How Does hGH Work, And
What Are its Biological Roles?

Because plays a critical role in so many biological processes, maintaining healthy GH levels can manifest positively in almost every aspect of your life.

As the name suggests, one of the main roles of growth hormone is to stimulate growth, cellular healing, and tissue regeneration. It exerts a number of direct effects in skeletal muscle, and also stimulates the production of insulin-like growth factor-I (IGF-I) in Kupffer cells in the liver, as well as various other tissues. IGF-I plays critical roles in a number of tissues, including muscle. For example, it increases proliferation, differentiation, and repair, as well as protein synthesis; it is essential for building muscle strength and mass.

GH also has a number of effects on carbohydrate, lipid, and protein metabolism; some of these effects are exerted directly by GH, and others indirectly via IGF-I. Specifically, GH stimulates protein synthesis, decreases protein oxidation, and increases amino acid uptake. For fat metabolism, GH stimulates triglyceride oxidation and uptake to enhance fat utilization. Finally, exogenous GH helps maintain healthy blood sugar levels by suppressing the ability of insulin to stimulate glucose uptake and synthesis. However, surprisingly, endogenously administered GH stimulates insulin secretion.

Taken together, these metabolic effects mean that GH help restore your metabolism back to the speeds you experienced when you were in your 20s. However, it is important to be realistic. GH is not a magic weight loss cure, and not everyone that administers hGH will experience significant weight loss. If you were able to eat whatever you wanted when you were young and not gain weight, then it is reasonable to expect hGH therapy to help bring your metabolism back to the rate that allowed you to indulge and remain in great physical shape.

Although GH is released from the pituitary gland into the circulation, it also has important roles in the brain, including neurogenesis, myelin synthesis, neural stem cell activation, and dendritic branching. Therefore, the combination of hGH therapy and additional physician-supervised medicinal protocols may actually repair damaged brain tissue and stimulate the growth of neurons.

GH and IGF-I also have several important functions in the bone, including regulating bone growth, mass, remodeling, and metabolism. The increase in bone mass that occurs during childhood, puberty, and into the mid-20s is caused by the combination of bone remodeling (new bone formation and bone resorption) and growth. GH stimulates IGF-I production, which promotes bone resorption by enhancing bone formation, stimulating osteoclast differentiation, and increasing osteoblast proliferation. As we age, the reduced circulating levels of GH decrease bone remodeling and lead to a gradual reduction in bone mineral density. A long-term deficiency in GH levels has a serious impact on bone health. Therefore, GH supplementation can help repair damaged bones and improve bone strength and rigidity.

As mentioned above, GH and IGF-I are critical for a number of processes in muscle. For example, they help worn muscle tissue recuperate after working out. The successful building of muscle mass requires existing muscle fibers to be repeatedly injured and repaired. These complex processes are regulated by a variety of proteins including GH and IGF-I and a resident cell population within skeletal muscles called satellite cells. Muscle damage activates satellite cells via a variety of signaling factors; active satellite cells then repair the muscle fibers by multiplying and fusing together to form muscle fibers. As muscle grows, myofibers become larger. Protein synthesis, which is also activated by GH and IGF-I, also plays a key role.

As you can see, GH and IGF-I have critical functions in numerous aspects of our biology and physiology. If you have any specific questions related to the actions of hGH and their effects on your physiology, please contact us directly at AAI Clinics. We will answer all basic therapy-related questions you might have without charge. We will be with you on every step of your journey, from the beginning to the very end, when you will feel younger, healthier, and have more energy. How does hGH work?

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