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January 28, 2019 by Joseph Fermin 0 Comments

The importance of Testosterone Post Cycle Therapy? 0 (0)

Why Is Testosterone
Post Cycle Therapy Is Need It?

Why is Post Cycle Therapy (PCT) is perhaps the most critical aspect of testosterone use? The concept of the post cycle therapy (PCT), did not exist before the late 1980s, and 1990s and the mechanisms by which testosterone affected, the body were not wholly understood during the 1950s, 1960s, and 1970s.

This period were doctors, scientists, and testosterone injections users were only beginning to learn about the dynamics of testosterone and how they affect the endocrine system. We believed and understood since the beginning of testosterone injections use, the administration of testosterone resulted in triggering the body’s negative loop of the (HPTA) Hypothalamic Pituitary Testicular Axis. That endogenous Testosterone production would result become suppressed and shut down. The, unfortunately, is during the early periods of testosterone use between the 1950s and 1990, there was limited access to the compounds or knowledge or effectively.

Today it is a very different story. Now scientific and medical understanding of bio-identical testosterone use has soared exponentially since the old ‘golden era’ days of looking young and testosterone therapy use in athletics. Countless developments of beneficial compounds for hormonal recovery after testosterone therapy use, alongside the increased scientific and medical knowledge, has enabled testosterone use and its associated endocrine disruptions. The proper knowledge on how to recover the body’s from Hypothalamic Pituitary Testicular Axis (HPTA). Through post cycle therapy (PCT), we can not only emerge from their testosterone therapy while holding on to almost all of their benefits, but they can also increase the chances upwards to 90 percent or higher range of emerging with a fully healthy (HPTA).

Following the use of exogenous testosterone injections, the majority of users will experience what has been a hormonal crash or post cycle therapy crash, which is a physical environment in which key hormones essential is has been suppressed or shut down. The critical hormones in question are Luteinizing Hormone (LH), Follicle Stimulating Hormone (FSH), and subsequently (and are most importantly), for our natural testosterone. The Luteinizing Hormone (LH), and the Follicle Stimulating Hormone (FSH), known as phototropism. These hormones increase Testosterone secretion. Also alongside low levels of these hormones, to balance the essential hormones that have been thrown off balance, whereby Testosterone levels will be small, and most of the time, depending on the factors, estrogen levels will be higher than usual, and levels of Cortisol a steroid hormone that destroys muscle tissue. With the testosterone levels low and Cortisol levels in the average or high, Cortisol now can become a threat to the new muscle during the new testosterone therapy (“Testosterone correctly suppresses and counteracts Cortisol’s catabolic effects on muscle tissue”). The SHBG (Sex Hormone Binding Globulin) is also a concern here as well, which is a protein that binds to sex hormones Testosterone renders them inactive, essentially ‘handcuffing’ them and preventing them from exerting their effects. SHBG will also usually elevated during the post cycle therapy weeks as a result of the supraphysiological levels of androgens from the new testosterone therapy.

The human body will generally and restore this imbalance of hormones and recover from testosterone levels on its own, over time with no outside assistance or post cycle therapy (PCT), but the studies have demonstrated and shown us that without the intervention of testosterone stimulating agents, this will occur throughout one to four months. Therefore, all testosterone therapy should be concerned with the fastest possible hormonal recovery, assisted and boosted with the use of Testosterone stimulating compounds correctly, also the attempt to allow the body to recover on its own, from a very high probability of long-term endocrine damage to the Hypothalamic Pituitary Testicular Axis (HPTA), whereby the individual will develop-induced hypogonadism to inability the production of proper levels of Testosterone to rest. So therefore paramount that an appropriate post cycle therapy that includes multiple recovery compounds to be utilized to not only restore the (HPTA) function but also to normalize the levels as quickly as possible. To avoid any possible permanent damage, which can take priority over the concern of maintain to the recently gained muscle mass and any other benefits from it.

What Post Cycle Therapy Protocol?

There are many different types of post cycle therapy (PCT) protocols that have overdeveloped over the years; any individual will become extremely confused about how many different opinions exist among the testosterone community, This article will present the best possible and most efficient post cycle therapy protocol valid scientific data, also myths in regards to post cycle therapy (PCT), and outline which post cycle therapy (PCT) protocols should not follow due to recent more advanced developments, as well as contemporary better scientific and medical understandings of how a proper post cycle therapy protocol should work. This point, there still exists very obsolete – and subsequently ineffective – post cycle therapy (PCT) contracts that are still utilized by many testosterone users, and this presents a severe hazard not only for the individual unknowingly using a post cycle therapy.

For example:

There are several therapeutic and safety reasons why you should not continue with testosterone injections indefinitely without giving your body time to normalize to reset. Because of the decline in benefits after six months of a testosterone therapy, the physicians need to regularly incorporate a cleanse therapy post cycle therapy (PCT) in an attempt to reactivate the endocrine in the body, as you increase your testosterone levels using any testosterone therapy, now the levels of testosterone circulating the body will shut down the natural production of your endogenous testosterone; and also increases the production of estrogen in your body, which can lead to a series of undesirable and unwanted side effects in the body. `This means that the synthesis of (LH) luteinizing hormone in your body; this hormone is produced by your brain to stimulate testosterone production. and follicle-stimulating hormone in the body; the hormone produced by your mind to boost sperm production suddenly stops. When Luteinizing Hormone (LH) and Follicle Stimulating Hormone (FSH) levels are no longer detectable, your body will not experience the exceptional health benefits, and energy-optimizing results expected from a testosterone injection program.

Another critical concern for men is testicular atrophy in patients that participate in testosterone therapy and may experience shrinkage of the testes, This occurs as the result of the lack of testosterone, and sperm production has been shut down, in response to the testosterone therapy.

What does post cycle therapy (PCT) consist of, an example?

Your post cycle therapy consists of a testosterone secretagogue to stimulate the secretion of endogenous testosterone from the testes to reignite natural production. The medication mimics the signal from your brain. The Luteinizing Hormone (LH) induce the production of testosterone. An example of a testosterone secretagogue is human chorionic gonadotropin (hCG), which is administered either using sublingual troches or subcutaneous injections once or twice a week during therapy and then on 10–15 consecutive days as part of a post cycle therapy (PCT). Human chorionic gonadotropin (hCG), mimics Luteinizing Hormone (LH) to stimulate testosterone production by the testes. It works by effectively tricking the testes into thinking that they are being instructed to produce testosterone, even though levels are comfortably elevated because of the injectable testosterone therapy. The testosterone production stimulated by human chorionic gonadotropin (hCG) is not sufficient to sustain healthy testosterone levels on its own, but that is not the reason for this supplementation. The purpose is to ensure that the testes remain functioning during therapy to help avoid any shrinkage or atrophy.

You will also take an anti-estrogen or aromatase inhibitor. For example, Clomid/clomiphene blocks certain types of estrogen from getting to the pituitary and hypothalamus, where it elicits signals that stop testosterone production. Anti-estrogens or aromatase inhibitors also help to reactivate the standard functionality of Luteinizing Hormone (LH) and Follicle Stimulating Hormone (FSH) signaling, while also helping to flush out any residual estrogen that has accumulated during therapy. The estrogen that collects during treatment is responsible for many of the adverse side effects associated with testosterone therapy.

An example of a post cycle therapy (PCT) protocol is as follows (note that the exact drug and dose prescribed will depend on the specific information contained within each patient file, as well as the individual patient goals):

  • 250–800 units of a testosterone secretagogue every day for ten consecutive days
  • One estrogen blocker or antagonist by mouth every day for 10–15 straight days

Without the proper understanding of what is explicitly occurring within the endocrine system during these crucial weeks, as well as a lack of knowledge of which compounds to utilize, what each compound does, and how to properly use them, serious problems can result.

post cycle therapy

The Hypothalamic Pituitary Testicular Axis (HPTA):

The (HPTA), which is an axis interconnected endocrine glands in the body that deals with control the production Testosterone.

Post-Cycle-therapy:

Outlined above is a diagram of the Hypothalamic Pituitary Testicular Axis (HPTA), Regulates the body produces the amount of Testosterone at any given time. Every individual is essentially programmed by (DNA) genetics as to maximum Testosterone they will provide.

The Hypothalamic Pituitary Testicular Axis (HPTA) and the functions that undergo a negative feedback loop, and the body will reduce secretion of Testosterone, f have too much Testosterone the body will be detected, known as the negative feedback loop. This controlled by the hypothalamus, which is mostly considered the ‘master’ gland for all endocrine system and the hormonal functions in the body. The negative feedback will loop ultimately in the body to attempt to maintain the hormonal homeostasis, and all endocrine glands operate by way of the negative feedback loop in one way or another in varying degrees, In the case of post cycle therapy, the concern is a negative feedback loop of the (HPTA).

