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December 22, 2017 by Joseph Fermin 0 Comments

The Truth About Testosterone Decrease 5 (1)

Why Does Testosterone Decrease | The Truth About Testosterone

HPTA = Hypothalamic Pituitary Gonadal Axis

This axis produces circulating steroids necessary for male sexual function, fertility, and development.

Prostate and penis are steroid sensitive organs impacted by the regulation of the HPTA.

This reproductive axis consists of three parts:

  • Hypothalamus – produces GnRH (gonadotropin-releasing hormone)
  • Pituitary Gland – GnRH sent to the pituitary gland where it stimulates the synthesis and release of gonadotropic hormones LH and FSH.
  • Testis – Gonads carry LH to the testis where they encourage testosterone production through the testicular Leydig cells
  • Conversion of cholesterol produces testosterone
  • FSH is crucial for spermatogenesis

Dihydrotestosterone (DHT) is the activated 2% of testosterone is free or unbound, with the remainder bound to SHBG (sex hormone-binding globulin), albumin- and cortisol-binding globulin. Bioavailable testosterone is the testosterone that will not attach to SHBG. Testosterone and DHT act on organs.

  • Causes development of secondary sexual characteristics
  • Inhibit secretion of LH and FSH by the pituitary gland, thus stops further testosterone production = negative feedback loop.
  • There exist androgen receptors in the pituitary and the

hypothalamic neurons that bind to testosterone and signal to stop GnRH release

Homeostasis maintained through this loop – once testosterone stops production, this inhibited secretion stops and GnRH again causes LH and FSH release to produce further testosterone. As men age, they undergo hormonal level changes:

  • Testosterone decrease
  • LH and FSH increase
  • Other hormones that decrease: T3, insulin, growth hormone/insulin-like growth factor 1, stimulating thyroid hormone
  • Also an increase in SHBG
  • Dihydrotestosterone levels are unchanged
  • Estrogen levels unchanged

As men age, the decrease in testosterone paired with the increase in SHBG leads to a decline in free, or bioavailable, testosterone. These hormonal changes start in the 30s and are well established by the 50s.

The Purpose of Testosterone injections Therapy:

  • Improve Motivation and Memory Loss
  • Increase Sex Drive & Desire
  • Improve Depression and Energy
  • Improve Cholesterol and Osteoporosis
  • Decrease Erectile Dysfunction
  • Increase Muscle Mass and Better Sleep
  • Improve Wounds healing & Illness
  • Improve Thyroid Dysfunction

 

December 20, 2017 by Joseph Fermin 0 Comments

How Testosterone Affects Fat Loss: Real Science of Low-T 5 (1)

How Testosterone Affects Fat Loss: Real Science of Low-T

Testosterone Affects Fat Loss, As men age, their testosterone levels decline. This increase in SHBG (sex-hormone binding globulin), which binds to testosterone and thus reduces the amount of free testosterone in the body. Low testosterone levels, obesity, and many other health problems, including fatigue, memory problems and decreased muscle and bone mass. So what is the impact of testosterone on the body and how Testosterone Affects Fat Loss?

Testosterone and energy – low levels of testosterone can cause low energy levels. Regaining natural testosterone levels can increase strength and lead to weight loss. Studies have found that testosterone supplementation reduces total body fat percentages. Obesity is related to low testosterone levels in men. Just as testosterone therapy is associated with decreased obesity, losing weight is associated with increased testosterone levels.

An article in 2014 in the journal of Current Opinion in Endocrinology, Diabetes, and Obesity looked at the existing data regarding testosterone therapy in overweight and obese men with testosterone deficiency (hypogonadism).

  • Many weight loss supplements have dangerous side effects or are ineffective
  • Looked at weight loss, BMI, waist circumference and body composition
  • Evaluated long-term testosterone therapy
  • About 40% of obese nondiabetic men and 50% of overweight diabetic men over 45 have low levels of free testosterone
  • Many studies have found that testosterone therapy in overweight men helps increased lean body mass, weight loss, decreased BMI and reduced waist circumference.
  • Weight loss is significant and sustained with long-term testosterone therapy
  • Testosterone plays a part in protein, fat and carbohydrate metabolism.
  • Testosterone is involved in mitochondrial function and thus energy production and utilization
  • This interference with energy production is likely why those with low testosterone levels experience a lack of energy
  • Testosterone therapy has been found to increase lipid oxidation and normalize glucose use in the body. It was found to increase strength and motivation.

Weight gain associated with an 88% increase in body fat and a 12% increase in lean body mass (LBM) and weight loss with a 72% decrease in body fat and a 28% decrease in LBM.

  • With testosterone therapy, LBM has been shown to increase.
  • Increased LBM means increased energy expenditure at rest
  • Testosterone therapy with improved cardiometabolic function

Testosterone deficiency decrease in energy metabolism from fat and an increase in energy metabolism from glucose.

  • Testosterone therapy has been shown to increase lipid metabolism

Safety? Safety is the primary concern with testosterone replacement therapy. Possible risks discussed in the literature include:

  • Increased risk of prostate and breast cancer
  • Liver toxicity and tumors
  • Sleep apnea exacerbation
  • Testicular infertility and atrophy

Talking with your doctor before starting testosterone injections therapy is necessary.

Summary: If you are a male struggling to lose weight, testosterone therapy is a promising treatment to help with not only weight loss but for body composition, energy levels and overall health.