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March 5, 2019 by Joseph Fermin 0 Comments

What is Follicle Stimulating Hormone (FSH)?

What is Follicle Stimulating Hormone

What is Follicle Stimulating Hormone (FSH), is one of the gonadotrophic hormones, and the other being a Luteinizing Hormone (LH). The pituitary gland releases both into the bloodstream and body, and Follicle Stimulating Hormone (FSH) is one of the hormones essential for the development function of women’s ovaries and men’s testes. In women, Follicle Stimulating Hormone (FSH) stimulates the growth in the ovary before the release of an egg from one follicle to the ovulation. It also increases estradiol production. In men, Stimulating Follicle Hormone (FSH) acts on the Sertoli cells of the testes to stimulate sperm production (spermatogenesis).

How is Follicle Stimulating Hormone (FSH) control?

The release of Follicle Stimulating Hormone (FSH) is regulated by the levels of some circulating hormones released by the ovaries and testes. This system is called the hypothalamic–pituitary–gonadal axis. The gonadotropin-releasing hormone is published in the hypothalamus and the receptors in the anterior pituitary gland to stimulate both the synthesis release of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The released Follicle Stimulating Hormone (FSH) is carried in the bloodstream, where it binds to receptors in the testes and the ovaries. Using this mechanism Follicle Stimulating Hormone (FSH), along with Luteinizing Hormone (LH), can control the functions of the ovaries and testes.

follicle stimulating hormone

In women, when hormone levels are deficient, and it has complication the menstrual cycle, this is sensed by nerve cells in the hypothalamus. These cells produce the more gonadotrophin-releasing hormone, which in turn stimulates the pituitary gland to produce more Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH), and release these into the bloodstream. The rise in Follicle Stimulating Hormone (FSH) and stimulates the growth of the follicle in the ovary, and the cells of the follicles produce increasing amounts of estradiol. In turn, this production of these hormones is sensed by the hypothalamus, and pituitary gland and less gonadotrophin-releasing hormone and Follicle Stimulating Hormone (FSH) will be released, However, as the follicle grows, and more and more estrogen is produced from the follicles, it simulates a surge in luteinizing hormone (LH) and Follicle Stimulating Hormone (FSH), which stimulates the released egg from a mature follicle – ovary.

During women menstrual cycle, there is a rise the Follicle Stimulating Hormone (FSH) secretion in the first half of the period and stimulates follicular growth in the ovary, after ovulation, each month the ruptured follicle forms and Corpus luteum that produces high levels of progesterone. This inhibits the release of stimulating Follicle Stimulating Hormone (FSH), and towards the end of the cycle the Corpus luteum breaks down, and progesterone production decreases. The next menstrual period begins when Follicle Stimulating Hormone (FSH) starts the production again, and get back to normal…

follicle stimulating hormone

Now In men, the production of Follicle Stimulating Hormone (FSH) is regulated by levels of testosterone and inhibin, both produced by the testes. Follicle Stimulating Hormone (FSH) regulates testosterone levels and when this rise they are sensed by nerve cells in the hypothalamus so that gonadotropin-releasing hormone secretion and consequently Follicle Stimulating Hormone (FSH) is decreased. The opposite occurs when testosterone levels drop. This is known as a ‘Negative Feedback in the body’ control so that the production of testosterone remains steady. But the sensed by cells in the anterior pituitary gland rather than the hypothalamus.

What happens if you have too much Follicle Stimulating Hormone (FSH)?

Most often, and raised levels of Follicle Stimulating Hormone (FSH) are a sign of malfunction in the ovary or testis. If the gonads fail to create enough estrogen, testosterone and inhibit, the right feedback control of Follicle Stimulating Hormone (FSH) production from the pituitary gland is lost, and the levels of both Follicle Stimulating Hormone (FSH) will rise. This condition is called hypogonadotropic-hypogonadism and is associated with primary ovarian failure or testicular failure. This is seen in states such as Klinefelter’s syndrome in men and Turner syndrome in women.

In women, Follicle Stimulating Hormone (FSH) levels also start to rise naturally in women around the menopausal period, reflecting a reduction in the function of the ovaries and decline of estrogen and progesterone production.

There are rare pituitary conditions that can raise the levels of Follicle Stimulating Hormone (FSH) in the bloodstream. This overwhelms the regular negative feedback and can cause ovarian hyperstimulation syndrome in women ovaries.

Symptoms: This includes enlarging of the ovaries and potentially dangerous accumulation of fluid in the abdomen, and triggered the rise in ovarian steroid output. Which leads to pain and other problems in the pelvic area of the body.

What happens if don’t produce enough Follicle Stimulating Hormone (FSH)?

In women, lack of Follicle-Stimulating-Hormone (FSH) leads to incomplete development in puberty o poor ovarian function (ovarian failure), and In this situation ovarian follicles do not grow properly and do not release in the egg, thus leading to infertility. Since levels of Follicle-Stimulating-Hormone (FSH) in the bloodstream are low, this condition is called hypogonadotropic-hypogonadism. This condition is called Kallman’s syndrome, which is associated with a reduced sense of smell.