Within the Hypothalamic Pituitary Testicular Axis (HPTA), the concern during post cycle therapy (PCT) is the restoration and regulation of the following five hormones to homeostasis:

  • GnRH (Gonadotropin Releasing Hormone)
  • LH (Luteinizing Hormone)
  • FSH (Follicle Stimulating Hormone)
  • Testosterone production

The Hypothalamic Pituitary Testicular Axis (HPTA), the hypothalamus, which will detect a need for the human body to produce more Testosterone, and will release varying amounts of GnRH, Is a hormone that signals the pituitary gland, to begin the production and release of two essential gonadotropins: Luteinizing Hormone (LH) and Follicle Stimulating Hormone (FSH). Two hormones that work together to start the secretion of Testosterone.

Two primary hormonal factors serve to inhibit, reduce, suppress, or shut down Testosterone production in the Hypothalamic Pituitary Testicular Axis (HPTA):

  • Testosterone Excess
  • Estrogen Excess

Although there exist other hormones that serve to inhibit and suppress Hypothalamic Pituitary Testicular Axis (HPTA) function (such as Progestins and Prolactin), these are the two primary conditional hormones that are of concern. When the hypothalamus detects excess levels of Testosterone and Estrogen in the body (either from the use of exogenous androgens on an testosterone therapy or otherwise), the hypothalamus will act to attempt to restore a balance by essentially doing the opposite of what was previously described. The hypothalamus will reduce or stop its production of GnRH, which halts production of Luteinizing Hormone (LH) and Follicle Stimulating Hormone (FSH), which ultimately reduces or halts production of Testosterone. Until the hypothalamus’ ideal hormonal environment is restored, the output of the various signaling hormones within the (HPTA) will not begin, and this will often require months for the body to do this on its own without the intervention of any Testosterone stimulating agents. The reason as to why the recovery of the (HPTA) naturally takes such a long time should be very clear due to the described workings of the (HPTA).

This fundamental understanding of the mechanisms of the Hypothalamic Pituitary Testicular Axis (HPTA) and negative feedback loop described above is essential to understanding how and why a proper post cycle therapy (PCT) program must be developed and utilized following an testosterone therapy.

Determining Factors In Difficulty Recovering the Hypothalamic Pituitary Testicular Axis (HPTA):

With testosterone therapy use, there are several different major determining factors in how much difficulty an individual will experience in recovery of their Hypothalamic Pituitary Testicular Axis (HPTA) and endogenous Testosterone function during post cycle therapy (PCT).

They are the following factors, in no particular order of importance:

  • Individual response
  • Type of testosterone(s) used
  • Length of the cycle (degree of testicular desensitization)

Individual response:

Every single individual will respond differently to any chemical, compound, testosterone, food or drug in existence. While some individuals might experience no Hypothalamic Pituitary Testicular Axis (HPTA) suppression or shutdown at all, other individuals might experience severe Hypothalamic Pituitary Testicular Axis (HPTA) suppression and closure to the extent where they might require far more extended periods to ensure full recovery than most. This, like anything else, is a spectrum whereby there are the very ‘lucky’ individuals that recover very quickly and easily on one end of the spectrum, and the ‘unlucky’ individuals that have extreme difficulty recovering during post cycle therapy. In between the two extremes is the average. Once again, this is due to the individual’s genetic programming as to how the Hypothalamic Pituitary Testicular Axis (HPTA) will respond and attempt to maintain homeostasis.

Type of Testosterone Therapy(s) used:

All testosterone therapy exhibit suppression or shutdown of the Hypothalamic Pituitary Testicular Axis (HPTA) through the mechanisms of the negative feedback loop, and there are no exceptions to this. Various testosterone therapy are known as being mildly suppressive, while others are identified as being profoundly suppressive. This is all reliant on multiple different reasons, many of which will not be discussed here. In any case, no matter how mild or severe an testosterone therapy exerts Hypothalamic Pituitary Testicular Axis (HPTA) suppression, all testosterone therapy when utilized for typical cycle lengths of weeks at a time will eventually cause the Hypothalamic Pituitary Testicular Axis (HPTA) to shut down, or at the very least severely suppress its hormonal signal processes.

Length of the cycle degree of testicular desensitization:

This is perhaps the most important and most influential factor. As the range of testosterone therapy use continues, the majority of the Leydig cells of the testes remain dormant and inactive, and the longer these interstitial cells stay dormant and idle, the higher the difficulty is essentially getting these cells to respond to the stimulus of Luteinizing Hormone (LH) and Follicle Stimulating Hormone (FSH) once again. It has been discovered in studies that the issue of recovery of the Leydig cells following testosterone therapy use is not due to a lack of Luteinizing Hormone (LH), but due instead to the desensitization of the Leydig cells to (LH). In one study in which exogenous Testosterone was administered to male test subjects for 21 weeks, Luteinizing Hormone (LH) levels were suppressed shortly after beginning administration. However, at the end of the 21 weeks, Luteinizing Hormone (LH) levels were observed to rise within three weeks once the exogenous Testosterone administration stopped, but Testosterone levels did not arise until many weeks later in most of the test subjects.

Recovery During The Post Cycle Therapy (PCT).

To stimulating hormonal recovery during post cycle therapy, it is essential for individuals to understand that the use of any medication except for a single select one or two is inadequate for hormonal recovery during post cycle therapy (PCT). Ideally, all post cycle therapy programs should be a multi-component post cycle therapy (PCT) program that includes several different compounds that work in tandem with one another to provide the most effective and fastest possible Hypothalamic Pituitary Testicular Axis (HPTA) recovery following an testosterone therapy.

The three categories of compounds are in order of importance:

  • SERMs (Selective Estrogen Receptor Modulators)
  • Aromatase Inhibitors
  • HCG (Human Chorionic Gonadotropin)

SERMs:

Classes of drugs in the SERM category include: Nolvadex (Tamoxifen Citrate), Clomid (Clomiphene Citrate), Raloxifene, and Fareston (Toremifene Citrate). The nature of a SERM is that it exhibits mixed Estrogen agonist and Estrogen antagonist effects on the body. This means that although a SERM might block the effect of Estrogen at the cellular level in specific tissues, it can enhance Estrogenic impacts in other areas of the body. These can be positive effects as well as adverse effects. Nolvadex, for example, exhibits Estrogenic agonistic effects in the liver, which is a positive effect, as its effects here result in a positive change in cholesterol profiles (something desired by many). All SERMs to varying degrees serve to act as an Estrogen antagonist in this area, working to mitigate Estrogen’s effects on breast tissue, reducing or blocking the side effect of gynecomastia. Regarding the impact of SERMs on endogenous Testosterone stimulation, they serve to act as an Estrogen antagonist at the pituitary gland, triggering the release of Luteinizing Hormone (LH) and Follicle Stimulating Hormone (FSH) as a result. Elevated levels of Estrogen in men can and does suppress the output of endogenous Testosterone via the negative feedback loop, leading to hypogonadism. SERMs for this purpose are an essential addition to any post cycle therapy (PCT) protocol and are not to be excluded under any circumstance. Regardless of this, however, the sole focus should not be on SERMs.

Aromatase Inhibitors:

These are compounds such as Aromasin (Exemestane), Arimidex (Anastrozole), and Letrozole (Femara). Rather than block the activity of Estrogen at the cellular level in different tissues, aromatase inhibitors (AIs) serve to lower total circulating Estrogen levels in the body by way of inhibiting the aromatase enzyme, which is the enzyme responsible for the conversion of androgens into Estrogen. The transformation of androgens into Estrogen results in excess Estrogen levels, which, as explained earlier in this article, will trigger the negative feedback loop leading to suppression of Testosterone production. By way of lowering total circulating blood plasma Estrogen levels, AIs will positively engage the negative feedback loop and result in the release of Luteinizing Hormone (LH) and Follicle Stimulating Hormone (FSH) for the manufacture and secretion of more Testosterone. This is mainly due to the hypothalamus realizing that circulating. Estrogen levels are too low and will attempt to increase circulating levels of Testosterone for a portion of the Testosterone secreted to be able to become aromatized into Estrogen to restore the hormonal balance. The other importance of aromatase inhibitors is the ability to mitigate the Estrogenic effects of human chorionic gonadotropin (HCG), which will be explained shortly. It is important to note, however, that the majority of aromatase inhibitors do not comply very well with SERMs such as Nolvadex, and those particular choices should be made in regards as to which AI is used during post cycle therapy (PCT).

HCG:

Human Chorionic Gonadotropin is, for the most part, synthetic Luteinizing Hormone (LH). It is a protein hormone manufactured in high amounts by pregnant females that contains a protein subunit that is 100% identical to Luteinizing Hormone (LH), and therefore when administered to men, it will mimic the action of Luteinizing Hormone (LH) in target tissues, such as the testes. What results is an increase in Testosterone production via stimulation of the Leydig cells by human chorionic gonadotropin (HCG). Human chorionic gonadotropin (HCG) should never be utilized alone, as its nature as a gonadotropin will itself trigger a negative feedback loop whereby once human chorionic gonadotropin (HCG) is used, the pituitary gland will halt output of Luteinizing Hormone (LH) until human chorionic gonadotropin (HCG) use has discontinued. Therefore, human chorionic gonadotropin (HCG) must be utilized with a SERM and especially an aromatase inhibitor, as human chorionic gonadotropin (HCG) has demonstrated to increase aromatase activity in the testes, resulting in rising Estrogen levels.

