What are the different forms of testosterone?
The Different Forms of Testosterone
Forms of Testosterone, there are several chemical forms of testosterone. People who are prescribed hormone therapy often ask about the fact that hormones come in different forms, chemically. While sometimes it doesn’t matter what exact chemical form a nutrient or supplement is in, for hormones, the different chemical forms do matter. There are two popularly prescribed forms of testosterone injections: testosterone cypionate and testosterone enanthate. Although they both eventually act in the form of free testosterone in the body, each has different initial characteristics and effects on male physiology.
A patient recently asked Dr. Larry:
Dr. Larry responded:
- Enanthate has been reported in patients to provide a more immediate, observable effect compared to cypionate. This is due to the slight chemical difference between the two.
- Enanthate has a 7-carbon ester chain while cypionate has an 8-carbon ester chain. The more carbons the ester group has, the more soluble in oil and the less soluble in water it becomes. As a result, cypionate has a slightly slower release and longer active life.
- Enanthate is manufactured widely throughout the world, while cypionate is less common outside the USA. Hence, cypionate tends to be more common in the States.
- Enanthate is suspended in sesame oil; cypionate is suspended in cottonseed oil.
- Due to being one atom lighter, enanthate has more testosterone per mg. The difference is insignificant, though, perhaps a few milligrams amount of steroid more.
- propionate was first described in 1935 as a drug that increased the therapeutic potential of synthetic testosterone by slowing its release into the bloodstream. It was released for clinical use two years later by Schering AG in Germany as a hybrid blend with testosterone enanthate under the brand name Testoviron. This was also the first commercially available version of testosterone Therapy on the U.S. prescription drug market, and it remained the dominant form of testosterone globally until 1960.