Sufficient Follicle-Stimulating-Hormone (FSH), this action is also needed for proper sperm production in men, in case of complete absence of Follicle Stimulating in men, and the lack of puberty and infertility due no production of sperm is called (azoospermia). Partial Follicle-Stimulating-Hormone (FSH) deficiency in young men, can also cause delayed puberty and low sperm production, called (oligozoospermia), but fathering a child may still be possible. Follicle-Stimulating-Hormone (FSH) occurs after puberty; there will be a similar loss of fertility…

May 20, 2018 by Joseph Fermin 0 Comments

To Understand the Hormonal Imbalance in Women

To Understand the Hormonal Imbalance in Women

Hormonal Imbalance

Hormonal Imbalance and why can it be so difficult or impossible to clear up acne? As you probably know, you’re hormonal and acne has a vast array of potential causes.

For some people putting cream or simple dietary changes can clear up their skin (Yeah!), but for others, it can be a long and hard arduous journey to clear up.

However, it doesn’t have to be a long struggle for clear skin if you can pinpoint the underlying triggers. Hormonal Imbalance is a cause of acne, and I’m going to talk about the topic in detail so you can understand or have an idea why this can occur, and how you can treat it!

Hormones are abundant when we are young in the body, always involved in complex and far-reaching processes. No Hormonal Imbalance acts in isolation; they work together, so when one is out of balance, it can disrupt the whole endocrine system or worse. This article will discuss Hormonal Imbalance related to pre-menstrual and acne problems.

A brief overview of the menstrual cycle in women and its Hormonal Imbalance, to understand the Hormonal Imbalance in women, it’s essential first to know what hormonal balance is and what should occur ideally.

Your period is a monthly report on your health, and if everything is in balance, you should expect to have an average length cycle, with little-to-no PMS symptoms and a painless period without heavy bleeding. You might be thinking ‘As if that exists?!’ right now, but unfortunately, so many women experience Hormonal Imbalance, stress, nutritional deficiencies, and general ill-health, that things like PMS and period pain have become the norm. PMS is common, but it’s not normal. So, let’s get into it:

Menstrual cycle will starts on the first day of your period bleed, right until the first day of your next period. An average cycle length is anywhere between 23 and 35 days in length and varies from woman to woman. Although the menstrual cycle based on 28 days, Now this is not the case always. Anything outside this 23-35 day cycle length will be considered abnormal or will often indicate a Hormonal Imbalance dysfunction along the line in life.

Hormonal Imbalance

 

There are many hormones involved in the body that can regulate the menstrual cycle, but (so it doesn’t get too confusing!) the main ones are:

  1. Estrogen
  2. Progesterone
  3. Follicle Stimulating Hormone (FSH)
  4. Luteinizing hormone (LH)
  5. Testosterone

Testosterone and other androgens, If implantation of an egg occurs, the above hormones kick in to promote all the requirements for a healthy pregnancy. If fertilization does not happen, after ovulation the uterus lining will shed to make way for a new uterine lining for next ovulation (the body is always hoping!).

Ovulation is meant to occur smack-bang in the middle of your menstrual cycle- at text-book day 14 if you have a 28-day cycle. You will usually get your period 14 days later of ovulation, so if your menstrual cycle is 25 days, you may ovulate on day 11.

The Ovulation shares the menstrual period into two stages: the first phase is when estrogen is the star, and the second stage focuses on progesterone. Progesterone usually is secreted from the ovarian follicle after ovulation (a tiny bit released from your adrenal glands), which develops into a sac called the corpus luteum. Therefore, to have adequate levels of progesterone, you need to have ovulated.

Now, central to the discussion of hormonal balance because many women don’t ovulate every menstrual cycle due to stress, illness, and nutritional inadequacies. Estrogen and progesterone-like to work together in balance, and the ratio between the levels of these hormones is critical. Estrogen is ‘proliferative,’ meaning it promotes cells growth (things like breast and hip development in puberty) and promotes smooth, plump skin, healthy bones, and arteries. Progesterone is ‘secrete,’ meaning that it promotes vascular development and the maintenance of the uterine lining after ovulation.

Hormonal Imbalance

Hormonal Imbalance can occur in women when:

  1. Estrogen levels are high or low, and progesterone is normal
  2. Estrogen levels are high or low, and progesterone is low
  3. Estrogen levels are reasonable, and progesterone levels are low
  4. Pre-Menstrual, Acne, and Estrogen levels
  5. Pre-Menstrual, Acne, and Testosterone levels

Pre-menstrual and acne can occur anywhere in the 1-2 weeks before your period, now this acne is related to the hormonal of a woman’s menstrual period and includes the hormones testosterone, estrogen, progesterone also some androgens and others.

After the ovulation, in the second part of the menstrual cycle the amount of hormones increases, because we know we have testosterone, estrogen, and progesterone. Estrogen will naturally start to decline soon while progesterone begins to rise.

But how do estrogen levels drop?