Putting Them Together:

The reader may be wondering which compounds to select of the three categories listed, and how to use them properly. The answer lies in understanding the properties of each and, in interpreting these properties, how to use them efficiently and appropriately.

Human chorionic gonadotropin (HCG):

The first item to be examined will be human chorionic gonadotropin (HCG). The majority of testosterone therapy users from the 1960s – mid-1980s did not even utilize any compounds for hormonal recovery, and the term post cycle therapy (PCT) did not even exist at that time. When the use of human chorionic gonadotropin (HCG) became increasingly popular (circa 1980), it was the only compound utilized. Since then, the medical and scientific understanding of such things has increased exponentially, and there should be no reason for any informed and adequately educated individual to utilize human chorionic gonadotropin (HCG) on its own for post cycle therapy (PCT). When used in conjunction with one of the other two categories of compounds (an AI and a SERM), the dynamics change considerably.

It has been mentioned already that much of the difficulty in recovering the Hypothalamic Pituitary Testicular Axis (HPTA) following an testosterone therapy is the result of Leydig cell desensitization. Human chorionic gonadotropin (HCG) is necessarily an analog of Luteinizing Hormone (LH), and the testes after a prolonged testosterone therapy would be as equally desensitized to human chorionic gonadotropin (HCG) as they are to Luteinizing Hormone (LH). The human body, however, produces Luteinizing Hormone (LH) amounts on its own that is far too inefficient for proper and rapid Testosterone production. The body’s natural increase of Luteinizing Hormone (LH) and Follicle Stimulating Hormone (FSH), evidenced by the study referenced earlier in which it was not until three weeks when Luteinizing Hormone (LH) levels only began to reach the standard physiological measurements following the cessation of Testosterone. Therefore, the body’s natural Luteinizing Hormone (LH) production does not provide a high enough dose for stimulation, nor an immediate stimulus to the tests required for the initial increase in Testosterone needed during the post cycle therapy weeks.

Human chorionic gonadotropin (HCG), utilized in a specific manner during the first 1 – 2 weeks of post cycle therapy (PCT) at a dose of 100-1,500IU every 2 days, is what allows the individual to provide the testes with a high dose to provide them with a ‘shock’ effect, and sustain this shock effect on the Leydig cells of the testes for a sustained period of the first 1 – 2 weeks of post cycle therapy. Studies have demonstrated the incredible effectiveness of human chorionic gonadotropin (HCG) for this purpose, it been suggested that human chorionic gonadotropin (HCG) therapy is utilized to treat low testosterone and hypogonadism. Following this line of thought, the other two compounds (the SERM and the AI) are to be used as supportive compounds for human chorionic gonadotropin (HCG) use in this 1 – 2 week period, and after human chorionic gonadotropin (HCG) is discontinued early on in post cycle therapy (PCT), only the SERM is to be used in order to carry along the hormonal recovery process.

In spite of the good news in regards to the ability for human chorionic gonadotropin (HCG) to assist in hormonal recovery, there are still two remaining issues to be addressed:

  • The fact that human chorionic gonadotropin (HCG) causes increased production of aromatase, leading to increased Estrogen levels.
  • Following the discontinuation of human chorionic gonadotropin (HCG), the body is left with very little endogenous Luteinizing Hormone (LH), and Follicle Stimulating Hormone (FSH) production due to the exogenous administration of human chorionic gonadotropin (HCG).

Aromatase Inhibitors:

Aromasin (Exemestane) Above All Else The first of the two remaining issues to be addressed will be the fact that human chorionic gonadotropin (HCG) will trigger increases in testicular aromatase expression, and result in Estrogen increases in the body. It should also be noted that it will cause an increase in testicular progesterone levels. Estrogen rising is, of course, undesirable during post cycle therapy (PCT), as it has already been explained that Estrogen will trigger suppression of endogenous Testosterone production, and there is no doubt that any individual wishes to encounter Estrogenic side effects during post cycle therapy (PCT) either.

Therefore, the option here is to include an aromatase inhibitor. However, there exists a big problem in regards to the other two of the three major aromatase inhibitors (Arimidex and Letrozole). The issue is the fact that in a post cycle therapy (PCT) program that includes the use of SERMs such as Nolvadex and Clomid, which are known as essential components to a post cycle therapy (PCT) program, Arimidex and Letrozole have direct negative interactions with Nolvadex. The problem here is that Arimidex (or Letrozole) and Nolvadex both directly counteract one another. One study has demonstrated that when Arimidex is utilized with Nolvadex, Nolvadex will decrease the blood plasma concentration of Arimidex (as well as Letrozole, another commonly used aromatase inhibitor). The conclusion here is that the use of Arimidex or Letrozole with Nolvadex together is a terrible idea and may work together in a post cycle therapy (PCT) protocol. Aromasin completely circumvents this problem, as it has been demonstrated to have no interactions what so ever with Nolvadex, unlike the other two aromatase above inhibitors. In one study, Aromasin displayed no such reduced effectiveness or any reduced blood plasma levels when utilized with Nolvadex.

The other benefit of selecting Aromasin over all other AIs is the fact that Aromasin has demonstrated in several studies to impact cholesterol profiles in a negative manner far less than other aromatase inhibitors have, wherein one particular review on cancer patients, 24 weeks of Aromasin (Exemestane) administration held no impact on cholesterol profiles. Some other studies have also demonstrated a nil effect on cholesterol profiles from the use of Aromasin. Although there have also been some studies that have shown a negative impact on cholesterol profiles resultant from Aromasin use, it is evident that there is not as a significant or as a negatively impacting effect from Aromasin on cholesterol as other aromatase inhibitor.

Finally, in addition to these benefits from Aromasin, it is evident that Aromasin holds the ability to increase Testosterone levels in males as demonstrated by studies. For example, one particularly notable study selected 12 healthy young male test subjects, and were administered random Aromasin doses of 25mg and 50mg for a 10 day period, and not only was Estrogen suppressed by a significant amount (38%), but Testosterone levels in the test subjects were observed to have increased by an incredible 60%.

Following these details, Aromasin would be the best possible aromatase inhibitor of choice to combat the increased aromatase activity caused by human chorionic gonadotropin (HCG). Therefore, Aromasin would then be utilized at a full 25mg daily dose, and only while human chorionic gonadotropin (HCG) is used. Once human chorionic gonadotropin (HCG) is discontinued, Aromasin too should be halted.

The only following issue to cover now is that of stimulating and maintaining proper endogenous Luteinizing Hormone (LH) release to carry recovery along until the body can become self-sufficient once again.

Nolvadex and Clomid: 

The question is often asked among the testosterone therapy using community: Clomid or Nolvadex? Which one for post cycle therapy (PCT)?

First of all, the best possible addition to human chorionic gonadotropin (HCG) in a post cycle therapy (PCT) protocol is Nolvadex (Tamoxifen Citrate), as studies have demonstrated that human chorionic gonadotropin (HCG) and Nolvadex utilized together have exhibited a remarkable synergistic effect in terms of stimulating endogenous Testosterone production and that Nolvadex will actually work to block the desensitization effect on the Leydig cells of the testes caused by high doses of human chorionic gonadotropin (HCG). This is very important because just as too little Luteinizing Hormone (LH) secretion for extended periods can cause desensitization to gonadotropins, too much gonadotropin stimulation (in the form of human chorionic gonadotropin (HCG) or otherwise) will likewise create a desensitization effect.

Secondly, Nolvadex on an mg for mg basis is far more effective than Clomid in stimulating endogenous Testosterone production, as well as being a more cost-effective choice than Clomid itself. Studies have demonstrated that 150mg of Clomid (Clomiphene Citrate) administered daily raised endogenous Testosterone levels of 10 healthy males by approximately 150%, while incidentally, 20mg of Nolvadex (Tamoxifen Citrate) daily raised endogenous Testosterone levels by the same amount. It is very evident here that Clomid is very useful for this purpose, but Nolvadex seems to be a more cost-effective choice seeing as though it is more effective than Clomid when compared mg for mg. The benefits of Nolvadex over Clomid do not end there – Clomid, although it does exhibit Estrogen antagonist effects at the pituitary gland as Nolvadex does, actually shows Estrogen agonist effects there too. What this means is that Clomid will work in varying degrees as an Estrogen at the pituitary gland, triggering the negative feedback loop and reducing the output of Testosterone stimulating gonadotropins Luteinizing Hormone (LH) and Follicle Stimulating Hormone (FSH). This is a severe problem during post cycle therapy, which is a period in which individuals are trying to recover their Hypothalamic Pituitary Testicular Axis (HPTA) function rather than halt it even further. Ideally, one would want a SERM that exhibits almost 100% Estrogen antagonistic effects on the pituitary gland, and Nolvadex is the perfect choice for this.

