol can cross the placenta. See WARNINGS.

Nursing Mothers

Testosterone Cypionate description is not recommended for use in nursing mothers.

Pediatric Use

Safety and effectiveness in pediatric patients below the age of 12 years have not been established.

Adverse Reactions

The following adverse reactions in the male have occurred with some androgens:

Endocrine and urogenital: Gynecomastia and excessive frequency and duration of penile erections. Oligospermia may occur at high dosages.

Skin and Appendages: Hirsutism, male pattern of baldness, seborrhea, and acne.

Cardiovascular Disorders – myocardial infarction, stroke

Fluid and electrolyte disturbances: Retention of sodium, chloride, water, potassium, calcium, and inorganic phosphates.

Gastrointestinal: Nausea, cholestatic jaundice, alterations in liver function tests, rarely hepatocellular neoplasms and peliosis hepatis (see WARNINGS).

Hematologic: Suppression of clotting factors II, V, VII, and X, bleeding in patients on concomitant anticoagulant therapy, and polycythemia.

Nervous system: Increased or decreased libido, headache, anxiety, depression, and generalized paresthesia.

Allergic: Hypersensitivity, including skin manifestations and anaphylactoid reactions.

Vascular Disorders: venous thromboembolism

Miscellaneous: Inflammation and pain at the site of intramuscular testosterone injection.

Testosterone Therapy Information

July 28, 2015 by admin 0 Comments

Testosterone Levels Impact Sexual Function In Body 5 (1)

The influence of testosterone towards sexual function and libido isn’t emphasized enough. Even though it is implicated in study after study, the need for all persons to have their testosterone therapy levels properly balanced is essential. It’s an intricate part of a properly functioning endocrine system, which is critical for feeling healthy. Testosterone injections are among the most potent of libido-enhancing agents known to mankind. Testosterone therapy is effective in raising a person’s testosterone levels. This can certainly have a positive, “rising” effect on the desire for sexual contact.

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