Too high or too little estrogen can disrupt the menstrual cycle and can impact progesterone levels by impairing ovulation. So, we want estrogen to be at just the right amount- not too high and not too low. Estrogen is broken down (metabolized) through the liver and eliminated via the kidneys and intestines (in your pee and poop). If estrogen is not working or metabolized correctly, then the levels build and build which can result in estrogen excess. Too much estrogen and specific metabolites of estrogen can cause inflammation. Here is where high estrogen levels can trigger pre-menstrual acne.

The cause? Too much re-circulating estrogen and not enough proper liver detoxification going on and extra estrogen can turn in testosterone.

Pre-Menstrual and acne are a sign that your liver needs some love!

Higher amounts of hormones place a higher burden on the liver’s detoxification pathways in the body. Don’t forget! The liver has to metabolize every single thing or substance that enters into our bodies food, environmental toxins, metabolic waste products, red blood cells and much more. It also metabolizes our hormones, especially estrogen (and all the estrogen metabolites).

Some are signs that your liver needs some support or attention:

  1. Headaches and migraines
  2. Constipation
  3. Acne
  4. Eczema
  5. Irritability
  6. PMS
  7. Nausea and indigestion
  8. Sinus congestion (sinusitis, rhinitis)
  9. Allergies
  10. Metabolic syndrome
  11. Insulin resistance

How can you help your liver and make sure you’re eliminating excess hormones?

Make sure you’re pooping at least once per day. If your bowels are congested, this increases your overall toxic load, which has to get processed in the liver.

Eat enough fiber- we require at least 30 grams per day, and many of us reach about half of this. Thread connects into metabolized hormones, cholesterol and moves them out of the body via the intestines. Up your intake of veggies, seeds, beans, legumes, nuts and gluten-free grains.

Cruciferous vegetables contain glucosinolates, which are broken down to indole-3-carbinol. This compound supports the detoxification of estrogens. So eat more broccoli, cauliflower, cabbage, and kale every day.

Eat bitter foods- bitter greens like the rocket (arugula), endive and bitter lettuces stimulate the production of digestive secretions, such bile in the liver. Bile contains metabolized hormones and waste products, so we make sure it leaves the body, so the liver can continually process new fresh bile and help the organization.

Include rosemary and turmeric in your diet as much as possible. This help reduces inflammation in the body, liver and also support detoxification pathways or microbiota.

Make sure you don’t have any hidden food intolerances. These will cause the body inflammation in the GIT and place an extra burden on your liver.

Balance your gut bugs! Your microbiota (intestinal bacteria) also play a significant role in metabolizing of estrogens. Consume fermented foods with each meal: fermented veggies and kombucha, yogurts, kefir, sauerkraut, and feed your bugs with probiotic fibers: green bananas, cold potatoes, whole grains, legumes, fruits, and vegetables.

Acne, Pre-Menstrual, and Progesterone testosterone, and estrogen

Now If your progesterone levels are out of balance, this can also lead to hormonal acne, as other symptoms related to PMS and infertility. Balance progesterone levels have been shown to help block the activity of DHT, and the most potent of androgens, also this present in the skin and contributes to the formation of acne.

We have discussed this earlier in this blog, progesterone mainly produced once ovulation has occurred. The egg released from a structure called the follicle, and once ovulation has occurred, the follicle forms the ‘corpus luteum,’ which is a secretory endocrine structure that produces most of our progesterone.

Progesterone, testosterone, and estrogen work together in a balanced ratio, and when this occurs there will be no more PMS symptoms, fertility will be optimal, and you will feel young. This Issues will arise when a woman fails to ovulate her self, or her body does not have the requirements to maintain and therefore her progesterone, testosterone, and estrogen levels are insufficient.

The reasons why women fail to ovulate and why?

High estrogen levels block the hormonal cascade that triggers ovulation, Polycystic ovarian syndrome (PCOS), Nutritional insufficiency, Low body fat percentage, Stress and Ovarian failure and menopause.

The Insufficient nutrients required to maintain the corpus luteum and produce hormones, Stress, and Inflammation

How can these issues be addressed and ensure we make and maintain progesterone?

We have to ensure to balance our nutritional intake in our body. The corpus luteum requires sufficient levels of magnesium, zinc, iron, B vitamins, vitamin A, vitamin C and iron (for a start).

We also need fats to make our hormones, so it is vital to include healthy fats in your diet. Manage your stress! Stress responses burn through nutrients faster than anything else, so if you chronically stressed you would be depriving your reproductive system of the nutrients, it needs to perform. Stress also inhibits the HPOA axis (hypothalamic-pituitary-ovarian axis). The hypothalamus (a master control center in your brain) needs to convinced that you are safe and nourishing for you to reproduce (which is the ultimate function of your reproductive system).

Acne can associate with insulin resistance and PCOS will primary be due to impaired glucose metabolism, so this is the critical area to address. Insulin promotes androgen production, which is a driving factor in the production of acne. Necessary but effective strategies to combat this include eliminating all refined and added sugar from your diet and eating more protein, fats and complex carbohydrates. Supplementing with chromium, magnesium and B vitamins will also support proper glucose metabolism and insulin function.