When it comes to the dosing aspect of Nolvadex, The standard dose for post cycle therapy (PCT) and for stimulating the release of GnRH (Gonadotropin Releasing Hormone), Luteinizing Hormone (LH), Follicle Stimulating Hormone (FSH), and ultimately Testosterone is that of a single Nolvadex dose of 20 – 40mg daily. In all studies involving Nolvadex doses used to stimulate endogenous Testosterone production, only 20 – 40mg daily of Nolvadex was utilized, and it has been shown that doubling the dose to 40mg or any higher will not produce any significant difference in endogenous Testosterone secretion. The only reason why many elects to utilize 40mg daily of Nolvadex for the first 1-2 weeks of a post cycle therapy (PCT) program is to achieve optimal peak blood plasma levels quicker to ensure Hypothalamic Pituitary Testicular Axis (HPTA) recovery faster.

The ideal post cycle therapy protocol for 4 – 6 weeks Total post cycle therapy (PCT) time (depending on the recovery ability of the individual):

01) Weeks 1 – 2:

  • human chorionic gonadotropin at 1000iu/E2D.
  • Aromasin (Exemestane) at 25mg/day.
  • Nolvadex (Tamoxifen Citrate) at 40mg/day.

02) Weeks 2 – 6:

  • Nolvadex or (Tamoxifen Citrate).

Additional and Optional, Vitamins, Supplements, Compounds to Aid During post cycle therapy (PCT), Aside from the principal components discussed, various other parts are mostly optional, but still very useful for hormonal recovery of the Hypothalamic Pituitary Testicular Axis (HPTA) during the post cycle therapy weeks.

Vitamin B12 Health Benefits, There has been a lot of controversy over whether or not there is indeed a benefit from taking B12 supplements. Some doctors suggest that as long as a person is not vegan (though probiotics in the gut can produce some B12), they are probably getting sufficient B12 from the basic foods they are ingesting.

vitamin b12

Let us reference some studies:

There is documented research from the Framingham Study suggesting that 40% of all people are deficient in B12. The American Journal of Clinical Nutrition researched in 2009, and they published a study suggesting close to 6% of U.S. and U.K. residents over the age of 60 are B12 deficient. Another 20% were referenced as “marginal status.”

Vitamin B12 Health Benefits has the most multifaceted and prevalent chemical structure of all vitamins. One area where it differentiates from other vitamins is in the fact that it’s the only vitamin that contains a metal commonly referred to as Cobalamin, which is also a universal term for all the various compounds that may have some B12 properties in it.

B12 can improve energy by aiding in thyroid function and cellular methylation, That being said, B12 is not only useful in supporting healthy energy levels. It is unequivocally essential to life and whole existence. People deficient in B12 will suffer from serious health issues if the problem is not addressed.

What role B12 plays in the following human biological processes:

  • Nerve and brain regeneration
  • Adrenal gland support
  • Male and female reproductive health
  • Nutrient absorption
  • Red blood cell formation
  • Cellular energy
  • Memory recall
  • DNA synthesis

Here are some of the risks associated depleted B12 levels are:

  • Pernicious anemia
  • Migraine headaches
  • Macular degeneration
  • Tinnitus
  • Fatigue (adrenal fatigue and CFS)
  • Multiple sclerosis
  • Memory loss
  • Neuropathy
  • Anemia
  • Asthma
  • Shingles
  • Kidney disease
  • Depression

July 31, 2018 by Joseph Fermin 0 Comments

The 6 Effects of Testosterone in Your Body 0 (0)

The 6 Effects of Testosterone in Your Body

6 Effects of Testosterone in Your Body, However, the body changes as we age and loses some of its regenerative capacity. A fundamental part of this decline roots from a slow-down in our hormonal secretions. Simply put, even young people with glandular issues who do not produce enough testosterone and/or HGH experience side effects and maladies that are usually only associated with much older individuals. Conversely, older patients with higher hormone levels, be it naturally or via hormone replacement therapy, have health benefits normally associated with younger individuals.

Also, Women’s Can Be at Risk for Low Testosterone:

The ovaries are responsible for producing both testosterone and estrogen, as the ovaries age, they produce less estrogen and testosterone. As women enter peri-menopause and pre-menopause, testosterone will be diminished by the age of 30’s, and once a women reach full menopause, it’s common for them to produce 75% less testosterone than they did in the there 21’s. Every woman becomes at risk of low testosterone as she ages, and women who go through hysterectomy or oophorectomy have an even higher chance of dealing or having low testosterone in women levels.

6 Effects of Testosterone in Your Body.

  • Changes the Brain:

Research has shown that women have a significant advantage when it comes to a few things, Like memory and language, while men tend to have stronger spatial skills (though this too has been disputed). But due to ethical restrictions, no study had been able to track the direct effect that testosterone exposure has on the brain—until now.

The hormone also plays a role in your state of mind, including how well your brain works. That’s why low testosterone has linked to symptoms such as mood swings, increased stress, and depression. … “Cells in the brain have testosterone receptors, and low testosterone in those receptors are significantly affected mental health.”

  • Muscle and Strength:

Recent studies have shown that men as they age, they lose more muscle mass than women of the same period, and has led researchers to believe that the loss of muscle strength and has it has a direct link to the predominantly male decline hormone, like testosterone. Testosterone helps to build muscle mass and strength in young men.

Testosterone supplementation in men increases fat-free mass, but whether measures of muscle performance, such as maximal voluntary strength, power, fatigability, or specific tension, are improved has not been determined. … A seated leg press exercise defined maximal voluntary muscle strength and fatigability.

  • Bone Density and Osteoporosis:

As men age, their serum testosterone concentrations decrease, as do their bone densities. Because bone density is also low in hypogonadal men, we hypothesized that increasing the serum testosterone concentrations of men over 65 yr to those found in young men would raise their bone densities.

Testosterone increases levels of growth hormone. That makes the exercise more likely to build muscle. Testosterone increases bone density and tells the bone marrow to manufacture red blood cells. … Dropping the levels of testosterone can cause an increase in body fat.

  • Sex Drive and Libido:

Some men maintain sexual desire at relatively to low testosterone level. For other men, libido may lag even with normal testosterone levels and low testosterone is one of the possible causes of low desire and sex drive, however. If testosterone has lowered far enough, virtually all men will experience some decline in sex drive.

Growth hormone (GH) has also been used to reverse or correct erectile dysfunction and other sexually impeding disorders and the primarily by improving circulation and blood flow, which results in a firmer, more sustainable erection.

  • Bone Marrow and Red Blood Cells:

Erythropoiesis affects the production of new red blood cells. One is accomplished primarily in the bone marrow, the red blood cell factory. Erythropoiesis is stimulated mainly by erythropoietin (hence, the clever naming of that hormone!). … Androgens, including testosterone, are another type of hormone.

Testosterone and other androgens have an erythropoietic stimulating effect that can cause polycythemia, which manifests as an increase in hemoglobin, hematocrit, or red blood cell count. … If hematocrit elevated before starting testosterone, the cause should determine before beginning androgen therapy

  • Skin and Collagen:

A man or women with shrinking levels of testosterone actually may lose some body hair. Testosterone replacement therapy comes with a few potential side effects, including acne and breast enlargement. Testosterone patches may cause minor skin irritation.

In fact, research now suggests that bioidentical hormone replacement therapy (or BHRT) can actually reverse many of the signs of aging and that you may have come to accept – weight gain, low libido, reduced muscle mass – and can even help to prevent conditions such as osteoporosis, heart disease, and dementia.

 

(more…)

December 20, 2017 by Joseph Fermin 0 Comments

How Testosterone Affects Fat Loss: Real Science of Low-T 0 (0)

How Testosterone Affects Fat Loss: Real Science of Low-T

Testosterone Affects Fat Loss, As men age, their testosterone levels decline. This increase in SHBG (sex-hormone binding globulin), which binds to testosterone and thus reduces the amount of free testosterone in the body. Low testosterone levels, obesity, and many other health problems, including fatigue, memory problems and decreased muscle and bone mass. So what is the impact of testosterone on the body and how Testosterone Affects Fat Loss?

Testosterone and energy – low levels of testosterone can cause low energy levels. Regaining natural testosterone levels can increase strength and lead to weight loss. Studies have found that testosterone supplementation reduces total body fat percentages. Obesity is related to low testosterone levels in men. Just as testosterone therapy is associated with decreased obesity, losing weight is associated with increased testosterone levels.

An article in 2014 in the journal of Current Opinion in Endocrinology, Diabetes, and Obesity looked at the existing data regarding testosterone therapy in overweight and obese men with testosterone deficiency (hypogonadism).

  • Many weight loss supplements have dangerous side effects or are ineffective
  • Looked at weight loss, BMI, waist circumference and body composition
  • Evaluated long-term testosterone therapy
  • About 40% of obese nondiabetic men and 50% of overweight diabetic men over 45 have low levels of free testosterone
  • Many studies have found that testosterone therapy in overweight men helps increased lean body mass, weight loss, decreased BMI and reduced waist circumference.
  • Weight loss is significant and sustained with long-term testosterone therapy
  • Testosterone plays a part in protein, fat and carbohydrate metabolism.
  • Testosterone is involved in mitochondrial function and thus energy production and utilization
  • This interference with energy production is likely why those with low testosterone levels experience a lack of energy
  • Testosterone therapy has been found to increase lipid oxidation and normalize glucose use in the body. It was found to increase strength and motivation.

Weight gain associated with an 88% increase in body fat and a 12% increase in lean body mass (LBM) and weight loss with a 72% decrease in body fat and a 28% decrease in LBM.

  • With testosterone therapy, LBM has been shown to increase.
  • Increased LBM means increased energy expenditure at rest
  • Testosterone therapy with improved cardiometabolic function

Testosterone deficiency decrease in energy metabolism from fat and an increase in energy metabolism from glucose.

  • Testosterone therapy has been shown to increase lipid metabolism

Safety? Safety is the primary concern with testosterone replacement therapy. Possible risks discussed in the literature include:

  • Increased risk of prostate and breast cancer
  • Liver toxicity and tumors
  • Sleep apnea exacerbation
  • Testicular infertility and atrophy

Talking with your doctor before starting testosterone injections therapy is necessary.

Summary: If you are a male struggling to lose weight, testosterone therapy is a promising treatment to help with not only weight loss but for body composition, energy levels and overall health.

April 21, 2016 by admin 0 Comments

Can testosterone therapy help anemia? 0 (0)

Can testosterone therapy help anemia?

Can testosterone therapy help anemia? Can testosterone injections help? This is a unique question. One we feel could use a little light in lieu of recently documented developments. In an effort to bring some interesting and unique ideas surrounding the potentials of Testosterone therapy, we bring you this insert on the possibility of testosterone therapy aiding hypogonadal men with anemia in reversing their symptoms and bettering their blood abnormalities.

can testosterone therapy help anemia

What’s most interesting is our ability to analyze this variable from numerous angles and still ultimately hypothesize the same conclusion. If we put together some already-known facts about testosterone, introduce this new study and use a little common sense, it may be safe to conclude that Testosterone therapy does, in fact, help reverse or improve the symptoms of anemia in patients that have clinically low testosterone levels. It will help us determine once and for all: Can Testosterone therapy help anemia?

  • Let’s begin with the obviously required knowledge, what is anemia:can testosterone therapy help anemia
    Google defines it as a condition marked by a deficiency of red blood cells or of hemoglobin in the blood, resulting in pallor and weariness.
  • Second, we know that when you participate in testosterone therapy, one of the key elements your prescribing physician looks for in your follow-up blood work is that your blood viscosity doesn’t elevate. What’s happening in these cases is the blood is over packed with red blood cells due to therapy, which causes thickening of the plasma.
  • A study from the Department of Clinical Science, Intervention and Technology, Division of Renal Medicine, Karolinska Institutet, Stockholm, Sweden concluded that men that were hypogonadal (clinically diagnosed as producing little to no testosterone) were 5.3 times (95% confidence interval 2.2-12.5) more likely to be anemic.

The last bullet point mentioned above is the first angle to look at this question from: People with low testosterone are more likely to develop anemia than people with normal testosterone levels. So again, can testosterone therapy help anemia? Let’s conjoin all the facts with the subsequent new study details. The following is angle number two: a study completed by The Journal of Urology, which indicated that men that had diagnosed anemia with mildly low to low testosterone who participated in testosterone therapy saw significant alleviation to their anemia symptoms. The study details are as follows:

can testosterone therapy help anemia

Testosterone undecanoate reduces anemia in patients with subnormal testosterone levels, according to a study published in the April issue of The Journal of Urology.

Li Tao Zhang, from Chonbuk National University in Jeonju, South Korea, and colleagues conducted a registry study involving 58 participants with a subnormal total testosterone level and at least mild symptoms of testosterone deficiency. At the initial visit, all patients received an injection of 1,000 mg testosterone undecanoate, followed by injection at six, 18, 30, 42, and 54 weeks.

The researchers found that testosterone undecanoate therapy restored total testosterone and free testosterone (both P<0.001). can testosterone therapy help anemiaAfter testosterone undecanoate therapy, hemoglobin and hematocrit significantly increased by an average of 2.46 gm/dL and 3.03%, respectively (both P<0.001). There was a significant decrease in the prevalence of anemia (from 29.6 to 10.0%; P<0.001); after testosterone undecanoate therapy, patients with anemia showed a significant increase in erythropoietin (P=0.047). Compared with baseline, there was a reduction in total cholesterol, increased whole blood viscosity, and increased hematocrit until week 54. After 18 weeks, whole blood viscosity and hematocrit stabilized.

“After 54 weeks, testosterone undecanoate decreased the prevalence of anemia and components of the metabolic syndrome,” the authors write.

Even though the above study is mainly focused on using testosterone undecanoate, the fact of the matter is that this particular medication still falls under the giant umbrella of “testosterone therapy”, which ultimately promotes proportionally Can testosterone therapy help anemiasimilar biological responses in the body as other testosterone esters or anabolics. Some kinds may promote more estrogenic conversion than others but the stimulation of red blood cell production is the same across the board for all forms of testosterone.

This most recent development is fantastic news in any way you look at it but, especially for men suffering from anemia whom also happen to have lower production levels of testosterone. It really helps us to positively conclude and answer the question: Can testosterone therapy help anemia? The answer is a resounding “yes”.

At AAI Rejuvenation Clinic we can help you to check your hormone levels to see if you’d qualify for this life-transforming can testosterone therapy help anemia program. Not only would you experience the best patient care with us (please look up our Google reviews, we are the best in South Florida) but, if you do a little research you will also find that we have the absolute best pricing in the industry if you compare us to like, law-abiding and operating facilities.

You can fill out our Medical History Form by clicking here and you will be contacted within 24 business hours by one of our Wellness Advisors. If you want to reach us more quickly and it’s during normal business hours, you are welcome to call us directly by dialing:

The study above from the April issue of The Journal of Urology was derived from the source: Healthy Day News

Testosterone Therapy Information

March 16, 2016 by admin 0 Comments

Testosterone Increasing Foods | Pineapple Testosterone Boosting Smoothie 0 (0)

Testosterone increasing Natural Options
(Testosterone Boosting Smoothies Series)

https://www.youtube.com/watch?v=ooyjsVpt_7E

Testosterone increasing smoothies are delicious and efficient. Today in our Testosterone Boosting Smoothies series, we want to incorporate a delicious contender. The all-mighty testosterone increasing Pineapple smoothie.

Before we begin, we want to thank all the readers for liking our postings and really taking a look at understanding the foundation of AAI Rejuvenation Clinic’s true intentions: To help everyone we touch better themselves in one way or another.

Of course, the nature of our business, our bread and butter are helping people balance their hormones correctly and Testosterone increasingeffectively through the efforts of bio-identical hormone programs like Testosterone therapyHGH therapy, and Sermorelin Therapy. However, before anyone jumps right into contemplating pills, supplements, nutraceuticals and pharmaceuticals, it’s important for this person with declining hormone levels to first aid the body in maximizing its own hormone production efforts.

Boosting your own Testosterone naturally before jumping right into an exogenous testosterone therapy will:

  • help your own endocrine system stay on track longer.
  • ensure other areas of your endocrine system aren’t prematurely hindered by the introduction of an external agent.
  • keep your whole body in better health, as the requirements would inevitably provide the results.
  • save hundreds if not thousands of dollars on therapy that could/should have been avoided.
  • ensure better overall results, as long as you are able to maintain “healthy” levels.

Remember that we are organic creatures. We like to mention this often in our posts. Absolutely: Western medicine has revolutionized humanity and extended our lives by more than double the original life expectancy. That being said, it’s unequivocal that it is also wreaking havoc on our biology. As many lives as we are able to save with western medication, there are equally as high and concerning numbers that can be drawn by counting victims of western medicine side effects. The point is, we need western medicine. We must have it, and in some cases, it is actually one of the real only hopes (such as blood pressure medication) however if we find natural, effective, organic options that can really help our health without the potentiality of hindering our internal systems, we have to take a look at them. Now, IMAGINE IF THEY TASTE GOOD TOO!!!

Testosterone increasing

There are real testosterone injections increasing options out there. Natural ones that are effective and cost-effective. Now, of course, there are situations where these options may not be sufficiently effective at maintaining your hormones at the level that they need to be to really maintain your health as you’ve always enjoyed it. In these cases, it’s important to try to qualify for therapy.

If you’d like to contact us to discuss today’s blog, other testosterone increasing options, or if you are interested in talking about the requirements for qualifying for hormone therapy, call us at:

 

Testosterone Therapy Information

February 4, 2016 by admin 0 Comments

Depo Testosterone Description and Information 0 (0)

Depo Testosterone

Depo Testosterone Injection, for intramuscular injection, contains testosterone cypionate which is the oil-soluble 17 (beta)- cyclopentyl propionate ester of the androgenic hormone testosterone.

Testosterone cypionate is a white or creamy white crystalline powder, odorless or nearly so and stable in air. It is insoluble in water, freely soluble in alcohol, chloroform, dioxane, ether, and soluble in vegetable oils.

The chemical name for testosterone cypionate is androst-4-en-3-one, 17-(3-cyclopentyl-1-oxopropoxy)-, (17β)-. Its molecular formula is C27H40O3, and the molecular weight 412.61.

The structural formula is represented below:


Depo-Testosterone Injection is available in two strengths, 100 mg/mL, and 200 mg/mL testosterone cypionate.

Each mL of the 100 mg/mL solution contains:
Testosterone cypionate……………………………………………………………………….. 100 mg
Benzyl benzoate …………………………………………………………………………………. 0.1 mL
Cottonseed oil …………………………………………………………………………………… 736 mg
Benzyl alcohol (as preservative) …………………………………………………………… 9.45 mg

Each mL of the 200 mg/mL solution contains:
Testosterone cypionate ………………………………………………………………………. 200 mg
Benzyl benzoate …………………………………………………………………………………. 0.2 mL
Cottonseed oil …………………………………………………………………………………… 560 mg
Benzyl alcohol (as preservative) …………………………………………………………… 9.45 mg

Depo Testosterone – Clinical Pharmacology
Endogenous androgens are responsible for normal growth and development of the male sex organs and for maintenance of secondary sex characteristics. These effects include growth and maturation of the prostate, seminal vesicles, penis, and scrotum; development of male hair distribution, such as beard, pubic, chest, and axillary hair; laryngeal enlargement, vocal cord thickening, and alterations in body musculature and fat distribution. Drugs in this class also cause retention of nitrogen, sodium, potassium, and phosphorous, and decreased urinary excretion of calcium. Androgens have been reported to increase protein anabolism and decrease protein catabolism. Nitrogen balance is improved only when there is sufficient intake of calories and protein.

Androgens are responsible for the growth spurt of adolescence and for eventual termination of linear growth, brought about by fusion of the epiphyseal growth centers. In children, exogenous androgens accelerate linear growth rates but may cause a disproportionate advancement in bone maturation. Use over long periods may result in fusion of the epiphyseal growth centers and termination of the growth process. Androgens have been reported to stimulate the production of red blood cells by enhancing production of erythropoietic stimulation factor.

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During exogenous administration of androgens, endogenous testosterone release is inhibited through feedback inhibition of pituitary luteinizing hormone (LH). At large doses of exogenous androgens, spermatogenesis may also be suppressed through feedback inhibition of pituitary follicle-stimulating hormone (FSH).

There is a lack of substantial evidence that androgens are effective in fractures, surgery, convalescence, and functional uterine bleeding.

Pharmacokinetics
Testosterone esters are less polar than free testosterone. Testosterone esters in oil injected intramuscularly are absorbed slowly from the lipid phase; thus, testosterone cypionate can be given at intervals of two to four weeks.

Testosterone in plasma is 98 percent bound to a specific testosterone-estradiol binding globulin, and about 2 percent is free. Generally, the amount of this sex-hormone binding globulin in the plasma will determine the distribution of testosterone between free and bound forms, and the free testosterone concentration will determine its half-life.

About 90 percent of a dose of testosterone is excreted in the urine as glucuronic and sulfuric acid conjugates of testosterone and its metabolites; about 6 percent of a dose is excreted in the feces, mostly in the unconjugated form. Inactivation of testosterone occurs primarily in the liver. Testosterone is metabolized to various 17-keto steroids through two different pathways.

The half-life of testosterone cypionate, when injected intramuscularly, is approximately eight days.

In many tissues, the activity of testosterone therapy appears to depend on reduction to dihydrotestosterone, which binds to cytosol receptor proteins. The steroid-receptor complex is transported to the nucleus where it initiates transcription events and cellular changes related to androgen action.

Indications and Usage for Depo Testosterone

Depo Testosterone Injection is indicated for replacement therapy in the male in conditions associated with symptoms of deficiency or absence of endogenous testosterone.

1. Primary hypogonadism (congenital or acquired)-testicular failure due to cryptorchidism, bilateral torsion, orchitis, vanishing testis syndrome; or orchidectomy.

2. Hypogonadotropic hypogonadism (congenital or acquired)- gonadotropin or LHRH deficiency, or pituitary-hypothalamic injury from tumors, trauma, or radiation.

Safety and efficacy of Depo Testosterone (testosterone cypionate) in men with “age-related hypogonadism” (also referred to as “late-onset hypogonadism”) have not been established.

Contraindications

  1. Known hypersensitivity to the drug
  2. Males with carcinoma of the breast
  3. Males with known or suspected carcinoma of the prostate gland
  4. Women who are or who may become pregnant
  5. Patients with serious cardiac, hepatic or renal disease

Warnings

Hypercalcemia may occur in immobilized patients. If this occurs, the drug should be discontinued.

Prolonged use of high doses of androgens (principally the 17-α alkyl-androgens) has been associated with the development of hepatic adenomas, hepatocellular carcinoma, and peliosis hepatis —all potentially life-threatening complications.

Geriatric patients treated with androgens may be at an increased risk of developing prostatic hypertrophy and prostatic carcinoma although conclusive evidence to support this concept is lacking.

There have been postmarketing reports of venous thromboembolic events, including deep vein thrombosis (DVT) and pulmonary embolism (PE), in patients using testosterone products, such as testosterone cypionate. Evaluate patients who report symptoms of pain, edema, warmth, and erythema in the lower extremity for DVT and those who present with acute shortness of breath for PE. If a venous thromboembolic event is suspected, discontinue treatment with testosterone cypionate and initiate appropriate workup and management.

Long-term clinical safety trials have not been conducted to assess the cardiovascular outcomes of testosterone replacement therapy in men. To date, epidemiologic studies and randomized controlled trials have been inconclusive for determining the risk of major adverse cardiovascular events (MACE), such as non-fatal myocardial infarction, non-fatal stroke, and cardiovascular death, with the use of testosterone compared to non-use. Some studies, but not all, have reported an increased risk of MACE in association with the use of testosterone replacement therapy in men. Patients should be informed of this possible risk when deciding whether to use or to continue to use Depo Testosterone (testosterone cypionate).

Edema, with or without congestive heart failure, may be a serious complication in patients with pre-existing cardiac, renal or hepatic disease.

Gynecomastia may develop and occasionally persists in patients being treated for hypogonadism.

The preservative benzyl alcohol has been associated with serious adverse events, including the “gasping syndrome”, and death in pediatric patients. Although normal therapeutic doses of this product ordinarily deliver amounts of benzyl alcohol that are substantially lower than those reported in association with the “gasping syndrome”, the minimum amount of benzyl alcohol at which toxicity may occur is not known. The risk of benzyl alcohol toxicity depends on the quantity administered and the hepatic capacity to detoxify the chemical. Premature and low-birth weight infants may be more likely to develop toxicity.

Androgen therapy should be used cautiously in healthy males with delayed puberty. The effect on bone maturation should be monitored by assessing the bone age of the wrist and hand every 6 months. In children, androgen treatment may accelerate bone maturation without producing the compensatory gain in linear growth. This adverse effect may result in compromised adult stature. The younger the child the greater the risk of compromising final mature height.

This drug has not been shown to be safe and effective for the enhancement of athletic performance. Because of the potential risk of serious adverse health effects, this drug should not be used for such purpose.

Precautions

General

Patients with benign prostatic hypertrophy may develop acute urethral obstruction. Priapism or excessive sexual stimulation may develop. Oligospermia may occur after prolonged administration or excessive dosage. If any of these effects appear, the androgen should be stopped and if restarted, a lower dosage should be utilized.

Testosterone cypionate should not be used interchangeably with testosterone propionate because of differences in duration of action.

Testosterone cypionate is not for intravenous use.

Information for patients

Patients should be instructed to report any of the following: nausea, vomiting, changes in skin color, ankle swelling, too frequent or persistent erections of the penis.

Laboratory tests

Hemoglobin and hematocrit levels (to detect polycythemia) should be checked periodically in patients receiving long-term androgen administration.

Serum cholesterol may increase during androgen therapy.

Drug interactions

Androgens may increase sensitivity to oral anticoagulants. The dosage of the anticoagulant may require the reduction in order to maintain satisfactory therapeutic hypoprothrombinemia.

Concurrent administration of oxyphenbutazone and androgens may result in elevated serum levels of oxyphenbutazone.

In diabetic patients, the metabolic effects of androgens may decrease blood glucose and, therefore, insulin requirements.

Drug/Laboratory test Interferences

Androgens may decrease levels of thyroxine-binding globulin, resulting in decreased total T4 serum levels and increased resin uptake of T3 and T4. Free thyroid hormone levels remain unchanged, however, and there is no clinical evidence of thyroid dysfunction.

Carcinogenesis

Animal data

Testosterone has been tested by subcutaneous injection and implantation in mice and rats. The implant induced cervical-uterine tumors in mice, which metastasized in some cases. There is suggestive evidence that injection of testosterone into some strains of female mice increases their susceptibility to hepatoma. Testosterone is also known to increase the number of tumors and decrease the degree of differentiation of chemically induced carcinomas of the liver in rats.

Human data

There are rare reports of hepatocellular carcinoma in patients receiving long-term therapy with androgens in high doses. Withdrawal of the drugs did not lead to regression of the tumors in all cases.

Geriatric patients treated with androgens may be at an increased risk of developing prostatic hypertrophy and prostatic carcinoma although conclusive evidence to support this concept is lacking.

Pregnancy

Teratogenic Effects

Pregnancy Category X. (See CONTRAINDICATIONS.)

Benzyl alcohol can cross the placenta. See WARNINGS.

Nursing Mothers

Depo Testosterone is not recommended for use in nursing mothers.

Pediatric use

Safety and effectiveness in pediatric patients below the age of 12 years have not been established.

Adverse Reactions

The following adverse reactions in the male have occurred with some androgens:

Endocrine and urogenital: Gynecomastia and excessive frequency and duration of penile erections. Oligospermia may occur at high dosages.

Skin and appendages: Hirsutism, male pattern of baldness, seborrhea, and acne.

Cardiovascular Disorders: myocardial infarction, stroke.

Fluid and electrolyte disturbances: Retention of sodium, chloride, water, potassium, calcium, and inorganic phosphates.

Gastrointestinal: Nausea, cholestatic jaundice, alterations in liver function tests, rarely hepatocellular neoplasms and peliosis hepatis (see WARNINGS).

Hematologic: Suppression of clotting factors II, V, VII, and X, bleeding in patients on concomitant anticoagulant therapy, and polycythemia.

Nervous system: Increased or decreased libido, headache, anxiety, depression, and generalized paresthesia.

Allergic: Hypersensitivity, including skin manifestations and anaphylactoid reactions.

Vascular disorders: Venous thromboembolism.

Miscellaneous: Inflammation and pain at the site of intramuscular injection.

Drug Abuse and Dependence

Controlled Substance Class

Testosterone is a controlled substance under the Anabolic Steroids Control Act, and Depo Testosterone Injection has been assigned to Schedule III.

Overdosage

There have been no reports of acute overdosage with the androgens.

Depo Testosterone Dosage and Administration

Prior to initiating Depo Testosterone (testosterone cypionate), confirm the diagnosis of hypogonadism by ensuring that serum testosterone concentrations have been measured in the morning on at least two separate days and that these serum testosterone concentrations are below the normal range.

Depo Testosterone Injection is for intramuscular use only.

It should not be given intravenously. Intramuscular injections should be given deep in the gluteal muscle.

The suggested dosage for Depo Testosterone Injection varies depending on the age, sex, and diagnosis of the individual patient. Dosage is adjusted according to the patient’s response and the appearance of adverse reactions.

Various dosage regimens have been used to induce pubertal changes in hypogonadal males; some experts have advocated lower dosages initially, gradually increasing the dose as puberty progresses, with or without a decrease to maintenance levels. Other experts emphasize that higher dosages are needed to induce pubertal changes and lower dosages can be used for maintenance after puberty. The chronological and skeletal ages must be taken into consideration, both in determining the initial dose and in adjusting the dose.

For replacement in the hypogonadal male, 50400 mg should be administered every two to four weeks.

Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. Warming and shaking the vial should redissolve any crystals that may have formed during storage at temperatures lower than recommended.

How is Depo Testosterone Supplied

Depo Testosterone Injections is available as follows:

100 mg/mL
10 mL vials                    NDC 0009-0347-02

200 mg/mL
1 mL vials                      NDC 0009-0417-01
10 mL vials                    NDC 0009-0417-02

Vials should be stored at controlled room temperature 20° to 25°C (68° to 77°F) [see USP]. Protect from light.

January 6, 2016 by admin 0 Comments

What is Testosterone-Cypionate? 0 (0)

Testosterone-Cypionate the form of testosterone provided most often in testosterone therapy. It’s a specific form of testosterone, slightly different than what human bodies produce on their own, but for reasons essential to its administration to the body. To maximize the benefits of male hormone therapy, testosterone Cypionate is one of the types of testosterone a person can inject or get in a gel. There are very specific reasons why this form of testosterone is most popular for therapy.

Testosterone is the substance produced in human bodies that regulate the expression of male characteristics. It also promotes healing and mental well-being. It’s a relatively small organic molecule that isn’t a protein or peptide-like HGH, but instead is very similar to cholesterol or Vitamin E; it’s a hydrocarbon ring, an oil-soluble type of substance. It travels to all parts of the body through the blood. In males, it’s produced by specific cells in the testicles, triggered by signals from the brain, which also travel through the blood. The amount of testosterone in a man’s blood correlates directly with the masculine traits he exhibits, i.e., being hairy, being strong, and having physical and mental energy.

The human body produces a natural form of testosterone.

When humans produce testosterone in their body, the specific type of testosterone that’s produced is just plain testosterone. No additional fragment is stuck to it, as in the case of testosterone-Cypionate where what’s called a Cypionate moiety is stuck to one end of the testosterone molecule.  Technically, human bodies don’t produce the Cypionate form, but doses of testosterone injections are taken in the Cypionate form as opposed to just plain testosterone by itself.

what is testosterone cypionate used if the body doesn’t make that form?

When testosterone-Cypionate is administered in the form of a gel or injection, the body converts the Cypionate form into plain testosterone. There are enzymes called esterases that target the connection between the Cypionate moiety and the testosterone molecule, breaking off the Cypionate from testosterone, leaving plain testosterone in the form that the body uses it. These esterases yield the same molecule of testosterone the body produces. This is why testosterone-Cypionate is referred to as bio-identical testosterone, putting it into the body is essentially equivalent to increasing what the body has made at one time and is already capable of using, natural testosterone in the form the body uses it.

A time-release effect provides stable hormone levels.

The reason the Cypionate form is administered, as opposed to just plain testosterone, is to provide a time-release type of effect. Making the molecule more oil-soluble tends to stabilize the blood levels of free testosterone, releasing more gradually over time. If free testosterone were injected directly, we’d observe a peak in its blood concentration immediately after injection followed by a rapid decrease thereafter. By injecting the Cypionate form, more of the testosterone gets absorbed by the body’s fatty tissue to be released more gradually over time. It gets dissolved into the blood more slowly, and the blood concentrations of testosterone Therapy resemble a more stable pattern useful for therapy. Instead of having to get multiple injections daily, with testosterone-Cypionate you can instead space out injections on the order of weeks.

As we discussed in our previous blog post about the different forms of testosterone, testosterone-Cypionate is only one out of several that are included in therapeutic doses. The dosage and forms that are prescribed to anti-aging patients differ from patient to patient. Whatever form is prescribed, it’s important to follow dosage instructions as precisely as possible. Both the form and the dosage times are chosen together to provide the most stable, consistent hormone levels possible, getting the most benefits with the least side effects.

 

 

December 27, 2015 by Joseph Fermin 0 Comments

Sleep Disturbance and the link Between Hormones 0 (0)

Sleep Disturbance and the link Between Hormones

Sleep disturbance affects every facet of our existence. Many sleep-related problems can be overcome with testosterone therapy. Men with lower testosterone levels have lower sleep efficiency, with increased nocturnal awakenings and less slow-wave (REM) sleep. Studies have even shown that sleep disturbances caused by sleep apnea, a chronic breathing problem, may be linked to low testosterone levels.

In a 2011 study published in the Journal of the American Medical Association (JAMA), ten men volunteered to have their testosterone levels checked during eight nights of Sleep Disturbance restriction. They were only allowed five hours of sleep per night. The study found their daytime testosterone levels decreased by 10 to 15 percent. The lowest testosterone levels were in the afternoon and evening. The study also found a progressive loss of energy over the course of the week.

The Danger of Low Testosterone, Risks Associated with Low hGH in Men, HGH Side Effects, What Causes Low Testosterone, testosterone therapy preventive medicine

Thus, there appears to be a direct correlation between testosterone levels and Sleep quantity and quality. Here at AAI Rejuvenation Clinic, we’re ready to help. Our services are discrete and confidential. Contact us today or fill out our medical history form. Our trained wellness team is eager to get you started on the path to a better night’s sleep.

Sleep Studies

There have been an array of medical studies pointing to the fact that Sleep Disturbance, or lack thereof, has a direct correlation to our energy levels, cognitive functions and even organ and cellular health. Most commonly, adults are expected to sleep around 9 hours a day in order to get the adequate amount necessary for optimal systemic function. Unfortunately, the great majority of people get far less sleep than is necessary and recommended. Moreover, the number of people that are getting poor quality of sleep is slowly but surely increasing, leaving us to walk around in a world full of sleep-deprived, moody zombies.

Let’s talk about scary numbers:

– 60% of adults are not getting enough sleep
– The average American is in bed 7.5 hours but only asleep about 6.1.

Recommended sleep requirements:

– Toddlers   = 14 – 12 hours
– Children   = 11 – 10 hours
– Adults     = 9 – 7 hours

  • Sleep just 6 hours a night and increase the chances of being overweight by 27% (about 14lbs a year).
  • Sleep 6 hours a day and increase the possibility of heart disease by 48%.
  • Sleep only 5 hours and increase this risk to 73%.
  • Sleeping less than 5 hours a day reduces your hormonal production by 27% and interferes with other endocrine functions so complex, you cannot measure them by a simple % indication.
  • Sleep only 4 hours a night and you will increase daily calorie intake by 22%.
  • Reducing your average night sleep by 1.5 hours impairs alertness by 32%.
  • If you only sleep 6 hours a night for 2 weeks straight your cognitive equivalence to blood alcohol level will be .10%.
  • Driving while sleepy can be equally, if not more dangerous than driving while drunk.
  • Driving while sleepy accounts for 20% of all annual car accidents.
  • There is a gene that allows people to function well only 6 hours of sleep but, it only exists in 3% of the population.

Positive sleeping points:

  • Sleeping more is not an option? Take a nap: a 20-minute nap increases cognitive function by 40%, enhancing concentration, alertness and motor skills.
  • A 45-minute nap with REM sleep enhances creative thinking and boosts sensory processing.
  • Naps over 45 or 90 minutes will leave you groggy and disoriented.
  • Complete darkness stimulates melatonin – sleep hormone.

AAI Clinics can help you with Sleep Disturbance issues. If you find that you are not acquiring the adequate amount of sleep necessary to really promote your best potential and healthiest self, contact us for assistance. Despite the fact that well-balanced hormone levels significantly aid and promote restful quality of sleep, there are other nutraceuticals that we can provide needing patients with in order to promote real deep, quality sleep that isn’t induced by synthetic drug absorption.

Depending on your particular issues and life circumstances, you will want to click on the below medications to read the herbal facts and medicinal details of each of the below body-and-mind calming options to see which one of these, or combination of these, will best aid you in your quest for real quality sleep.

        • L-Tryptophan
        • Sereniten Plus
        • Relora ®-Plex
        • Seditol ® Plus
        • Brain CALM
        • Valerian Root Max-V
        • Valsed
        • Melatonin (3 mg)
        • Controlled-Release Melatonin

 

**NOTE**  The content contained in this blog is subject to interpretation and is the opinion of the content writer.  We do not claim it to be fact.  We encourage you to consult a medical doctor before taking any prescribed medications or supplements.

October 27, 2015 by Joseph Fermin 1 Comment

NANDROLONE DECANOATE INJECTION 0 (0)

NANDROLONE DECANOATE INJECTION

NANDROLONE DECANOATE General Information

Nandrolone decanoate is a parenteral anabolic steroid. It is primarily used to treat anemia, chronic renal failure, osteoporosis, and AIDS-associated wasting syndrome. This agent is known to increase hemoglobin and red cell mass. With the development of recombinant human erythropoietin, nandrolone decanoate use in anemia associated with chronic renal failure has declined. It has also been the subject of drug misuse and abuse, often producing adverse effects such as changes in libido, hepatotoxicity, increased risk of cardiovascular disease, and antisocial behavior. Some of the masculinizing effects in women can be irreversible. Nandrolone decanoate was approved by the FDA in 1983 and became a controlled substance in 1991.

Mechanism of Action

Nandrolone decanoate shares the actions of endogenous androgens such as testosterone. Exogenous androgens such as nandrolone decanoate promote protein anabolism and stimulate appetite which results in a reversal of catabolic processes and negative nitrogen balance. Increases in lean body mass in patients with cachexia (e.g., malnourished dialysis patients) and decreased bone resorption and increased bone density in patients with osteoporosis are often noted. Blood glucose, erythrocyte production, and the balance of calcium are also affected by androgens. Increased erythrocyte production is apparently due to enhanced production of an erythropoietic stimulating factor. Patients with anemia associated with renal disease will have increases in red blood cell volume and hemoglobin after receiving nandrolone decanoate.

Since nandrolone decanoate has actions similar to endogenous androgens, administration of nandrolone decanoate has the possibility of causing serious disturbances of growth and sexual development if given to young children and causing unwanted adverse effects in women. Exogenous androgens suppress gonadotropin-releasing hormone, thereby reducing the gonadotropic function of the pituitary through a negative-feedback mechanism. This results in a reduction of endogenous testosterone, luteinizing hormone, and follicle-stimulating hormone. Exogenous androgens may also have a direct effect on the testes. Reversible increases in low-density lipoproteins (LDL) and decreases in high-density lipoproteins (HDL) also occur.

**NOTE**  The content contained in this blog is subject to interpretation and is the opinion of the content writer.  We do not claim it to be fact.  We encourage you to consult a medical doctor before taking any prescribed medications or supplements.

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October 5, 2015 by admin 0 Comments

Why Do We Age? The Reasons for Aging Explained 0 (0)

Why Do We Age? The Reasons for Aging Explained

Why do we age? This is the one question everyone wonders about but never gets an answer to. The whole Anti-Aging industry talks about everything else under the sun but avoids the question. “why do we age?” Why do they avoid it? They avoid it because they don’t know the answers. The problem is if one does not know the answer to that thorny question, a proposed treatment protocol for aging, while effective, leaves a lingering doubt in the minds of patients that something is not wholly right.

Patients may still buy a protocol, but we do not want any lingering doubts concerning anything having to do with the Anti-Aging subject. In fact the question “why do we age at all?” is so fundamentally basic that almost no patient even asks the question verbally. But, in their deeper mind, that question lingers unanswered for as long as the patient is involved in Anti-Aging and Rejuvenation.

How do I know? In 2003 I gave a questionnaire to some 400 clients with 20 questions. They were asked out of these 20 questions which one would they like answered the most? 78% checked.

Why Do We Age?, Why Do We Age? The Reasons for Aging Explained

Let us now look at some of the reasons we age.

  • Wear and tear theory. In this theory, medical scientists agree that constant use of the human body wears out its vital parts and components. Did you know that 2.5 million red blood cells die every second and are instantly replaced by another 2.5 million new red blood cells every second? The human heart must pump 2000 gallons of blood a day. In a lifetime we will pump 2 million gallons of blood, enough to fill 2 supertankers. The heart must beat 100,000 times per day…that is 35 million beats per year and over 2.5 Billion beats in the average lifetime. So the extreme repetitive use of the body simply wears out all of its parts over time. This is, without the doubt, one of the reasons the body ages, but not the only one….and not a reason that can not be overcome by the correct Anti-Aging Protocol.
  • Genes vs. Lifestyles. According to this theory of aging, your biological clock is ticking away at a predetermined rate. This theory says that your genetic DNA holds the key to your planned rate of demise from day one. Basically, this theory of aging says your genes determine everything about you including the exact age you will live to be. While there is a genetic component to aging, scientists have found that what you do with your environmental factors has a greater determination on how you will age and how long you will live.
  • Use it or lose it the theory of aging. This is a very simple theory which says the body is in need of constant daily tune-ups. So if you do not use your muscles they will atrophy and this is true. The less you use your muscles the less they will be in their peak prime condition. The less sexual activity you have the less well your sex organs will function and so on. In a way, this theory is the opposite of the wear and tear theory of aging. Without question, there is some merit to this theory. Scientists who believe in this theory even say we should allow ourselves to be exposed to germs so our immune system will get a workout and be in better shape for the long run. True enough but this theory alone does not fully explain aging even though it is a part of how we do age.
  • Short Telomere Theory of Aging. This is one of the most important discoveries ever made to the way our bodies age and why. Inside the nucleus of our cells, genes are arranged along twisted double-stranded molecules of DNA called chromosomes. At the ends of the chromosomes are stretches of DNA called telomeres, which protect our genetic data, make it possible for cells to regenerate and divide, and hold some great secrets to how we age. Telomeres have been compared with the plastic tips on shoelaces because they keep chromosome ends from fraying and sticking to each other, which would destroy our genetic information. Here is the massive problem: Each time a cell divides the telomeres get shorter… when they get too short the cell cannot regenerate anymore and dies. The telomeres in cancer cells never shorten and thus make cancer immortal cells which divide forever unless we kill them with radiation and chemo. So what we are looking for as in the starfish which is immortal and has telomeres that never shorten is the same for humans…we want to figure out how to make it so that human cells telomeres do not shorten with each cell division. One substance we have found that makes telomeres longer is HGH (Human Growth Hormone.) We have also discovered that a key component in the Ashwagandha herb, makes telomeres longer. Without question, this is a way to increase lifespan and foster better health. Both HGH and Ashwagandha work to make telomeres longer by creating the enzyme telomerase. Youthful blood levels of both Estrogen and Testosterone increase the length of telomeres by creating more telomerase. So much of what Anti-Aging protocols are doing actually eventuate in making more telomerase and thus longer telomeres. Here at AAI, we find this extremely important and exciting as we are always researching daily how to find new methods of creating longer telomeres and thus longer, healthier life.

We are just scratching the surface in the expose of what makes humans age and how to reverse that process. Here at AAI. we will continue to make new information like this available to the public as well as keeping some important discoveries private and proprietary to AAI and their clients only.

We are greatly encouraged that our longevity educational doctor; Our Dr. has discovered several additional herbs from Russia which makes the telomeres longer. Our Dr. is committed to finding enough telomere increasing substances from nature to keep all of our telomeres long enough to make a very serious contribution to increased lifespan and vigorous, perfected states of good health.

If you want to know more about how anti-aging therapies can work for you, don’t wait.

Contact AAI Rejuvenation Clinics today

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Why do we age

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